{"product_id":"the-lock-and-key-principle-isbn-9780471939023","title":"The Lock-and-Key Principle","description":"Published 100 years after Emil Fischer first proposed the lock-and-key principle, this volume provides a complete review of the subject to date and offers suggestions for futher research. The major impact of the lock-and-key principle on the chemical, biomedical and materials sciences is discussed by leaders in the field, with chapters dedicated to molecular recognition, nucleic acid and protein chemistry, crystallography and the development of Emil Fischer's initial ideas. \u003ci\u003eThe Lock-and-Key Principle\u003c\/i\u003e is the most up-to-date review of progress in supramolecular chemistry and the lock-and-key principle and will become the essential guide to the past, present and future of this remarkable principle. \u003cp\u003eContributors vii\u003c\/p\u003e \u003cp\u003ePreface ix\u003c\/p\u003e \u003cp\u003e1 Emil Fischer’s Lock-and-Key Hypothesis after 100 Years—Towards a Supracellular Chemistry 1\u003c\/p\u003e \u003cp\u003e\u003ci\u003eFriedrich Cramer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Molecular Recognition in Biology: Models for Analysis of Protein-Ligand Interactions 25\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDoron Lancet, Amnon Horovitz and Ephraim Katchalski-Katzir\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 New Biocatalysts via Chemical Modification 73\u003c\/p\u003e \u003cp\u003e\u003ci\u003eIan M. Bell and Donald Hilvert\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Oligonucleotides: Superspecific Ligands for Targeting Nucleic Acids and Proteins and Development of Molecular Devices 89\u003c\/p\u003e \u003cp\u003e\u003ci\u003eV. V. Vlassov\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Macrocycles and Antibodies as Catalysts 149\u003c\/p\u003e \u003cp\u003e\u003ci\u003eD. B. Smithrud and S. J. Benkovic\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Lock-and-Key Processes at Crystalline Interfaces: Relevance to the Spontaneous Generation of Chirality 173\u003c\/p\u003e \u003cp\u003e\u003ci\u003eIsabelle Weissbuch, Ronit Popovitz-Biro, Leslie Leiscrowitz and Meir Lahav\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 A Model of the Origin of Life and Perspectives in Supramolecular Engineering 247\u003c\/p\u003e \u003cp\u003e\u003ci\u003eH. Kuhn and J. Waser\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Perspectives in Supramolecular Chemistry—From the Lock-and-Key Image to the Information Paradigm 307\u003c\/p\u003e \u003cp\u003e\u003ci\u003eJean-Marie Lehn\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 319 \u003c\/p\u003e \u003cp\u003e\u003cb\u003eJean-Paul Behr\u003c\/b\u003e is the editor of \u003ci\u003eThe Lock-and-Key Principle: The State of the Art--100 Years On\u003c\/i\u003e, published by Wiley.\u003c\/p\u003e \u003cb\u003ePerspectives in Supramolecular Chemistry\u003c\/b\u003e Editorial Board Founding Editor J.-M. Lehn, Université Louis Pasteur, Strasbourg, France Editors J.-P. Behr, Université Louis Pasteur, Strasbourg, France G. R. Desiraju, University of Hyderabad, Hyderabad, India A. D. Hamilton, University of Pittsburgh, Pittsburgh, USA T. Kunitake, Kyushu University, Fukuoka, Japan D.N. Reinhoudt, University of Twente, AE Enschede, The Netherlands J.-P. Sauvage, Université Louis Pasteur, Strasbourg, France\u003cbr\u003e\u003cbr\u003e\u003cb\u003ePerspectives in Supramolecular Chemistry\u003c\/b\u003e — Volume 1 The Lock and Key Principle The State of the Art—100 Years On Edited by Jean-Paul Behr Université Louis Pasteur, Strasbourg, France Contributors Ian M. Bell, The Scripps Research Institute, La Jolla, USA S. J. Benkovic, Pennsylvania State University, Pennsylvania, USA F. Cramer, Max-Plank Institut für Experimentelle Medizin, Göttingen, Germany D. Hilvert, The Scripps Research Institute, La Jolla, USA E. A. Horovitz, The Weizmann Institute of Science, Rehovot, Israel E. Katchalski-Katzir, The Weizmann Institute of Science, Rehovot, Israel H. Kuhn, formerly Max-Planck-Institut für biophysikalische Chemie, Göttingen M. Lahav, The Weizmann Institute of Science, Rehovot, Israel D. Lancet, The Weizmann Institute of Science, Rehovot, Israel J.-M. Lehn, Université Louis Pasteur, Strasbourg, France L. Leiserowitz The Weizmann Institute of Science, Rehovot, Israel D. B. Smithrud, Pennsylvania State University, Pennsylvania, USA V. V. Vlassov, Institute of Bioorganic Chemistry, Novosibirsk, Russia\u003cbr\u003e\u003cbr\u003eForthcoming titles in \u003cb\u003ePerspectives in Supramolecular Chemistry\u003c\/b\u003e \u003ci\u003eVolume 2: Supramolecular Chemistry in the Solid State\u003c\/i\u003e Edited by Gautam Desiraju, University of Hyderabad, India\u003cbr\u003e\u003cbr\u003eThis volume will concentrate on the crystalline structures of supramolecules. Contributions will include Crystals as Supramolecules, Molecular Shape Considerations in Crystals Engineering, The Intermolecular Implication of Protein Function and Molecular Engineering of Crystals by Electrostatic Templating. Volume 3: Supramolecular Control of Structure and Reactivity Edited by Andrew Hamilton, Massachusetts Institute of Technology, Cambridge, USA This volume will deal with the catalytic properties of supramolecules, particularly in biological systems. Topics covered include Design of Self-Replicating Molecules, Synthetic Control of Oligonucleotide Structure, Micellar Catalysis and A Survey of Recent Developments in Supramolecular Catalysis.","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47990281208037,"sku":"NP9780471939023","price":701.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780471939023.jpg?v=1761787185","url":"https:\/\/k12savings.com\/products\/the-lock-and-key-principle-isbn-9780471939023","provider":"K12savings","version":"1.0","type":"link"}