{"product_id":"protein-families-isbn-9780470624227","title":"Protein Families","description":"\u003cp\u003eNew insights into the evolution and nature of proteins\u003c\/p\u003e \u003cp\u003eExploring several distinct approaches, this book describes the methods for comparing protein sequences and protein structures in order to identify homologous relationships and classify proteins and protein domains into evolutionary families. Readers will discover the common features as well as the key philosophical differences underlying the major protein classification systems, including Pfam, Panther, SCOP, and CATH. Moreover, they'll discover how these systems can be used to understand the evolution of protein families as well as understand and predict the degree to which structural and functional information are shared between relatives in a protein family.\u003c\/p\u003e \u003cp\u003eEdited and authored by leading international experts, \u003ci\u003eProtein Families\u003c\/i\u003e offers new insights into protein families that are important to medical research as well as protein families that help us understand biological systems and key biological processes such as cell signaling and the immune response. The book is divided into three sections:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e\n\u003cb\u003eSection I: Concepts Underlying Protein Family Classification\u003c\/b\u003e reviews the major strategies for identifying homologous proteins and classifying them into families.\u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eSection II: In-Depth Reviews of Protein Families\u003c\/b\u003e focuses on some fascinating super protein families for which we have substantial amounts of sequence, structural and functional data, making it possible to trace the emergence of functionally diverse relatives.\u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eSection III: Review of Protein Families in Important Biological Systems\u003c\/b\u003e examines protein families associated with a particular biological theme, such as the cytoskeleton.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eAll chapters are extensively illustrated, including depictions of evolutionary relationships. References at the end of each chapter guide readers to original research papers and reviews in the field.\u003c\/p\u003e \u003cp\u003eCovering protein family classification systems alongside detailed descriptions of select protein families, this book offers biochemists, molecular biologists, protein scientists, structural biologists, and bioinformaticians new insight into the evolution and nature of proteins.\u003c\/p\u003e  \u003cp\u003e\u003ci\u003eIntroduction vii\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eContributors xiii\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION I. CONCEPTS UNDERLYING PROTEIN FAMILY CLASSIFICATION 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Automated Sequence-Based Approaches for Identifying Domain Families 3\u003cbr\u003e \u003ci\u003eLiisa Holm and Andreas Heger\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Sequence Classification of Protein Families: Pfam and other Resources 25\u003cbr\u003e \u003ci\u003eAlex Bateman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Classifying Proteins into Domain Structure Families 37\u003cbr\u003e \u003ci\u003eAlison Cuff, Alexey Murzin, and Christine Orengo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Structural Annotations of Genomes with Superfamily and Gene3D 69\u003cbr\u003e \u003ci\u003eJulian Gough, Corin Yeats, and Christine Orengo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Phylogenomic Databases and Orthology Prediction 99\u003cbr\u003e \u003ci\u003eKimmen Sj¨olander\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION II. IN-DEPTH REVIEWS OF PROTEIN FAMILIES 125\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6 The Nucleophilic Attack Six-Bladed β-Propeller (N6P) Superfamily 127\u003cbr\u003e \u003ci\u003eMichael A. Hicks, Alan E. Barber II, and Patricia C. Babbitt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Functional Diversity of the HUP Domain Superfamily 159\u003cbr\u003e \u003ci\u003eBenoit H. Dessailly and Christine Orengo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 The NAD Binding Domain and the Short-Chain Dehydrogenase\/Reductase (SDR) Superfamily 191\u003cbr\u003e \u003ci\u003eNicholas Furnham, Gemma L. Holliday, and Janet M. Thornton\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 The Globin Family 207\u003cbr\u003e \u003ci\u003eArthur M. Lesk and Juliette T.J. Lecomte\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION III. REVIEW OF PROTEIN FAMILIES IN IMPORTANT BIOLOGICAL SYSTEMS 237\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10 Functional Adaptation and Plasticity in Cytoskeletal Protein Domains: Lessons from the Erythrocyte Model 239\u003cbr\u003e \u003ci\u003eAnthony J. Baines\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Unusual Species Distribution and Horizontal Transfer of Peptidases 285\u003cbr\u003e \u003ci\u003eNeil D. Rawlings\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Deducing Transport Protein Evolution Based on Sequence, Structure, and Function 315\u003cbr\u003e \u003ci\u003eSteven T. Wakabayashi, Maksim A. Shlykov, Ujjwal Kumar, Vamsee S. Reddy, Ankur Malhotra, Erik L. Clarke, Jonathan S. Chen, Rostislav Castillo, Russell De La Mare, Eric I. Sun, and Milton H. Saier\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Crispr-CAS Systems and CAS Protein Families 341\u003cbr\u003e \u003ci\u003eKira S. Makarova, Daniel H. Haft, and Eugene V. Koonin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Families of Sequence-Specific DNA-Binding Domains in Transcription Factors across the Tree of Life 383\u003cbr\u003e \u003ci\u003eVarodom Charoensawan and Sarah Teichmann\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Evolution of Eukaryotic Chromatin Proteins and Transcription Factors 421\u003cbr\u003e \u003ci\u003eL. Aravind, Vivek Anantharaman, Saraswathi Abhiman, and Lakshminarayan M. Iyer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eIndex 503\u003c\/i\u003e\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eCHRISTINE ORENGO, PhD,\u003c\/b\u003e is Professor of Bioinformatics at University College London. Dr. Orengo's research focuses on protein structure comparison, classification, and analysis. Her group develops the CATH domain family classification and algorithms for predicting protein functions and functional networks.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eALEX BATEMAN, PhD,\u003c\/b\u003e is Senior Investigator at Wellcome Trust Sanger Institute, where he leads the Pfam database project. Dr. Bateman also participates in the European InterPro project, which seeks to merge the annotations from Pfam, PRINTS, Prosite, and other domain databases.\u003c\/p\u003e  \u003cp\u003eNew insights into the evolution and nature of proteins\u003c\/p\u003e \u003cp\u003eExploring several distinct approaches, this book describes the methods for comparing protein sequences and protein structures in order to identify homologous relationships and classify proteins and protein domains into evolutionary families. Readers will discover the common features as well as the key philosophical differences underlying the major protein classification systems, including Pfam, Panther, SCOP, and CATH. Moreover, they'll discover how these systems can be used to understand the evolution of protein families as well as understand and predict the degree to which structural and functional information are shared between relatives in a protein family.\u003c\/p\u003e \u003cp\u003eEdited and authored by leading international experts, \u003ci\u003eProtein Families\u003c\/i\u003e offers new insights into protein families that are important to medical research as well as protein families that help us understand biological systems and key biological processes such as cell signaling and the immune response. The book is divided into three sections:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e\n\u003cb\u003eSection I: Concepts Underlying Protein Family Classification\u003c\/b\u003e reviews the major strategies for identifying homologous proteins and classifying them into families.\u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eSection II: In-Depth Reviews of Protein Families\u003c\/b\u003e focuses on some fascinating super protein families for which we have substantial amounts of sequence, structural and functional data, making it possible to trace the emergence of functionally diverse relatives.\u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eSection III: Review of Protein Families in Important Biological Systems\u003c\/b\u003e examines protein families associated with a particular biological theme, such as the cytoskeleton.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eAll chapters are extensively illustrated, including depictions of evolutionary relationships. References at the end of each chapter guide readers to original research papers and reviews in the field.\u003c\/p\u003e \u003cp\u003eCovering protein family classification systems alongside detailed descriptions of select protein families, this book offers biochemists, molecular biologists, protein scientists, structural biologists, and bioinformaticians new insight into the evolution and nature of proteins.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989880160485,"sku":"NP9780470624227","price":162.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470624227.jpg?v=1761785771","url":"https:\/\/k12savings.com\/products\/protein-families-isbn-9780470624227","provider":"K12savings","version":"1.0","type":"link"}