{"product_id":"primer-on-the-metabolic-bone-diseases-and-disorders-of-mineral-metabolism-isbn-9781119266563","title":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","description":"\u003cp\u003e\u003cb\u003eThe authoritative reference to bone diseases and disorders of mineral metabolism, revised and updated\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eNow in its ninth edition, \u003ci\u003eThe Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism \u003c\/i\u003eoffers an updated and comprehensive guide to bone and mineral health. Since it was first published 30 years ago, the Primer has become the leading reference on the topic. With contributions from noted experts, the text explores basic biological factors of healthy development and disease states and makes the information accessible for clinical interventions. The ninth edition provides concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism.\u003c\/p\u003e \u003cp\u003eThe new edition of this invaluable reference expands coverage and includes the most recent developments in the field that help to strengthen its usefulness and ensure that the \u003ci\u003ePrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism\u003c\/i\u003e maintains its place as the pre-eminent reference on bone and mineral health. This vital resource: \u003c\/p\u003e \u003cul\u003e \u003cli\u003eProvides the most accurate, up-to-date evidence-based information on basic and clinical bone science\u003c\/li\u003e \u003cli\u003eIncludes more than 10 new chapters and contributions from 300 authors from wide-ranging international research centers\u003c\/li\u003e \u003cli\u003eCaptures the very cutting edge of research covering mineral homeostasis, osteoporosis and other metabolic bone diseases, skeletal measurement technologies, and genetics\u003c\/li\u003e \u003cli\u003ePresents a new companion website with useful supplementary materials at www.asbmrprimer.com\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eWritten for advanced students, clinicians, and researchers working in the field of bone health and disease, \u003ci\u003ePrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolis\u003c\/i\u003em is the definitive, one-stop reference for anyone working in the field of bone health and disease.\u003c\/p\u003e \u003cp\u003eContributors xi\u003c\/p\u003e \u003cp\u003ePreface to the Ninth Edition of the Primer:\u003cbr\u003eJohn P. Bilezikian xxiv\u003c\/p\u003e \u003cp\u003eAbout ASBMR xxv\u003c\/p\u003e \u003cp\u003ePresident’s Preface Michael J. Econs xxvi\u003c\/p\u003e \u003cp\u003eAbout the Companion Website xxvii\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection I Molecular and Cellular Determinants of Bone Structure and Function 1\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSection Editor Karen Lyons\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1 Early Skeletal Morphogenesis in Embryonic Development 3\u003cbr\u003e\u003ci\u003eYingzi Yang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Endochondral Ossification 12\u003cbr\u003e\u003ci\u003eCourtney M. Karner and Matthew J. Hilton\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Local and Circulating Osteoprogenitor Cells and Lineages 20\u003cbr\u003e\u003ci\u003eNaomi Dirckx and Christa Maes\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Osteoblasts Function, Development, and Regulation 31\u003cbr\u003e\u003ci\u003eElizabeth W. Bradley, Jennifer J. Westendorf, Andre J. van Wijnen, and Amel Dudakovic\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Osteocytes 38\u003cbr\u003e\u003ci\u003eLynda F. Bonewald\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Osteoclast Biology and Bone Resorption 46\u003cbr\u003e\u003ci\u003eHiroshi Takayanagi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Signal Transduction Cascades Controlling Osteoblast Differentiation 54\u003cbr\u003e\u003ci\u003eDavid J.J. de Gorter, Gonzalo Sánchez‐Duffhues, and Peter ten Dijke\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 The TGF‐β Superfamily in Bone Formation and Maintenance 60\u003cbr\u003e\u003ci\u003eCe Shi and Yuji Mishina\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Recent Developments in Understanding the Role of Wnt Signaling in Skeletal Development and Disease 68\u003cbr\u003e\u003ci\u003eZhendong A. Zhong, Nicole J. Ethen, and Bart O. Williams\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Mechanotransduction in Bone Formation and Maintenance 75\u003cbr\u003e\u003ci\u003eWhitney A. Bullock, Lilian I. Plotkin, Alexander G. Robling, and Fredrick M. Pavalko\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 The Composition of Bone 84\u003cbr\u003e\u003ci\u003eAdele L. Boskey and Pamela G. Robey\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Assessment of Bone Mass, Structure, and Quality in Rodents 93\u003cbr\u003e\u003ci\u003eJeffry S. Nyman and Deepak Vashishth\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Skeletal Healing Cellular and Molecular Determinants 101\u003cbr\u003e\u003ci\u003eAlayna E. Loiselle and Michael J. Zuscik\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Biomechanics of Fracture Healing 108\u003cbr\u003e\u003ci\u003eElise F. Morgan, Amira I. Hussein, and Thomas A. Einhorn\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection II Skeletal Physiology 115\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSection Editor Ego Seeman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Human Fetal and Neonatal Bone Development 117\u003cbr\u003e\u003ci\u003eTao Yang, Monica Grover, Kyu Sang Joeng, and Brendan Lee\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Skeletal Growth a Major Determinant of Bone’s Structural Diversity in Women and Men 123\u003cbr\u003e\u003ci\u003eEgo Seeman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Racial Differences in the Acquisition and Age‐related Loss of Bone Strength 131\u003cbr\u003e\u003ci\u003eShane A. Norris, Marcella D. Walker, Kate Ward, Lisa K. Micklesfield, and John M. Pettifor\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Calcium, Vitamin D, and Other Nutrients During Growth 135\u003cbr\u003e\u003ci\u003eTania Winzenberg and Graeme Jones\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Mechanical Loading and the Developing Skeleton 141\u003cbr\u003e\u003ci\u003eMark R. Forwood\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Pregnancy and Lactation 147\u003cbr\u003e\u003ci\u003eChristopher S. Kovacs and Henry M. Kronenberg\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Menopause and Age‐related Bone Loss 155\u003cbr\u003e\u003ci\u003eCarlos M. Isales and Ego Seeman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection III Mineral Homeostasis 163\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSection Editors David Goltzman and Harald Jüppner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 Regulation of Calcium Homeostasis 165\u003cbr\u003e\u003ci\u003eLine Vautour and David Goltzman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 Magnesium Homeostasis 173\u003cbr\u003e\u003ci\u003eAliya Aziz Khan, Asiya Sbayi, and Karl Peter Schlingmann\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 Fetal Calcium Metabolism 179\u003cbr\u003e\u003ci\u003eChristopher S. Kovacs\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25 FGF23 and the Regulation of Phosphorus Metabolism 187\u003cbr\u003e\u003ci\u003eKenneth E. White and Michael J. Econs\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26 Gonadal Steroids 194\u003cbr\u003e\u003ci\u003eStavros C. Manolagas and Maria Schuller Almeida\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e27 Parathyroid Hormone 205\u003cbr\u003e\u003ci\u003eThomas J. Gardella, Robert A. Nissenson, and Harald Jüppner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e28 Parathyroid Hormone‐Related Protein 212\u003cbr\u003e\u003ci\u003eJohn J. Wysolmerski and T. John Martin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e29 Calcium‐Sensing Receptor 221\u003cbr\u003e\u003ci\u003eGeoffrey N. Hendy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e30 Vitamin D Production, Metabolism, Action, and Clinical Requirements 230\u003cbr\u003e\u003ci\u003eDaniel D. Bikle, John S. Adams, and Sylvia Christakos\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection IV Investigation of Metabolic Bone Diseases 241\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSection Editors Douglas C. Bauer and Klaus Engelke\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e31 Techniques of Bone Mass Measurement in Children with Risk Factors for Osteoporosis 243\u003cbr\u003e\u003ci\u003eNicola J. Crabtree and Leanne M. Ward\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e32 Standard Techniques of Bone Mass Measurement in Adults 252\u003cbr\u003e\u003ci\u003eE. Michael Lewiecki, Paul D. Miller, and Nelson B. Watts\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e33 Advanced Techniques of Bone Mass Measurements and Strength in Adults 260\u003cbr\u003e\u003ci\u003eKyle K. Nishiyama, Enrico Dall’Ara, and Klaus Engelke\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e34 Magnetic Resonance Imaging of Bone 272\u003cbr\u003e\u003ci\u003eSharmila Majumdar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e35 Trabecular Bone Score 277\u003cbr\u003e\u003ci\u003eBarbara C. Silva and William D. Leslie\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e36 Reference Point Indentation 287\u003cbr\u003e\u003ci\u003eAdolfo Diez‐Perez and Joshua N. Farr\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e37 Biochemical Markers of Bone Turnover in Osteoporosis 293\u003cbr\u003e\u003ci\u003ePawel Szulc, Douglas C. Bauer, and Richard Eastell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e38 Scintigraphy and PET in Metabolic Bone Disease 302\u003cbr\u003e\u003ci\u003eLorenzo Nardo, Paola A. Erba, and Benjamin L. Franc\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e39 Bone Histomorphometry in Clinical Practice 310\u003cbr\u003e\u003ci\u003eRobert R. Recker and Carolina Aguiar Moreira\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e40 Diagnosis and Classification of Vertebral Fracture 319\u003cbr\u003e\u003ci\u003eJames F. Griffith and Harry K. Genant\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e41 FRAX Assessment of Fracture Risk 331\u003cbr\u003e\u003ci\u003eJohn A. Kanis, Eugene V. McCloskey, Nicholas C. Harvey, and William D. Leslie\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection V Genetics of Bone 341\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSection Editor Rajesh V. Thakker\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e42 Introduction to Genetics 343\u003cbr\u003e\u003ci\u003ePaul J. Newey, Michael P. Whyte, and Rajesh V. Thakker\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e43 Animal Models Genetic Manipulation 351\u003cbr\u003e\u003ci\u003eKaren Lyons\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e44 Animal Models Allelic Determinants for Bone Mineral Density 359\u003cbr\u003e\u003ci\u003eJ. H. Duncan Bassett, Graham R. Williams, and Robert D. Blank\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e45 Transcriptional Profiling for Genetic Assessment 367\u003cbr\u003e\u003ci\u003eAimy Sebastian and Gabriela G. Loots\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e46 Approaches to Genetic Testing 373\u003cbr\u003e\u003ci\u003eChristina Jacobsen, Yiping Shen, and Ingrid A. Holm\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e47 Human Genome‐Wide Association Studies 378\u003cbr\u003e\u003ci\u003eDouglas P. Kiel, Emma L. Duncan, and Fernando Rivadeneira\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e48 Translational Genetics of Osteoporosis From Population Association to Individualized Assessment 385\u003cbr\u003e\u003ci\u003eBich Tran, Jacqueline R. Center, and Tuan V. Nguyen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection VI Osteoporosis 393\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSection Editors Paul D. Miller, Socrates E. Papapoulos, and Michael R. McClung\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e49 Osteoporosis an Overview 395\u003cbr\u003e\u003ci\u003eMichael R. McClung, Paul D. Miller, and Socrates E. Papapoulos\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e50 The Epidemiology of Osteoporotic Fractures 398\u003cbr\u003e\u003ci\u003eNicholas C. Harvey, Elizabeth M. Curtis, Elaine M. Dennison, and Cyrus Cooper\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e51 Fracture Liaison Service 405\u003cbr\u003e\u003ci\u003ePiet Geusens, John A. Eisman, Andrea Singer, and Joop van den Bergh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e52 Sex Steroids and the Pathogenesis of Osteoporosis 412\u003cbr\u003e\u003ci\u003eMatthew T. Drake and Sundeep Khosla\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e53 Juvenile Osteoporosis 419\u003cbr\u003e\u003ci\u003eFrancis H. Glorieux and Craig Munns\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e54 Transplantation Osteoporosis 424\u003cbr\u003e\u003ci\u003ePeter R. Ebeling\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e55 Premenopausal Osteoporosis 436\u003cbr\u003e\u003ci\u003eAdi Cohen and Elizabeth Shane\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e56 Osteoporosis in Men 443\u003cbr\u003e\u003ci\u003eEric S. Orwoll and Robert A. Adler\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e57 Bone Stress Injuries 450\u003cbr\u003e\u003ci\u003eStuart J. Warden and David B. Burr\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e58 Inflammation‐Induced Bone Loss in the Rheumatic Diseases 459\u003ci\u003e \u003cbr\u003eEllen M. Gravallese and Steven R. Goldring\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e59 Glucocorticoid‐Induced Osteoporosis 467\u003cbr\u003e\u003ci\u003eKenneth Saag and Robert A. Adler\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e60 Human Immunodeficiency Virus and Bone 474\u003cbr\u003e\u003ci\u003eMichael T. Yin and Todd T. Brown\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e61 Effects on the Skeleton from Medications Used to Treat Nonskeletal Disorders 482\u003cbr\u003e\u003ci\u003eNelson B. Watts\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e62 Diabetes and Fracture Risk 487\u003cbr\u003e\u003ci\u003eSerge Ferrari, Nicola Napoli, and Ann Schwartz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e63 Obesity and Skeletal Health 492\u003cbr\u003e\u003ci\u003eJuliet Compston\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e64 Sarcopenia and Osteoporosis 498\u003cbr\u003e\u003ci\u003eGustavo Duque and Neil Binkley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e65 Management of Osteoporosis in Patients with Chronic Kidney Disease 505\u003cbr\u003e\u003ci\u003ePaul D. Miller\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e66 Other Secondary Causes of Osteoporosis 510\u003cbr\u003e\u003ci\u003eNeveen A. T. Hamdy and Natasha M. Appelman‐Dijkstra\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e67 Exercise for Osteoporotic Fracture Prevention and Management 517\u003cbr\u003e\u003ci\u003eRobin M. Daly and Lora Giangregorio\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e68 Prevention of Falls 526\u003cbr\u003e\u003ci\u003eHeike A. Bischoff‐Ferrari\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e69 Nutritional Support for Osteoporosis 534\u003cbr\u003e\u003ci\u003eConnie M. Weaver, Bess Dawson‐Hughes, Rene Rizzoli, and Robert P. Heaney\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e70 Estrogens, Selective Estrogen Receptor Modulators, and Tissue‐Selective Estrogen Complex 541\u003cbr\u003e\u003ci\u003eTobias J. de Villiers\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e71 Bisphosphonates for Postmenopausal Osteoporosis 545\u003cbr\u003e\u003ci\u003eAndrea Giusti and Socrates E. Papapoulos\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e72 Denosumab 553\u003cbr\u003e\u003ci\u003eAline Granja Costa, E. Michael Lewiecki, and John P. Bilezikian\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e73 Parathyroid Hormone and Abaloparatide Treatment for Osteoporosis 559\u003cbr\u003e\u003ci\u003eFelicia Cosman and Susan L. Greenspan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e74 Combination Anabolic and Antiresorptive Therapy for Osteoporosis 567\u003cbr\u003e\u003ci\u003eJoy N. Tsai and Benjamin Z. Leder\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e75 Strontium Ranelate and Calcitonin 573\u003cbr\u003e\u003ci\u003eLeonardo Bandeira and E. Michael Lewiecki\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e76 Adverse Effects of Drugs for Osteoporosis 579\u003cbr\u003e\u003ci\u003eBo Abrahamsen and Daniel Prieto‐Alhambra\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e77 Orthopedic Principles of Fracture Management 588\u003cbr\u003e\u003ci\u003eManoj Ramachandran and David G. Little\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e78 Adherence to Osteoporosis Therapies 593\u003cbr\u003e\u003ci\u003eStuart L. Silverman and Deborah T. Gold\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e79 Cost‐Effectiveness of Osteoporosis Treatment 597\u003cbr\u003e\u003ci\u003eAnna N.A. Tosteson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e80 Future Therapies 603\u003cbr\u003e\u003ci\u003eMichael R. McClung\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection VII Metabolic Bone Diseases 611\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSection Editors Suzanne M. Jan de Beur and Peter R. Ebeling\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e81 Approach to Parathyroid Disorders 613\u003cbr\u003e\u003ci\u003eJohn P. Bilezikian\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e82 Primary Hyperparathyroidism 619\u003cbr\u003e\u003ci\u003eShonni J. Silverberg, Francisco Bandeira, Jianmin Liu, Claudio Marcocci, and Marcella D. Walker\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e83 Familial States of Primary Hyperparathyroidism 629\u003cbr\u003e\u003ci\u003eAndrew Arnold, Sunita K. Agarwal, and Rajesh V. Thakker\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e84 Non‐Parathyroid Hypercalcemia 639\u003cbr\u003e\u003ci\u003eMara J. Horwitz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e85 Hypocalcemia Definition, Etiology, Pathogenesis, Diagnosis, and Management 646\u003cbr\u003e\u003ci\u003eAnne L. Schafer and Dolores M. Shoback\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e86 Hypoparathyroidism 654\u003cbr\u003e\u003ci\u003eTamara Vokes, Mishaela R. Rubin, Karen K. Winer, Michael Mannstadt, Natalie E. Cusano, Harald Jüppner, and John P. Bilezikian\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e87 Pseudohypoparathyroidism 661\u003cbr\u003e\u003ci\u003eAgnès Linglart, Michael A. Levine, and Harald Jüppner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e88 Disorders of Phosphate Homeostasis 674\u003cbr\u003e\u003ci\u003eMary D. Ruppe and Suzanne M. Jan de Beur\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e89 Rickets and Osteomalacia 684\u003cbr\u003e\u003ci\u003eMichaël R. Laurent, Nathalie Bravenboer, Natasja M. Van Schoor, Roger Bouillon, John M. Pettifor, and Paul Lips\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e90 Pathophysiology and Treatment of Chronic Kidney Disease–Mineral and Bone Disorder 695\u003cbr\u003e\u003ci\u003eMark R. Hanudel, Sharon M. Moe, and Isidro B. Salusky\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e91 Disorders of Mineral Metabolism in Childhood 705\u003cbr\u003e\u003ci\u003eThomas O. Carpenter and Nina S. Ma\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e92 Paget Disease of Bone 713\u003cbr\u003e\u003ci\u003eJulia F. Charles, Ethel S. Siris, and G. David Roodman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e93 Epidemiology, Diagnosis, Evaluation, and Treatment of Nephrolithiasis 721\u003cbr\u003e\u003ci\u003eMurray J. Favus and David A. Bushinsky\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e94 Immobilization and Burns Other Conditions Associated with Osteoporosis 730\u003cbr\u003e\u003ci\u003eWilliam A. Bauman, Christopher Cardozo, and Gordon L. Klein\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection VIII Cancer and Bone 737\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSection Editors Theresa Guise and G. David Roodman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e95 Mechanisms of Osteolytic and Osteoblastic Skeletal Lesions 739\u003cbr\u003e\u003ci\u003eG. David Roodman and Theresa Guise\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e96 Clinical and Preclinical Imaging in Osseous Metastatic Disease 743\u003cbr\u003e\u003ci\u003eSiyang Leng and Suzanne Lentzsch\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e97 Metastatic Tumors and Bone 752\u003cbr\u003e\u003ci\u003eJulie A. Sterling and Rachelle W. Johnson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e98 Myeloma Bone Disease and Other Hematological Malignancies 760\u003cbr\u003e\u003ci\u003eClaire M. Edwards and Rebecca Silbermann\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e99 Osteogenic Osteosarcoma 768\u003cbr\u003e\u003ci\u003eYangjin Bae, Huan‐Chang Zeng, Linchao Lu, Lisa L. Wang, and Brendan Lee\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e100 Skeletal Complications of Breast and Prostate Cancer Therapies 775\u003cbr\u003e\u003ci\u003eCatherine Van Poznak and Pamela Taxel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e101 Bone Cancer and Pain 781\u003cbr\u003e\u003ci\u003eDenis Clohisy and Lauren M. MacCormick\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e102 Radiotherapy‐Induced Osteoporosis 788\u003cbr\u003e\u003ci\u003eLaura E. Wright\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e103 Skeletal Complications of Childhood Cancer 793\u003cbr\u003e\u003ci\u003eManasa Mantravadi and Linda A. DiMeglio\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e104 Medical Prevention and Treatment of Bone Metastases 799\u003cbr\u003e\u003ci\u003eCatherine Handforth, Stella D’Oronzo, and Janet Brown\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e105 Radiotherapy of Skeletal Metastases 809\u003cbr\u003e\u003ci\u003eSrinivas Raman, K. Liang Zeng, Oliver Sartor, Edward Chow, and Øyvind S. Bruland\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e106 Concepts and Surgical Treatment of Metastatic Bone Disease 816\u003cbr\u003e\u003ci\u003eKristy Weber and Scott L. Kominsky\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection IX Sclerosing and Dysplastic Bone Diseases 823\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSection Editor Michael P. Whyte\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e107 Sclerosing Bone Disorders 825\u003cbr\u003e\u003ci\u003eMichael P. Whyte\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e108 Fibrous Dysplasia 839\u003cbr\u003e\u003ci\u003eMichael T. Collins, Alison M. Boyce, and Mara Riminucci\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e109 The Osteochondrodysplasias 848\u003cbr\u003e\u003ci\u003eFabiana Csukasi and Deborah Krakow\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e110 Ischemic and Infiltrative Disorders of Bone 853\u003cbr\u003e\u003ci\u003eMichael P. Whyte\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e111 Tumoral Calcinosis – Dermatomyositis 861\u003cbr\u003e\u003ci\u003eNicholas J. Shaw\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e112 Genetic Disorders of Heterotopic Ossification: Fibrodysplasia Ossificans Progressiva and Progressive Osseous\u003cbr\u003eHeteroplasia 865\u003cbr\u003e\u003ci\u003eFrederick S. Kaplan, Robert J. Pignolo, Mona Al Mukaddam, and Eileen M. Shore\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e113 Osteogenesis Imperfecta 871\u003cbr\u003e\u003ci\u003eJoan C. Marini\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e114 Fibrillinopathies Skeletal Manifestations of Marfan Syndrome and Marfan‐Related Conditions 878\u003cbr\u003e\u003ci\u003eGary S. Gottesman and Michael P. Whyte\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e115 Hypophosphatasia and Other Enzyme Deficiencies Affecting the Skeleton 886\u003cbr\u003e\u003ci\u003eMichael P. Whyte\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection X Oral and Maxillofacial Biology and Pathology 891\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSection Editor Laurie McCauley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e116 Craniofacial Morphogenesis 893\u003cbr\u003e\u003ci\u003eErin Ealba Bumann and Vesa Kaartinen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e117 Development and Structure of Teeth and Periodontal Teeth 901\u003cbr\u003e\u003ci\u003ePetros Papagerakis and Thimios Mitsiadis\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e118 Genetic Craniofacial Disorders Affecting the Dentition 911\u003cbr\u003e\u003ci\u003eYong‐Hee Patricia Chun, Paul H. Krebsbach, and James P. Simmer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e119 Pathology of the Hard Tissues of the Jaws 918\u003cbr\u003e\u003ci\u003ePaul C. Edwards\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e120 Osteonecrosis of the Jaw 927\u003cbr\u003e\u003ci\u003eSotirios Tetradis, Laurie McCauley, and Tara Aghaloo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e121 Alveolar Bone Homeostasis in Health and Disease 933\u003cbr\u003e\u003ci\u003eChad M. Novince and Keith L. Kirkwood\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e122 Oral Manifestations of Metabolic Bone Diseases 941\u003cbr\u003e\u003ci\u003eErica L. Scheller, Charles Hildebolt, and Roberto Civitelli\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e123 Dental Implants and Osseous Healing in the Oral Cavity 949\u003cbr\u003e\u003ci\u003eTakashi Matsuura and Junro Yamashita\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection XI Integrative Physiology of the Skeleton 957\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSection Editors Mone Zaidi and Clifford J. Rosen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e124 Integrative Physiology of the Skeleton 959\u003cbr\u003e\u003ci\u003eClifford J. Rosen and Mone Zaidi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e125 The Hematopoietic Niche and Bone 966\u003cbr\u003e\u003ci\u003eStavroula Kousteni, Benjamin J. Frisch, Marta Galan‐Diez, and Laura M. Calvi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e126 Adipocytes and Bone 974\u003cbr\u003e\u003ci\u003eClarissa S. Craft, Natalie K. Wee, and Erica L. Scheller\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e127 The Vasculature and Bone 983\u003cbr\u003e\u003ci\u003eMarie Hélène Lafage‐Proust and Bernard Roche\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e128 Immunobiology and Bone 992\u003cbr\u003e\u003ci\u003eRoberto Pacifici and M. Neale Weitzmann\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e129 Cellular Bioenergetics of Bone 1004\u003cbr\u003e\u003ci\u003eWen‐Chih Lee and Fanxin Long\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e130 Endocrine Bioenergetics of Bone 1012\u003cbr\u003e\u003ci\u003ePatricia F. Ducy and Gerard Karsenty\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e131 Central Neuronal Control of Bone Remodeling 1020\u003cbr\u003e\u003ci\u003eHiroki Ochi, Paul Baldock, and Shu Takeda\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e132 Peripheral Neuronal Control of Bone Remodeling 1028\u003cbr\u003e\u003ci\u003eKatherine J. Motyl and Mary F. Barbe\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e133 The Pituitary–Bone Axis in Health and Disease 1037\u003cbr\u003e\u003ci\u003eMone Zaidi, Tony Yuen, Wahid Abu‐Amer, Peng Liu, Terry F. Davies, Maria I. New, Harry C. Blair, Alberta Zallone, Clifford J. Rosen, and Li Sun\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e134 Neuropsychiatric Disorders and the Skeleton 1047\u003cbr\u003e\u003ci\u003eMadhusmita Misra and Anne Klibanski\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e135 Interactions Between Muscle and Bone 1055\u003cbr\u003e\u003ci\u003eMarco Brotto\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 1063\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJohn P. Bilezikian\u003c\/b\u003e is the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians \u0026amp; Surgeons, Columbia University. He is Chief Emeritus of the Division of Endocrinology and Vice-chair of the Department of Medicine for International Research and Education. He is also Director Emeritus of the Metabolic Bone Diseases Program at Columbia University Medical Center.\u003c\/p\u003e   \u003cp\u003e\u003cb\u003e\u003csmall\u003eTHE AUTHORITATIVE REFERENCE TO BONE DISEASES AND DISORDERS OF MINERAL METABOLISM, REVISED AND UPDATED\u003c\/small\u003e\u003c\/b\u003e  \u003c\/p\u003e\u003cp\u003eNow in its ninth edition, the\u003ci\u003e Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism\u003c\/i\u003e offers an updated and comprehensive guide to bone and mineral health. Since it was first published 30 years ago, the Primer has become the leading reference on the topic. With contributions from noted experts, the text explores basic biological factors of healthy development and disease states and makes the information accessible for clinical interventions. The ninth edition provides concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism.  \u003c\/p\u003e\u003cp\u003eThe new edition of this invaluable reference expands coverage and includes the most recent developments in the field that help to strengthen its usefulness and ensure that the \u003ci\u003ePrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism\u003c\/i\u003e maintains its place as the pre-eminent reference on bone and mineral health. This vital resource: \u003c\/p\u003e\u003cul\u003e \u003cb\u003e\u003cli\u003eProvides the most accurate, up-to-date evidence-based information on basic and clinical bone science\u003c\/li\u003e\u003c\/b\u003e \u003cb\u003e\u003cli\u003eIncludes more than 10 new chapters and contributions from 300 authors from wide-ranging international research centers\u003c\/li\u003e\u003c\/b\u003e \u003cb\u003e\u003cli\u003eCaptures the very cutting edge of research covering mineral homeostasis, osteoporosis and other metabolic bone diseases, skeletal measurement technologies, and genetics\u003c\/li\u003e\u003c\/b\u003e \u003cb\u003e\u003cli\u003ePresents a new companion website with useful supplementary materials at www.wiley.com\/go\/asbmrprimer\u003c\/li\u003e\u003c\/b\u003e \u003c\/ul\u003e \u003cp\u003eWritten for advanced students, clinicians, and researchers, the \u003ci\u003ePrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism\u003c\/i\u003e is the definitive, one-stop reference for anyone working in the field of bone health and disease.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989848309989,"sku":"NP9781119266563","price":175.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119266563.jpg?v=1761785662","url":"https:\/\/k12savings.com\/products\/primer-on-the-metabolic-bone-diseases-and-disorders-of-mineral-metabolism-isbn-9781119266563","provider":"K12savings","version":"1.0","type":"link"}