{"product_id":"the-tumour-microenvironment-isbn-9780471499596","title":"The Tumour Microenvironment","description":"Several fundamentally important questions form the basis for this book. What are the relationships between tumour formation and tumour pH? What are the effects of tumour pH and hypoxia on carcinogenesis or tumorigenesis? What are the therapeutic consequences of tumour pH?  \u003cp\u003eIt is hypothesised that low extracellular pH is not only an important consequence of tumour growth but may also promote further tumorigenic transformation. Furthermore, \u003ci\u003ein vitro\u003c\/i\u003e studies suggest that low pH strongly affects the efficacy of chemo- and radiotherapy.  Better understanding of the influence of pH on tumour growth, coupled with manipulation of the pH of the tumour microenvironment, may lead to the development of more effective therapies. \u003c\/p\u003eErgebnisse von in vitro-Studien lassen vermuten, dass sich der pH-Wert in einem Tumor auf die Wirksamkeit von Chemo- oder Strahlentherapien auswirken kann. Wie aber sieht die Beziehung zwischen der Tumorentwicklung und dem pH-Wert aus? Können ein niedriger pH-Wert oder ein Sauerstoffmangel die Carcinogenese hemmen? Wo bieten sich therapeutische Ansätze? Anwort auf diese und andere Fragen finden Sie in diesem Band. In interdisziplinärer Weise wurden Beiträge aus der Grundlagenforschung und der klinischen Praxis zusammengetragen.  Introduction (Robert J Gillies).\u003cbr\u003e \u003cbr\u003e Frontiers in the Measurement of Cell and Tissue pH (Robert J Gillies and Ronald M Lynch).\u003cbr\u003e \u003cbr\u003e The Physiological Environment in Cancer Vascularization, Invasion and Metastasis (Zaver M Bhujwalla et al).\u003cbr\u003e \u003cbr\u003e Why are Cancers Acidic? A Carrier-Mediated Diffusion Model for H+ Transport in the Interstitial Fluid (J R Griffiths et al).\u003cbr\u003e \u003cbr\u003e pH and Therapy of Human Cancers (Jeffrey L Evelhoch).\u003cbr\u003e \u003cbr\u003e Mathematical Models of Tumour Invasion Mediated by Transformation-Induced Alteration of Microenvironmental pH (Robert A Gatenby and Edward T Gawlinski).\u003cbr\u003e \u003cbr\u003e pH Regulation of Renal Gene Expression (Norman P Curthoys et al)).\u003cbr\u003e \u003cbr\u003e Genetic Determinants that influence Hypoxia-Induced Apoptosis (Rodolfo M Alarcon et al).\u003cbr\u003e \u003cbr\u003e Genomic Instability in Cancer (Sara Rockwell et al).\u003cbr\u003e \u003cbr\u003e pH, Hypoxia and Metastasis (R P Hill et al).\u003cbr\u003e \u003cbr\u003e Modelling Tumour Acidity and Invasion (Steven D Webb et al).\u003cbr\u003e \u003cbr\u003e pH, Aerobic Glycolysis and Vascular Endothelial Growth Factor in Tumour Growth (Jacques Pouyssé gur et al).\u003cbr\u003e \u003cbr\u003e pH and Chemotherapy (Natarajan Raghunand).\u003cbr\u003e \u003cbr\u003e The HIF Pathway: Implications for Patterns of Gene Expression in Cancer (Charles C Wykoff et al).\u003cbr\u003e \u003cbr\u003e pH and Multidrug Resistance (Paul D Roepe).\u003cbr\u003e \u003cbr\u003e 'The Metabolism of Tumours' 70 Years Later (Gregg L Semenza et al).\u003cbr\u003e \u003cbr\u003e The Multiple Mechanisms of Multidrug Resistance and Cellular pH (Sanford Simon).\u003cbr\u003e \u003cbr\u003e Summing Up (Robert J Gillies).\u003cbr\u003e \u003cbr\u003e Index of Contributors.\u003cbr\u003e \u003cbr\u003e Subject Index.  I read this book from A to Z and I really enjoyed it...makes you wish you had been there, but if you were not, you can always buy this book...\" (NMR in Biomedicine, October 2002)  \u003cp\u003e\"...an excellent compilation of some specific and significant work...\" (\u003ci\u003ePharmaceutical Research\u003c\/i\u003e, Vol. 19, No. 10, October 2002)\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJamie Goode\u003c\/b\u003e is a British author with a PhD in plant biology, and a wine columnist of The Sunday Express. Goode also contributes to wine publications such as \u003ci\u003eHarpers\u003c\/i\u003e, \u003ci\u003eThe World of Fine Wine\u003c\/i\u003e, \u003ci\u003eDecanter\u003c\/i\u003e, \u003ci\u003eGrapesTALK\u003c\/i\u003e and \u003ci\u003eSommelier Journal\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eDerek J. Chadwick\u003c\/b\u003e is the editor of \u003ci\u003eThe Tumour Microenvironment: Causes and Consequences of Hypoxia and Acidity\u003c\/i\u003e, published by Wiley.\u003c\/p\u003e  In recent years, there has been great interest in exploiting the hypoxic tumour microenvironment for therapeutic gain. It has also become clear that this microenvironment is acidic and thus hostile to the growth and survival of viable normal cells. These observations lead to several fundamentally important questions that form the basis for this book. What are the relationships between tumour perfusion and tumour pH? What are the effects of tumour pH and hypoxia on carcinogenesis or tumorigenesis? What are the therapeutic consequences of tumour pH?\u003cbr\u003e \u003cbr\u003e This exciting book brings together leading clinicians and researchers to address some of these key issues. It is hypothesized that low extracellular pH is not only an important consequence of tumour growth but may also promote further tumorigenic transformation. Furthermore, in vitro studies suggest that low pH strongly affects the efficacy of chemo- and radiotherapy. Therapeutic strategies taking into account the consequences of altered pH, or which seek to manipulate tumour pH, more be more effective than those currently employed.","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47990358343909,"sku":"NP9780471499596","price":211.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780471499596.jpg?v=1761787501","url":"https:\/\/k12savings.com\/products\/the-tumour-microenvironment-isbn-9780471499596","provider":"K12savings","version":"1.0","type":"link"}