{"product_id":"periodontal-medicine-and-systems-biology-isbn-9781405122191","title":"Periodontal Medicine and Systems Biology","description":"This book provides a systems-based approach to periodontology and offers a scientific roadmap of the interactions which can lead to periodontal disease. \u003cbr\u003e \u003cp\u003eThe content is divided into five sections. The first introduces the reader to the concept of systems theory and its mathematical foundation. The second section provides the reader with a current view of periodontal medicine including the microbiology, molecular genetics, relationship to systemic disease and current and future therapies. Periodontitis is caused by members of the oral microbiota and the third section provides the reader with various views of the relationship of the microbiota to the host. The fourth section moves from the bacterium to the host and its immune responses to altered host: bacteria interactions. The final section deals specifically with bone destruction in periodontitis and brings the reader up-to-date with the current view of the control network that exists between mesenchymal cells such as osteoblasts, immune cells and osteoclast precursor cells that controls bone remodelling in health and disease.\u003c\/p\u003e  Preface.  \u003cp\u003eContributors.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I SYSTEMS THEORY AND COOPERATIVE BACTERIA.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Systems thinking in biology (\u003ci\u003eRobert M. Seymour\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e2 Metagenomics and its applications to human bacterial diseases (\u003ci\u003eJulian R. Marchesi\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART II PERIODONTITIS: THE CLINICAL DISEASE.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3 Periodontitis: a modern clinical picture (\u003ci\u003eNikos Donos and Francesco D’Aiuto\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e4 Plaque microbiology in (periodontal) health and disease (\u003ci\u003eAnne D. Haffajee\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e5 Population molecular genetics of periodontitis (\u003ci\u003eMarja L. Laine, Ubele van der Velden and Bruno G. Loos\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e6 Mechanisms linking periodontitis to systemic disease (\u003ci\u003ePanos N. Papapanou and Jan H. Behle\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e7 The impact of diabetes-enhanced inflammation on periodontal disease and bone destruction (\u003ci\u003eDana T. Graves\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART III PERIODONTITIS: COPINGWITH THE MICROBIOTA.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8 The microbiota of humans (\u003ci\u003eGerald W. Tannock\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e9 The normal oral microbiota (\u003ci\u003eWilliam G. Wade\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e10 Bacterial coaggregation and periodontitis (\u003ci\u003ePaul E. Kolenbrander, Natalia I. Chalmers, Saravanan Periasamy, A.M. Ding and Shayla L. West-Barnette\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e11 Dynamics of biofilm formation and relationship to periodontitis (\u003ci\u003eJonathan Pratten and Nicola Mordan\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e12 Quorum sensing as a means of biofilm communication (\u003ci\u003eHanjuan Shao and Donald R. Demuth\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e13 Genomics of \u003ci\u003ePorphyromonas gingivalis\u003c\/i\u003e (\u003ci\u003eKeisuke Nakayama\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e14 Genomics of \u003ci\u003eFusobacterium nucleatum\u003c\/i\u003e (\u003ci\u003eVinayak Kapatral\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e15 The \u003ci\u003eAggregatibacter\u003c\/i\u003e (formerly \u003ci\u003eActinobacillus\u003c\/i\u003e) \u003ci\u003eactinomycetemcomitans\u003c\/i\u003e genome – annotation, analysis and metabolic reconstruction (\u003ci\u003eFares Najar, Shaoping Lin, Lin Song, Hongshing Lai, James White, Steven Kenton and Bruce A. Roe\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART IV PERIODONTITIS: INNATE AND ACQUIRED IMMUNITY.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e16 A new view of innate immunity for the twenty-first century (\u003ci\u003eJohn Wright and Clare E. Bryant\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e17 Innate immunity and homeostasis in the periodontium (\u003ci\u003eRichard P. Darveau\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e18 Antimicrobial host defence peptides in oral health and periodontitis (\u003ci\u003eDeirdre A. Devine and Celine Cosseau\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e19 Control of inflammation in periodontal disease (\u003ci\u003eHatice Hasturk, Alpdogan Kantarci and Thomas E. Van Dyke\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e20 Antigen-presenting cells in chronic periodontitis (\u003ci\u003eRavi Jotwani and Christopher W. Cutler\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e21 B-cell responses in periodontitis (\u003ci\u003eSuzanne E. Barbour, John G. Tew and Harvey A. Schenkein\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e22 T-cell responses in periodontitis (\u003ci\u003eGregory J. Seymour, Erica Gemmell and Kazuhisa Yamazaki\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART V PERIODONTITIS: BONE DESTRUCTION.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e23 Current paradigms of osteoblast–osteoclast interactions and bacterial pathogen-induced bone resorption (\u003ci\u003eNaoyuki Takahashi, Masanori Koide, Toshihide Noguchi and Tatsuo Suda\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e24 Bacterial osteolytic mediators (\u003ci\u003eBrian Henderson and Sean P. Nair\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e25 Immune cell involvement in periodontal bone loss (\u003ci\u003eAndy Y.-T. Teng\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e26 How can periodontal bone loss be stopped? (\u003ci\u003eColin R. Dunstan\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eIndex.\u003c\/p\u003e  Brian Henderson is Professor of Cell Biology in the Division of Microbial Diseases at UCL Eastman Dental Institute, University College London.\u003cbr\u003e \u003cp\u003eMichael A Curtis is Professor of Microbiology and Director of the Institute of Cell and Molecular Science at Barts and The London School of Medicine and Dentistry.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eRobert M Seymour is Professor in the UCL Department of Mathematics, University College London.\u003cbr\u003e \u003c\/p\u003e \u003cp\u003eProfessor Nikos Donos is Director of Research Strategy and Head of Periodontology at UCL Eastman Dental Institute, University College London.\u003c\/p\u003e  This book provides a systems-based approach to periodontology and offers a scientific roadmap of the interactions which can lead to periodontal disease. \u003cbr\u003e \u003cp\u003eThe content is divided into five sections. The first introduces the reader to the concept of systems theory and its mathematical foundation. The second section provides the reader with a current view of periodontal medicine including the microbiology, molecular genetics, relationship to systemic disease and current and future therapies. Periodontitis is caused by members of the oral microbiota and the third section provides the reader with various views of the relationship of the microbiota to the host. The fourth section moves from the bacterium to the host and its immune responses to altered host: bacteria interactions. The final section deals specifically with bone destruction in periodontitis and brings the reader up-to-date with the current view of the control network that exists between mesenchymal cells such as osteoblasts, immune cells and osteoclast precursor cells that controls bone remodelling in health and disease.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989766193381,"sku":"NP9781405122191","price":246.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781405122191.jpg?v=1761785397","url":"https:\/\/k12savings.com\/products\/periodontal-medicine-and-systems-biology-isbn-9781405122191","provider":"K12savings","version":"1.0","type":"link"}