{"product_id":"viral-oncology-isbn-9780470379912","title":"Viral Oncology","description":"Clinical oncologists and researchers now have a comprehensive single source of current information on cancer viruses obtained from bench and bedside. This important refernce allows further development of translational approaches for the effective treatment of patients with virus-associated malignancies. The book contains 25 chapters covering basic and clinical aspects of viruses, including HPV, HBV, HCV, polyomaviruses, Kaposi’s associated viruses, retroviruses (including HIV-1 associated malignancies), and EBV. Several chapters are devoted to basic science of oncogenic viruses for the study of their pathogenesis, drug development, and employment of viral vectors for vaccine and gene therapy. Clinical materials are embedded within chapters, and there are also complementary, clinically based chapters describing natural courses and treatments. \u003cp\u003eForeword vii\u003c\/p\u003e \u003cp\u003ePreface xi\u003c\/p\u003e \u003cp\u003eContributors xiii\u003c\/p\u003e \u003cp\u003e1 HUMAN PAPILLOMAVIRUS-ASSOCIATED CANCERS 1\u003cbr\u003e\u003ci\u003eRachel A. Katzenellenbogen and Denise A. Galloway\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 MOLECULAR EVENTS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS-INDUCED HUMAN CANCERS 23\u003cbr\u003e\u003ci\u003eAmy Baldwin and Karl Münger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 THE ROLE OF THE HUMAN PAPILLOMAVIRUS E6 ONCOPROTEIN IN MALIGNANT PROGRESSION 57\u003cbr\u003e\u003ci\u003eMiranda Thomas, David Pim, and Lawrence Banks\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 JC VIRUS ASSOCIATION WITH BRAIN TUMORS: THE ROLE OF T ANTIGEN AND INSULIN-LIKE GROWTH FACTOR 1 IN DNA REPAIR FIDELITY 89\u003cbr\u003e\u003ci\u003eKrzysztof Reiss, Kamel Khalili, and Luis Del Valle\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 INVOLVEMENT OF THE POLYOMAVIRUS, JC VIRUS, IN COLORECTAL CANCER 113\u003cbr\u003e\u003ci\u003eC. Richard Boland, Luigi Ricciardiello, and Ajay Goel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 POSSIBLE ASSOCIATION OF BK VIRUS WITH PROSTATE CANCER 129\u003cbr\u003e\u003ci\u003eMichael J. Imperiale and Dweepanita Das\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 ONCOGENIC TRANSFORMATION BY POLYOMAVIRUS LARGE T ANTIGEN 149\u003cbr\u003e\u003ci\u003eAbhilasha V. Rathi and James M. Pipas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 SIMIAN VIRUS 40, HUMAN INFECTIONS, AND CANCER: EMERGING CONCEPTS AND CAUSALITY CONSIDERATIONS 165\u003cbr\u003e\u003ci\u003eJanet S. Butel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 SIMIAN VIRUS 40 AND MESOTHELIOMA 191\u003cbr\u003e\u003ci\u003eNatalya Baranova and Michele Carbone\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 MOLECULAR IMMUNOBIOLOGY OF HEPATITIS B-ASSOCIATED VIRAL CANCER 211\u003cbr\u003e\u003ci\u003eTimothy M. Block and Anand S. Mehta\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 HEPATITIS B VACCINE AND HEPATOCELLULAR CARCINOMA 225\u003cbr\u003e\u003ci\u003eMei-Hwei Chang and Ding-Shinn Chen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 PATHOGENESIS OF ACUTE AND CHRONIC HEPATITIS C VIRUS INFECTION 243\u003cbr\u003e\u003ci\u003eMark A. Feitelson, Helena M.G.P.V. Reis, Jingbo Pan, and Bill Sun\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 MOLECULAR MECHANISMS OF HEPATITIS C VIRUS-INDUCED CELLULAR TRANSFORMATION 267\u003cbr\u003e\u003ci\u003eDonna Sir and Jing-Hsiung James Ou\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 CLINICAL ASPECTS OF HTLV-1-ASSOCIATED CANCER 279\u003cbr\u003e\u003ci\u003eMasao Matsuoka\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 ONCOGENIC POTENTIAL OF THE HTLV-1 TAX PROTEIN 295\u003cbr\u003e\u003ci\u003eSusan J. Marriott\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 HIV-1-ASSOCIATED MALIGNANCY: BASIC AND CLINICAL ASPECTS 317\u003cbr\u003e\u003ci\u003eMelissa Agsalda and Bruce Shiramizu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 HIV-RELATED LYMPHOMA 337\u003cbr\u003e\u003ci\u003eGiulia De Falco, Cristiana Bellan, Stefano Lazzi, and Lorenzo Leoncini\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 BIOLOGY AND EPIDEMIOLOGY OF HHV-8 351\u003cbr\u003e\u003ci\u003eVeenu Minhas and Charles Wood\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 THE ROLE OF KSHV IN PATHOGENESIS OF KAPOSI’S SARCOMA 377\u003cbr\u003e\u003ci\u003eGary S. Hayward, Donald J. Alcendor, and Ravit Arav-Boger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 MOLECULAR PATHOBIOLOGY OF EBV INFECTION 409\u003cbr\u003e\u003ci\u003eJoseph S. Pagano\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 EPSTEIN–BARR VIRUS AS A PATHOGEN 425\u003cbr\u003e\u003ci\u003eWasim A. Dar and Bill Sugden\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 453\u003c\/p\u003e \"The book is addressed to medical students as well as clinical scientists and students of molecular biology. In a rapidly growing field it is a great advantage to have all this valuable information in one volume.\" (Journal Tropical Ped, 2012)  \u003cp\u003e \"I would recommend this book to all interested in the role that viruses play in cancer development, students and experienced researchers alike.\" (\u003ci\u003eSociety for General Microbiology\u003c\/i\u003e, July 2010)\u003c\/p\u003e \u003cp\u003e\u003cb\u003eKamel Khalili\u003c\/b\u003e, PhD, Professor and Chair, Department of Neuroscience, Temple University, and \u003cb\u003eKuan-Teh Jeang\u003c\/b\u003e, MD, PhD, Head, Molecular Virology Section, National Institute of Allergy and Infectious Diseases, NIH, are among the leading scientists in the field of human DNA and RNA viruses. Each of them has more than 25 years' experience in studying oncogenic viruses.\u003c\/p\u003e  \u003cb\u003eA comprehensive look at the latest research findings and clinical applications of oncogenic viruses\u003c\/b\u003e  \u003cp\u003eWritten by a panel of academic experts, \u003ci\u003eViral Oncology\u003c\/i\u003e is the first self-contained and comprehensive book to present both scientific and clinical information on viruses linked to some of the most important human cancers. Readers can turn to this book for the most in-depth and up-to-date coverage of: HPV-associated cancers; molecular events associated with HPV-induced human cancer; the role of the HPV E6 oncoprotein in malignant progression; virus association with brain tumors; involvement of the polyomavirus JCV in colorectal cancer; possibleassociation of BKV with prostate cancer; oncogenic transformation bypolyomavirus large T antigen; SV40 and human cancer; SV40 and mesothelioma; molecular immunology of hepatitis B–associated viral cancer; hepatitis B vaccine and hepatocellular carcinoma; pathogenesis of acute and chronic hepatitis Cvirus infection; molecular mechanisms of hepatitis C virus-induced cellulartransformation; clinical aspects of HTLV-1 associated cancer; oncogenic potential of the HTLV-1 tax protein; HIV-associated malignancy; HIV-related lymphoma; biology and epidemiology of HHV-8; the role of KSHV in pathogenesis of Kaposi'ssarcoma; molecular pathobiology of EBV infection; and EBV as a pathogen.\u003c\/p\u003e \u003cp\u003eSeveral chapters are devoted to the basic science of oncogenic viruses for thestudy of their pathogenesis, drug development, and employment of viral vectorsfor vaccine and gene therapy. The book also includes complementary clinically based chapters describing natural courses and treatments. Additionally, bonusclinical materials are embedded within chapters and an easy-to-use indexcompletes the book.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eViral Oncology\u003c\/i\u003e is an essential resource for clinical and research oncologists in medical facilities and biological research laboratories; clinicians and scientists working in related biomedical areas; medical students working toward a first or higher degree in the life sciences and other biomedical fields; and pharmaceutical scientists and developers.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47990454386917,"sku":"NP9780470379912","price":213.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470379912.jpg?v=1761787897","url":"https:\/\/k12savings.com\/products\/viral-oncology-isbn-9780470379912","provider":"K12savings","version":"1.0","type":"link"}