{"product_id":"tinkering-isbn-9780470034293","title":"Tinkering","description":"Much recent research in evolutionary developmental biology has focused on the origin of new body plans. However, most evolutionary change at the population and species level consists of tinkering: small-scale alterations in developmental pathways within a single body plan. Such microevolutionary events have been well studied on a population genetic level and from the perspective of adaptive phenotypic evolution, but their developmental mechanisms remain poorly studied.  \u003cp\u003eThis book explores both theoretical and practical issues of tinkering. It features a wide range of perspectives to address several fundamental questions. How does tinkering occur developmentally, and how is it manifested phenotypically? Are the developmental mechanisms by which tinkering occur different from those that underlie larger evolutionary changes? What are the developmental constraints on tinkering? And how do we test hypotheses about microevolutionary shifts in development from the fossil record?\u003c\/p\u003e \u003cp\u003eWith contributions from experts in a range of fields, this fascinating book makes exciting reading for anyone studying evolution, developmental biology or genetics.\u003c\/p\u003e  Symposium on Tinkering: the microevolution of development, held at the Novartis Foundation, London, 11-13 July 2006.  \u003cp\u003eEditors: Gregory Bock (Organizer) and Jamie Goode.\u003c\/p\u003e \u003cp\u003eThis symposium is based on a proposal made by Brian Hall.\u003c\/p\u003e \u003cp\u003eDaniel E. Lieberman The evolutionary developmental biology of tinkering: an introduction to the challenge.\u003c\/p\u003e \u003cp\u003eManfred D. Laubichler Tinkering: a conceptual and historical evaluation\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003eRudolf A. Raff and Elizabeth C. Raff Tinkering: new embryos from old-rapidly and cheaply.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003eJames M. Cheverud The relationship between development and evolution through heritable variation.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003eAdam S. Wilkins Genetic networks as transmitting and amplifying devices for natural genetic tinkering.\u003cbr\u003e Discussion.\u003cbr\u003e  \u003cbr\u003e \u003c\/p\u003e \u003cp\u003ePaul M. Brakefield Butterfly eyespot patterns and how evolutionary tinkering yields diversity.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003eGeneral discussion I.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eGünter P. Wagner and Anna Marie Pyle Tinkering with transcription factor proteins: the role of transcription factor adaptation in developmental evolution.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003eDenis Duboule, Basile Tarchini, Jozsef Zàkàny and Marie Kmita Tinkering with constraints in the evolution of the vertebrate limb anterior-posterior polarity.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003eIrma Thesleff, Elina Järvinen and Marika Suomalainen Affecting tooth morphology and renewal by fine-tuning the signals mediating cell and tissue interactions.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003eGeneral discussion II.\u003c\/p\u003e \u003cp\u003eBenedikt Hallgrimsson, Daniel E. Lieberman, Nathan M. Young, Trish Parsons and Steven Wat Evolution of covariance in the mammalian skull.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003eDavid L. Stern The developmental genetics of microevolution.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003eJukka Jernvall and Isaac Salazar-Ciudad The economy of tinkering mammalian teeth.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003e\u003cbr\u003e Michael A. Bell, Kaitlyn E. Ellis and Howard I. Sirotkin Pelvic skeleton reduction and Pitx1 expression in threespine stickleback populations.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003eMichael I. Coates, Marcello Ruta and Peter J. Wagner Using patterns of fin and limb phylogeny to test developmental-evolutionary scenarios.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003eRebecca R. Ackermann Craniofacial variation and developmental divergence in primate and human evolution.\u003cbr\u003e Discussion.\u003c\/p\u003e \u003cp\u003eContributor Index.\u003c\/p\u003e \u003cp\u003eSubject Index.\u003c\/p\u003e  The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.  \u003cp\u003e\u003cb\u003eChair:\u003c\/b\u003e DANIEL LIEBERMAN, Harvard University, Cambridge, USA\u003c\/p\u003e  Much recent research in evolutionary developmental biology has focused on the origin of new body plans. However, most evolutionary change at the population and species level consists of tinkering: small-scale alterations in developmental pathways within a single body plan. Such microevolutionary events have been well studied on a population genetic level and from the perspective of adaptive phenotypic evolution, but their developmental mechanisms remain poorly studied.  \u003cp\u003eThis book explores both theoretical and practical issues of tinkering. It features a wide range of perspectives to address several fundamental questions. How does tinkering occur developmentally, and how is it manifested phenotypically? Are the developmental mechanisms by which tinkering occur different from those that underlie larger evolutionary changes? What are the developmental constraints on tinkering? And how do we test hypotheses about microevolutionary shifts in development from the fossil record?\u003c\/p\u003e \u003cp\u003eWith contributions from experts in a range of fields, this fascinating book will make exciting reading for anyone studying evolution, developmental biology or genetics.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47990392652005,"sku":"NP9780470034293","price":211.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470034293.jpg?v=1761787643","url":"https:\/\/k12savings.com\/products\/tinkering-isbn-9780470034293","provider":"K12savings","version":"1.0","type":"link"}