Preimplantation Genetic Diagnosis

Preimplantation Genetic Diagnosis (PGD) is the detection and screening of genetic abnormality in gametes prior to fertilisation and embryos fertilised in vitro prior to implantation. This exciting new text provides an introduction and overview of the principles of PGD.
An exciting fusion of prenatal diagnosis (PD) with in vitro fertilisation (IVF), this book is will appeal to both the prenatal diagnosis community, of clinical geneticists and foetal medicine specialists within obstetrics and gynaecology, and the IVF community within reproductive medicine. It is also an essential introduction to PD, clinical genetics and IVF for non-specialists.

• A concise introduction to the field of PGD
• Detailed explanations of the techniques and procedures used
• The law and ethical implications of PGD
• Future uses of PGD

Eine Einführung in die Grundlagen der Präimplantationsdiagnostik. Dieses Buch schafft die Verbindung zwischen Pränataldiagnostik und In-vitro-Fertilisation. Es richtet sich an Experten der Pränataldiagnostik, klinischen Genetik und fetalen Medizin sowie der In-vitro-Fertilisation und Reproduktionsmedizin. Mit einer ausführlichen Beschreibung der verwendeten Techniken und Verfahren sowie Erläuterungen zu rechtlichen und ethischen Konsequenzen und einem Ausblick auf künftige Anwendungsgebiete. List of Contributors.

Foreword.

BACKGROUND.

Introduction (J. Harper).

Genetic Basis of Inherited Disease (J. Delhanty).

Prenatal Diagnosis (A. Cockell & C. Rodeck).

Genetic Counselling (S. Raeburn).

In Vitro Fertilization (K. Elder).

Gametogenesis and Preimplantation Embryo Development (K. Elder & S. Fleming).

Preimplantation Genetics (E. Pergament, et al.).

PROCEDURES USED IN PGD.

Clinical Aspects of Preimplantation Diagnosis (C. Overton, et al.).

Embryo Biopsy (J. Harper & A. Thornhill).

Diagnosis of Single Gene Disorders (D. Wells & J. Sherlock).

FISH and Embryo Sexing to Avoid X-linked Disease (J. Harper & L. Wilton).

Preimplantation Genetic Diagnosis of Chromosome Abnormalities: Specific Chromosomal Rearrangements and Age-related Aneuploidy (J. Delhanty & C. Conn).

THE FUTURE.

Ethical Perspectives and Regulation of Preimplantation Genetic Diagnostic Practice (S. Viville, et al.).

Future Developments in PGD (J. Harper & D. Wells).

Index. "Scientists...report on recent developments in performing genetic analysis of human preimplantation embryos to predict the success of the implantation." (SciTech Book News, Vol. 25, No. 4, December 2001)

"This is a welcome and comprehensive introduction to PGD, which I recommend to anyone interested in this exciting and rapidly evolving field." (Human Genetics, Vol.110, 2002)

Joyce C. Harper has been working in the fields of IVF and reproductive genetics since 1987. After completing her PhD at Kings College London, she worked as the Laboratory Director at the London Fertility Centre with Ian Craft and then joined the Hammersmith Hospital preimplantation genetic diagnosis.

Joy D. A. Delhanty is the editor of Preimplantation Genetic Diagnosis, published by Wiley.

Alan H. Handyside is the editor of Preimplantation Genetic Diagnosis, published by Wiley.

Preimplantation Genetic Diagnosis provides a valuable introduction and overview of the principles and practice of this relatively new branch of medicine, which has been formed by the fusion of Prenatal Diagnosis (PD) with in vitro fertilisation (IVF). This book contains research from leading scientists and clinicians within this field.

Features include:
* A concise introduction to the field of Preimplantation Genetic Diagnosis (PGD)
* Detailed explanations of the techniques and procedures used
* The law and ethical implications of PGD
* Future uses of PGD
Preimplantation Genetic Diagnosis has been carefully written for both the prenatal diagnosis community (clinical geneticists and fetal medicine specialists within obstetrics and gynaecology) and the IVF and reproductive medicine community, with special introductory chapters for non-specialists.