{"product_id":"primer-on-the-metabolic-bone-diseases-and-disorders-of-mineral-metabolism-isbn-9781118453889","title":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","description":"\u003ci\u003ePrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8th Edition\u003c\/i\u003e is the comprehensive revision of the field-leading reference on bone and mineral health. The eighth edition has been fully revised by the leading researchers and clinicians in the field to provide concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. Chapters look to explain basic biological factors of healthy development and disease states and make it easily translatable to clinical interventions.\u003cbr\u003e \u003cbr\u003e \u003ci\u003ePrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism\u003c\/i\u003e is the definitive, one-stop reference for anyone working in the field of bone health and disease.\u003cbr\u003e \u003cbr\u003e Visit the \u003ca title=\"Rosen: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8th Edition\" href=\"http:\/\/www.asbmrprimer.com\/\" target=\"_blank\"\u003ecompanion site\u003c\/a\u003e to access supplementary materials including videos, editorial team details, \u003ca title=\"Downloadable Figures\" href=\"http:\/\/www.asbmrprimer.com\/figures.asp\" target=\"_blank\"\u003edownloadable figures\u003c\/a\u003e, and more.  \u003cp\u003eContributors x\u003c\/p\u003e \u003cp\u003ePrimer Corporate Sponsors xxii\u003c\/p\u003e \u003cp\u003ePreface to the Eighth Edition of the Primer: Clifford J. Rosen xxiii\u003c\/p\u003e \u003cp\u003eAbout ASBMR xxiv\u003c\/p\u003e \u003cp\u003ePresident’s Preface: Lynda F. Bonewald xxv\u003c\/p\u003e \u003cp\u003eAbout the Companion Website xxvi\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection I: Molecular, Cellular, and Genetic Determinants of Bone Structure and Formation 1\u003c\/b\u003e\u003cbr\u003e Section Editor Karen M. Lyons\u003c\/p\u003e \u003cp\u003e1 Skeletal Morphogenesis and Embryonic Development 3\u003cbr\u003e Yingzi Yang\u003c\/p\u003e \u003cp\u003e2 Signal Transduction Cascades Controlling Osteoblast Differentiation 15\u003cbr\u003e David J.J. de Gorter and Peter ten Dijke\u003c\/p\u003e \u003cp\u003e3 Osteoclast Biology and Bone Resorption 25\u003cbr\u003e F. Patrick Ross\u003c\/p\u003e \u003cp\u003e4 Osteocytes 34\u003cbr\u003e Lynda F. Bonewald\u003c\/p\u003e \u003cp\u003e5 Connective Tissue Pathways That Regulate Growth Factors 42\u003cbr\u003e Gerhard Sengle and Lynn Y. Sakai\u003c\/p\u003e \u003cp\u003e6 The Composition of Bone 49\u003cbr\u003e Adele L. Boskey and Pamela Gehron Robey\u003c\/p\u003e \u003cp\u003e7 Assessment of Bone Mass and Microarchitecture in Rodents 59\u003cbr\u003e Blaine A. Christiansen\u003c\/p\u003e \u003cp\u003e8 Animal Models: Genetic Manipulation 69\u003cbr\u003e Karen M. Lyons\u003c\/p\u003e \u003cp\u003e9 Animal Models: Allelic Determinants for BMD 76\u003cbr\u003e Robert D. Blank\u003c\/p\u003e \u003cp\u003e10 Neuronal Regulation of Bone Remodeling 82\u003cbr\u003e Florent Elefteriou and Gerard Karsenty\u003c\/p\u003e \u003cp\u003e11 Skeletal Healing 90\u003cbr\u003e Michael J. Zuscik\u003c\/p\u003e \u003cp\u003e12 Biomechanics of Fracture Healing 99\u003cbr\u003e Elise F. Morgan and Thomas A. Einhorn\u003c\/p\u003e \u003cp\u003e13 Human Genome-Wide Association (GWA) Studies 106\u003cbr\u003e Douglas P. Kiel\u003c\/p\u003e \u003cp\u003e14 Circulating Osteogenic Cells 111\u003cbr\u003e Robert J. Pignolo and Moustapha Kassem\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection II: Skeletal Physiology 119\u003c\/b\u003e\u003cbr\u003e Section Editor Ego Seeman\u003c\/p\u003e \u003cp\u003e15 Human Fetal and Neonatal Bone Development 121\u003cbr\u003e Tao Yang, Monica Grover, Kyu Sang Joeng, and Brendan Lee\u003c\/p\u003e \u003cp\u003e16 Skeletal Growth and Peak Bone Strength 127\u003cbr\u003e Qingju Wang and Ego Seeman\u003c\/p\u003e \u003cp\u003e17 Ethnic Differences in Bone Acquisition 135\u003cbr\u003e Shane A. Norris, Lisa K. Micklesfi eld, and John M. Pettifor\u003cbr\u003e \u003cbr\u003e 18 Calcium and Other Nutrients During Growth 142\u003cbr\u003e Tania Winzenberg and Graeme Jones\u003c\/p\u003e \u003cp\u003e19 Growing a Healthy Skeleton: The Importance of Mechanical Loading 149\u003cbr\u003e Mark R. Forwood\u003c\/p\u003e \u003cp\u003e20 Pregnancy and Lactation 156\u003cbr\u003e Christopher S. Kovacs and Henry M. Kronenberg\u003c\/p\u003e \u003cp\u003e21 Menopause 165\u003cbr\u003e Ian R. Reid\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection III: Mineral Homeostasis 171\u003c\/b\u003e\u003cbr\u003e Section Editor Ego Seeman\u003c\/p\u003e \u003cp\u003e22 Regulation of Calcium and Magnesium 173\u003cbr\u003e Murray J. Favus and David Goltzman\u003c\/p\u003e \u003cp\u003e23 Fetal Calcium Metabolism 180\u003cbr\u003e Christopher S. Kovacs\u003c\/p\u003e \u003cp\u003e24 Fibroblast Growth Factor-23 (FGF23) 188\u003cbr\u003e Kenneth E. White and Michael J. Econs\u003c\/p\u003e \u003cp\u003e25 Gonadal Steroids 195\u003cbr\u003e Stavros C. Manolagas, Maria Almeida, and Robert L. Jilka\u003c\/p\u003e \u003cp\u003e26 Parathyroid Hormone 208\u003cbr\u003e Robert A. Nissenson and Harald Jüppner\u003c\/p\u003e \u003cp\u003e27 Parathyroid Hormone-Related Protein 215\u003cbr\u003e John J. Wysolmerski\u003c\/p\u003e \u003cp\u003e28 Ca2+-Sensing Receptor 224\u003cbr\u003e Edward M. Brown\u003c\/p\u003e \u003cp\u003e29 Vitamin D: Production, Metabolism, Mechanism of Action, and Clinical Requirements 235\u003cbr\u003e Daniel Bikle, John S. Adams, and Sylvia Christakos\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection IV: Investigation of Metabolic Bone Diseases 249\u003c\/b\u003e\u003cbr\u003e Section Editor Douglas C. Bauer\u003c\/p\u003e \u003cp\u003e30 DXA in Adults and Children 251\u003cbr\u003e Glen Blake, Judith E. Adams, and Nick Bishop\u003c\/p\u003e \u003cp\u003e31 Quantitative Computed Tomography in Children and Adults 264\u003cbr\u003e C.C. Glüer\u003c\/p\u003e \u003cp\u003e32 Magnetic Resonance Imaging of Bone 277\u003cbr\u003e Sharmila Majumdar\u003c\/p\u003e \u003cp\u003e33 Radionuclide Scintigraphy in Metabolic Bone Disease 283\u003cbr\u003e Gary J.R. Cook, Gopinath Gnanasegaran, and Ignac Fogelman\u003c\/p\u003e \u003cp\u003e34 FRAX®: Assessment of Fracture Risk 289\u003cbr\u003e John A Kanis\u003c\/p\u003e \u003cp\u003e35 Biochemical Markers of Bone Turnover in Osteoporosis 297\u003cbr\u003e Pawel Szulc, Douglas C. Bauer, and Richard Eastell\u003c\/p\u003e \u003cp\u003e36 Bone Biopsy and Histomorphometry in Clinical Practice 307\u003cbr\u003e Robert R. Recker\u003c\/p\u003e \u003cp\u003e37 Diagnosis and Classifi cation of Vertebral Fracture 317\u003cbr\u003e James F. Griffi th, Judith E. Adams, and Harry K. Genant\u003c\/p\u003e \u003cp\u003e38 Approaches to Genetic Testing 336\u003cbr\u003e Christina Jacobsen, Yiping Shen, and Ingrid A. Holm\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection V: Osteoporosis 343\u003c\/b\u003e\u003cbr\u003e Section Editors Paul D. Miller and Socrates E. Papapoulos\u003c\/p\u003e \u003cp\u003e39 Osteoporosis Overview 345\u003cbr\u003e Michael Kleerekoper\u003c\/p\u003e \u003cp\u003e40 The Epidemiology of Osteoporotic Fractures 348\u003cbr\u003e Nicholas Harvey, Elaine Dennison, and Cyrus Cooper\u003c\/p\u003e \u003cp\u003e41 Overview of Pathogenesis 357\u003cbr\u003e Ian R. Reid\u003c\/p\u003e \u003cp\u003e42 Nutrition and Osteoporosis 361\u003cbr\u003e Connie M. Weaver and Robert P. Heaney\u003c\/p\u003e \u003cp\u003e43 The Role of Sex Steroids in the Pathogenesis of Osteoporosis 367\u003cbr\u003e Matthew T. Drake and Sundeep Khosla\u003c\/p\u003e \u003cp\u003e44 Translational Genetics of Osteoporosis: From Population Association to Individualized Prognosis 376\u003cbr\u003e Bich H. Tran, Jacqueline R. Center, and Tuan V. Nguyen\u003c\/p\u003e \u003cp\u003e45 Prevention of Falls 389\u003cbr\u003e Heike A. Bischoff-Ferrari\u003c\/p\u003e \u003cp\u003e46 Exercise and the Prevention of Osteoporosis 396\u003cbr\u003e Clinton T. Rubin, Janet Rubin, and Stefan Judex\u003c\/p\u003e \u003cp\u003e47 Calcium and Vitamin D 403\u003cbr\u003e Bess Dawson-Hughes\u003c\/p\u003e \u003cp\u003e48 Estrogens, Estrogen Agonists\/Antagonists, and Calcitonin 408\u003cbr\u003e Nelson B. Watts\u003c\/p\u003e \u003cp\u003e49 Bisphosphonates for Postmenopausal Osteoporosis 412\u003cbr\u003e Socrates E. Papapoulos\u003c\/p\u003e \u003cp\u003e50 Denosumab 420\u003cbr\u003e Michael R. McClung\u003c\/p\u003e \u003cp\u003e51 Parathyroid Hormone Treatment for Osteoporosis 428\u003cbr\u003e Felicia Cosman and Susan L. Greenspan\u003cbr\u003e \u003cbr\u003e 52 Strontium Ranelate in the Prevention of Osteoporotic Fractures 437\u003cbr\u003e René Rizzoli\u003c\/p\u003e \u003cp\u003e53 Combination Anabolic and Antiresorptive Therapy for Osteoporosis 444\u003cbr\u003e John P. Bilezikian and Natalie E. Cusano\u003c\/p\u003e \u003cp\u003e54 Compliance and Persistence with Osteoporosis Medications 448\u003cbr\u003e Deborah T. Gold\u003c\/p\u003e \u003cp\u003e55 Cost-Effectiveness of Osteoporosis Treatment 455\u003cbr\u003e Anna N.A. Tosteson\u003c\/p\u003e \u003cp\u003e56 Future Therapies of Osteoporosis 461\u003cbr\u003e Kong Wah Ng and T. John Martin\u003c\/p\u003e \u003cp\u003e57 Juvenile Osteoporosis 468\u003cbr\u003e Nick Bishop and Francis H. Glorieux\u003c\/p\u003e \u003cp\u003e58 Glucocorticoid-Induced Bone Disease 473\u003cbr\u003e Robert S. Weinstein\u003c\/p\u003e \u003cp\u003e59 Inflammation-Induced Bone Loss in the Rheumatic Diseases 482\u003cbr\u003e Steven R. Goldring\u003c\/p\u003e \u003cp\u003e60 Secondary Osteoporosis: Other Causes 489\u003cbr\u003e Neveen A.T. Hamdy\u003c\/p\u003e \u003cp\u003e61 Transplantation Osteoporosis 495\u003cbr\u003e Peter R. Ebeling\u003c\/p\u003e \u003cp\u003e62 Osteoporosis in Men 508\u003cbr\u003e Eric S. Orwoll\u003c\/p\u003e \u003cp\u003e63 Premenopausal Osteoporosis 514\u003cbr\u003e Adi Cohen and Elizabeth Shane\u003c\/p\u003e \u003cp\u003e64 Skeletal Effects of Drugs 520\u003cbr\u003e Juliet Compston\u003c\/p\u003e \u003cp\u003e65 Orthopedic Surgical Principles of Fracture Management 527\u003cbr\u003e Manoj Ramachandran and David G. Little\u003c\/p\u003e \u003cp\u003e66 Abnormalities in Bone and Calcium Metabolism After Burns 531\u003cbr\u003e Gordon L. Klein\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection VI: Disorders of Mineral Homeostasis 535\u003c\/b\u003e\u003cbr\u003e Section Editors Marie Demay and Suzanne M. Jan de Beur\u003c\/p\u003e \u003cp\u003e67 Approach to Parathyroid Disorders 537\u003cbr\u003e John P. Bilezikian\u003c\/p\u003e \u003cp\u003e68 Primary Hyperparathyroidism 543\u003cbr\u003e Shonni J. Silverberg\u003c\/p\u003e \u003cp\u003e69 Familial Primary Hyperparathyroidism (Including MEN, FHH, and HPT-JT) 553\u003cbr\u003e Andrew Arnold and Stephen J. Marx\u003c\/p\u003e \u003cp\u003e70 Non-Parathyroid Hypercalcemia 562\u003cbr\u003e Mara J. Horwitz, Steven P. Hodak, and Andrew F. Stewart\u003c\/p\u003e \u003cp\u003e71 Hypocalcemia: Defi nition, Etiology, Pathogenesis, Diagnosis, and Management 572\u003cbr\u003e Anne L. Schafer and Dolores Shoback\u003c\/p\u003e \u003cp\u003e72 Hypoparathyroidism and Pseudohypoparathyroidism 579\u003cbr\u003e Mishaela R. Rubin and Michael A. Levine\u003c\/p\u003e \u003cp\u003e73 Pseudohypoparathyroidism 590\u003cbr\u003e Harald Jüppner and Murat Bastepe\u003c\/p\u003e \u003cp\u003e74 Disorders of Phosphate Homeostasis 601\u003cbr\u003e Mary D. Ruppe and Suzanne M. Jan de Beur\u003c\/p\u003e \u003cp\u003e75 Vitamin D–Related Disorders 613\u003cbr\u003e Paul Lips, Natasja M. van Schoor, and Nathalie Bravenboer\u003c\/p\u003e \u003cp\u003e76 Vitamin D Insuffi ciency and Defi ciency 624\u003cbr\u003e J. Christopher Gallagher\u003c\/p\u003e \u003cp\u003e77 Pathophysiology of Chronic Kidney Disease Mineral Bone Disorder (CKD–MBD) 632\u003cbr\u003e Keith A. Hruska and Michael Seifert\u003c\/p\u003e \u003cp\u003e78 Treatment of Chronic Kidney Disease Mineral Bone Disorder (CKD–MBD) 640\u003cbr\u003e Hala M. Alshayeb and L. Darryl Quarles\u003c\/p\u003e \u003cp\u003e79 Disorders of Mineral Metabolism in Childhood 651\u003cbr\u003e Thomas O. Carpenter\u003c\/p\u003e \u003cp\u003e80 Paget’s Disease of Bone 659\u003cbr\u003e Ethel S. Siris and G. David Roodman\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection VII: Cancer and Bone 669\u003c\/b\u003e\u003cbr\u003e Section Editor Theresa A. Guise\u003c\/p\u003e \u003cp\u003e81 Overview of Mechanisms in Cancer Metastases to Bone 671\u003cbr\u003e Gregory A. Clines\u003c\/p\u003e \u003cp\u003e82 Clinical and Preclinical Imaging in Osseous Metastatic Disease 677\u003cbr\u003e Geertje van der Horst and Gabri van der Pluijm\u003c\/p\u003e \u003cp\u003e83 Metastatic Solid Tumors to Bone 686\u003cbr\u003e Rachelle W. Johnson and Julie A. Sterling\u003c\/p\u003e \u003cp\u003e84 Hematologic Malignancies and Bone 694\u003cbr\u003e Rebecca Silbermann and G. David Roodman\u003c\/p\u003e \u003cp\u003e85 Osteogenic Osteosarcoma 702\u003cbr\u003e Jianning Tao, Yangjin Bae, Lisa L. Wang, and Brendan Lee\u003c\/p\u003e \u003cp\u003e86 Skeletal Complications of Breast and Prostate Cancer Therapies 711\u003cbr\u003e Catherine Van Poznak and Pamela Taxel\u003c\/p\u003e \u003cp\u003e87 Bone Cancer and Pain 720\u003cbr\u003e Patrick W. O’Donnell and Denis R. Clohisy\u003c\/p\u003e \u003cp\u003e88 Radiation Therapy-Induced Osteoporosis 728\u003cbr\u003e Jeffrey S. Willey, Shane A.J. Lloyd, and Ted A. Bateman\u003c\/p\u003e \u003cp\u003e89 Skeletal Complications of Childhood Cancer 734\u003cbr\u003e Ingrid A. Holm\u003c\/p\u003e \u003cp\u003e90 Treatment and Prevention of Bone Metastases and Myeloma Bone Disease 741\u003cbr\u003e Jean-Jacques Body\u003c\/p\u003e \u003cp\u003e91 Radiotherapy of Skeletal Metastases 754\u003cbr\u003e Edward Chow, Luluel M. Khan, and Øyvind S. Bruland\u003c\/p\u003e \u003cp\u003e92 Concepts and Surgical Treatment of Metastatic Bone Disease 760\u003cbr\u003e Kristy Weber and Scott L. Kominsky\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection VIII: Sclerosing and Dysplastic Bone Diseases 767\u003c\/b\u003e\u003cbr\u003e Section Editor Richard W. Keen\u003c\/p\u003e \u003cp\u003e93 Sclerosing Bone Disorders 769\u003cbr\u003e Michael P. Whyte\u003c\/p\u003e \u003cp\u003e94 Fibrous Dysplasia 786\u003cbr\u003e Michael T. Collins, Mara Riminucci, and Paolo Bianco\u003c\/p\u003e \u003cp\u003e95 Osteochondrodysplasias 794\u003cbr\u003e Yasemin Alanay and David L. Rimoin\u003c\/p\u003e \u003cp\u003e96 Ischemic and Infi ltrative Disorders 805\u003cbr\u003e Richard W. Keen\u003c\/p\u003e \u003cp\u003e97 Tumoral Calcinosis—Dermatomyositis 810\u003cbr\u003e Nicholas Shaw\u003c\/p\u003e \u003cp\u003e98 Fibrodysplasia Ossifi cans Progressiva 815\u003cbr\u003e Frederick S. Kaplan, Robert J. Pignolo, and Eileen M. Shore\u003c\/p\u003e \u003cp\u003e99 Osteogenesis Imperfecta 822\u003cbr\u003e Joan C. Marini\u003c\/p\u003e \u003cp\u003e100 Skeletal Manifestations in Marfan Syndrome and Related Disorders of the Connective Tissue 830\u003cbr\u003e Emilio Arteaga-Solis and Francesco Ramirez\u003c\/p\u003e \u003cp\u003e101 Enzyme Defects and the Skeleton 838\u003cbr\u003e Michael P. Whyte\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection IX: Approach to Nephrolithiasis 843\u003c\/b\u003e\u003cbr\u003e Section Editor Rajesh V. Thakker\u003c\/p\u003e \u003cp\u003e102 Renal Tubular Physiology of Calcium Excretion 845\u003cbr\u003e Peter A. Friedman and David A. Bushinsky\u003c\/p\u003e \u003cp\u003e103 Epidemiology of Nephrolithiasis 856\u003cbr\u003e Murray J. Favus\u003c\/p\u003e \u003cp\u003e104 Diagnosis and Evaluation of Nephrolithiasis 860\u003cbr\u003e Stephen J. Knohl and Steven J. Scheinman\u003c\/p\u003e \u003cp\u003e105 Kidney Stones in the Pediatric Patient 869\u003cbr\u003e Amy E. Bobrowski and Craig B. Langman\u003c\/p\u003e \u003cp\u003e106 Treatment of Renal Stones 878\u003cbr\u003e John R. Asplin\u003c\/p\u003e \u003cp\u003e107 Genetic Basis of Renal Stones 884\u003cbr\u003e Rajesh V. Thakker\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection X: Oral and Maxillofacial Biology and Pathology 893\u003c\/b\u003e\u003cbr\u003e Section Editor Laurie K. McCauley\u003c\/p\u003e \u003cp\u003e108 Development of the Craniofacial Skeleton 895\u003cbr\u003e Maiko Matsui and John Klingensmith\u003c\/p\u003e \u003cp\u003e109 Development and Structure of Teeth and Periodontal Tissues 904\u003cbr\u003e Petros Papagerakis and Thimios Mitsiadis\u003c\/p\u003e \u003cp\u003e110 Craniofacial Disorders Affecting the Dentition: Genetic 914\u003cbr\u003e Yong-Hee P. Chun, Paul H. Krebsbach, and James P. Simmer\u003c\/p\u003e \u003cp\u003e111 Pathology of the Hard Tissues of the Jaws 922\u003cbr\u003e Paul C. Edwards\u003c\/p\u003e \u003cp\u003e112 Bisphosphonate-Associated Osteonecrosis of the Jaws 929\u003cbr\u003e Hani H. Mawardi, Nathaniel S. Treister, and Sook-Bin Woo\u003c\/p\u003e \u003cp\u003e113 Periodontal Diseases and Oral Bone Loss 941\u003cbr\u003e Mary G. Lee and Keith L. Kirkwood\u003c\/p\u003e \u003cp\u003e114 Oral Manifestations of Metabolic Bone Diseases 948\u003cbr\u003e Roberto Civitelli and Charles Hildebolt\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection XI: The Skeleton and Its Integration with Other Tissues 959\u003c\/b\u003e\u003cbr\u003e Section Editor Mone Zaidi\u003c\/p\u003e \u003cp\u003e115 Central Neuronal Control of Bone Remodeling 961\u003cbr\u003e Shu Takeda and Paul Baldock\u003c\/p\u003e \u003cp\u003e116 The Pituitary–Bone Connection 969\u003cbr\u003e Mone Zaidi, Tony Yuen, Li Sun, Terry F. Davies, Alberta Zallone, and Harry C. Blair\u003c\/p\u003e \u003cp\u003e117 Skeletal Muscle Effects on the Skeleton 978\u003cbr\u003e William J. Evans\u003c\/p\u003e \u003cp\u003e118 Glucose Control and Integration by the Skeleton 986\u003cbr\u003e Patricia Ducy and Gerard Karsenty\u003c\/p\u003e \u003cp\u003e119 Obesity and Skeletal Mass 993\u003cbr\u003e Sue Shapses and Deeptha Sukumar\u003c\/p\u003e \u003cp\u003e120 Neuropsychiatric Disorders and the Skeleton 1002\u003cbr\u003e Itai Bab and Raz Yirmiya\u003c\/p\u003e \u003cp\u003e121 Vascular Disease and the Skeleton 1012\u003cbr\u003e Dwight A. Towler\u003c\/p\u003e \u003cp\u003e122 Spinal Cord Injury: Skeletal Pathophysiology and Clinical Issues 1018\u003cbr\u003e William A. Bauman and Christopher P. Cardozo\u003c\/p\u003e \u003cp\u003e123 Hematopoiesis and Bone 1028\u003cbr\u003e Benjamin J. Frisch and Laura M. Calvi\u003c\/p\u003e \u003cp\u003e124 Bone and Immune Cell Interactions 1036\u003cbr\u003e Brendan F. Boyce\u003c\/p\u003e \u003cp\u003eIndex 1043\u003c\/p\u003e  \u003cp\u003e\u003cstrong\u003eClifford Rosen\u003c\/strong\u003e, M.D. is Director of the Center for Clinical and Translational Research at the Maine Medical Center Research Institute. Dr. Rosen is a former President of the American Society of Bone and Mineral Research. He serves as an Associate Editor on the \u003cem\u003eJournal of Bone and Mineral Research\u003c\/em\u003e and is former Editor of \u003cem\u003eThe Journal of Clinical Densitometry\u003c\/em\u003e.   \u003c\/p\u003e\u003cp\u003e\u003ci\u003eThe Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition\u003c\/i\u003e is the comprehensive revision of the field-leading reference on bone and mineral health. Chapters look to explain basic biological factors of healthy development and disease states and make it easily translatable to clinical interventions. The new edition has been fully revised by the leading researchers and clinicians in the field to provide concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism.\u003c\/p\u003e \u003cp\u003eThe eighth edition of this esteemed reference expands coverage and includes exciting new features that strengthen its usefulness and ensure that the \u003ci\u003ePrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism\u003c\/i\u003e maintains its place as the pre-eminent reference on bone and mineral health. Features new to this edition include:\u003c\/p\u003e \u003cp\u003e• A new section: “The Skeleton and its Integration with Other Disorders”\u003cbr\u003e \u003cbr\u003e • New chapters covering a diverse range of topics from “Denosumab” to “Radiation-Induced   Bone Loss”\u003cbr\u003e \u003cbr\u003e • Full-color figures throughout the text\u003cbr\u003e \u003cbr\u003e • User-friendly chapter layout\u003cbr\u003e \u003cbr\u003e • A new companion website with useful supplementary materials at \u003ca href=\"http:\/\/www.asbmrprimer.com\/\"\u003ewww.asbmrprimer.com\u003c\/a\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eThe Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition\u003c\/i\u003e is the definitive, one-stop reference for advanced students, clinicians, and researchers working in the field of bone health and disease.\u003c\/p\u003e \u003cp\u003ePrimer readers, don’t miss out on another valuable resource, the \u003ci\u003eJournal of Bone and Mineral Research\u003c\/i\u003e. This top-ranked and most cited journal in the field, with an impact factor of 6.373, is published monthly by the American Society for Bone and Mineral Research\u003cbr\u003e (ASBMR). The JBMR publishes highly competitive original manuscripts, reviews, and special articles in basic, translational, and clinical science relevant to bone, muscle, and mineral metabolism.\u003cbr\u003e \u003cbr\u003e \u003cb\u003eRECEIVE JBMR AS AN ASBMR MEMBER\u003c\/b\u003e\u003cbr\u003e This pre-eminent journal is just one of many advantages of ASBMR membership. From grant opportunities to quality educational programming to abstract submissions and more, ASBMR membership offers you unparalleled benefits. Be sure to visit \u003ca href=\"http:\/\/www.asbmr.org\/\"\u003ewww.asbmr.org\u003c\/a\u003e to learn how ASBMR promotes research, translates science into clinical care, and connects a worldwide audience within and beyond bone research boundaries.\u003cbr\u003e T\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989848408293,"sku":"NP9781118453889","price":148.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118453889.jpg?v=1761785661","url":"https:\/\/k12savings.com\/products\/primer-on-the-metabolic-bone-diseases-and-disorders-of-mineral-metabolism-isbn-9781118453889","provider":"K12savings","version":"1.0","type":"link"}