{"product_id":"tuberous-sclerosis-complex-isbn-9781898683391","title":"Tuberous Sclerosis Complex","description":"\"This is clearly the most authoritative and contemporary statement of current knowledge yet published.\" \u003cbr\u003e from the Foreword by H. Sarnat\u003cbr\u003e \u003cp\u003eTuberous sclerosis is the prototype of a category of malformations uniquely characterized by disturbances in cellular differentiation and growth. It presents with a complex association of different neurological phenotypes, including seizures, cognitive impairments and autism. It is important not only because it is a relatively common hereditary neurological disease with high morbidity, but because it has implications in other pathological processes, such as dysplasia and neoplasia, hamartoma formation and other disturbances in morphogenic processes.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eThis book correlates new genetic data and basic science, covers clinical presentation, reviews the historical background and current diagnostic criteria, and deals with the recent advances in neuropathology, molecular genetics and neurobiology which give a better understanding of the pathogenesis of the disease.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003ePaediatricians and child neurologists will find this book uniquely useful.\u003c\/p\u003e  Index. \u003cp\u003eForeword by H. Sarnat.\u003c\/p\u003e \u003cp\u003ePreface\u003cbr\u003e \u003c\/p\u003e \u003col\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eHistorical background, \u003ci\u003ePaolo Curatolo\u003c\/i\u003e\n\u003c\/li\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eDiagnostic criteria, \u003ci\u003ePaolo Curatolo\u003c\/i\u003e\n\u003c\/li\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eNeurological manifestations, \u003ci\u003ePaolo Curatolo and Magda Verdecchia\u003c\/i\u003e\n\u003c\/li\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eSeizures, \u003ci\u003ePaolo Curatolo and Stefano Seri\u003c\/i\u003e\n\u003c\/li\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eIntellectual and cognitive impairments, \u003ci\u003ePatrick F. Bolton\u003c\/i\u003e\n\u003c\/li\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eAutism, \u003ci\u003eMichael Dowling and Paolo Curatolo\u003c\/i\u003e\n\u003c\/li\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eNeuroimaging, \u003ci\u003eAlessandro Bozzao, Guglielmo Manenti and Paolo Curatolo\u003c\/i\u003e\n\u003c\/li\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003ePositron emission tomography, \u003ci\u003eEishi Asano, Diane C. Chugani and Harry T. Chugani\u003c\/i\u003e\n\u003c\/li\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eDermatologic and stomatologic manifestations, \u003ci\u003eSergiusz Jozwiak and Robert Schwartz\u003c\/i\u003e\n\u003c\/li\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eOphthalmologic manifestations, \u003ci\u003eSergiusz Jozwiak\u003c\/i\u003e\n\u003c\/li\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eRenal involvement, \u003ci\u003eSergiusz Jozwiak\u003c\/i\u003e\n\u003c\/li\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eCardiac and vascular involvement, \u003ci\u003eSergiusz Jozwiak\u003c\/i\u003e\n\u003c\/li\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eHepatic, lung, splenic and pancreatic involvement, \u003ci\u003eSergiusz Jozwiak and Paolo Curatolo\u003c\/i\u003e\n\u003c\/li\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eMolecular genetics, \u003ci\u003eDavid J. Kwiatkowski, Mary Pat Reeve, Jeremy P. Cheadle and Julian R. Sampson\u003c\/i\u003e\n\u003c\/li\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eNeuropathology, \u003ci\u003eMasashi Mizuguchi and Okio Hino\u003c\/i\u003e\n\u003c\/li\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eMolecular neurobiology, \u003ci\u003ePeter B. Crino\u003c\/i\u003e\n\u003c\/li\u003e \u003cli style=\"list-style: none\"\u003e\n\u003cbr\u003e \u003c\/li\u003e \u003cli\u003eFuture directions, \u003ci\u003ePaolo Curatolo\u003c\/i\u003e\n\u003c\/li\u003e \u003c\/ol\u003e \"The previous giant of tuberous sclerosis was Manuel Gomez of the Mayo Clinic. The present giant is surely Paolo Curatolo. Others will surely stand on his shoulders, some of whom may have their enthusiasm first lit by reading this book. Pediatric neurologists, make sure you have it.\" \u003ci\u003e\u003cb\u003eJournal of Pediatric Neurology\u003c\/b\u003e\u003c\/i\u003e Edited by Paolo Curatolo, Università degli Studi di Roma 'Tor Vergata'  \"This is clearly the most authoritative and contemporary statement of current knowledge yet published.\" \u003cbr\u003e from the Foreword by H. Sarnat\u003cbr\u003e \u003cp\u003eTuberous sclerosis is the prototype of a category of malformations uniquely characterized by disturbances in cellular differentiation and growth. It presents with a complex association of different neurological phenotypes, including seizures, cognitive impairments and autism. It is important not only because it is a relatively common hereditary neurological disease with high morbidity, but because it has implications in other pathological processes, such as dysplasia and neoplasia, hamartoma formation and other disturbances in morphogenic processes.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eThis book correlates new genetic data and basic science, covers clinical presentation, reviews the historical background and current diagnostic criteria, and deals with the recent advances in neuropathology, molecular genetics and neurobiology which give a better understanding of the pathogenesis of the disease.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003ePaediatricians and child neurologists will find this book uniquely useful.\u003cbr\u003e \u003c\/p\u003e","brand":"Mac Keith Press","offers":[{"title":"Default Title","offer_id":47990417719525,"sku":"NP9781898683391","price":77.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781898683391.jpg?v=1761787744","url":"https:\/\/k12savings.com\/products\/tuberous-sclerosis-complex-isbn-9781898683391","provider":"K12savings","version":"1.0","type":"link"}