{"product_id":"the-retinoids-isbn-9781118627983","title":"The Retinoids","description":"\u003ci\u003eThe Retinoids: Biology, Biochemistry, and Disease\u003c\/i\u003e provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives. \u003cbr\u003e \u003cbr\u003e The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy.\u003cbr\u003e \u003cbr\u003e Comprehensive in scope and written by leading researchers in the field,\u003ci\u003e \u003c\/i\u003e\u003ci\u003eThe Retinoids: Biology, Biochemistry, and Disease \u003c\/i\u003ewill be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids. \u003cp\u003eContributors ix\u003c\/p\u003e \u003cp\u003ePreface xiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I: Vitamin A metabolic and enzymatic pathways 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Vitamin a Metabolism, Storage and Tissue Delivery Mechanisms 3\u003cbr\u003e\u003ci\u003eWilliam S. Blaner and Yang Li\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Assimilation and Conversion of Dietary Vitamin a into Bioactive Retinoids 35\u003cbr\u003e\u003ci\u003eEarl H. Harrison and Carlo dela Senã’s\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Intracellular Storage and Metabolic Activation of Retinoids: Lipid Droplets 57\u003cbr\u003e\u003ci\u003eJoseph L. Napoli and Charles R. Krois\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Evolution of the Retinoic Acid Signaling Pathway 75\u003cbr\u003e\u003ci\u003eVincent Laudet, Elisabeth Zieger, and Michael Schubert\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II: Biochemistry and cellular biology of retinoic acid signaling 91\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5 Control of Gene Expression by Nuclear Retinoic Acid Receptors: Post-Translational And Epigenetic Regulatory Mechanisms 93\u003cbr\u003e\u003ci\u003eMarilyn Carrier and Cécile Rochette-Egly\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Retinoic Acid Receptor Coregulators in Epigenetic Regulation of Target Genes 117\u003cbr\u003e\u003ci\u003eLi-Na Wei\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Retinoid Receptors: Protein Structure, Dna Recognition and Structure–Function Relationships 131\u003cbr\u003e\u003ci\u003eWilliam Bourguet and Dino Moras\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 How the RAR–RXR Heterodimer Recognizes the Genome 151\u003cbr\u003e\u003ci\u003eSylvia Urban, Tao Ye, and Irwin Davidson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Retinoid Receptor-Selective Modulators: Chemistry, 3D Structures and Systems Biology 165\u003cbr\u003e\u003ci\u003eMarco-Antonio Mendoza-Parra, William Bourguet, Angel R. de Lera, and Hinrich Gronemeyer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Use of Retinoid Receptor Ligands to Identify Other Nuclear Receptor Ligands: Retinoid-Related Molecules are Ligands for the Small Heterodimer Partner (SHP) “Orphan” Receptor 193\u003cbr\u003e\u003ci\u003eMarcia I. Dawson and Zebin Xia\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 The Dual Transcriptional Activity of Retinoic Acid 273\u003cbr\u003e\u003ci\u003eNoa Noy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Retinoids, epigenetic changes during stem cell differentiation, and cell lineage choice 291\u003cbr\u003e\u003ci\u003eLorraine J. Gudas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III: RETINOIC ACID SIGNALING IN DEVELOPMENT 307\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13 Retinoic Acid Signaling and Central Nervous System Development 309\u003cbr\u003e\u003ci\u003eMalcolm Maden\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 The Role of Retinoic Acid in Limb Development 339\u003cbr\u003e\u003ci\u003eGregg Duester\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Retinoic Acid Signaling and Heart Development 353\u003cbr\u003e\u003ci\u003eStéphane Zaffran and Karen Niederreither\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Retinoic Acid in the Developing Lung and Other Foregut Derivatives 371\u003cbr\u003e\u003ci\u003eWellington V. Cardoso and Felicia Chen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Retinoic Acid and the Control of Meiotic Initiation 383\u003cbr\u003e\u003ci\u003eJosephine Bowles and Peter Koopman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV: RETINOIDS AND PHYSIOLOGICAL FUNCTIONS 401\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e18 Retinoids and the Visual Cycle: New Actors for an “OLD” Function 403\u003cbr\u003e\u003ci\u003eDarwin Babino and Johannes von Lintig\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Retinoid Signaling in the Central Nervous System 421\u003cbr\u003e\u003ci\u003ePeter McCaffery and Wojciech Krężel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Retinoid Turnover and Catabolism: Influences of Diet and Inflammation 449\u003cbr\u003e\u003ci\u003eA. Catharine Ross and Reza Zolfaghari\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Retinoids and the Immune System 465\u003cbr\u003e\u003ci\u003eJ. Rodrigo Mora and Makoto Iwata\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 Retinoic Acid Receptor Signaling in Post-Natal Male Germ Cell Differentiation 485\u003cbr\u003e\u003ci\u003eManuel Mark and Norbert B. Ghyselinck\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart V: RETINOIDS, DISEASE AND THERAPY 505\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e23 Epidemiology and Prevention of Vitamin a Deficiency Disorders 507\u003cbr\u003e\u003ci\u003eKeith P. West, Jr.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 Retinoid Pathway Gene Mutations and the Pathophysiology Of Related Visual Diseases 529\u003cbr\u003e\u003ci\u003eYaroslav Tsybovsky and Krzysztof Palczewski\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25 Retinoic Acid in Acute Myeloid Leukemias 543\u003cbr\u003e\u003ci\u003eHugues de Thé and Pierre Fenaux\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26 Advances in the Use of Retinoids in Cancer Therapy and Prevention 557\u003cbr\u003e\u003ci\u003eMichael J. Spinella, Sarah J. Freemantle, and Ethan Dmitrovsky\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 575\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePascal Dollé\u003c\/b\u003e, M.D., Ph.D., is Team Leader and Department Head at the Institute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch, France\u003c\/p\u003e \u003cp\u003e\u003cb\u003eKaren Niederreither\u003c\/b\u003e, Ph.D, is an Associate Professor at the University of Strasbourg, School of Dentistry in Strasbourg, France, and performs research at the IGBMC, Illkirch, France\u003c\/p\u003e \u003cp\u003e\u003ci\u003eThe Retinoids: Biology, Biochemistry, and Disease\u003c\/i\u003e provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. The book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives.\u003c\/p\u003e \u003cp\u003eThe text is divided into five parts, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy.\u003c\/p\u003e \u003cp\u003eComprehensive in scope and written by leading researchers in the field, The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.\u003c\/p\u003e \u003cp\u003e• An up-to-date synthesis of research on retinoids\u003c\/p\u003e \u003cp\u003e• Covers molecular mechanisms, pathway evolution, control of gene expression, and functions in development and adult physiology\u003c\/p\u003e \u003cp\u003e• Integrates basic biology and biochemistry with roles in disease and potential for therapies\u003c\/p\u003e \u003cp\u003e• Authored by internationally recognized leaders in the field\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47990329934053,"sku":"NP9781118627983","price":196.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118627983.jpg?v=1761787382","url":"https:\/\/k12savings.com\/products\/the-retinoids-isbn-9781118627983","provider":"K12savings","version":"1.0","type":"link"}