{"product_id":"the-ah-receptor-in-biology-and-toxicology-isbn-9780470601822","title":"The AH Receptor in Biology and Toxicology","description":"This book provides a thorough and up-to-date overview of the aryl hydrocarbon receptor (AHR) and its unique dual role in toxicology and biology. The coverage includes epigenetic mechanisms, gene expression, reproductive and developmental toxicity, signal transduction, and transgenic animal models. Featuring an internationally recognized team of authors at the forefront of AHR research, this resource provides a comprehensive reference for readers interested in understanding the full spectrum of AHR, from basic concepts, toxicology analysis, and models to polymorphism and related diseases.  Preface.  \u003cp\u003e\u003cb\u003eA. Historical background.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1. History of Research on the AHR (\u003ci\u003eThomas A. Gasiewocz and Ellen C. Henry\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eB. AHR as a ligand-activated transcription factor.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2. Overview of AHR functional domains and the classical signaling pathway: induction of drug-metabolizing enzymes (\u003ci\u003eQiang Ma\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e3. Role of chaperone proteins in AHR function (\u003ci\u003eIain A. Murray and Gary H. Perdew\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e4. AHR Ligands: Promiscuity in Binding and Diversity in Response (\u003ci\u003eDanica DeGroot, Guochun He, Domenico Fraccalvieri, Laura Bonati, Allesandro Pandin and Michael S. Denison\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e5. Dioxin response elements and regulation of gene transcription (\u003ci\u003eHollie Swanson\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e6. The AHR\/ARNT dimer and transcriptional coactivators (\u003ci\u003eOliver Hankinson\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e7. Regulation of AHR by the AHR repressor (AHRR) (\u003ci\u003eYoshiaki Fujii-Kuriyama and Kaname Kawajiri\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e8. Influence of HIF-1α and Nrf2 signaling on AHR-mediated gene expression, toxicity and biological functions (\u003ci\u003eThomas Haarmann-Stemmann and Josef Abel\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e9. Functional interactions of AHR with other receptors (\u003ci\u003eSara Brunnberg, Elin Swedenborg and Jan-Åke Gustafsson\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e10. The E3 ubiquitin ligase activity of transcription factor AHR permits non-genomic regulation of biological pathways (\u003ci\u003eFumiaki Ohtake and Shigeaki Kato\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e11. Epigenetic mechanisms in AHR function (\u003ci\u003eChia-I Ko and Alvaro Puga\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eC. AHR as a mediator of xenobiotic toxicities: dioxins as a key example.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12. Role of the AHR and its structure in TCDD toxicity (\u003ci\u003eRaimo Pohjanvirta, Merja Korkalainen, Ivy D. Moffat, Paul C. Boutros, Allan B. Okey\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e13. Nongenomic route of action of TCDD: Identity, characteristics and toxicological significance (\u003ci\u003eFumio Matsumura\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e14. Inter-species heterogeneity in the hepatic transcriptomic response to AHR activation by dioxin (\u003ci\u003ePaul Boutros\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e15. Dioxin-activated AHR: toxic responses and the induction of oxidative stress (\u003ci\u003eSidney J. Stohs and Ezdihar A. Hassoun\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e16. Dioxin-activated AHR and cancer in laboratory animals (\u003ci\u003eDieter Schrenk and Martin Chopra\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e17. Teratogenic impact of dioxin-activated AHR in laboratory animals (\u003ci\u003eBarbara D. Abbott\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e18. The developmental toxicity of dioxin to the developing male reproductive system in the rat; relevance of the AHR for risk assessment (\u003ci\u003eDavid R. Bell\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e19. TCDD, AHR and immune regulation (\u003ci\u003eNancy I. Kerkvliet\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e20. Effects of dioxins on teeth and bone: the role of AHR (\u003ci\u003eMatti Viluksela, Hanna M. Miettinen and Merja Korkalainen\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e21. Impacts of dioxin-activated AHR signaling in fish and birds (\u003ci\u003eMichael T. Simonich and Robert L. Tangray\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e22. Adverse Health Outcomes Caused By Dioxin-Activated AHR in Humans (\u003ci\u003eSally S. White, Suzanne E. Fenton, and Linda S. Birnbaum\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e23. The toxic equivalency principle and its application in dioxin risk assessment (\u003ci\u003eJouko Tuomisto\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e24. AHR-active compounds in the human diet (\u003ci\u003eStephen Safe, Gayathri Chadalapaka and Indira Jutooru\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e25. Modulation of AHR function by heavy metals and disease states (\u003ci\u003eAnwar Anwar-Mohammed and Ayman O.S. El-Kadi\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e26. Transgenic mice with a constitutively active AHR: a model for human exposure to dioxin an other AHR ligands (\u003ci\u003ePatrik Andersson, Sara Brunnberg, Carolina Wejheden, Lorenz Poellinger and Annika Hanberg\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003eD. AHR as a physiological regulator.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e27. Structural and functional diversification of AHRs during metazoan evolution (\u003ci\u003eMark E. Hahn and Sibel I. Karchner\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e28. Invertebrate AHR homologs: Ancestral functions in sensory systems (\u003ci\u003eJo Anne Powell-Coffman and Hongtao Qin\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e29. Role of AHR in the development of the liver and blood vessels (\u003ci\u003eSahoko Ichihara\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e30. Involvement of the AHR in cardiac function and regulation of blood pressure (\u003ci\u003eJason A. Scott and Mary K. Walker\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e31. Involvement of the AHR in development and functioning of the female and male reproductive systems (\u003ci\u003eBethany N. Karman, Isabel Hernández-Ochoa, Ayelet Ziv-Gal, Jodi A. Fl\u003c\/i\u003eaws).\u003c\/p\u003e \u003cp\u003e32. The AHR in the control of cell cycle and apoptosis (\u003ci\u003eCornelia Dietrich\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e33. The AHR regulates cell adhesion and migration by interacting with oncogene and growth factor-dependent signaling (\u003ci\u003eAngel Carlos Roman, Jose M. Carvajal-Gonzalez, Sonia Mulero-Navarro, Aurea Gomez-Duran, Eva M. Rico-Leo and Pedro M. Fernandez-Salguero\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e34. The physiological role of AHR in the mouse immune system (\u003ci\u003eCharlotte Esser\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e35. AHR and the circadian clock (\u003ci\u003eShelley A. Tischkau\u003c\/i\u003e). \u003c\/p\u003e    \u003cp\u003eRaimo Pohjanvirta, PhD, is Professor of Toxicology at the University of Helsinki. He has been studying the effects and action mechanisms of dioxins for over twenty years, publishing over a hundred peer-reviewed papers on dioxins and AHR. Dr. Pohjanvirta has been an invited lecturer at major international conferences, including the Society of Toxicology, EUROTOX, and the British Toxicology Society.\u003c\/p\u003e  \u003cp\u003eThe complete guide to the aryl hydrocarbon receptor (AHR)—what it is, what it does, and what it might mean for the future of drug metabolism\u003c\/p\u003e \u003cp\u003eProviding a thorough and up-to-date overview of the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor that mediates the induction of drug-metabolizing enzymes and diverse toxicities caused by dioxins, The AH Receptor in Biology and Toxicology is essential reading for toxicologists, chemists, biologists, pharmacologists, and other experts studying drug metabolism.\u003c\/p\u003e \u003cp\u003eEvidence suggests that the AHR protein imparts important physiological functions that place it at the crossroad of biology and toxicology, making it the focus of extensive research activity. Examining the unique dual role of AHR as both a toxicant and a factor in biological processes, this comprehensive reference work covers the full spectrum of AHR topics from basic concepts, toxicological risk analysis, and models, to polymorphisms and related diseases. Addressing epigenetic mechanisms, gene expression, reproductive\/developmental toxicity, signal transduction, and transgenic animal models, the book runs the gamut of AHR knowledge.\u003c\/p\u003e \u003cp\u003eWith contributions from renowned international experts, The AH Receptor in Biology and Toxicology puts the forefront of AHR research at your fingertips.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47990154526949,"sku":"NP9780470601822","price":191.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470601822.jpg?v=1761786711","url":"https:\/\/k12savings.com\/products\/the-ah-receptor-in-biology-and-toxicology-isbn-9780470601822","provider":"K12savings","version":"1.0","type":"link"}