{"product_id":"transition-metal-mediated-aromatic-ring-construction-isbn-9781118148921","title":"Transition-Metal-Mediated Aromatic Ring Construction","description":"\u003cp\u003e\u003cb\u003eState-of-the-science methods, synthetic routes, and strategies to construct aromatic rings\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe development of new reactions for the synthesis of aromatic compounds is a highly active research area in organic synthesis, providing new functional organic materials, functional reagents, and biologically active compounds. Recently, significant advances in transition-metal-mediated reactions have enabled the efficient and practical construction of new aromatic rings with useful properties and applications. This book draws together and reviews all the latest discoveries and methods in transition-metal-mediated reactions, offering readers promising new routes to design and construct complex aromatic compounds.\u003c\/p\u003e \u003cp\u003eIntegrating metal catalysis with aromatic compound synthesis, \u003ci\u003eTransition-Metal-Mediated Aromatic Ring Construction\u003c\/i\u003e offers a practical guide to the methods, synthetic routes, and strategies for constructing aromatic compounds. The book's five parts examine:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e[2+2+2], [2+2+1], and related cycloaddition reactions\u003c\/li\u003e \u003cli\u003e[4+2], [3+2], and related cycloaddition reactions\u003c\/li\u003e \u003cli\u003eElectrocyclization reactions\u003c\/li\u003e \u003cli\u003eCoupling and addition reactions\u003c\/li\u003e \u003cli\u003eOther important transformations, including methathesis reactions and skeletal rearrangement reactions\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eEdited by Ken Tanaka, an internationally recognized expert in the field of transition-metal catalysis, the book features authors who are leading pioneers and researchers in synthetic reactions. Their contributions reflect a thorough review and analysis of the literature as well as their own firsthand laboratory experience developing new aromatic compounds.\u003c\/p\u003e \u003cp\u003eAll chapters end with a summary and outlook, setting forth new avenues of research and forecasting new discoveries. There are also references at the end of each chapter, guiding readers to important original research reports and reviews.\u003c\/p\u003e \u003cp\u003eIn summary, \u003ci\u003eTransition-Metal-Mediated Aromatic Ring Construction\u003c\/i\u003e offers synthetic chemists a promising new avenue for the development of important new aromatic compounds with a broad range of applications.\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eCONTRIBUTORS xvii\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePREFACE xxi\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I [2 + 2 + 2] AND RELATED CYCLOADDITION REACTIONS\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Cobalt-Mediated [2+2+2] Cycloaddition 3\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eVincent Gandon\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction, 3\u003c\/p\u003e \u003cp\u003e1.2 Synthesis of Benzenes, 4\u003c\/p\u003e \u003cp\u003e1.3 Synthesis of Heterocycles, 15\u003c\/p\u003e \u003cp\u003e1.4 Mechanistic Aspects, 24\u003c\/p\u003e \u003cp\u003e1.5 Synthetic Applications, 26\u003c\/p\u003e \u003cp\u003e1.6 Summary and Outlook, 30\u003c\/p\u003e \u003cp\u003eReferences, 31\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Nickel-Mediated [2+2+2] Cycloaddition 37\u003c\/b\u003e\u003cbr\u003e \u003ci\u003ePuneet Kumar and Janis Louie\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction, 37\u003c\/p\u003e \u003cp\u003e2.2 Synthesis of Benzenes, 37\u003c\/p\u003e \u003cp\u003e2.3 Cycloaddition of Alkynes and Nitriles, 45\u003c\/p\u003e \u003cp\u003e2.4 Cycloaddition of Alkynes and Imines, 49\u003c\/p\u003e \u003cp\u003e2.5 Cycloaddition of Alkynes and Carbon Dioxide, 50\u003c\/p\u003e \u003cp\u003e2.6 Cycloaddition of Alkynes and Isocyanates, 51\u003c\/p\u003e \u003cp\u003e2.7 Cycloaddition of Alkynes and Carbodiimide, 54\u003c\/p\u003e \u003cp\u003e2.8 Cycloaddition of Diynes and Ketenes, 54\u003c\/p\u003e \u003cp\u003e2.9 Cycloaddition of Arynes, 55\u003c\/p\u003e \u003cp\u003e2.10 Mechanism, 58\u003c\/p\u003e \u003cp\u003e2.11 Summary and Outlook, 69\u003c\/p\u003e \u003cp\u003eReferences, 69\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Ruthenium-Mediated [2+2+2] Cycloaddition 71\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eYoshihiko Yamamoto\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction, 71\u003c\/p\u003e \u003cp\u003e3.2 Synthesis of Benzenes, 72\u003c\/p\u003e \u003cp\u003e3.3 Synthesis of Heterocycles, 92\u003c\/p\u003e \u003cp\u003e3.4 Mechanism of Ruthenium-Catalyzed [2+2+2] Cycloadditions, 101\u003c\/p\u003e \u003cp\u003e3.5 Synthetic Applications, 111\u003c\/p\u003e \u003cp\u003e3.6 Summary and Outlook, 119\u003c\/p\u003e \u003cp\u003eReferences, 120\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Rhodium-Mediated [2+2+2] Cycloaddition 127\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eKen Tanaka\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction, 127\u003c\/p\u003e \u003cp\u003e4.2 Synthesis of Benzenes, 128\u003c\/p\u003e \u003cp\u003e4.3 Synthesis of Pyridines, 147\u003c\/p\u003e \u003cp\u003e4.4 Synthesis of Pyridones and Related Heterocycles, 153\u003c\/p\u003e \u003cp\u003e4.5 Summary and Outlook, 157\u003c\/p\u003e \u003cp\u003eReferences, 158\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Iridium-Mediated [2+2+2] Cycloaddition 161\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eRyo Takeuchi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction, 161\u003c\/p\u003e \u003cp\u003e5.2 Synthesis of Benzene Derivatives, 162\u003c\/p\u003e \u003cp\u003e5.3 Synthesis of Heterocyclic Compounds, 169\u003c\/p\u003e \u003cp\u003e5.4 Mechanistic Aspects, 175\u003c\/p\u003e \u003cp\u003e5.5 Summary and Outlook, 179\u003c\/p\u003e \u003cp\u003eReferences, 179\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 [2+2+2] and Related Cycloadditions Mediated by Other Transition Metals 183\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eKen Tanaka and Yu Shibata\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction, 183\u003c\/p\u003e \u003cp\u003e6.2 Palladium-Catalyzed [2+2+2] and [2+2+1] Cycloadditions, 183\u003c\/p\u003e \u003cp\u003e6.3 Iron-Catalyzed [2+2+2] Cycloaddition, 196\u003c\/p\u003e \u003cp\u003e6.4 Manganese-Catalyzed [2+2+2] Cycloaddition, 199\u003c\/p\u003e \u003cp\u003e6.5 Rhenium-Catalyzed [2+2+2], [2+1+2+1], and [2+2+1+1] Cycloadditions, 200\u003c\/p\u003e \u003cp\u003e6.6 Other Transition-Metal-Catalyzed [2+2+2] Cycloaddition, 202\u003c\/p\u003e \u003cp\u003e6.7 Summary and Outlook, 203\u003c\/p\u003e \u003cp\u003eReferences, 203\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Application to the Synthesis of Natural Products 207\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eBernhard Witulski and Julien Grand\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction, 207\u003c\/p\u003e \u003cp\u003e7.2 Construction of Benzene Rings, 209\u003c\/p\u003e \u003cp\u003e7.3 Construction of a Heterocyclic Ring, 226\u003c\/p\u003e \u003cp\u003e7.4 Miscellaneous, 231\u003c\/p\u003e \u003cp\u003e7.5 Summary and Outlook, 238\u003c\/p\u003e \u003cp\u003eReferences, 239\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Synthesis of Planar Chiral Aromatic Compounds via [2+2+2] Cycloaddition 243\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eTakanori Shibata and Ken Tanaka\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction, 243\u003c\/p\u003e \u003cp\u003e8.2 Cobalt-Catalyzed [2+2+2] Cycloaddition, 246\u003c\/p\u003e \u003cp\u003e8.3 Rhodium-Catalyzed [2+2+2] Cycloaddition, 247\u003c\/p\u003e \u003cp\u003e8.4 Enantioselective [2+2+2] Cycloaddition, 249\u003c\/p\u003e \u003cp\u003e8.5 Summary and Outlook, 252\u003c\/p\u003e \u003cp\u003eReferences, 252\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Synthesis of Axially Chiral Aromatic Compounds via [2+2+2] Cycloaddition 255\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eKen Tanaka and Takanori Shibata\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction, 255\u003c\/p\u003e \u003cp\u003e9.2 Cobalt-Catalyzed Enantioselective [2+2+2] Cycloaddition, 256\u003c\/p\u003e \u003cp\u003e9.3 Iridium-Catalyzed Enantioselective [2+2+2] Cycloaddition, 258\u003c\/p\u003e \u003cp\u003e9.4 Rhodium-Catalyzed Enantioselective [2+2+2] Cycloaddition, 263\u003c\/p\u003e \u003cp\u003e9.5 Enantioselective Synthesis of Axially Chiral Anilides and Bezamides, 275\u003c\/p\u003e \u003cp\u003e9.6 Summary and Outlook, 278\u003c\/p\u003e \u003cp\u003eReferences, 278\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Synthesis of Helically Chiral Aromatic Compounds via [2+2+2] Cycloaddition 281\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eKen Tanaka\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction, 281\u003c\/p\u003e \u003cp\u003e10.2 Nonasymmetric Synthesis, 281\u003c\/p\u003e \u003cp\u003e10.3 Diastereoselective Synthesis, 287\u003c\/p\u003e \u003cp\u003e10.4 Enantioselective Synthesis, 290\u003c\/p\u003e \u003cp\u003e10.5 Summary and Outlook, 296\u003c\/p\u003e \u003cp\u003eReferences, 297\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Aromatic Ring Construction from Zirconocenes and Titanocenes 299\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eShi Li and Tamotsu Takahashi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction, 299\u003c\/p\u003e \u003cp\u003e11.2 Aromatic Ring Construction from Zirconocenes, 300\u003c\/p\u003e \u003cp\u003e11.3 Aromatic Ring Construction from Titanocenes, 313\u003c\/p\u003e \u003cp\u003e11.4 Application to Synthesis of Substituted Acenes, 315\u003c\/p\u003e \u003cp\u003e11.5 Summary and Outlook, 317\u003c\/p\u003e \u003cp\u003eReferences, 318\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART II [4+2], [3+2], AND RELATED CYCLOADDITION REACTIONS\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 [4+2] and [3+2] Cycloaddition via Metallacycles 323\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eTakuya Kurahashi and Seijiro Matsubara\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction, 323\u003c\/p\u003e \u003cp\u003e12.2 [4+2] Cycloaddition via Elimination of Small Molecules, 326\u003c\/p\u003e \u003cp\u003e12.3 [3+2] Cycloaddition via Elimination of Small Molecules, 332\u003c\/p\u003e \u003cp\u003e12.4 [4+2] Cycloaddition via C C Bond Activation, 334\u003c\/p\u003e \u003cp\u003e12.5 [4+2] Cycloaddition via C–H Bond Activation, 336\u003c\/p\u003e \u003cp\u003e12.6 Summary and Outlook, 339\u003c\/p\u003e \u003cp\u003eReferences, 339\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Diels–Alder Reactions 341\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eGerhard Hilt and Florian P¨unner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction, 341\u003c\/p\u003e \u003cp\u003e13.2 Transition-Metal-Mediated Diels–Alder Reaction\/Aromatization Sequence, 342\u003c\/p\u003e \u003cp\u003e13.3 Intramolecular Diels–Alder Reactions toward Dihydroaromatic and Aromatic Products, 349\u003c\/p\u003e \u003cp\u003e13.4 Synthetic Applications, 350\u003c\/p\u003e \u003cp\u003e13.5 Summary and Outlook, 352\u003c\/p\u003e \u003cp\u003eReferences, 352\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 [4+2] Benzannulation of Enynes with Alkynes 355\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eVladimir Gevorgyan and Olga V. Zatolochnaya\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction, 355\u003c\/p\u003e \u003cp\u003e14.2 Benzannulation of Enyne with Alkyne: Gold-catalyzed Benzannulation Reaction, 356\u003c\/p\u003e \u003cp\u003e14.3 Benzannulation of Enyne with Enyne, 358\u003c\/p\u003e \u003cp\u003e14.4 Benzannulation of Enyne with Diyne, 365\u003c\/p\u003e \u003cp\u003e14.5 Synthetic Applications, 371\u003c\/p\u003e \u003cp\u003e14.6 Summary and Outlook, 376\u003c\/p\u003e \u003cp\u003eReferences, 376\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Formal [4+2] Benzannulation via Pyrylium Intermediates 379\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eNaoki Asao and Yoshifumi Ishikawa\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction, 379\u003c\/p\u003e \u003cp\u003e15.2 Benzannulation of Pyrylium Salts, 380\u003c\/p\u003e \u003cp\u003e15.3 Benzannulation of O-Alkynylbenzaldehydes, 380\u003c\/p\u003e \u003cp\u003e15.4 Intramolecular [4+2] Benzannulation, 392\u003c\/p\u003e \u003cp\u003e15.5 Application to Natural Product Synthesis, 394\u003c\/p\u003e \u003cp\u003e15.6 Summary and Outlook, 395\u003c\/p\u003e \u003cp\u003eReferences, 396\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Utilization of 1,3-Dipolar Compounds 399\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eYi-Feng Wang and Shunsuke Chiba\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16.1 Introduction, 399\u003c\/p\u003e \u003cp\u003e16.2 1,3-Dipolar Cycloaddition, 401\u003c\/p\u003e \u003cp\u003e16.3 Five-Membered Ring Construction via Decomposition of Azides, 410\u003c\/p\u003e \u003cp\u003e16.4 Six-Membered Ring Construction via Decomposition of Azides, 418\u003c\/p\u003e \u003cp\u003e16.5 Summary and Outlook, 421\u003c\/p\u003e \u003cp\u003eReferences, 422\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Utilization of Transition-Metal Carbenoids 425\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eJames Wallace Herndon, Jr.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17.1 Introduction, 425\u003c\/p\u003e \u003cp\u003e17.2 Five-membered Aromatic Ring Construction, 426\u003c\/p\u003e \u003cp\u003e17.3 Six-Membered Aromatic Ring Construction, 432\u003c\/p\u003e \u003cp\u003e17.3.1 D¨otz Benzannulation Reaction, 432\u003c\/p\u003e \u003cp\u003e17.4 Summary and Outlook, 450\u003c\/p\u003e \u003cp\u003eReferences, 450\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART III ELECTROCYCLIZATION REACTIONS\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Intramolecular Hydroarylation of Alkynes, Alkenes, and Allenes 457\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eTsugio Kitamura\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18.1 Introduction, 457\u003c\/p\u003e \u003cp\u003e18.2 Intramolecular Hydroarylation, 457\u003c\/p\u003e \u003cp\u003e18.3 Summary and Outlook, 482\u003c\/p\u003e \u003cp\u003eReferences, 483\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 Intramolecular C X Bond Formation between C X or X H andAlkynes 485\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eHiroaki Ohno\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19.1 Introduction, 485\u003c\/p\u003e \u003cp\u003e19.2 C X Bond Formation between C X and Alkynes, 485\u003c\/p\u003e \u003cp\u003e19.3 C X Bond Formation between X H and Alkynes, 510\u003c\/p\u003e \u003cp\u003e19.4 Summary and Outlook, 529\u003c\/p\u003e \u003cp\u003eReferences, 529\u003c\/p\u003e \u003cp\u003e\u003cb\u003e20 Synthesis of Heterocycles via X H Bond Addition to Diynes 537\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eTakanori Matsuda\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20.1 Introduction, 537\u003c\/p\u003e \u003cp\u003e20.2 Synthesis of Pyrroles and Furans via Double trans Addition to 1,3-Diynes, 538\u003c\/p\u003e \u003cp\u003e20.3 Synthesis of Pyrroles via Hydroamination of 1,4- and 1,5-Diynes, 542\u003c\/p\u003e \u003cp\u003e20.4 Synthesis of Siloles and Germoles via Double trans Addition to 1,3-Diynes, 543\u003c\/p\u003e \u003cp\u003e20.5 Summary and Outlook, 546\u003c\/p\u003e \u003cp\u003eReferences, 546\u003c\/p\u003e \u003cp\u003e\u003cb\u003e21 Cycloaromatization via Transition Metal–Cumulenylidenes 549\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eYoshiaki Nishibayashi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21.1 Introduction, 549\u003c\/p\u003e \u003cp\u003e21.2 Cycloaromatization via Chromium–, Molybdenum–, and Tungsten–Vinylidene Complexes, 550\u003c\/p\u003e \u003cp\u003e21.3 Cycloaromatization via Ruthenium–Vinylidene Complexes, 554\u003c\/p\u003e \u003cp\u003e21.4 Cycloaromatization via Rhodium–Vinylidene Complexes, 558\u003c\/p\u003e \u003cp\u003e21.5 Cycloaromatization via Gold–Vinylidene Complexes, 561\u003c\/p\u003e \u003cp\u003e21.6 Cycloaromatization via Ruthenium–Allenylidene Complexes, 565\u003c\/p\u003e \u003cp\u003e21.7 Summary and Outlook, 565\u003c\/p\u003e \u003cp\u003eReferences, 566\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART IV COUPLING AND ADDITION REACTIONS\u003c\/b\u003e\u003cbr\u003e \u003cbr\u003e \u003cb\u003e22 C C Bond-Forming Coupling Reactions 573\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eMasaki Shimizu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22.1 Introduction, 573\u003c\/p\u003e \u003cp\u003e22.2 Cyclization, 574\u003c\/p\u003e \u003cp\u003e22.3 Annulation, 597\u003c\/p\u003e \u003cp\u003e22.4 Summary and Outlook, 612\u003c\/p\u003e \u003cp\u003eReferences, 612\u003c\/p\u003e \u003cp\u003e\u003cb\u003e23 Synthesis of Carbazoles and Related Compounds via C E Bond-Forming Coupling Reactions 617\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eKoji Nakano\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23.1 Introduction, 617\u003c\/p\u003e \u003cp\u003e23.2 Synthesis of Carbazoles, 618\u003c\/p\u003e \u003cp\u003e23.3 Synthesis of Dibenzofurans and Dibenzothiophenes, 633\u003c\/p\u003e \u003cp\u003e23.4 Synthesis of Other Dibenzoheteroles, 637\u003c\/p\u003e \u003cp\u003e23.5 Summary and Outlook, 642\u003c\/p\u003e \u003cp\u003eReferences, 642\u003c\/p\u003e \u003cp\u003e\u003cb\u003e24 Synthesis of Aromatic Benzo-Fused Five- and Six-Membered Heterocycles via Palladium- and Copper-Catalyzed C X Bond-Forming Reactions 645\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eCatherine J. Ball and Michael C. Willis\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24.1 Introduction, 645\u003c\/p\u003e \u003cp\u003e24.2 C N Bond Formation, 646\u003c\/p\u003e \u003cp\u003e24.3 C O Bond Formation, 662\u003c\/p\u003e \u003cp\u003e24.4 C S Bond Formation, 667\u003c\/p\u003e \u003cp\u003e24.5 Annulation of Anilines and Related Compounds with Alkynes, 671\u003c\/p\u003e \u003cp\u003e24.6 Summary and Outlook, 676\u003c\/p\u003e \u003cp\u003eReferences, 677\u003c\/p\u003e \u003cp\u003e\u003cb\u003e25 Coupling Reactions of the sp2 C H Bond with Alkynes 683\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eTetsuya Satoh and Masahiro Miura\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25.1 Introduction, 683\u003c\/p\u003e \u003cp\u003e25.2 Synthesis of Arenes, 685\u003c\/p\u003e \u003cp\u003e25.3 Synthesis of Heterocycles, 697\u003c\/p\u003e \u003cp\u003e25.4 Summary and Outlook, 716\u003c\/p\u003e \u003cp\u003eReferences, 716\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART V OTHER IMPORTANT TRANSFORMATIONS\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e26 Metathesis Reactions 721\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eKazuhiro Yoshida\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26.1 Introduction, 721\u003c\/p\u003e \u003cp\u003e26.2 Alkene Metathesis, 722\u003c\/p\u003e \u003cp\u003e26.3 Ene–Yne Metathesis, 736\u003c\/p\u003e \u003cp\u003e26.4 Other Applications, 738\u003c\/p\u003e \u003cp\u003e26.5 Summary and Outlook, 740\u003c\/p\u003e \u003cp\u003eReferences and Notes, 741\u003c\/p\u003e \u003cp\u003e\u003cb\u003e27 Skeletal Rearrangement Reactions 743\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eItaru Nakamura\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e27.1 Introduction, 743\u003c\/p\u003e \u003cp\u003e27.2 π-Electrophilic Transition-Metal-Mediated Aromatization Reactions, 743\u003c\/p\u003e \u003cp\u003e27.3 π-Electrophilic Transition-Metal-Mediated Aromatization Reactions, 768\u003c\/p\u003e \u003cp\u003e27.4 Summary and Outlook, 769\u003c\/p\u003e \u003cp\u003eReferences, 769\u003c\/p\u003e \u003cp\u003e\u003cb\u003e28 Dearomatization–Aromatization Sequence 773\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eHiroto Yoshida\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e28.1 Introduction, 773\u003c\/p\u003e \u003cp\u003e28.2 Reactions via Arynes, 774\u003c\/p\u003e \u003cp\u003e28.3 Reactions via o-Quinodimethanes, 787\u003c\/p\u003e \u003cp\u003e28.4 Summary and Outlook, 793\u003c\/p\u003e \u003cp\u003eReferences, 794\u003c\/p\u003e \u003cp\u003e\u003cb\u003eINDEX 797\u003c\/b\u003e\u003c\/p\u003e  \u003cp\u003e“In summary, I personally have read Transition-Metal-Mediated Aromatic Ring Construction with great interest, and I believe this book is a rich source for both academic and industrial researchers.  It provides a valuable addition to the range of textbooks on organic synthesis, aromatic rings, and heterocyclic chemistry. Therefore, I warmly recommend this book and I will strongly encourage my students and colleagues to explore it.”  (\u003ci\u003eAngew. Chem. Int. Ed\u003c\/i\u003e, 1 May 2014)\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e  \u003cp\u003e\u003cb\u003eKEN TANAKA\u003c\/b\u003e is Professor in the Department of Applied Chemistry at the Tokyo University of Agriculture and Technology. Previously, he worked for the Mitsubishi Chemical Corporation in organic process research. Dr. Tanaka has published more than 100 scientific papers concerning transition-metal catalysis.\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eState-of-the-science methods, synthetic routes, and strategies to construct aromatic rings\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe development of new reactions for the synthesis of aromatic compounds is a highly active research area in organic synthesis, providing new functional organic materials, functional reagents, and biologically active compounds. Recently, significant advances in transition-metal-mediated reactions have enabled the efficient and practical construction of new aromatic rings with useful properties and applications. This book draws together and reviews all the latest discoveries and methods in transition-metal-mediated reactions, offering readers promising new routes to design and construct complex aromatic compounds.\u003c\/p\u003e \u003cp\u003eIntegrating metal catalysis with aromatic compound synthesis, \u003ci\u003eTransition-Metal-Mediated Aromatic Ring Construction\u003c\/i\u003e offers a practical guide to the methods, synthetic routes, and strategies for constructing aromatic compounds. The book's five parts examine:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e[2+2+2], [2+2+1], and related cycloaddition reactions\u003c\/li\u003e \u003cli\u003e[4+2], [3+2], and related cycloaddition reactions\u003c\/li\u003e \u003cli\u003eElectrocyclization reactions\u003c\/li\u003e \u003cli\u003eCoupling and addition reactions\u003c\/li\u003e \u003cli\u003eOther important transformations, including methathesis reactions and skeletal rearrangement reactions\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eEdited by Ken Tanaka, an internationally recognized expert in the field of transition-metal catalysis, the book features authors who are leading pioneers and researchers in synthetic reactions. Their contributions reflect a thorough review and analysis of the literature as well as their own firsthand laboratory experience developing new aromatic compounds.\u003c\/p\u003e \u003cp\u003eAll chapters end with a summary and outlook, setting forth new avenues of research and forecasting new discoveries. There are also references at the end of each chapter, guiding readers to important original research reports and reviews.\u003c\/p\u003e \u003cp\u003eIn summary, \u003ci\u003eTransition-Metal-Mediated Aromatic Ring Construction\u003c\/i\u003e offers synthetic chemists a promising new avenue for the development of important new aromatic compounds with a broad range of applications.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47990407889125,"sku":"NP9781118148921","price":209.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118148921.jpg?v=1761787707","url":"https:\/\/k12savings.com\/products\/transition-metal-mediated-aromatic-ring-construction-isbn-9781118148921","provider":"K12savings","version":"1.0","type":"link"}