{"product_id":"telomerases-isbn-9780470592045","title":"Telomerases","description":"This book is a comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research.  Chapters in this volume cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase.  Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed.\u003cbr\u003e \u003cbr\u003e \u003cp\u003ePreface vii\u003c\/p\u003e \u003cp\u003eContributors ix\u003c\/p\u003e \u003cp\u003e1 The Telomerase Complex: An Overview 1\u003cbr\u003e \u003ci\u003eJohanna Mancini and Chantal Autexier\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Telomerase RNA: Structure, Function, and Molecular Mechanisms 23\u003cbr\u003e \u003ci\u003eYehuda Tzfati and Julian J.-L. Chen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 TERT Structure, Function, and Molecular Mechanisms 53\u003cbr\u003e \u003ci\u003eEmmanuel Skordalakes and Neal F. Lue\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Telomerase Biogenesis: RNA Processing, Trafficking, and Protein Interactions 79\u003cbr\u003e \u003ci\u003eTara Beattie and Pascal Chartrand\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Transcriptional Regulation of Human Telomerase 105\u003cbr\u003e \u003ci\u003eAntonella Farsetti and Yu-Sheng Cong\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Telomerase Regulation and Telomere-Length Homeostasis 135\u003cbr\u003e \u003ci\u003eJoachim Lingner and David Shore\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Telomere Structure in Telomerase Regulation 157\u003cbr\u003e \u003ci\u003eMomchil D. Vodenicharov and Raymund J. Wellinger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Off-Telomere Functions of Telomerase 201\u003cbr\u003e \u003ci\u003eKenkichi Masutomi and William C. Hahn\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Murine Models of Dysfunctional Telomeres and Telomerase 213\u003cbr\u003e \u003ci\u003eYie Liu and Lea Harrington\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Cellular Senescence, Telomerase, and Cancer in Human Cells 243\u003cbr\u003e \u003ci\u003ePhillip G. Smiraldo, Jun Tang, Jerry W. Shay, and Woodring E. Wright\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Telomerase, Retrotransposons, and Evolution 265\u003cbr\u003e \u003ci\u003eIrina R. Arkhipova\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 301\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eNEAL F. LUE, MD, P\u003csmall\u003eH\u003c\/small\u003eD,\u003c\/b\u003e is Professor in the Department of Microbiology and Immunology at Weill Cornell Medical College. He received his BS from Johns Hopkins University and his MD and PhD from Stanford University. His laboratory studies the structures and mechanisms of the telomere and telomerase complexes in a variety of fungal model systems. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eCHANTAL AUTEXIER, P\u003csmall\u003eH\u003c\/small\u003eD,\u003c\/b\u003e is Professor in the Department of Anatomy and Cell Biology and the Department of Medicine at McGill University. She received her BSc from Concordia University and her PhD from McGill University. Her laboratory studies the mechanisms that regulate telomerase and telomere functions in mammalian cells, and evaluates the principles of anticancer strategies that target these mechanisms. \t   \t\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExplores the structure, function, and emerging applications of telomerases\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eWith contributions from leading experts and pioneers in the field, this book offers a comprehensive review of telomerase structure and function in a variety of organisms, including yeasts, ciliates, plants, and mammals. Chapters provide integrated discussions that examine the connections between the chemistry, biology, and emerging clinical applications of the telomerase enzyme. In particular, readers will gain new insights into the role of telomerases in cellular senescence, aging, and cancer. \u003c\/p\u003e\u003cp\u003eTelomerases begins with an overview of the telomerase complex, followed by in-depth discussions of the chemistry of its two critical components: TERT and TER. Next, the book brings readers up to date with our current understanding of telomerases, including: \u003c\/p\u003e\u003cul\u003e \u003cli\u003eBiological regulatory mechanisms that control the synthesis and assembly of the telomerase complex\u003c\/li\u003e \u003cli\u003eRegulations imposed by the nucleoprotein complex at chromosome ends\u003c\/li\u003e \u003cli\u003eStudies underscoring the role of the telomerase enzyme as a promising target and a useful tool in medical interventions\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThe book concludes with an essay that places the telomerase enzyme in an evolutionary context, illustrating its place within the highly diverse family of reverse transcriptases. \u003c\/p\u003e\u003cp\u003eTelomerases is recommended for biochemists, enzymologists, protein scientists, cancer researchers, biophysicists, geneticists, and cell, molecular, and chromosome biologists. Explaining what the latest research in the field reveals about the structure and function of telomerases and how this research has informed investigations into their clinical applications, the book points to future avenues of research that will enable us to better understand the chemistry, biology, and clinical applications of telomerases.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47990143123685,"sku":"NP9780470592045","price":153.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470592045.jpg?v=1761786668","url":"https:\/\/k12savings.com\/products\/telomerases-isbn-9780470592045","provider":"K12savings","version":"1.0","type":"link"}