{"product_id":"vaccinology-isbn-9781405185745","title":"Vaccinology","description":"\u003cp\u003eCovering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe.\u003c\/p\u003e \u003cul\u003e \u003cli\u003eReviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application\u003c\/li\u003e \u003cli\u003eIncludes evaluation of vaccine efficacy and safety\u003c\/li\u003e \u003cli\u003eDetails clinical trial design, including regulatory requirements\u003c\/li\u003e \u003cli\u003eDiscusses the emerging field of active cellular immunotherapy\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eVaccinology: Principles and Practice\u003c\/i\u003e provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.\u003c\/p\u003e \u003cp\u003eList of Contributors viii\u003c\/p\u003e \u003cp\u003ePreface xii\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 1 Introduction\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Concept and Scope of Modern Vaccines 3\u003cbr\u003e\u003ci\u003eD. Huw Davies, Clint S. Schmidt, \u0026amp; Nadeem A. Sheikh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 2 Principles of Vaccine Design\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2 Strategies to Stimulate Innate Immunity for Designing Effective Vaccine Adjuvants 15\u003cbr\u003e\u003ci\u003eHeather L. Wilson, Scott Napper, George K. Mutwiri, Sylvia van Drunen Littel-van den Hurk, Hugh Townsend, Lorne A. Babiuk, Andrew A. Potter, \u0026amp; Volker Gerdts\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules 29\u003cbr\u003e\u003ci\u003eAntony N. Antoniou, Izabela Lenart, David B. Guiliano, \u0026amp; Simon J. Powis\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Understanding the Mucosal Immune System for Better Mucosal Vaccine Design 47\u003cbr\u003e\u003ci\u003eJanine Bilsborough \u0026amp; Joanne L. Viney\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Immunologic Memory: T Cells in Humans 61\u003cbr\u003e\u003ci\u003eMaria Candela Iglesias, Victor Appay, \u0026amp; Arnaud Moris\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Immunologic Memory: B cells 79\u003cbr\u003e\u003ci\u003eF. Eun-Hyung Lee \u0026amp; Iñaki Sanz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Utility of Mouse Models in Vaccine Design and Development 94\u003cbr\u003e\u003ci\u003eCatharine M. Bosio, Megan MacLeod, Philippa Marrack, \u0026amp; Ross M. Kedl\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Utility of Nonhuman Primate Models for Vaccines 110\u003cbr\u003e\u003ci\u003ePreston A. Marx, Jr \u0026amp; Alexander F. Voevodin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 3 Antigen Discovery\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9 Sequence-Based Computational Approaches to Vaccine Discovery and Design 133\u003cbr\u003e\u003ci\u003eDarrick Carter\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Antigen Discovery for Vaccines Using High-throughput Proteomic Screening Technologies 150\u003cbr\u003e\u003ci\u003eD. Huw Davies\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Phage Libraries 168\u003cbr\u003e\u003ci\u003eAaron K. Sato\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 4 Antigen Engineering\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12 Attenuated Bacterial Vaccines 181\u003cbr\u003e\u003ci\u003eRichard W. Titball \u0026amp; Helen S. Atkins\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Virus-like Particles as Antigen Scaffolds 196\u003cbr\u003e\u003ci\u003eBryce Chackerian \u0026amp; John T. Schiller\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Recombinant MVA vaccines: Optimization, Preclinical, and Product Development 209\u003cbr\u003e\u003ci\u003eYper Hall \u0026amp; Miles W. Carroll\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Recombinant Adenoviruses for Vaccination 224\u003cbr\u003e\u003ci\u003eNelson Cesar Di Paolo, Dmitry Shayakhmetov, \u0026amp; André Lieber\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Recombinant Avipoxviruses 237\u003cbr\u003e\u003ci\u003eMichael A. Skinner \u0026amp; Stephen M. Laidlaw\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Intracellular Facultative Bacterial Vectors for Cancer Immunotherapy 255\u003cbr\u003e\u003ci\u003ePatrick Guirnalda, Laurence Wood, Matthew Seavey, \u0026amp; Yvonne Paterson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Nucleic Acid Vaccination 275\u003cbr\u003e\u003ci\u003eBritta Wahren \u0026amp; Margaret A. Liu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Artificial Antigen-presenting Cells: Large Multivalent Immunogens 286\u003cbr\u003e\u003ci\u003eMatthew F. Mescher \u0026amp; Julie M. Curtsinger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 5 Delivery Systems\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e20 Transcutaneous Immunization via Vaccine Patch Delivery System 303\u003cbr\u003e\u003ci\u003eRobert C. Seid, Jr \u0026amp; Gregory M. Glenn\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Needle-free Jet Injection for Vaccine Administration 324\u003cbr\u003e\u003ci\u003eBrian R. Sloat, Hoi K. Tran, \u0026amp; Zhengrong Cui\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 Oral Vaccines: An Old Need and Some New Possibilities 336\u003cbr\u003e\u003ci\u003eAmit A. Lugade, Kalathil Suresh, \u0026amp; Yasmin Thanavala\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 Adjuvants: From Serendipity to Rational Discovery 348\u003cbr\u003e\u003ci\u003eDerek T. O’Hagan \u0026amp; Andreas Wack\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 Immunostimulatory Properties of Biodegradable Microparticles 361\u003cbr\u003e\u003ci\u003eFiona A. Sharp \u0026amp; Ed C. Lavelle\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25 Co-administration of Co-stimulatory Moieties 375\u003cbr\u003e\u003ci\u003eCarolina Arancibia-Cárcamo \u0026amp; Yvette Latchman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26 Toll Receptors in Relation to Adjuvant Effects 393\u003cbr\u003e\u003ci\u003eDipshikha Chakravortty, Amit Lahiri, \u0026amp; Priyanka Das\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 6 Regulatory Considerations\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e27 Regulatory Issues (FDA and EMA) 403\u003cbr\u003e\u003ci\u003eMurrium Ahmad, Victoria Byers, \u0026amp; Peter Wilson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 7 Evaluating Vaccine Efficacy\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e28 Immune Monitoring Design within the Developmental Pipeline for an Immunotherapeutic or Preventive Vaccine 419\u003cbr\u003e\u003ci\u003eSylvia Janetzki, Pedro Romero, Mario Roederer, Diane L. Bolton, \u0026amp; Camilla Jandus\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e29 Clinical Development Strategy: Nuts and Bolts 441\u003cbr\u003e\u003ci\u003eCandida Fratazzi \u0026amp; Claudio Carini\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e30 Current Approaches to Identify and Evaluate Cancer Biomarkers for Patient Stratification 452\u003cbr\u003e\u003ci\u003eRobert Rees, Stephanie Laversin, Cliff Murray, \u0026amp; Graham Ball\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 8 Implementing Immunizations\/Therapies\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e31 Mass Immunization Strategies 467\u003cbr\u003e\u003ci\u003eDavid L. Heymann, R. Bruce Aylward, \u0026amp; Rudolf H. Tangermann\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e32 The Role of Mathematical Models in Vaccine Development and Public Health Decision Making 480\u003cbr\u003e\u003ci\u003eMarie-Claude Boily, Marc Brisson, Benoit Mâsse, \u0026amp; Roy M. Anderson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e33 Vaccine Safety 509\u003cbr\u003e\u003ci\u003eJohn Iskander, Claudia Vellozzi, Jane Gidudu, \u0026amp; Robert T. Chen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 525\u003c\/p\u003e  \u003cp\u003e“Vaccinology provides an invaluable and authoritative resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.”  (\u003ci\u003eSir Read A lot\u003c\/i\u003e, 10 May 2012)\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eW. John W. Morrow\u003c\/b\u003e, Seattle, Washington, USA\u003c\/p\u003e \u003cp\u003e\u003cb\u003eNadeem A. Sheikh\u003c\/b\u003e, Dendreon, Inc., Seattle, Washington, USA\u003c\/p\u003e \u003cp\u003e\u003cb\u003eClint S. Schmidt\u003c\/b\u003e, NovaDigm Therapeutics, Inc., Grand Forks, North Dakota, USA\u003c\/p\u003e \u003cp\u003e\u003cb\u003eD. Huw Davies\u003c\/b\u003e, University of California at Irvine, USA\u003c\/p\u003e \u003cp\u003eCovering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe.\u003c\/p\u003e \u003cul\u003e \u003cli\u003eReviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application\u003c\/li\u003e \u003cli\u003eIncludes evaluation of vaccine efficacy and safety\u003c\/li\u003e \u003cli\u003eDetails clinical trial design, including regulatory requirements\u003c\/li\u003e \u003cli\u003eDiscusses the emerging field of active cellular immunotherapy\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eVaccinology: Principles and Practice\u003c\/i\u003e provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47990443737317,"sku":"NP9781405185745","price":211.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781405185745.jpg?v=1761787852","url":"https:\/\/k12savings.com\/products\/vaccinology-isbn-9781405185745","provider":"K12savings","version":"1.0","type":"link"}