{"product_id":"temperature-responsive-polymers-isbn-9781119157786","title":"Temperature-Responsive Polymers","description":"\u003cp\u003e\u003cb\u003eAn authoritative resource that offers an understanding of the chemistry, properties and applications of temperature-responsive polymers\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eWith contributions from a distinguished panel of experts, \u003ci\u003eTemperature-Responsive Polymers \u003c\/i\u003eputs the focus on hydrophilic polymers capable of changing their physicochemical properties in response to changes in environmental temperature. The contributors review the chemistry of these systems, and discuss a variety of synthetic approaches for preparation of temperature-responsive polymers, physicochemical methods of their characterisation and potential applications in biomedical areas.\u003c\/p\u003e \u003cp\u003eThe text reviews a wide-variety of topics including: The characterisation of temperature-responsive polymers; Infrared and Raman spectroscopy; Applications of temperature-responsive polymers grafted onto solid core nanoparticles; and much more. The contributors also explore how temperature-responsive polymers can be used in the biomedical field for applications such as tissue engineering. This important resource:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eOffers an important synthesis of the current research on temperature-responsive polymers\u003c\/li\u003e \u003cli\u003eCovers the chemistry, the synthetic approaches for presentation and the physiochemical method of temperature-responsive polymers\u003c\/li\u003e \u003cli\u003eIncludes a review of the fundamental characteristics of temperature-responsive polymers\u003c\/li\u003e \u003c\/ul\u003e \u003cul\u003e \u003cli\u003eExplores many of the potential applications in biomedical science, including drug delivery and gene therapy\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eWritten for polymer scientists in both academia and industry as well as postgraduate students working in the area of stimuli-responsive materials, this vital text offers an exploration of the chemistry, properties and current applications of temperature-responsive polymers.\u003c\/p\u003e \u003cp\u003eAbout the Editors xiii\u003c\/p\u003e \u003cp\u003eList of Contributors xv\u003c\/p\u003e \u003cp\u003ePreface xix\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I Chemistry 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Poly(N-isopropylacrylamide): Physicochemical Properties and Biomedical Applications 3\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMarzieh Najafi, Erik Hebels,WimE. Hennink, and Tina Vermonden\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 3\u003c\/p\u003e \u003cp\u003e1.2 PNIPAM as Thermosensitive Polymer 4\u003c\/p\u003e \u003cp\u003e1.3 Physical Properties of PNIPAM 5\u003c\/p\u003e \u003cp\u003e1.3.1 Phase Behavior of PNIPAM in Water\/Alcohol Mixtures 5\u003c\/p\u003e \u003cp\u003e1.3.2 Effect of Concentration and Molecular Weight of PNIPAM on LCST 5\u003c\/p\u003e \u003cp\u003e1.3.3 Effect of Surfactants on LCST 7\u003c\/p\u003e \u003cp\u003e1.3.4 Effect of Salts on LCST 7\u003c\/p\u003e \u003cp\u003e1.4 Common Methods for Polymerization of NIPAM 8\u003c\/p\u003e \u003cp\u003e1.4.1 Free Radical Polymerization 8\u003c\/p\u003e \u003cp\u003e1.4.2 Living Radical Polymerization 9\u003c\/p\u003e \u003cp\u003e1.4.2.1 ATRP of NIPAM 10\u003c\/p\u003e \u003cp\u003e1.4.2.2 RAFT Polymerization of NIPAM 11\u003c\/p\u003e \u003cp\u003e1.5 Dual Sensitive Systems 12\u003c\/p\u003e \u003cp\u003e1.5.1 pH and Thermosensitive Systems 12\u003c\/p\u003e \u003cp\u003e1.5.2 Reduction-Sensitive and Thermosensitive Systems 13\u003c\/p\u003e \u003cp\u003e1.5.3 Hybrid-Thermosensitive Materials 13\u003c\/p\u003e \u003cp\u003e1.6 Bioconjugation of PNIPAM 15\u003c\/p\u003e \u003cp\u003e1.6.1 Protein–PNIPAM Conjugates 16\u003c\/p\u003e \u003cp\u003e1.6.2 Peptide–PNIPAM Conjugates 18\u003c\/p\u003e \u003cp\u003e1.6.3 Nucleic Acid–PNIPAM Conjugates 21\u003c\/p\u003e \u003cp\u003e1.7 Liposome Surface Modification with PNIPAM 21\u003c\/p\u003e \u003cp\u003e1.8 Applications of PNIPAM in Cell Culture 22\u003c\/p\u003e \u003cp\u003e1.9 Crosslinking Methods for Polymers 23\u003c\/p\u003e \u003cp\u003e1.9.1 Crosslinking in PNIPAM-Based Hydrogels 23\u003c\/p\u003e \u003cp\u003e1.9.2 Crosslinking of PNIPAM-Based Micelles 26\u003c\/p\u003e \u003cp\u003e1.9.2.1 Shell Crosslinked (SCL) 26\u003c\/p\u003e \u003cp\u003e1.9.2.2 Core Crosslinked (CCL) 27\u003c\/p\u003e \u003cp\u003e1.10 Conclusion and Outlook of Applications of PNIPAM 27\u003c\/p\u003e \u003cp\u003eAcknowledgments 28\u003c\/p\u003e \u003cp\u003eReferences 28\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Thermoresponsive Multiblock Copolymers: Chemistry, Properties and Applications 35\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAnna P. Constantinou and Theoni K. Georgiou\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 35\u003c\/p\u003e \u003cp\u003e2.2 Chemistry of Thermoresponsive Block-based Copolymers 35\u003c\/p\u003e \u003cp\u003e2.3 Architecture, Number of Blocks and Block Sequence 38\u003c\/p\u003e \u003cp\u003e2.3.1 Why the Block Structure? 38\u003c\/p\u003e \u003cp\u003e2.3.2 Triblock Copolymers 39\u003c\/p\u003e \u003cp\u003e2.3.2.1 Micelles 40\u003c\/p\u003e \u003cp\u003e2.3.2.2 Gels 45\u003c\/p\u003e \u003cp\u003e2.3.2.3 Films and Membranes 52\u003c\/p\u003e \u003cp\u003e2.3.3 Tetrablock Copolymers 53\u003c\/p\u003e \u003cp\u003e2.3.4 Pentablock Copolymers 54\u003c\/p\u003e \u003cp\u003e2.3.4.1 Pluronic®Based 54\u003c\/p\u003e \u003cp\u003e2.3.4.2 Non-pluronic Based 56\u003c\/p\u003e \u003cp\u003e2.3.5 Multiblock Copolymers 57\u003c\/p\u003e \u003cp\u003e2.4 Applications 59\u003c\/p\u003e \u003cp\u003e2.5 Conclusions 61\u003c\/p\u003e \u003cp\u003eAcknowledgments 61\u003c\/p\u003e \u003cp\u003eReferences 61\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Star-shaped Poly(2-alkyl-2-oxazolines): Synthesis and Properties 67\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAndrey V. Tenkovtsev, Alina I. Amirova, and Alexander P. Filippov\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 67\u003c\/p\u003e \u003cp\u003e3.2 Synthesis of Star-shaped Poly(2-alkyl-2-oxazolines) 68\u003c\/p\u003e \u003cp\u003e3.3 Properties of Star-shaped Poly(2-alkyl-2-oxazolines) 78\u003c\/p\u003e \u003cp\u003e3.4 Conclusions 87\u003c\/p\u003e \u003cp\u003eReferences 88\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Poly(N-vinylcaprolactam): FromPolymer Synthesis to Smart Self-assemblies 93\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eFei Liu, Veronika Kozlovskaya, and Eugenia Kharlampieva\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 93\u003c\/p\u003e \u003cp\u003e4.2 Synthesis of PVCL Homo- and Copolymers 93\u003c\/p\u003e \u003cp\u003e4.2.1 Synthesis of Statistical PVCL Copolymers 95\u003c\/p\u003e \u003cp\u003e4.2.2 Synthesis of PVCL Block Copolymers 97\u003c\/p\u003e \u003cp\u003e4.2.3 Other PVCL-based Copolymers 99\u003c\/p\u003e \u003cp\u003e4.3 Properties of PVCL in Aqueous Solutions 99\u003c\/p\u003e \u003cp\u003e4.3.1 Dependence of the LCST of PVCL on Molecular Weight and Polymer Concentration 99\u003c\/p\u003e \u003cp\u003e4.3.2 LCST Dependence on Chemical Composition 100\u003c\/p\u003e \u003cp\u003e4.3.3 The Effect of Salt on the PVCL Temperature Response 102\u003c\/p\u003e \u003cp\u003e4.3.4 The Effect of Solvent on PVCL Temperature Response 102\u003c\/p\u003e \u003cp\u003e4.4 Assembly of PVCL-based Polymers in Solution 102\u003c\/p\u003e \u003cp\u003e4.4.1 PVCL Interpolymer Complexes 102\u003c\/p\u003e \u003cp\u003e4.4.2 PVCL-based Micelles 103\u003c\/p\u003e \u003cp\u003e4.4.3 Self-assembly of PVCL-based Copolymers into Polymersomes 105\u003c\/p\u003e \u003cp\u003e4.5 Templated Assemblies of PVCL Polymers 107\u003c\/p\u003e \u003cp\u003e4.5.1 Hydrogen-bonded PVCL-based Multilayers 107\u003c\/p\u003e \u003cp\u003e4.5.1.1 pH-sensitive Hydrogen-bonded PVCL Multilayers 107\u003c\/p\u003e \u003cp\u003e4.5.1.2 Enzymatically Sensitive Hydrogen-bonded PVCL Multilayers 108\u003c\/p\u003e \u003cp\u003e4.5.2 Multilayer Hydrogels of PVCL 110\u003c\/p\u003e \u003cp\u003e4.6 Outlook and Perspectives 113\u003c\/p\u003e \u003cp\u003eAcknowledgment 113\u003c\/p\u003e \u003cp\u003eReferences 114\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Sodium Alginate Grafted with Poly(N-isopropylacrylamide) 121\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eCatalina N. Cheaburu-Yilmaz, Cornelia Vasile, Oana-Nicoleta Ciocoiu, and Georgios Staikos\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Alginic Acid 121\u003c\/p\u003e \u003cp\u003e5.1.1 Monomeric and Polymeric Structure of Alginates 121\u003c\/p\u003e \u003cp\u003e5.2 Poly(N-Isopropylacrylamide) and Thermoresponsive Properties 122\u003c\/p\u003e \u003cp\u003e5.3 Synthesis and Characterization of Alginate-graft-PNIPAM Copolymers 123\u003c\/p\u003e \u003cp\u003e5.4 Solution Properties 124\u003c\/p\u003e \u003cp\u003e5.4.1 Turbidimetry 124\u003c\/p\u003e \u003cp\u003e5.4.2 Fluorescence 124\u003c\/p\u003e \u003cp\u003e5.4.3 Rheology 126\u003c\/p\u003e \u003cp\u003e5.4.4 Degradability 130\u003c\/p\u003e \u003cp\u003e5.4.5 Biocompatibility 131\u003c\/p\u003e \u003cp\u003e5.4.5.1 Cytotoxicity 132\u003c\/p\u003e \u003cp\u003e5.4.5.2 Pharmaceutical and Medical Applications 135\u003c\/p\u003e \u003cp\u003e5.5 Conclusions and Perspectives 137\u003c\/p\u003e \u003cp\u003eReferences 138\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Multi-stimuli-responsive Polymers Based on Calix[4]arenes and Dibenzo-18-crown-6-ethers 145\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSzymonWiktorowicz, Heikki Tenhu, and Vladimir Aseyev\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 145\u003c\/p\u003e \u003cp\u003e6.2 Single-stimuli-responsive Polymers 146\u003c\/p\u003e \u003cp\u003e6.2.1 Thermo-responsive Polymers in Polar Media 147\u003c\/p\u003e \u003cp\u003e6.2.2 pH-responsive Polymers 148\u003c\/p\u003e \u003cp\u003e6.2.3 Photoresponsive Polymers 148\u003c\/p\u003e \u003cp\u003e6.2.4 Other Single-stimuli-responsive Polymers 150\u003c\/p\u003e \u003cp\u003e6.3 Multi-stimuli-responsive Polymers 150\u003c\/p\u003e \u003cp\u003e6.4 Poly(azocalix[4]arene)s and Poly(azodibenzo-18-crown-6-ether)s 151\u003c\/p\u003e \u003cp\u003e6.4.1 Calixarenes 151\u003c\/p\u003e \u003cp\u003e6.4.2 Crown Ethers 152\u003c\/p\u003e \u003cp\u003e6.4.3 Structural Units of Poly(azocalix[4]arene)s 153\u003c\/p\u003e \u003cp\u003e6.4.4 Structural Units of Poly(azodibenzo-18-crown-6-ether)s 154\u003c\/p\u003e \u003cp\u003e6.5 Photoisomerization 154\u003c\/p\u003e \u003cp\u003e6.6 Host–guest Interactions 156\u003c\/p\u003e \u003cp\u003e6.7 Thermo-responsiveness 158\u003c\/p\u003e \u003cp\u003e6.7.1 LCST: Tegylated Poly(azocalix[4]arene)s inWater 158\u003c\/p\u003e \u003cp\u003e6.7.2 UCST: Tegylated Poly(azocalix[4]arene)s in Alcohols 159\u003c\/p\u003e \u003cp\u003e6.7.3 UCST and Photoisomerization of Tegylated Poly(azocalix[4]arene)s 160\u003c\/p\u003e \u003cp\u003e6.7.4 UCST and Poly(azodibenzo-18-crown-6-ether)s 161\u003c\/p\u003e \u003cp\u003e6.7.5 UCST and Photoisomerization of Poly(azodibenzo-18-crown-6-ether)s 162\u003c\/p\u003e \u003cp\u003e6.7.6 UCST in Water–alcohol Mixtures 162\u003c\/p\u003e \u003cp\u003e6.8 Solvatochromism and pH Sensitivity 163\u003c\/p\u003e \u003cp\u003e6.9 Summary and Outlook 164\u003c\/p\u003e \u003cp\u003eAcknowledgments 165\u003c\/p\u003e \u003cp\u003eReferences 165\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II Characterization of Temperature-responsive Polymers 175\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Small-Angle X-ray and Neutron Scattering of Temperature-Responsive Polymers in Solutions 177\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSergey K. Filippov, Martin Hruby, and Petr Stepanek\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 177\u003c\/p\u003e \u003cp\u003e7.2 Temperature-responsive Homopolymers 179\u003c\/p\u003e \u003cp\u003e7.3 Hydrophobically Modified Polymers 182\u003c\/p\u003e \u003cp\u003e7.4 Cross-Linked Temperature-Sensitive Polymers and Gels 184\u003c\/p\u003e \u003cp\u003e7.5 Temperature-Responsive Block Copolymers 185\u003c\/p\u003e \u003cp\u003e7.6 Hybrid Nanoparticles 187\u003c\/p\u003e \u003cp\u003e7.7 Gradient Temperature-Responsive Polymers 188\u003c\/p\u003e \u003cp\u003e7.8 Multi-responsive Copolymers 189\u003c\/p\u003e \u003cp\u003e7.9 Concluding Remarks 191\u003c\/p\u003e \u003cp\u003eAcknowledgments 191\u003c\/p\u003e \u003cp\u003eReferences 191\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Infrared and Raman Spectroscopy of Temperature-Responsive Polymers 197\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eYasushi Maeda\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 197\u003c\/p\u003e \u003cp\u003e8.2 Experimental Methods to Measure IR and Raman Spectra of Aqueous Solutions 198\u003c\/p\u003e \u003cp\u003e8.3 Poly(N-substituted acrylamide)s 200\u003c\/p\u003e \u003cp\u003e8.3.1 Overall Spectral Change 200\u003c\/p\u003e \u003cp\u003e8.3.2 Amide Bands 202\u003c\/p\u003e \u003cp\u003e8.3.3 C–H Stretching Bands 204\u003c\/p\u003e \u003cp\u003e8.3.4 C–D Stretching Band 206\u003c\/p\u003e \u003cp\u003e8.4 Poly(vinyl ether)s 207\u003c\/p\u003e \u003cp\u003e8.5 Poly(meth)acrylates 208\u003c\/p\u003e \u003cp\u003e8.6 Effects of Additives on Phase Behavior 210\u003c\/p\u003e \u003cp\u003e8.7 Temperature-Responsive Copolymers and Gels 217\u003c\/p\u003e \u003cp\u003eReferences 222\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Application of NMR Spectroscopy to Study Thermoresponsive Polymers 225\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJiří Spěváček\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 225\u003c\/p\u003e \u003cp\u003e9.2 Coil–Globule Phase Transition and Its Manifestation in NMR Spectra 225\u003c\/p\u003e \u003cp\u003e9.3 Temperature Dependences of High-Resolution NMR Spectra: Phase-Separated Fraction p 227\u003c\/p\u003e \u003cp\u003e9.4 Multicomponent Polymer Systems 230\u003c\/p\u003e \u003cp\u003e9.5 Effects of Low-Molecular-Weight Additives on Phase Transition 234\u003c\/p\u003e \u003cp\u003e9.6 Behavior of Water at the Phase Transition 236\u003c\/p\u003e \u003cp\u003e9.7 Conclusion 242\u003c\/p\u003e \u003cp\u003eAcknowledgment 242\u003c\/p\u003e \u003cp\u003eReferences 242\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Polarized Luminescence Studies of Nanosecond Dynamics of Thermosensitive Polymers in Aqueous Solutions 249\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eVladimir D. Pautov, Tatiana N. Nekrasova, Tatiana D. Anan’eva, and Ruslan Y. Smyslov\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 249\u003c\/p\u003e \u003cp\u003e10.2 Theoretical Part 250\u003c\/p\u003e \u003cp\u003e10.2.1 Polarization of Luminescence 250\u003c\/p\u003e \u003cp\u003e10.2.2 The Use of Polarized Luminescence in the Studies of Nanosecond Dynamics of Macromolecules 253\u003c\/p\u003e \u003cp\u003e10.3 Experimental Part 258\u003c\/p\u003e \u003cp\u003e10.3.1 Methods of Synthesis of Polymers Containing Luminescent Markers 258\u003c\/p\u003e \u003cp\u003e10.3.2 Technique for Measurement of Luminescence Polarization 260\u003c\/p\u003e \u003cp\u003e10.3.3 Thermosensitive Water-Soluble Polymers 263\u003c\/p\u003e \u003cp\u003e10.3.4 pH and Thermosensitive Water-Soluble Polymers 268\u003c\/p\u003e \u003cp\u003e10.3.5 Temperature-Induced Transitions in Polymers in Nonaqueous Solutions 271\u003c\/p\u003e \u003cp\u003e10.4 Conclusion 272\u003c\/p\u003e \u003cp\u003eReferences 273\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III Applications of Temperature-responsive Polymers 279\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Applications of Temperature-Responsive Polymers Grafted onto Solid Core Nanoparticles 281\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eEdward D. H. Mansfield, Adrian C.Williams, and Vitaliy V. Khutoryanskiy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 281\u003c\/p\u003e \u003cp\u003e11.2 Silica Nanoparticles 282\u003c\/p\u003e \u003cp\u003e11.2.1 pNIPAM-functionalised Silica Nanoparticles 282\u003c\/p\u003e \u003cp\u003e11.2.2 Poloxamer-functionalised Silica Nanoparticles 284\u003c\/p\u003e \u003cp\u003e11.2.3 Other Polymers 286\u003c\/p\u003e \u003cp\u003e11.3 Metallic Nanoparticles 286\u003c\/p\u003e \u003cp\u003e11.3.1 pNIPAM-functionalised Metallic Nanoparticles 287\u003c\/p\u003e \u003cp\u003e11.3.2 Poloxamer-functionalised Metallic Nanoparticles 288\u003c\/p\u003e \u003cp\u003e11.3.3 Elastin-functionalised Metallic Nanoparticles 288\u003c\/p\u003e \u003cp\u003e11.3.4 Other Polymer-functionalised Metallic Nanoparticles 289\u003c\/p\u003e \u003cp\u003e11.4 Magnetic Nanoparticles 290\u003c\/p\u003e \u003cp\u003e11.4.1 pNIPAM-functionalised Magnetic Nanoparticles 290\u003c\/p\u003e \u003cp\u003e11.4.2 Poloxamer-functionalised Magnetic Nanoparticles 291\u003c\/p\u003e \u003cp\u003e11.4.3 Other TRP-functionalised Magnetic Nanoparticles 293\u003c\/p\u003e \u003cp\u003e11.4.4 Summary 293\u003c\/p\u003e \u003cp\u003e11.5 Conclusions 294\u003c\/p\u003e \u003cp\u003eReferences 294\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Temperature-responsive Polymers for Tissue Engineering 301\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eKenichi Nagase, Masayuki Yamato, and Teruo Okano\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 301\u003c\/p\u003e \u003cp\u003e12.1.1 Thermo-responsive Cell Culture Dishes and Cell Sheets 301\u003c\/p\u003e \u003cp\u003e12.1.2 Thermo-responsive Cell Culture Dishes Prepared by Electron-beam-induced Polymerization 302\u003c\/p\u003e \u003cp\u003e12.1.3 Thermo-responsive Cell Culture Dishes for Enhancing Cell Adhesion and Proliferation by Immobilized Biological Ligands 303\u003c\/p\u003e \u003cp\u003e12.1.4 Thermo-responsive Cell Culture Dish Prepared by Living Radical Polymerization 304\u003c\/p\u003e \u003cp\u003e12.1.5 Patterned Thermo-responsive Cell Culture Substrates 306\u003c\/p\u003e \u003cp\u003e12.1.6 Thermo-responsive Surfaces for Cell Separation 309\u003c\/p\u003e \u003cp\u003e12.2 Conclusions 309\u003c\/p\u003e \u003cp\u003eAcknowledgments 309\u003c\/p\u003e \u003cp\u003eReferences 311\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Thermogel Polymers for Injectable Drug Delivery Systems 313\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eVidhiM. Shah, Duc X. Nguyen, Deepa A. Rao, Raid G. Alany, and AdamW.G. Alani\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 313\u003c\/p\u003e \u003cp\u003e13.2 Pluronics\u003csup\u003e®\u003c\/sup\u003e 314\u003c\/p\u003e \u003cp\u003e13.3 Polyester-based Polymers 315\u003c\/p\u003e \u003cp\u003e13.4 Chitosan and Derivatives 317\u003c\/p\u003e \u003cp\u003e13.5 Polypeptides 318\u003c\/p\u003e \u003cp\u003e13.6 Clinical Application of Thermogel Polymers 319\u003c\/p\u003e \u003cp\u003e13.6.1 \u003ci\u003eOcular Delivery\u003c\/i\u003e 319\u003c\/p\u003e \u003cp\u003e13.6.2 \u003ci\u003eNasal Delivery\u003c\/i\u003e 320\u003c\/p\u003e \u003cp\u003e13.6.3 \u003ci\u003eAntitumor Delivery\/Drug Delivery Systems\u003c\/i\u003e 321\u003c\/p\u003e \u003cp\u003e13.7 Summary 323\u003c\/p\u003e \u003cp\u003eReferences 323\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Thermoresponsive Electrospun Polymer-based (Nano)fibers 329\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMariliz Achilleos and Theodora Krasia-Christoforou\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 329\u003c\/p\u003e \u003cp\u003e14.2 Basic Principles of Electrospinning 330\u003c\/p\u003e \u003cp\u003e14.3 PNIPAM-based Electrospun (Nano)fibers 332\u003c\/p\u003e \u003cp\u003e14.3.1 Temperature-triggered Wettability 332\u003c\/p\u003e \u003cp\u003e14.3.2 Biomedicine 335\u003c\/p\u003e \u003cp\u003e14.3.2.1 Drug Delivery 336\u003c\/p\u003e \u003cp\u003e14.3.2.2 Tissue Engineering 339\u003c\/p\u003e \u003cp\u003e14.3.2.3 Biosensing 341\u003c\/p\u003e \u003cp\u003e14.3.2.4 Solid-phase Microextraction 341\u003c\/p\u003e \u003cp\u003e14.3.2.5 Molecular Recognition 342\u003c\/p\u003e \u003cp\u003e14.3.2.6 Organic–Inorganic PNIPAM-based Electrospun (Nano)fibers 342\u003c\/p\u003e \u003cp\u003e14.3.3 Sensing 343\u003c\/p\u003e \u003cp\u003e14.3.4 Other Applications 344\u003c\/p\u003e \u003cp\u003e14.4 Other Types of Thermoresponsive Electrospun (Nano)fibers 345\u003c\/p\u003e \u003cp\u003e14.5 Conclusions and Outlook 348\u003c\/p\u003e \u003cp\u003eReferences 348\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Catalysis by Thermoresponsive Polymers 357\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eNatalya A. Dolya and Sarkyt E. Kudaibergenov\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction 357\u003c\/p\u003e \u003cp\u003e15.2 Metal Complexes Immobilized Within Thermosensitive Polymers 358\u003c\/p\u003e \u003cp\u003e15.3 Thermoresponsive Polyampholytes 358\u003c\/p\u003e \u003cp\u003e15.4 Thermosensitive Hydrogels in Catalysis 361\u003c\/p\u003e \u003cp\u003e15.5 Thermoresponsive Catalytically Active Nano- and Microgels, Spheres, Capsules, and Micelles 364\u003c\/p\u003e \u003cp\u003e15.6 Thermosensitive Self-Assemblies 367\u003c\/p\u003e \u003cp\u003e15.7 Mono- and Bimetallic Nanoparticles Stabilized by Thermoresponsive Polymers 368\u003c\/p\u003e \u003cp\u003e15.8 Enzymes-Embedded Thermoresponsive Polymers 369\u003c\/p\u003e \u003cp\u003e15.9 Immobilization of Magnetic Nanoparticles into the Matrix of Thermoresponsive Polymers for Efficient Separation of Catalysts 369\u003c\/p\u003e \u003cp\u003e15.10 Summary 370\u003c\/p\u003e \u003cp\u003eAcknowledgments 371\u003c\/p\u003e \u003cp\u003eReferences 371\u003c\/p\u003e \u003cp\u003eIndex 379\u003c\/p\u003e   \u003cp\u003e\u003cb\u003eEdited by:\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003e\u003cb\u003eVitaliy V. Khutoryanskiy\u003c\/b\u003e, Ph.D., is Professor of Formulation Science, Reading School of Pharmacy, University of Reading, Whiteknights, Reading, UK. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTheoni K. Georgiou\u003c\/b\u003e, Ph.D., is a Senior Lecturer in Polymer Chemistry, Department of Materials, Imperial College London, UK.     \u003c\/p\u003e\u003cp\u003e\u003cb\u003eAn authoritative resource that offers an understanding of the chemistry, properties, and applications of temperature-responsive polymers\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eWith contributions from a distinguished panel of experts, \u003ci\u003eTemperature-Responsive Polymers\u003c\/i\u003e puts the focus on hydrophilic polymers capable of changing their physicochemical properties in response to changes in environmental temperature. The contributors review the chemistry of these systems, and discuss a variety of synthetic approaches for preparation of temperature-responsive polymers, physicochemical methods of their characterisation and potential applications in biomedical areas. \u003c\/p\u003e\u003cp\u003eThe text reviews a wide-variety of topics including: The characterisation of temperature- responsive polymers; Infrared and Raman spectroscopy; Applications of temperature- responsive polymers grafted onto solid core nanoparticles; and much more. The contributors also explore how temperature-responsive polymers can be used in the biomedical field for applications such as tissue engineering. \u003c\/p\u003e\u003cp\u003eThis important resource: \u003c\/p\u003e\u003cul\u003e \u003cli\u003eOffers an important synthesis of the current research on temperature- responsive polymers\u003c\/li\u003e \u003cli\u003eCovers the chemistry, the synthetic approaches for presentation and the physiochemical method of temperature- responsive polymers\u003c\/li\u003e \u003cli\u003eIncludes a review of the fundamental characteristics of temperature-responsive polymers\u003c\/li\u003e \u003cli\u003eExplores many of the potential applications in biomedical science, including drug delivery and gene therapy\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eWritten for polymer scientists in both academia and industry as well as postgraduate students working in the area of stimuli-responsive materials, this vital text offers an exploration of the chemistry, properties, and current applications of temperature-responsive polymers.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47990143320293,"sku":"NP9781119157786","price":199.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119157786.jpg?v=1761786669","url":"https:\/\/k12savings.com\/products\/temperature-responsive-polymers-isbn-9781119157786","provider":"K12savings","version":"1.0","type":"link"}