{"product_id":"pharmaceutical-data-mining-isbn-9780470196083","title":"Pharmaceutical Data Mining","description":"Leading experts illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development  \u003cp\u003eIn the era of post-genomic drug development, extracting and applying knowledge from chemical, biological, and clinical data is one of the greatest challenges facing the pharmaceutical industry. Pharmaceutical Data Mining brings together contributions from leading academic and industrial scientists, who address both the implementation of new data mining technologies and application issues in the industry. This accessible, comprehensive collection discusses important theoretical and practical aspects of pharmaceutical data mining, focusing on diverse approaches for drug discovery—including chemogenomics, toxicogenomics, and individual drug response prediction. The five main sections of this volume cover:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eA general overview of the discipline, from its foundations to contemporary industrial applications\u003c\/li\u003e \u003cli\u003eChemoinformatics-based applications\u003c\/li\u003e \u003cli\u003eBioinformatics-based applications\u003c\/li\u003e \u003cli\u003eData mining methods in clinical development\u003c\/li\u003e \u003cli\u003eData mining algorithms, technologies, and software tools, with emphasis on advanced algorithms and software that are currently used in the industry or represent promising approaches\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eIn one concentrated reference, Pharmaceutical Data Mining reveals the role and possibilities of these sophisticated techniques in contemporary drug discovery and development. It is ideal for graduate-level courses covering pharmaceutical science, computational chemistry, and bioinformatics. In addition, it provides insight to pharmaceutical scientists, principal investigators, principal scientists, research directors, and all scientists working in the field of drug discovery and development and associated industries.\u003c\/p\u003e  Preface.  \u003cp\u003eAcknowledgments.\u003c\/p\u003e \u003cp\u003eContributors.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I: DATA MINING IN THE PHARMACEUTICAL INDUSTRY: A GENERAL OVERVIEW.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 A History of the development of Data Mining in Pharmaceutical Research ( David J. Livingstone and John Bradshaw).\u003c\/p\u003e \u003cp\u003e2 Drug Gold and Data Dragons: Myths and Realities of Data Mining in the Pharmaceutical Industry (Barry Robson and Andy Vaithiligam).\u003c\/p\u003e \u003cp\u003e3 Application of Data Mining Algorithms in Pharmaceutical Research and Development (Konstantin V. Balakin and Nikolay P. Savchuk).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART II: CHEMOINFORMATICS-BASED APPLICATIONS.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4 Data Mining Approaches for Compound Selection and Iterative Screening (Martin Vogt and Jurgen Bajorath).\u003c\/p\u003e \u003cp\u003e5 Prediction of Toxic Effects of Pharmaceutical Agents (Andreas Maunz and Christoph Helma).\u003c\/p\u003e \u003cp\u003e6 Chemogenomics-Based Design of GPCR-Targeted Libraries Using Data Mining Techniques (Konstantin V. Balakin and Elena V. Bovina).\u003c\/p\u003e \u003cp\u003e7 Mining High-Throughput Screening Data by Novel Knowledge-Based Optimization Analysis (S. Frank Yan, Frederick J. King, Sumit K. Chanda, Jeremy S. Caldwell, Elizabeth A. Winzeler, and Yingyao Zhou).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART III: BIOINFORMATICS-BASED APPLICATIONS.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8 Mining DNA Microarray Gene Expression Data (Paolo Magni).\u003c\/p\u003e \u003cp\u003e9 Bioinformatics Approaches for Analysis of Protein-Ligand Interactions (Munazah Andrabi, Chioko Nagao, Kenji Mizuguchi, and Shandar Ahmad).\u003c\/p\u003e \u003cp\u003e10 Analysis of Toxicogenomic Databases (Lyle D. Burgoon).\u003c\/p\u003e \u003cp\u003e11 Bridging the Pharmaceutical Shortfall: Informatics Approaches to the Discovery of Vaccines, Antigens, Epitopes, and Adjuvants (Matthew N. Davies and Darren R. Flower).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART IV: DATA MINING METHODS IN CLINICAL DEVELOPMENT.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12 Data Mining in Pharmacovigilance (Manfred Hauben and Andrew Bate).\u003c\/p\u003e \u003cp\u003e13 Data Mining Methods as Tools for Predicting Individual Drug Response (Audrey Sabbagh and Pierre Darlu).\u003c\/p\u003e \u003cp\u003e14 Data Mining Methods in Pharmaceutical Formulation (Raymond C. Rowe and Elizabeth A Colbourn).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART V: DATA MINING ALGORITHMS AND TECHNOLOGIES.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e15 Dimensionality Reduction Techniques for Pharmaceutical Data Mining (Igor V. Pletnev, Yan A. Ivanenkov, and Alexey V. Tarasov).\u003c\/p\u003e \u003cp\u003e16 Advanced Artificial Intelligence Methods Used in the Design of Pharmaceutical Agents (Yan A. Ivanenkov and Ludmila M. Khandarova).\u003c\/p\u003e \u003cp\u003e17 Databases for Chemical and Biological Information (Tudor I. Oprea, Liliana Ostopovici-Halip, and Ramona Rad-Curpan).\u003c\/p\u003e \u003cp\u003e18 Mining Chemical Structural Information from the Literature (Debra L. Banville).\u003c\/p\u003e \u003cp\u003eIndex.\u003c\/p\u003e  \"Its strength is that it gives beginners a good impression of our contemporary data jungle.\" (\u003ci\u003eChemMedChem\u003c\/i\u003e, 2010)\u003cbr\u003e \u003cbr\u003e \u003cb\u003eKonstantin V. Balakin\u003c\/b\u003e is Head of the Laboratory of Information Technology in Medicinal Chemistry at the Institute of Physiologically Active Compounds at the Russian Academy of Sciences. He is also Director of the scientific consortium \"Orchemed\" (Organic Chemistry and Medicine), which currently includes 11 Russian academic institutes working in the field of organic, medicinal and biological chemistry, and drug discovery. Previously, he was Head of the Computational Chemistry Department at ChemDiv, Inc.¿Dr. Balakin¿is the author or coauthor of more than 90 peer reviewed research articles, reviews, and book chapters. He is the principal developer of the SmartMining and InformaGenesis software tools, which are special programs for pharmaceutical multivariate data mining.  Leading experts illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development  \u003cp\u003eIn the era of post-genomic drug development, extracting and applying knowledge from chemical, biological, and clinical data is one of the greatest challenges facing the pharmaceutical industry. Pharmaceutical Data Mining brings together contributions from leading academic and industrial scientists, who address both the implementation of new data mining technologies and application issues in the industry. This accessible, comprehensive collection discusses important theoretical and practical aspects of pharmaceutical data mining, focusing on diverse approaches for drug discovery—including chemogenomics, toxicogenomics, and individual drug response prediction. The five main sections of this volume cover:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eA general overview of the discipline, from its foundations to contemporary industrial applications\u003c\/li\u003e \u003cli\u003eChemoinformatics-based applications\u003c\/li\u003e \u003cli\u003eBioinformatics-based applications\u003c\/li\u003e \u003cli\u003eData mining methods in clinical development\u003c\/li\u003e \u003cli\u003eData mining algorithms, technologies, and software tools, with emphasis on advanced algorithms and software that are currently used in the industry or represent promising approaches\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eIn one concentrated reference, Pharmaceutical Data Mining reveals the role and possibilities of these sophisticated techniques in contemporary drug discovery and development. It is ideal for graduate-level courses covering pharmaceutical science, computational chemistry, and bioinformatics. In addition, it provides insight to pharmaceutical scientists, principal investigators, principal scientists, research directors, and all scientists working in the field of drug discovery and development and associated industries.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989772550373,"sku":"NP9780470196083","price":179.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470196083.jpg?v=1761785421","url":"https:\/\/k12savings.com\/products\/pharmaceutical-data-mining-isbn-9780470196083","provider":"K12savings","version":"1.0","type":"link"}