{"product_id":"the-pulmonary-endothelium-isbn-9780470723616","title":"The Pulmonary Endothelium","description":"\u003ci\u003eThe Pulmonary Endothelium\u003c\/i\u003e is a uniquely comprehensive compendium of our current knowledge of the pulmonary endothelium and is the first book dedicated specifically to the subject, offering insights into current and future approaches to management. The text provides the clinician with the most up-to-date information on one of the core physiological processes in airway disease and is an ideal point of reference for both postgraduates and professionals – specialist physicians in pulmonology and allergy and workers in biomedical and pharmaceutical research. \u003cp\u003eList of Contributors xi\u003c\/p\u003e \u003cp\u003eIntroduction xvii\u003cbr\u003e\u003ci\u003eSharon Rounds and Norbert Voelkel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection I: Normal Pulmonary Endothelium. Structure, Function, Cell Biology 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1: Development of the Pulmonary Endothelium in Development of the Pulmonary Circulation: Vasculogenesis and Angiogenesis 3\u003cbr\u003e\u003ci\u003eMargaret A. Schwarz and Ondine B. Cleaver\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2: Anatomy of the Pulmonary Endothelium 25\u003cbr\u003e\u003ci\u003eRadu V. Stan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3: Cadherins and Connexins in Pulmonary Endothelial Function 33\u003cbr\u003e\u003ci\u003eKaushik Parthasarathi and Sadiqa K. Quadri\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4: Pulmonary Endothelial Cell Interactions with the Extracellular Matrix 51\u003cbr\u003e\u003ci\u003eKatie L. Grinnell and Elizabeth O. Harrington\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5: Pulmonary Endothelial Cell Calcium Signaling and Regulation of Lung Vascular Barrier Function 73\u003cbr\u003e\u003ci\u003eNebojsa Knezevic, Mohammad Tauseef and Dolly Mehta\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6: Pulmonary Endothelium and Nitric Oxide 89\u003cbr\u003e\u003ci\u003eYunchao Su and Edward R. Block\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7: Pulmonary Endothelial Cell Surface Metabolic Functions 105\u003cbr\u003e\u003ci\u003eUsamah S. Kayyali and Barry L. Fanburg\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8: Cell Biology of Lung Endothelial Permeability 113\u003cbr\u003e\u003ci\u003eGuochang Hu and Richard D. Minshall\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9: Lung Endothelial Phenotypes: Insights Derived from the Systematic Study of Calcium Channels 129\u003cbr\u003e\u003ci\u003eDonna L. Cioffi, Songwei Wu and Troy Stevens\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10: Pulmonary Endothelial Interactions with Leukocytes and Platelets 143\u003cbr\u003e\u003ci\u003eRosana Souza Rodrigues and Guy A. Zimmerman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11: Mesenchymal–Endothelial Interactions in the Control of Angiogenic, Inflammatory, and Fibrotic Responses in the Pulmonary Circulation 167\u003cbr\u003e\u003ci\u003eKurt R. Stenmark, Evgenia V. Gerasimovskaya, Neil Davie and Maria Frid\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12: Pulmonary Endothelium and Vasomotor Control 185\u003cbr\u003e\u003ci\u003eNikki L. Jernigan, Benjimen R. Walker and Thomas C. Resta\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13: Pulmonary Endothelial Progenitor Cells 203\u003cbr\u003e\u003ci\u003eBernard Th\u003c\/i\u003e\u003ci\u003eébaud and Mervin C. Yoder\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14: Bronchial Vasculature: The Other Pulmonary Circulation 217\u003cbr\u003e\u003ci\u003eElizabeth Wagner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15: Mapping Protein Expression on Pulmonary Vascular Endothelium 229\u003cbr\u003e\u003ci\u003eKerri A. Massey and Jan E. Schnitzer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection II: Mechanisms and Consequences of Pulmonary Endothelial Cell Injury 241\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e16: Pulmonary Endothelial Cell Death: Implications for Lung Disease Pathogenesis 243\u003cbr\u003e\u003ci\u003eQing Lu and Sharon Rounds\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17: Oxidant-Mediated Signaling and Injury in Pulmonary Endothelium 261\u003cbr\u003e\u003ci\u003eKenneth E. Chapman, Shampa Chatterjee and Aron B. Fisher\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18: Hypoxia and the Pulmonary Endothelium 287\u003cbr\u003e\u003ci\u003eMatthew Jankowich, Gaurav Choudhary and Sharon Rounds\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19: Viral Infection and Pulmonary Endothelial Cells 303\u003cbr\u003e\u003ci\u003eNorbert F. Voelkel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20: Effects of Pressure and Flow on the Pulmonary Endothelium 309\u003cbr\u003e\u003ci\u003eWolfgang M. Kuebler\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21: Therapeutic Strategies to Limit Lung Endothelial Cell Permeability 337\u003cbr\u003e\u003ci\u003eRachel K. Wolfson, Gabriel Lang, Jeff Jacobson and Joe G. N. Garcia\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22: Targeted Delivery of Biotherapeutics to the Pulmonary Endothelium 355\u003cbr\u003e\u003ci\u003eVladimir R. Muzykantov\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection III: Pulmonary Endothelium In Disease 379\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e23: Endothelial Regulation of the Pulmonary Circulation in the Fetus and Newborn 381\u003cbr\u003e\u003ci\u003eYuansheng Gao and J. Usha Raj\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24: Genetic Insights into Endothelial Barrier Regulation in the Acutely Inflamed Lung 399\u003cbr\u003e\u003ci\u003eSumegha Mitra, Daniel Turner Lloveras, Shwu-Fan Ma and Joe G. N. Garcia\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25: Interactions of Pulmonary Endothelial Cells with Immune Cells and Platelets: Implications for Disease Pathogenesis 417\u003cbr\u003e\u003ci\u003eMark R. Nicolls, Rasa Tamosiuniene, Ashok N. Babu and Norbert F. Voelkel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26: Role of the Endothelium in Emphysema: Emphysema – A Lung Microvascular Disease 437\u003cbr\u003e\u003ci\u003eNorbert F. Voelkel and Ramesh Natarajan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e27: Pulmonary Endothelium and Pulmonary Hypertension 449\u003cbr\u003e\u003ci\u003eRubin M. Tuder and Serpil C. Erzurum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e28: Collagen Vascular Diseases and Pulmonary Endothelium 461\u003cbr\u003e\u003ci\u003ePradeep R. Rai and Carlyne D. Cool\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e29: Pulmonary Endothelium in Thromboembolism 471\u003cbr\u003e\u003ci\u003eIrene M. Lang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e30: Pulmonary Endothelium and Malignancies 485\u003cbr\u003e\u003ci\u003eAbu-Bakr Al-Mehdi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eEpilogue\u003cbr\u003e\u003ci\u003eNorbert F. Voelkel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 495\u003c\/p\u003e  \u003cp\u003eNorbert Voelkel and Sharon Rounds are the authors of The Pulmonary Endothelium: Function in Health and Disease, published by Wiley.  \u003cb\u003eThe pulmonary endothelium interacts with both blood and underlying vascular smooth muscle.\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eAs well as being critical for gas exchange, the lung endothelium is now implicated in the modulation of a variety of processes, such as inflammation, thrombosis, vasoconstriction, and vascular permeability. Our understanding of the pulmonary endothelium has increased enormously in recent years, particularly its role in several diseases, including pulmonary hypertension, emphysema, acute respiratory distress syndrome, and cancer.\u003c\/p\u003e \u003cp\u003eResearch in many fields continues to elucidate how the pulmonary endothelium contributes to the etiology and pathophysiology of lung disease and to identify possible therapeutic strategies. This book clearly presents the current body of knowledge and explores how this knowledge may be applied to increase our understanding of disease and develop new types of treatment. Above all, it aims to improve the outcomes of acute and chronic lung diseases.\u003c\/p\u003e \u003cp\u003eThe book is divided into three sections. The first describes the normal pulmonary endothelium, including development, structure, cell biology, signalling, function, heterogeneity, interactions with circulating cells and mesenchymal cells, and the endothelium of the bronchial circulation. The second section deals with mechanisms and consequences of pulmonary endothelial cell injury, ranging from effects on endothelial cells to organ injury, including protection against lung permeability and drug targeting to pulmonary endothelium. The third section focuses on the pulmonary endothelium in disease.\u003c\/p\u003e \u003cul\u003e \u003cli\u003eDescribes and discusses the lung endothelium as the first and principal locus of blood-born information processing\u003c\/li\u003e \u003cli\u003eReviews maintenance of normal lung vascular tone and modulation of vasoconstriction\u003c\/li\u003e \u003cli\u003eDiscusses the lung endothelium in modulation of pulmonary vascular remodelling\u003c\/li\u003e \u003cli\u003eHighlights recent work on the important role of the lung endothelium in the pathogenesis of lung diseases\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eThe Pulmonary Endothelium\u003c\/i\u003e provides specialist physicians and clinical researchers in pulmonology, critical care, and allergy with the most up to date information on core physiological processes in lung disease, and offers insights into current and future approaches to management.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47990324691173,"sku":"NP9780470723616","price":339.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470723616.jpg?v=1761787361","url":"https:\/\/k12savings.com\/products\/the-pulmonary-endothelium-isbn-9780470723616","provider":"K12savings","version":"1.0","type":"link"}