{"product_id":"the-brugada-syndrome-isbn-9781405127783","title":"The Brugada Syndrome","description":"Until recently, the cellular basis for sudden death, the Brugada Syndrome, has largely remained an unknown to modern arrhythmologists and cardiologists, particularly in the absence of any structural heart disease. Detailed observations of age-groups, especially the young, families and populations where sudden death frequently occurs, and improved understanding of its contributory factors and mechanisms are, however, showing the way forward. \u003cp\u003eThis addition to the \u003ci\u003eClinical Approaches to Tachyarrhythmias (CATA)\u003c\/i\u003e Series, written by the investigators who discovered and probed the Brugada Syndrome, discusses the history, etiology, pathology and clinical manifestations of sudden death. From diagnosis, prognosis, to therapeutic approaches using the latest in cathater ablation techniques, electrophysiological surgery, and genetic appraisal, the work is a testimony to the author's investigation. Using clinical cases in Thailand and Laos, they further unravel the syndrome's molecular mechanisms, studying related syndromes, such as the long-QT syndrome, infant death, and arryhthmogenic right ventricular cardiomyopathy.\u003c\/p\u003e \u003cp\u003eBy being informed of the electrophysiological abnormalities that contribute to familial and genetic diseases, physicians, cardiologists and all those who care for patients with cardiac arrhythmias will be better able to identify and treat patients in whom the Brugada Syndrome may strike next.\u003c\/p\u003e  Contributors. \u003cp\u003ePreface.\u003c\/p\u003e \u003cp\u003eDedication.\u003c\/p\u003e \u003cp\u003e1 Brugada Syndrome: Overview.\u003c\/p\u003e \u003cp\u003e2 History of the Brugada Syndrome.\u003c\/p\u003e \u003cp\u003e3 Biophysical Analysis of Mutant Sodium Channels in Brugada Syndrome.\u003c\/p\u003e \u003cp\u003e4 Molecular Genetics of the Brugada Syndrome.\u003c\/p\u003e \u003cp\u003e5 Cellular Mechanisms Underlying the Brugada Syndrome.\u003c\/p\u003e \u003cp\u003e6 Brugada Syndrome: Diagnostic Criteria.\u003c\/p\u003e \u003cp\u003e7 Value of 12 Lead ECG and Derived Methodologies in the Diagnosis of Brugada Disease.\u003c\/p\u003e \u003cp\u003e8 Brugada Syndrome: Relationship to Other Arrhythmogenic Syndromes.\u003c\/p\u003e \u003cp\u003e9 ST Segment Elevation and Sudden Death in the Athlete.\u003c\/p\u003e \u003cp\u003e10 Brugada Syndrome Genetics. Genetic Screening- Role in Diagnosis.\u003c\/p\u003e \u003cp\u003e11 Genotype-Phenotype Relationship in Brugada Syndrome.\u003c\/p\u003e \u003cp\u003e12 Gender Differences in Brugada Syndrome.\u003c\/p\u003e \u003cp\u003e13 Predisposing Factors.\u003c\/p\u003e \u003cp\u003e14 Acquired Forms of Brugada Syndrome.\u003c\/p\u003e \u003cp\u003e15 Brugada Syndrome and supraventricular tacharrhythmias.\u003c\/p\u003e \u003cp\u003e16 Prognosis in Individuals with the Brugada Syndrome.\u003c\/p\u003e \u003cp\u003e17 Treatment of the Brugada Syndrome with the Implantable Cardioverter Defibrillator.\u003c\/p\u003e \u003cp\u003e18 Pharmacologic Approach to Therapy of the Brugada Syndrome: Quinidine as an Alterative to ICD Therapy?.\u003c\/p\u003e \u003cp\u003e19 Potential for Ablation Therapy in Patients with the Brugada Syndrome.\u003c\/p\u003e \u003cp\u003eIndex\u003c\/p\u003e  Charles Antzelevitch, PhD, is Executive Director\/Director of Research; Gordon K. Moe Scholar; Professor of Pharmacology at the Masonic Medical Research Laboratory; Utica, New York.\u003cbr\u003e \u003cp\u003ePedro Brugada, MD, PhD, is Professor of Cardiology at the Cardiovascular Center OLV Hospital in Aalst, Belgium.\u003c\/p\u003e  Since its introduction as a new clinical entity in 1992, the Brugada syndrome has attracted great interest because of its high incidence in many parts of the world and its association with high risk for sudden death in infants, children and young adults. Recent years have witnessed an exponential rise in the number of reported cases and a striking proliferation of papers serving to define the clinical, genetic, cellular, ionic and molecular aspects of the disease. \u003cbr\u003e \u003cp\u003e\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eThis text delineates the diagnostic criteria for the syndrome and deals with risk stratification and approaches to therapy. The book handles this topic in a very comprehensive manner with the clinical, molecular, genetic, and cellular aspects of the Brugada syndrome authored by the leading experts in the field.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47990178578661,"sku":"NP9781405127783","price":133.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781405127783.jpg?v=1761786804","url":"https:\/\/k12savings.com\/products\/the-brugada-syndrome-isbn-9781405127783","provider":"K12savings","version":"1.0","type":"link"}