{"product_id":"the-septins-isbn-9780470519691","title":"The Septins","description":"\u003ci\u003e\"The authors represent most of the key figures and the work and the book as a whole is an essential reference for the newcomer or specialist in this area and for any student of eukaryotic cell structure and function. This is an important and wonderful reference.\"\u003c\/i\u003e –Microbiology Today, May 2009\u003cbr\u003e   \u003cp\u003eSeptins are an evolutionarily conserved group of GTP-binding and filament-forming proteins that were originally discovered in yeast. Once the preserve of a small band of yeast biologists, the field has grown rapidly in the past few years and now encompasses the whole of animal and fungal biology. Furthermore, septins are nowadays recognized to be involved in a variety of disease processes from neoplasia to neurodegenerative conditions.\u003c\/p\u003e \u003cp\u003eThis book \u003ca id=\"OLE_LINK1\" name=\"OLE_LINK1\"\u003ecomprehensively examines the\u003c\/a\u003e septin gene family and their proteins, providing those new to this research area with a detailed and wide ranging introduction to septin biology. It starts with a unique historical perspective on the development of the field, from its beginnings in the screen for cell division mutants by the Nobel Laureate Lee Hartwell. The evolution of the septin gene family then forms a basis for consideration of the biochemistry and functions of septins in yeast and other model organisms including \u003ci\u003eC. elegans\u003c\/i\u003e and \u003ci\u003eDrosophila\u003c\/i\u003e. \u003c\/p\u003e \u003cp\u003eA major part of the book considers the diversity of septins in mammals, their functions and properties as well as their involvement in normal and abnormal cellular states, followed by a speculative overview from the editors of the key questions in septin research and of where the field may be headed.\u003c\/p\u003e \u003cp\u003eIn addition, several appendices summarise important information for those in, or just entering, the field, e.g. nomenclature and septin and septin-like sequences.\u003c\/p\u003e \u003cp\u003eThis book is an essential source of reference material for researchers in septin biology, cell biology, genetics and medicine, in particular pathology, including areas of neurobiology, oncology, infectious disease and developmental biology.\u003c\/p\u003e  \u003cb\u003eContents\u003c\/b\u003e  \u003cp\u003e\u003cb\u003eAuthors and Affiliations vii\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAn introduction to the septins 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003ePeter A. Hall, S. E. Hilary Russell and John R. Pringle\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection I Setting the scene 5\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 1 Origins and development of the septin field 7\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eJohn R. Pringle\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 2 Evolution and conserved domains of the septins 35\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eMichelle Momany, Fangfang Pan and Russell L. Malmberg\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection II Septins in model systems 47\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 3 Biochemical properties and supramolecular architecture of septin hetero-oligomers and septin filaments 49\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eMichael A. McMurray and Jeremy Thorner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 4 Yeast septins: a cortical organizer 101\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eYves Barral\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 5 Septins in four model fungal systems: diversity in form and function 125\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eAmy Gladfelter and Peter Sudbery\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 6 Septins in the metazoan model systems\u003c\/b\u003e \u003cb\u003e\u003ci\u003eDrosophila melanogaster\u003c\/i\u003e\u003c\/b\u003e \u003cb\u003eand\u003c\/b\u003e \u003cb\u003e\u003ci\u003eCaenorhabditis elegans\u003c\/i\u003e\u003c\/b\u003e \u003cb\u003e147\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eChristine M. Field, Amy Shaub Maddox, John R. Pringle and Karen Oegema\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection III Septins in mammals 169\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 7 The genomics and regulation of the human septin\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003egenes 171\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eS.E. Hilary Russell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 8 The functions of septins in mammals 187\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eCarol D. Froese and William S. Trimble\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 9 Septin-interacting proteins in mammals 211\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eBrandon E. Kremer and Ian G. Macara\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 10 Septin functions in the mammalian cytoskeleton 229\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eElias T. Spiliotis and W. James Nelson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 11 Septins and the synapse 247\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eJing Xue, Victor Anggono and Phillip J. Robinson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 12 Septins and platelets 269\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eJerry Ware, Constantino Mart´ınez and Barbara Zieger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 13 Septins and apoptosis 281\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eMarie-Jeanne Carp and Sarit Larisch\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 14 Septins and human disease 295\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003ePeter A. Hall and Fern P. Finger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 15 Insight into septin functions from mouse models 319\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eMakoto Kinoshita\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection IV Envoi 337\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 16 Septins: 2008 and beyond 339\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003ePeter A. Hall, S.E. Hilary Russell and John R. Pringle\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAppendix A Septin and septin-like sequences 343\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eMichelle Momany, Fangfang Pan and Russell L. Malmberg\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAppendix B Mammalian septin nomenclature 351\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003ePeter A. Hall, Elspeth Bruford, Hilary Russell, Ian G. Macara and John R. Pringle\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAppendix C Septin meetings and workshops 355\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003ePeter A. Hall and John R. Pringle\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIndex 361\u003c\/b\u003e\u003c\/p\u003e \"The authors represent most of the key figures and the work and the book as a whole is an essential reference for the newcomer or specialist in this area and for any student of eukaryotic cell structure and function. This is an important and wonderful reference.\" (\u003ci\u003eMicrobiology Today\u003c\/i\u003e, May 2009)  \u003cp\u003e\u003cstrong\u003eSE Hilary Russell\u003c\/strong\u003e, Senior Lecturer in Oncology, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Northern Ireland. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003ePeter A. Hall\u003c\/strong\u003e, Musgrave Professor of Pathology \u0026amp; Consultant Pathologist, Queens University Department of Pathology \u0026amp; The Royal Hospitals Trust,?Belfast, Northern Ireland. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eJohn R. Pringle\u003c\/strong\u003e, Professor of Genetics, Stanford University Medical Center, CA, USA.   Septins are an evolutionarily conserved group of GTP-binding and filament-forming proteins that were originally discovered in yeast. Once the preserve of a small band of yeast biologists, the field has grown rapidly in the past few years and now encompasses the whole of animal and fungal biology. Furthermore, septins are nowadays recognized to be involved in a variety of disease processes from neoplasia to neurodegenerative conditions.  \u003c\/p\u003e\u003cp\u003e \u003ci\u003eThe Septins\u003c\/i\u003e is \u003ca id=\"OLE_LINK1\" name=\"OLE_LINK1\"\u003ethe first comprehensive book devoted to the\u003c\/a\u003e septin gene family and their proteins, providing those new to this research area with a detailed and wide ranging introduction to septin biology. It starts with a unique historical perspective on the development of the field, from its beginnings in the screen for cell division mutants by the Nobel Laureate Lee Hartwell. The evolution of the septin gene family then forms a basis for consideration of the biochemistry and functions of septins in yeast and other model organisms including \u003ci\u003eC. elegans\u003c\/i\u003e and \u003ci\u003eDrosophila\u003c\/i\u003e. \u003c\/p\u003e \u003cp\u003eA major part of the book considers the diversity of septins in mammals, their functions and properties as well as their involvement in normal and abnormal cellular states, followed by a speculative overview from the editors of the key questions in septin research and of where the field may be headed.\u003c\/p\u003e \u003cp\u003eIn addition, several appendices summarise important information for those in, or just entering, the field, e.g. nomenclature and septin and septin-like sequences.\u003c\/p\u003e \u003cp\u003e \u003ci\u003eThe Septins\u003c\/i\u003e is an essential source of reference material for researchers in septin biology, cell biology, genetics and medicine, in particular pathology, including areas of neurobiology, oncology, infectious disease and developmental biology.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47990339109093,"sku":"NP9780470519691","price":195.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470519691.jpg?v=1761787419","url":"https:\/\/k12savings.com\/products\/the-septins-isbn-9780470519691","provider":"K12savings","version":"1.0","type":"link"}