{"product_id":"sample-sizes-for-clinical-laboratory-and-epidemiology-studies-isbn-9781118874943","title":"Sample Sizes for Clinical, Laboratory and Epidemiology Studies","description":"\u003cp\u003e\u003cb\u003eAn authoritative resource that offers the statistical tools and software needed to design and plan valid clinical studies\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eNow in its fourth and extended edition, \u003ci\u003eSample Sizes for Clinical, Laboratory and Epidemiology Studies\u003c\/i\u003eincludes the sample size software (SSS) and formulae and numerical tables needed to design valid clinical studies. The text covers clinical as well as laboratory and epidemiology studies and contains the information needed to ensure a study will form a valid contribution to medical research. \u003c\/p\u003e \u003cp\u003eThe authors, noted experts in the field, explain step by step and explore the wide range of considerations necessary to assist investigational teams when deriving an appropriate sample size for their when planned study. The book contains sets of sample size tables with companion explanations and clear worked out examples based on real data. In addition, the text offers bibliography and references sections that are designed to be helpful with guidance on the principles discussed.\u003c\/p\u003e \u003cp\u003eThis revised fourth edition:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eOffers the only text available to include sample size software for use in designing and planning clinical studies\u003c\/li\u003e \u003cli\u003ePresents new and extended chapters with many additional and refreshed examples\u003c\/li\u003e \u003cli\u003eIncludes clear explanations of the principles and methodologies involved with relevant practical examples\u003c\/li\u003e \u003cli\u003eMakes clear a complex but vital topic that is designed to ensure valid methodology and publishable results \u003c\/li\u003e \u003cli\u003eContains guidance from an internationally recognised team of medical statistics experts\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eWritten for medical researchers from all specialities and medical statisticians, \u003ci\u003eSample Sizes for Clinical, Laboratory and EpidemiologyStudies\u003c\/i\u003e offers an updated fourth edition of the important guide for designing and planning reliable and evidence based clinical studies.\u003c\/p\u003eEin fundiertes Referenzwerk zu den statistischen Instrumenten und Softwareprogrammen, die für das Design und die Planung klinischer Studien erforderlich sind.\u003cbr\u003e \u003cbr\u003e Die erweiterte 4. Auflage von Sample Sizes for Clinical, Laboratory and Epidemiology Studies beinhaltet eine Sample-Size-Software (SSS), Formeln und nummerische Tabellen für die Gestaltung valider klinischer Studien. Das Fachbuch behandelt ebenfalls Labor- und epidemiologische Studien und stellt die Informationen zur Verfügung, damit Studien einen wesentlichen Beitrag zur medizinischen Forschung leisten.\u003cbr\u003e Die Autoren, allesamt anerkannte Experten des Fachgebiets, erläutern und untersuchen Schritt für Schritt die vielfältigen Überlegungen bei der Festlegung geeigneter Stichprobengrößen und helfen so bei der Planung von Studien. Bereitgestellt werden ebenfalls Stichprobentabellen mit Erläuterungen und aussagekräftige Beispiele auf der Basis von Echtdaten. Darüber hinaus enthält das Fachbuch ein Literaturverweise und Angaben zu weiterführenden Referenzen zur Unterstützung der vorgestellten Prinzipien.\u003cbr\u003e \u003cbr\u003e Diese überarbeitete 4. Auflage\u003cbr\u003e - ist das bislang einzige Referenzwerk mit einem Softwareprogramm für die Gestaltung und Planung klinischer Studien.\u003cbr\u003e - enthält neue und erweiterte Kapitel mit einer Vielzahl neuer und aktualisierter Beispiele.\u003cbr\u003e - erläutert verständlich die angewandten Prinzipien und Methoden anhand von Beispielen aus der Praxis.\u003cbr\u003e - präsentiert auf nachvollziehbare Weise ein komplexes und dennoch wichtiges Thema, damit die richtigen Methoden verwendet werden und fundierte Ergebnisse veröffentlicht werden können.\u003cbr\u003e - bietet Hilfestellung von einem Team international anerkannter Statistikexperten im medizinischen Bereich.\u003cbr\u003e \u003cbr\u003e Sample Sizes for Clinical, Laboratory and Epidemiology Studies richtet sich an medizinische Forscher aller Disziplinen sowie an Medizinstatistiker. Die aktualisierte 4. Auflage ist ein wichtiges Referenzwerk für die Gestaltung und Planung verlässlicher, evidenzbasierter klinischer Studien.\u003cbr\u003e \u003cp\u003ePreface vii\u003c\/p\u003e \u003cp\u003e1 Basic Design Considerations 1\u003c\/p\u003e \u003cp\u003e2 Further Design Considerations 29\u003c\/p\u003e \u003cp\u003e3 Binary Outcomes 41\u003c\/p\u003e \u003cp\u003e4 Ordered Categorical Outcomes 55\u003c\/p\u003e \u003cp\u003e5 Continuous Outcomes 67\u003c\/p\u003e \u003cp\u003e6 Rate Outcomes 83\u003c\/p\u003e \u003cp\u003e7 Survival Time Outcomes 99\u003c\/p\u003e \u003cp\u003e8 Paired Binary, Ordered Categorical and Continuous Outcomes 117\u003c\/p\u003e \u003cp\u003e9 Confidence Intervals 137\u003c\/p\u003e \u003cp\u003e10 Repeated Outcome Measures 157\u003c\/p\u003e \u003cp\u003e11 Non‐Inferiority and Equivalence 169\u003c\/p\u003e \u003cp\u003e12 Cluster Designs 195\u003c\/p\u003e \u003cp\u003e13 Stepped Wedge Designs 215\u003c\/p\u003e \u003cp\u003e14 More than Two Groups Designs 229\u003c\/p\u003e \u003cp\u003e15 Genomic Targets and Dose‐Finding 239\u003c\/p\u003e \u003cp\u003e16 Feasibility and Pilot Studies 251\u003c\/p\u003e \u003cp\u003e17 Therapeutic Exploratory Trials: Single Arm with Binary Outcomes 269\u003c\/p\u003e \u003cp\u003e18 Therapeutic Exploratory Trials: Survival, Dual Endpoints, Randomised and Genomic Targets 283\u003c\/p\u003e \u003cp\u003e19 The Correlation Coefficient 305\u003c\/p\u003e \u003cp\u003e20 Observer Agreement Studies 317\u003c\/p\u003e \u003cp\u003e21 Reference Intervals and Receiver Operating Curves 339\u003c\/p\u003e \u003cp\u003e22 Sample Size Software \u003csup\u003eS\u003c\/sup\u003eS\u003csub\u003eS\u003c\/sub\u003e 361\u003c\/p\u003e \u003cp\u003eCumulative References 363\u003c\/p\u003e \u003cp\u003eIndex 381\u003c\/p\u003e   \u003cp\u003e\u003cb\u003eDavid Machin,\u003c\/b\u003e Leicester Cancer Research Centre, University of Leicester, Leicester and Medical Statistics Group, School of Health and Related Research, University of Sheffield, Sheffield, UK. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eMichael J. Campbell,\u003c\/b\u003e Medical Statistics Group, School of Health and Related Research, University of Sheffield, Sheffield, UK. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eSay Beng Tan,\u003c\/b\u003e SingHealth Duke-NUS Academic Medical Centre, Singapore. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eSze Huey Tan,\u003c\/b\u003e Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore.    \u003c\/p\u003e\u003cp\u003e\u003cb\u003eSample Sizes for Clinical, Laboratory and Epidemiology Studies\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eNow in its fourth and extended edition, \u003ci\u003eSample Sizes for Clinical, Laboratory and Epidemiology Studies\u003c\/i\u003e includes the sample size software (SSS) and formulae and numerical tables needed to design valid clinical studies. The text covers clinical as well as laboratory and epidemiology studies and contains the information needed to ensure a study will form a valid contribution to medical research. \u003c\/p\u003e\u003cp\u003eThe authors, noted experts in the field, explain step-by-step and explore the wide range of considerations necessary to assist investigational teams when deriving an appropriate sample size for their planned study. The book contains sets of sample size tables with companion explanations and clear worked out examples based on real data. In addition, the text offers bibliography and references sections that are designed to be helpful with guidance on the principles discussed. \u003c\/p\u003e\u003cp\u003eThis revised fourth edition: \u003c\/p\u003e\u003cul\u003e \u003cli\u003eOffers the only text available to include sample size software for use in designing and planning clinical studies\u003c\/li\u003e \u003cli\u003ePresents new and extended chapters with many additional and refreshed examples\u003c\/li\u003e \u003cli\u003eIncludes clear explanations of the principles and methodologies involved with relevant practical examples\u003c\/li\u003e \u003cli\u003eMakes clear a complex but vital topic that is designed to ensure valid methodology and publishable results\u003c\/li\u003e \u003cli\u003eContains guidance from an internationally recognised team of medical statistics experts\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eWritten for medical researchers from all specialities and medical statisticians, \u003ci\u003eSample Sizes for Clinical, Laboratory and Epidemiology Studies\u003c\/i\u003e offers an updated fourth edition of this important guide for designing and planning reliable and evidence based clinical studies.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989986525413,"sku":"NP9781118874943","price":108.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118874943.jpg?v=1761786113","url":"https:\/\/k12savings.com\/products\/sample-sizes-for-clinical-laboratory-and-epidemiology-studies-isbn-9781118874943","provider":"K12savings","version":"1.0","type":"link"}