{"product_id":"radical-and-radical-ion-reactivity-in-nucleic-acid-chemistry-isbn-9780470255582","title":"Radical and Radical Ion Reactivity in Nucleic Acid Chemistry","description":"Comprehensive coverage of radical reactive intermediates in nucleic acid chemistry and biochemistry  \u003cp\u003eThe Wiley Series on Reactive Intermediates in Chemistry and Biology investigates reactive intermediates from the broadest possible range of disciplines. The contributions in each volume offer readers fresh insights into the latest findings, emerging applications, and ongoing research in the field from a diverse perspective.\u003c\/p\u003e \u003cp\u003eThe chemistry and biochemistry of reactive intermediates is central to organic chemistry and biochemistry, and underlies a significant portion of modern synthetic chemistry. \u003ci\u003eRadical and Radical Ion Reactivity in Nucleic Acid Chemistry\u003c\/i\u003e provides the only comprehensive review of the chemistry and biochemistry of nucleic acid radical intermediates.\u003c\/p\u003e \u003cp\u003eWith contributions by world leaders in the field, the text covers a broad range of topics, including:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eA discussion of the relevant theory\u003c\/li\u003e \u003cli\u003eIonization of DNA\u003c\/li\u003e \u003cli\u003eNucleic acid sugar radicals\u003c\/li\u003e \u003cli\u003eHalopyrimidines\u003c\/li\u003e \u003cli\u003eOxidative, reductive, and low energy electron transfer\u003c\/li\u003e \u003cli\u003eElectron affinity sensitizers\u003c\/li\u003e \u003cli\u003ePhotochemical generative of reactive oxygen species\u003c\/li\u003e \u003cli\u003eReactive nitrogen species\u003c\/li\u003e \u003cli\u003eEnediyne rearrangements\u003c\/li\u003e \u003cli\u003ePhenoxyl radicals\u003c\/li\u003e \u003c\/ul\u003e A unique compilation on the cutting edge of our understanding, \u003ci\u003eRadical and Radical Ion Reactivity in Nucleic Acid Chemistry\u003c\/i\u003e provides an unparalleled resource to student and professional researchers in such fields as organic chemistry, biochemistry, molecular biology, and physical chemistry, as well as the industries associated with these disciplines. \u003cp\u003ePreface to Series vii\u003c\/p\u003e \u003cp\u003eIntroduction ix\u003c\/p\u003e \u003cp\u003eContributors xi\u003c\/p\u003e \u003cp\u003e1. Theoretical Modeling of Radiation-Induced DNA Damage 1\u003cbr\u003e \u003ci\u003eAnil Kumar and Michael D. Sevilla\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2. Radical Reaction Pathways Initiated by Direct Energy Deposition in DNA by Ionizing Radiation 41\u003cbr\u003e \u003ci\u003eWilliam A. Bernhard\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3. Chemical Reactions of the Radical Cations of Nucleobases in Isolated and Cellular DNA. Formation of Single-Base Lesions 69\u003cbr\u003e \u003ci\u003eJean Cadet, Thierry Douki, Didier Gasparutto, Jean-Luc Ravanat, and J. Richard Wagner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4. Reactivity of Nucleic Acid Sugar Radicals 99\u003cbr\u003e \u003ci\u003eChryssostomos Chatgilialoglu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5. Pyrimidine Nucleobase Radical Reactivity 135\u003cbr\u003e \u003ci\u003eMarc M. Greenberg\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6. Reactivity of 5-Halopyrimidines in Nucleic Acids 163\u003cbr\u003e \u003ci\u003eRyu Tashiro and Hiroshi Sugiyama\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7. Kinetics of Long-Range Oxidative Electron Transfer Through DNA 191\u003cbr\u003e \u003ci\u003eKiyohiko Kawai and Tetsuro Majima\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8. Radical Intermediates During Reductive Electron Transfer Through DNA 211\u003cbr\u003e \u003ci\u003eReji Varghese and Hans-Achim Wagenknecht\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9. Low-Energy Electron Interaction with DNA: Bond Dissociation and Formation of Transient Anions, Radicals, and Radical Anions 239\u003cbr\u003e \u003ci\u003eLeon Sanche\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10. Electronic-Affinic Radiosensitizers 295\u003cbr\u003e \u003ci\u003ePeter Wardman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11. Reactions of Reactive Nitrogen Species and Carbonate Radical Anions with DNA 325\u003cbr\u003e \u003ci\u003eVladimir Shafirovich, Conor Crean, and Nicholas E. Geacintov\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12. Principles and Applications of Electrochemical Oxidation of Nucleic Acids 357\u003cbr\u003e \u003ci\u003eH. Holden Thorp and Julie M. Sullivan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13. DNA Damage Due to Diradical-Generating Cyclizations 389\u003cbr\u003e \u003ci\u003eSean M. Kerwin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14. DNA Damage by Phenoxyl Radicals 421\u003cbr\u003e \u003ci\u003eRichard A. Manderville\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 445\u003c\/p\u003e  \"Scientists who like to understand life sciences at a molecular level will use these reviews for at least the next 10 years.\" (\u003ci\u003eAngewandte Chemie,\u003c\/i\u003e 2010)\u003cbr\u003e \u003cbr\u003e  \"This is a valuable publication and is a worthwhile addition to the library of any researcher who has an interest in any one (or more) of the subtopics discussed.\"  (\u003ci\u003eJACS,\u003c\/i\u003e 2010)  \u003cb\u003eMarc M. Greenberg\u003c\/b\u003e is a Professor of Chemistry and Director of the Chemistry Biology Interface Graduate Training Program at Johns Hopkins University. His research uses chemistry, biochemistry, and biology to fundamentally understand how DNA is oxidatively damaged, and what the effects of that damage are.  \u003cp\u003e\u003cb\u003eSteven E. Rokita, PhD\u003c\/b\u003e, is Professor in the Department of Chemistry and Biochemistry at the University of Maryland. His research interests lie in sequence and conformation specific reactions of nucleic acids, enzyme-mediated activation of substrates and coenzymes, halogenation and dehalogenation reactions in biology, aromatic substitution and quinone methide generation in bioorganic chemistry, and copper- and nickel-mediated reactions in bioinorganic chemistry.\u003c\/p\u003e  \u003cb\u003eComprehensive coverage of radical reactive intermediates in nucleic acid chemistry and biochemistry\u003c\/b\u003e  \u003cp\u003eThe Wiley Series on Reactive Intermediates in Chemistry and Biology investigates reactive intermediates from the broadest possible range of disciplines. The contributions in each volume offer readers fresh insights into the latest findings, emerging applications, and ongoing research in the field from a diverse perspective.\u003c\/p\u003e \u003cp\u003eThe chemistry and biochemistry of reactive intermediates is central to organic chemistry and biochemistry, and underlies a significant portion of modern synthetic chemistry. \u003ci\u003eRadical and Radical Ion Reactivity in Nucleic Acid Chemistry\u003c\/i\u003e provides the only comprehensive review of the chemistry and biochemistry of nucleic acid radical intermediates.\u003c\/p\u003e \u003cp\u003eWith contributions by world leaders in the field, the text covers a broad range of topics, including:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eA discussion of the relevent theory\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eIonization of DNA\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eNucleic acid sugar radicals\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eNucleobase radicals\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eHalopyrimidines\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eOxidative, reductive, and low energy electron transfer\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eElectron affinity sensitizers\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003ePhotochemical generative of reactive oxygen species\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eReactive nitrogen species\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eElectrochemical oxidation of nucleic acids\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eEnediyne rearrangements\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eDNA photochemistry\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003ePhenoxyl radicals\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eA unique compilation on the cutting edge of our understanding, \u003ci\u003eRadical and Radical Ion Reactivity in Nucleic Acid Chemistry\u003c\/i\u003e provides an unparalleled resource to student and professional researchers in such fields as organic chemistry, biochemistry, molecular biology, and physical chemistry, as well as the industries associated with these disciplines.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989904900325,"sku":"NP9780470255582","price":179.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470255582.jpg?v=1761785864","url":"https:\/\/k12savings.com\/products\/radical-and-radical-ion-reactivity-in-nucleic-acid-chemistry-isbn-9780470255582","provider":"K12savings","version":"1.0","type":"link"}