{"product_id":"role-of-the-sarcoplasmic-reticulum-in-smooth-muscle-isbn-9780470844793","title":"Role of the Sarcoplasmic Reticulum in Smooth Muscle","description":"Smooth muscle contraction is a vital component of the functioning of blood vessels, the uterus, airways and the bladder. Its malfunction can lead to serious pathological conditions, such as hypertension and pre-term labour. The calcium ion plays a central role in smooth muscle function, increasing in concentration for contraction and decreasing for relaxation. Calcium entry into the cell is facilitated by the sarcoplasmic reticulum (SR). \u003cp\u003eThis book explores the latest research on the role of the sarcoplasmic reticulum (SR) in smooth muscle function. It examines the control and modulation of the SR and how this may vary among smooth muscle types. Potential therapeutic implications are also discussed.\u003c\/p\u003e \u003cul\u003e \u003cli\u003eDiscusses new and exciting work in this area and identifies promising new research directions.\u003c\/li\u003e \u003cli\u003eConsiders the advances in this relatively unexplored field, offering new insights into the role of the SR muscle.\u003c\/li\u003e \u003cli\u003eBrings together contributions from key workers, both in basic and clinical science, whose studies range from physiological to pathological and molecular to whole animal.\u003c\/li\u003e \u003c\/ul\u003e  Chair's introduction (David Eisner).\u003cbr\u003e \u003cbr\u003e Role of the sarcoplasmic reticulum in uterine smooth muscle (Susan Wray, Sajeera Kupittayanant and Tony Shmigol).\u003cbr\u003e Discussion.\u003cbr\u003e \u003cbr\u003e Relationship between the sarcoplasmic reticulum and the plasma membrane (Cheng-Han Lee, Damon Poburko, Kuo-Hsing Kuo, Chun Seow and Cornelis van Breemen).\u003cbr\u003e Discussion.\u003cbr\u003e \u003cbr\u003e General discussion I The role of calmodulin in smooth muscle contraction.\u003cbr\u003e \u003cbr\u003e Ca?2+ signalling and Ca?2+-activated K?+ channels in smooth muscle (John G. McCarron, Karen N. Bradley and Thomas C. Muir).\u003cbr\u003e Discussion.\u003cbr\u003e \u003cbr\u003e Additional fluxes of activator Ca?2+ accompanying Ca?2+ release from the sarcoplasmic reticulum triggered by InsP3-mobilizing agonists (Luc Raeymaekers, Bernd Nilius, Thomas Voets, Ludwig Missiaen, Kurt Van Baelen, Jo Vanoevelen and Frank Wuytack).\u003cbr\u003e Discussion.\u003cbr\u003e \u003cbr\u003e Molecular candidates for capacitative and non-capacitative Ca?2+ entry in smooth muscle (Ryuji Inoue and Yasuo Mori).\u003cbr\u003e \u003cbr\u003e Regulation of Ca?2+ entry pathways by both limbs of the phosphoinositide pathway (Colin W. Taylor).\u003cbr\u003e Discussion.\u003cbr\u003e \u003cbr\u003e Calcium release by ryanodine receptors in smooth muscle (M. I. Kotlikoff, Yong-Xiao Wang, Hong-Bo Xin and Guanju Ji).\u003cbr\u003e Discussion.\u003cbr\u003e \u003cbr\u003e Organization of Ca?2+ stores in vascular smooth muscle: functional implications (Mordecai P. Blaustein, Vera A. Golovina, Hong Song, Jacqueline Choate, Lubomira Lencesova, Shawn W. Robinson, and W. Gil Wier).\u003cbr\u003e Discussion.\u003cbr\u003e \u003cbr\u003e Molecular basis and physiological functions of dynamic Ca?2+ signalling in smooth muscle cells (Masamitsu Iino).\u003cbr\u003e Discussion.\u003cbr\u003e \u003cbr\u003e Calcium release events in excitation-contraction coupling in smooth muscle (T. B. Bolton, D. V. Gordienko, V. Pucovsk?, S. Parsons and O. Povstyan).\u003cbr\u003e Discussion.\u003cbr\u003e \u003cbr\u003e Sarcoplasmic reticulum, calcium waves and myometrial signalling (Roger C. Young).\u003cbr\u003e Discussion.\u003cbr\u003e \u003cbr\u003e Sarcoplasmic reticulum and membrane currents (Gerald M. Herrera and Mark T. Nelson).\u003cbr\u003e Discussion.\u003cbr\u003e \u003cbr\u003e Sarcoplasmic reticulum function and contractile consequences in ureteric smooth muscles (Theodor Burdyga and Susan Wray).\u003cbr\u003e Discussion.\u003cbr\u003e \u003cbr\u003e General discussion II The physiological significance of smooth muscle Ca?2+ stores.\u003cbr\u003e \u003cbr\u003e The sarcoplasmic reticulum and smooth muscle function: evidence from transgenic mice (R. J. Paul, G. E. Shull and E. G. Kranias).\u003cbr\u003e Discussion.\u003cbr\u003e \u003cbr\u003e The sarcoplasmic reticulum in disease and smooth muscle dysfunction: therapeutic potential (A. F. Brading).\u003cbr\u003e Discussion.\u003cbr\u003e \u003cbr\u003e The sarcoplasmic reticulum: then and now (Andrew P. Somlyo and Avril V. Somlyo).\u003cbr\u003e Discussion.\u003cbr\u003e \u003cbr\u003e Final General Discussion.\u003cbr\u003e \u003cbr\u003e Index of Contributors.\u003cbr\u003e \u003cbr\u003e Subject Index.  \u003cp\u003e\"... an interesting read....\" (\u003cem\u003eCell Biochemistry \u0026amp; Function,\u003c\/em\u003e May-June 2004)  \u003c\/p\u003e\u003cp\u003e\u003cb\u003eDerek J. Chadwick\u003c\/b\u003e and \u003cb\u003eJamie A. Goode\u003c\/b\u003e are editors for \u003ci\u003eRole of the Sarcoplasmic Reticulum in Smooth Muscle\u003c\/i\u003e and other scientific titles.\u003c\/p\u003e  Smooth muscle contraction is a vital component of the functioning of blood vessels, the uterus, airways and the bladder. Its malfunction can lead to serious pathological conditions, such as hypertension and pre-term labour. The calcium ion plays a central role in its function, increasing in concentration for contraction and decreasing for relaxation. The source of calcium is through entry across the surface membrane and release from the sarcoplasmic reticulum (SR). However, recent data have challenged the view that the SR is simply a source and sink of calcium ions. Indeed, the SR probably also acts to limit contraction, via ion channel-based feedback mechanisms.  \u003cp\u003eThis book explores the latest research on the role of the SR in smooth muscle function. Separate chapters examine the relationship between calcium release and inhibition and\/or promotion of contraction, the control and modulation of the SR in smooth muscle and the extent to which the SR may vary between smooth muscles. Potential therapeutic implications of this research are discussed.\u003c\/p\u003e \u003cp\u003eWith contributions from an international group of experts, ranging from clinicians to molecular biologists, this book discusses new and exciting work in this area and identifies promising new research directions.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989971648741,"sku":"NP9780470844793","price":211.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470844793.jpg?v=1761786078","url":"https:\/\/k12savings.com\/products\/role-of-the-sarcoplasmic-reticulum-in-smooth-muscle-isbn-9780470844793","provider":"K12savings","version":"1.0","type":"link"}