Stoichiometric Asymmetric Synthesis

This volume provides, at postgraduate student level, an accessible introduction to stoichiometric asymmetric synthesis. The authors focus on stereoselective C-C bond formation in acyclic systems, with an emphasis on the use of chiral auxiliaries and reagents.

The book is extensively referenced and so provides a convenient point of entry to the research literature.

1 Introduction.

2 Additions to carbonyl compounds.

3 Formation and alkylation of enolates.

4 Substrate-directed aldol reactions.

5 Reagent-controlled aldol reactions.

6 Allylation and crotylation reactions.

7 Pericyclic processes.

8 Reactions of alkenes.

9 Free radical processes.

Index.

Dr. Mark A. Rizzacasa is at the School of Chemistry, The University of Melbourn, Victoria, Australia.

Dr. Michael Perkins is at the Department of Chemistry, Flinders University, Adelaide, Australia.

Stoichiometric asymmetric synthesis is widely used in the academic and industrial sectors for the synthesis of chiral molecules of biological importance. Although catalytic asymmetric synthesis is an alternative, the use of equimolar amounts of chirality provides high selectivities over a wider range of substrates, without extensive modifications of reaction conditions.

This volume provides, at postgraduate student level, an accessible introduction to stoichiometric asymmetric synthesis. The authors focus on stereoselective C-C bond formation in acyclic systems, with an emphasis on the use of chiral auxiliaries and reagents.

The book is extensively references and so provides a convenient point of entry to the research literature.

This volume provides, at postgraduate student level, an accessible introduction to stoichiometric asymmetric synthesis. The authors focus on stereoselective C-C bond formation in acyclic systems, with an emphasis on the use of chiral auxiliaries and reagents.

The book is extensively referenced and so provides a convenient point of entry to the research literature.