{"product_id":"pharmaceutical-emulsions-isbn-9780470976838","title":"Pharmaceutical Emulsions","description":"\u003ci\u003ePharmaceutical Emulsions: A Drug Developer's Toolbag\u003c\/i\u003e covers all the key aspects of pharmaceutical emulsions, starting from the fundamental scientific basics, to the pharmaceutical forms and the chemical tests for its application. The author uses his extensive experience in both industry and academic experience to provide a concise, student friendly guide to the essential fundamentals of physical pharmacy.  \u003cp\u003eDivided into three clear sections, the text begins with Section A - \u003ci\u003eConsideration for Product: Medicinal Formulation\u003c\/i\u003e which includes a historical perspective, explanation of what is an emulsion, stability and instability, and manufacture. Section B - \u003ci\u003eForms, Use and Application\u003c\/i\u003e follows, with chapters on creams and ointments, pastes and bases, colloids, transdermal, gels and implants. The final Section, \u003ci\u003eTests: Chemistry to control the quality\u003c\/i\u003e, efficacy and fitness for purpose of the product includes chapters on physic-chemical properties, sizing and microscopy, rheology, QC and finally questions, calculations and dilemmas. Throughout the text there are numerous figures, diagrams and tables to engage the reader.\u003c\/p\u003e \u003cp\u003eThis is an invaluable reference for all students of pharmaceutical sciences, pharmacy industrial pharmaceutical sciences, physical pharmacy and pharmaceutical forms as well as industry professionals\u003c\/p\u003e  Mathematical symbols (with normal units) xi  \u003cp\u003eAcronyms and abbreviations xiii\u003c\/p\u003e \u003cp\u003ePreface xv\u003c\/p\u003e \u003cp\u003eAcknowledgements xvii\u003c\/p\u003e \u003cp\u003eAbout the companion website xix\u003c\/p\u003e \u003cp\u003e\u003cb\u003eI Product considerations: medicinal formulations 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Historical perspective 5\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Landmarks 5\u003c\/p\u003e \u003cp\u003e1.2 Significant discoveries 7\u003c\/p\u003e \u003cp\u003e1.3 Difficulties 8\u003c\/p\u003e \u003cp\u003e1.4 Traditional uses 10\u003c\/p\u003e \u003cp\u003e1.5 Product regulation 13\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 What is an emulsion? 15\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 States of matter 24\u003c\/p\u003e \u003cp\u003e2.2 Summary thermodynamics 34\u003c\/p\u003e \u003cp\u003e2.3 Interfacial tension and wetting 36\u003c\/p\u003e \u003cp\u003e2.4 Shear and size reduction 46\u003c\/p\u003e \u003cp\u003e2.5 Raw materials 47\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Stability, metastability and instability 49\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Stokes’ law 51\u003c\/p\u003e \u003cp\u003e3.2 Derjaguin–Landau–Verwey–Overbeek (DLVO) theory 52\u003c\/p\u003e \u003cp\u003e3.3 Interfacial rheology 56\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Manufacture 63\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Premixing 63\u003c\/p\u003e \u003cp\u003e4.2 High-shear mixers and size reduction 64\u003c\/p\u003e \u003cp\u003e4.3 Multiple and microemulsions 65\u003c\/p\u003e \u003cp\u003e4.4 Hot melt (steriles) 65\u003c\/p\u003e \u003cp\u003e4.5 Filling 66\u003c\/p\u003e \u003cp\u003e\u003cb\u003eII Forms, uses and applications: biopharmaceutics 67\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Creams and ointments 69\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Nutraceuticals and cosmeceuticals 71\u003c\/p\u003e \u003cp\u003e5.2 Medicinals 71\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Pastes and bases 77\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Emolliency 77\u003c\/p\u003e \u003cp\u003e6.2 Suppositories 78\u003c\/p\u003e \u003cp\u003e6.3 Pessaries 79\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 IV colloids 81\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Needle free 86\u003c\/p\u003e \u003cp\u003e7.2 Ocular therapy 87\u003c\/p\u003e \u003cp\u003e7.3 Cancer 88\u003c\/p\u003e \u003cp\u003e7.4 Antimicrobials 90\u003c\/p\u003e \u003cp\u003e7.5 Temperature-sensitive matrices and release forms 93\u003c\/p\u003e \u003cp\u003e7.6 Targeted endosomal use 94\u003c\/p\u003e \u003cp\u003e7.7 Solid lipid nanoparticles 95\u003c\/p\u003e \u003cp\u003e7.8 Diagnostic emulsions 98\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Transdermal patches: semisolids 99\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Hormones 104\u003c\/p\u003e \u003cp\u003e8.2 Analgesia 104\u003c\/p\u003e \u003cp\u003e8.3 Anaesthesia 104\u003c\/p\u003e \u003cp\u003e8.4 Nicotine 105\u003c\/p\u003e \u003cp\u003e8.5 Inserts: vaginal rings 105\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Gels 107\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Micro- and nanogels 107\u003c\/p\u003e \u003cp\u003e9.2 Semisolids 107\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Implants 109\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Plastics and glasses 109\u003c\/p\u003e \u003cp\u003e10.2 Thermoresponsive materials 110\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 De novo science, sustainable novel products and platform applications 111\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 Tablets 113\u003c\/p\u003e \u003cp\u003e11.2 Metered-dose inhalers 113\u003c\/p\u003e \u003cp\u003e11.3 Blood substitutes 114\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIII Tests: chemistry to control the quality, efficacy and fitness for purpose of a product 117\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Physicochemical properties 119\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12.1 Thermal evaluation (differential scanning calorimetry) and lipid polymorphs 124\u003c\/p\u003e \u003cp\u003e12.2 Drug form, log P and Lipinski rules 129\u003c\/p\u003e \u003cp\u003e12.3 Skin and epithelial models 133\u003c\/p\u003e \u003cp\u003e12.4 Drug delivery routes 134\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Sizing and microscopy 137\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13.1 ζ -potential 137\u003c\/p\u003e \u003cp\u003e13.2 Hydrodynamic diameter 139\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Rheology, texture, consistency and spreadability 141\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14.1 Bulk properties 141\u003c\/p\u003e \u003cp\u003e14.2 Solid-state and nanorheological properties 144\u003c\/p\u003e \u003cp\u003e14.3 Interfacial properties 144\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Quality control, process analytical technology and accelerated testing 149\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e15.1 Preformulation, high-throughput screening 150\u003c\/p\u003e \u003cp\u003e15.2 Industrial concerns 151\u003c\/p\u003e \u003cp\u003e15.3 Rancimat and other methods 152\u003c\/p\u003e \u003cp\u003eQuestions 155\u003c\/p\u003e \u003cp\u003eGuide for readers 155\u003c\/p\u003e \u003cp\u003eSpecimen 'test' questions 155\u003c\/p\u003e \u003cp\u003eAnswers 168\u003c\/p\u003e \u003cp\u003eReferences 173\u003c\/p\u003e \u003cp\u003eIndex 181\u003c\/p\u003e \u003cb\u003eDipak K. Sarker\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSchool of Pharmacy and Biomolecular Sciences, University of Brighton, UK\u003c\/i\u003e \u003ci\u003ePharmaceutical Emulsions: A Drug Developer's Toolbag\u003c\/i\u003e covers all the key aspects of pharmaceutical emulsions, starting from the fundamental scientific basics, to the pharmaceutical forms and the chemical tests for their application. The author uses his extensive experience in both industry and academia to provide a concise, student-friendly guide to the essential fundamentals of physical pharmacy. \u003cp\u003eEmulsions are explained in terms of their stability, instability and manufacture. Descriptions are provided for a whole variety of forms, from creams and ointments to pastes and bases, colloids, gels and implants. Finally tests that are used to control the quality, efficacy and safety of preparations are included; ranging from physical-chemical properties to sizing and microscopy, rheology, and quality control.\u003c\/p\u003e \u003cul\u003e \u003cli\u003eProvides students and those in industry with a concise and student-friendly guide to the essential fundamentals in physical pharmacy\u003c\/li\u003e \u003cli\u003eIncludes key aspects of pharmaceutical emulsions including scientific basics, pharmaceutical forms and the chemical tests for their application\u003c\/li\u003e \u003cli\u003eHighly-regarded author with both industry and academic experience\u003c\/li\u003e \u003cli\u003eSpecimen case studies, 'test' questions and MCQs are included\u003c\/li\u003e \u003cli\u003eCompanion website with further case studies\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThis is an invaluable reference for all students of pharmaceutical sciences, pharmacy industrial pharmaceutical sciences, physical pharmacy and pharmaceutical forms. It will also appeal to industry professionals.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989772386533,"sku":"NP9780470976838","price":145.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470976838.jpg?v=1761785421","url":"https:\/\/k12savings.com\/products\/pharmaceutical-emulsions-isbn-9780470976838","provider":"K12savings","version":"1.0","type":"link"}