{"product_id":"the-hidden-life-of-the-basal-ganglia-isbn-9780262543118","title":"The Hidden Life of the Basal Ganglia","description":"\u003cb\u003eThe anatomy and physiology of the basal ganglia and their relation to brain and behavior, disorders and therapies, and philosophy of mind and moral values.\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003eThe main task of the basal ganglia—a group of subcortical nuclei, located at the base of the brain—is to optimize and execute our automatic behavior. In this book, Hagai Bergman analyzes the anatomy and physiology of the basal ganglia, discussing their relation to brain and behavior, to disorders and therapies, and even to moral values. Drawing on his forty years of studying the basal ganglia, Bergman presents new information on physiology and computational models, Parkinson’s disease and other ganglia-related disorders, and such therapies as deep brain stimulation.\u003cbr\u003e            Focusing on studies of nonhuman primates and human basal ganglia and relying on system physiology and in vivo extra-cellular recording techniques, Bergman first describes the major brain structures that constitute the basal ganglia, the morphology of their cellular elements, their synaptic connectivity and their physiological function in health and disease. He discusses the computational physiology of the healthy basal ganglia, describing four generations of computational models, and then traces the computational physiology of basal ganglia–related disorders and their treatments, including Parkinson’s disease and its pharmacological and surgical therapies. Finally, Bergman considers the implications of these findings for such moral concerns as free will. Explaining this leap into domains rarely explored in neuroscientific accounts, Bergman writes that the longer he studies the basal ganglia, the more he is convinced that they are truly the base of both brain and mind.Preface xi\u003cbr\u003eAcknowledgments xiii\u003cbr\u003eI Introduction and Background \u003cbr\u003e1 The Basal Ganglia: Why and Where? 3\u003cbr\u003e2 Cellular Anatomy and Biochemistry of the Basal Ganglia 15\u003cbr\u003e3 The Synaptic Connections of the Basal Ganglia Network 27\u003cbr\u003e4 Computational Modeling of Brain and Behavior 39\u003cbr\u003e5 Principles of Neurophysiological Data Acquisition 43\u003cbr\u003e6 Principles of Neurophysiological Analysis 61\u003cbr\u003eII Computational Physiology of the Healthy Basal Ganglia\u003cbr\u003e7 Physiology of the Basal Ganglia 77\u003cbr\u003e8 Basal Ganglia Physiology: The Roads Less Traveled 89\u003cbr\u003e9 Box-and-Arrow Rate Models of the Basal Ganglia 105\u003cbr\u003e10 Reinforcement-Learning Actor\/Critic Models of the Basal Ganglia 117\u003cbr\u003e11 Multiple-Critics, Multiobjective Optimization Models of the Basal Ganglia 133\u003cbr\u003e12 The Basal Ganglia as one of many State-to-Action Loops 145\u003cbr\u003eIII Computational Physiology of Basal Ganglia Disorders and their Therapy\u003cbr\u003e13 Parkinson's Disease and other Basal Ganglia-Related Human Disorders 163\u003cbr\u003e14 Animal Models of Parkinson's Disease 171\u003cbr\u003e15 Physiology of Parkinson's Disease: Animal Models 179\u003cbr\u003e16 Physiology of Parkinson's Disease: Human 195\u003cbr\u003e17 Pharmacotherapy of Parkinson's Disease 203\u003cbr\u003e18 Deep Brain Stimulation Therapy for Parkinson's Disease 215\u003cbr\u003e19 Closing the Loop on Parkinson's Disease and Basal Ganglia-Related Disorders 225\u003cbr\u003eIV From the Basal Ganglia and Brain to the Mind \u003cbr\u003e20 The Basal Ganglia, Free Will, and Human Responsibility 241\u003cbr\u003eNotes 247\u003cbr\u003eReferences 261\u003cbr\u003eIndex 295“Hagai Bergman has written a splendid, very human, and witty text; this epic odyssey into the cradle of our motions and emotions is a tour de force of translational neuroscience.”\u003cbr\u003e—\u003cb\u003eMarwan Hariz, Emeritus Professor, University College London, and Adjunct Professor, Umeå, Sweden\u003c\/b\u003e\u003cbr\u003e \u003cbr\u003e“This book provides a masterful summary of how these crucial sets of brain nuclei are organized functionally and affect our behavior, written by an international expert with both clinical and academic experience in working on these amazing deep brain structures.”\u003cbr\u003e—\u003cb\u003eAnn M. Graybiel, McGovern Institute for Brain Research, MIT\u003c\/b\u003e\u003cbr\u003e \u003cbr\u003e“Excellent, insightful, and lively. In his unique, passionate style, Hagai Bergman takes the reader on a journey through his lifelong quest for understanding the fundamental role of the basal ganglia within the brain orchestra. A must-read for neuroscientists interested in the mechanisms of human behavior.”\u003cbr\u003e—\u003cb\u003ePaul Krack, Head of the Center of Parkinson’s Disease and Movement Disorders, Neurology Department, University Hospital Bern, Switzerland\u003c\/b\u003eHagai Bergman is Simone and Bernard Guttman Chair in Brain Research and Professor of Physiology in the Edmond and Lily Safra Center (ELSC) for Brain Research and Faculty of Medicine at the Hebrew University of Jerusalem.","brand":"The MIT Press","offers":[{"title":"Default Title","offer_id":46303593332965,"sku":"NP9780262543118","price":55.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780262543118.jpg?v=1767739779","url":"https:\/\/k12savings.com\/products\/the-hidden-life-of-the-basal-ganglia-isbn-9780262543118","provider":"K12savings","version":"1.0","type":"link"}