{"product_id":"perinatal-stem-cells-isbn-9781118209448","title":"Perinatal Stem Cells","description":"\u003ci\u003ePerinatal Stem Cells, 2nd Edition\u003c\/i\u003e builds on the first edition to provide an updated tutorial on perinatal stem cells, including stem cells harvested from the amniotic fluid, placenta, maternal blood supply, umbilical cord and Wharton's Jelly. As in the first edition, coverage includes the underlying biology of each of the sources of pregnancy related stem cells, cell culture, and potential therapeutic uses, as well as insights on the impact of these stem cells from obstetricians and gynecologists, cardiologists, hematologists, tissue engineers, and cord blood bankers.  \u003cp\u003eNormally discarded as medical waste, perinatal stem cells offer a powerful therapeutic tool box alternative to the controversial embryonic stem cells. Since publication of the first edition, a burgeoning commerical industry has developed around various sources of perinatal cells, and the second edition now includes an overview of this growing industry.\u003c\/p\u003e \u003cp\u003eWith contributions from some of the top academic stem cell laboratories in the United States as well as new chapters from international stem cell scientists, \u003ci\u003ePerinatal Stem Cells\u003c\/i\u003e presents an update on the cutting-edge research in the field while maintaining its signature clinical focus.\u003c\/p\u003e  \u003cp\u003eContributors xi\u003c\/p\u003e \u003cp\u003eIntroduction xv\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 AMNIOTIC FLUID STEM CELLS 1\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eSean Vincent Murphy and Anthony Atala\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 1\u003c\/p\u003e \u003cp\u003eDevelopment of Gestational Stem Cells 2\u003c\/p\u003e \u003cp\u003eIsolation and Characterization of Amniotic Fluid Stem Cells 2\u003c\/p\u003e \u003cp\u003eMultipotency of Amniotic Fluid Stem Cells 3\u003c\/p\u003e \u003cp\u003eClinical Application of Amniotic Fluid Stem Cells 8\u003c\/p\u003e \u003cp\u003eConclusion 13\u003c\/p\u003e \u003cp\u003eReferences 13\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 CORD BLOOD TRANSPLANTS: PERINATAL STEM CELLS IN CLINICAL PRACTICE 17\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eRichard L. Haspel and Karen K. Ballen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 17\u003c\/p\u003e \u003cp\u003eHematopoietic Stem Cell Transplants: Adult Donor Collection 17\u003c\/p\u003e \u003cp\u003eHematopoietic Stem Cell Transplants: HLA Matching 18\u003c\/p\u003e \u003cp\u003eCollection and Processing of Cord Blood Units 19\u003c\/p\u003e \u003cp\u003eHematopoietic Stem Cell Transplants: Recipient Issues 20\u003c\/p\u003e \u003cp\u003eBone Marrow versus Single Cord Blood: Pediatric 21\u003c\/p\u003e \u003cp\u003eBone Marrow versus Cord Blood: Adults 23\u003c\/p\u003e \u003cp\u003eCord Blood Transplant: Advantages and Disadvantages 23\u003c\/p\u003e \u003cp\u003eDouble Cord Blood Transplants: Ablative Regimens 24\u003c\/p\u003e \u003cp\u003eDouble Cord Blood Transplant: Non-Myeloablative Regimens 26\u003c\/p\u003e \u003cp\u003eAre Two Cords Better Than One? 27\u003c\/p\u003e \u003cp\u003eChimerism 28\u003c\/p\u003e \u003cp\u003ePredicting the Winner 28\u003c\/p\u003e \u003cp\u003eOther Experimental Strategies 30\u003c\/p\u003e \u003cp\u003eSummary 31\u003c\/p\u003e \u003cp\u003eReferences 31\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 HEMATOPOIETIC STEM CELL DEVELOPMENT IN THE PLACENTA 37\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eKatrin E.R. Ericson, Akanksha Chhabra, and Hanna K.A. Mikkola\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 37\u003c\/p\u003e \u003cp\u003eThe Hematopoietic System 37\u003c\/p\u003e \u003cp\u003eHistorical Perspective on Placental Hematopoiesis 38\u003c\/p\u003e \u003cp\u003eThe Development and Structure of the Mouse Placenta 39\u003c\/p\u003e \u003cp\u003eHematopoietic Activity in the Mouse Placenta 40\u003c\/p\u003e \u003cp\u003eIdentification of Placental HSCs 42\u003c\/p\u003e \u003cp\u003eThe Origin and Localization of Placental HSCs 43\u003c\/p\u003e \u003cp\u003eHematopoietic Activity in the Human Placenta 45\u003c\/p\u003e \u003cp\u003eHematopoietic Microenvironment in the Placenta 46\u003c\/p\u003e \u003cp\u003eConclusions and Perspectives 47\u003c\/p\u003e \u003cp\u003eReferences 49\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 PERINATAL MESENCHYMAL STEM CELL BANKING FOR UMBILICAL CORD BLOOD TRANSPLANTATION AND REGENERATIVE MEDICINE 53\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eRouzbeh R. Taghizadeh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 53\u003c\/p\u003e \u003cp\u003eHematopoiesis 54\u003c\/p\u003e \u003cp\u003eHematopoietic Transplantations 54\u003c\/p\u003e \u003cp\u003eUmbilical Cord: Source of Perinatal HSCs and MSCs 56\u003c\/p\u003e \u003cp\u003eHematopoietic Transplantations of Umbilical Cord Blood 57\u003c\/p\u003e \u003cp\u003eStrategies to Overcome the Transplant-Related Limitations of Umbilical Cord Blood 58\u003c\/p\u003e \u003cp\u003eUmbilical Cord Tissue MSC Banking 61\u003c\/p\u003e \u003cp\u003eReferences 63\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 MAKING ORGAN AND STEM CELL TRANSPLANTATION SAFER: THE ROLE OF MESENCHYMAL STEM CELLS 71\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eHans Klingemann\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 71\u003c\/p\u003e \u003cp\u003eMSC to Prevent Rejection After Solid Organ Transplantation 72\u003c\/p\u003e \u003cp\u003eMSC in the Treatment of Graft-versus-Host Disease 73\u003c\/p\u003e \u003cp\u003eMSC to Support Hematopoietic Recovery of Stem Cells After Stem Cell Transplantation 74\u003c\/p\u003e \u003cp\u003eReferences 75\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 WHARTON’S JELLY MESENCHYMAL STEM CELLS AND IMMUNE MODULATION: REGENERATIVE MEDICINE MEETS TISSUE REPAIR 77\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eRita Anzalone, Felicia Farina, Melania Lo Iacono, Simona Corrao, Tiziana Corsello, Giovanni Zummo, and Giampiero La Rocca\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 77\u003c\/p\u003e \u003cp\u003eExpression of Relevant Immunomodulatory Molecules in Vitro by MSCs 79\u003c\/p\u003e \u003cp\u003eTolerance Induction by MSCs: Rediscovering the Embryo Immune Evasion Mechanisms 79\u003c\/p\u003e \u003cp\u003eImmune Modulation in Vivo: Contrasting Data on the Immune Privilege of MSCs 80\u003c\/p\u003e \u003cp\u003eWJ-MSC in in Vivo Models: Enhancing the Immunomodulatory Features of Adult MSC Populations 82\u003c\/p\u003e \u003cp\u003eConclusions and Future Perspectives 83\u003c\/p\u003e \u003cp\u003eReferences 84\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 IMMUNOGENICITY VERSUS IMMUNOMODULATION OF PERINATAL STEM CELLS 89\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eBram Lutton and Raimon Duran-Struuck\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 89\u003c\/p\u003e \u003cp\u003eMechanisms of Immunomodulation by Umbilical Cord- and Bone Marrow-Derived MSCs 90\u003c\/p\u003e \u003cp\u003eInnate Immune System 90\u003c\/p\u003e \u003cp\u003eAdaptive Immune System 92\u003c\/p\u003e \u003cp\u003eNatural Tolerance and Umbilical Cord Tissues 94\u003c\/p\u003e \u003cp\u003eTolerance versus Immunogenicity: The Yin and Yang of Host Responses to Umbilical Cord-Derived Cells 95\u003c\/p\u003e \u003cp\u003eConclusions 97\u003c\/p\u003e \u003cp\u003eReferences 98\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 THE TRANSLATIONAL POTENTIAL OF PERINATAL STEM CELLS IN CLINICAL MEDICINE: MESENCHYMAL STEM CELLS 105\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eRadbeh Torabi, Vincenzo Villani, Christopher A. Mallard, and Curtis L. Cetrulo, Jr.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 105\u003c\/p\u003e \u003cp\u003eGraft-versus-Host Disease 106\u003c\/p\u003e \u003cp\u003eAcute GVHD 107\u003c\/p\u003e \u003cp\u003eChronic GVHD 108\u003c\/p\u003e \u003cp\u003eGVHD Prevention 109\u003c\/p\u003e \u003cp\u003eHematopoetic Recovery and HCT Engraftment 109\u003c\/p\u003e \u003cp\u003eHematopoietic Recovery 110\u003c\/p\u003e \u003cp\u003eHCT Engraftment 111\u003c\/p\u003e \u003cp\u003eMSC Potential Uses 111\u003c\/p\u003e \u003cp\u003eReferences 113\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 NEWBORN STEM CELLS: IDENTITY, FUNCTION, AND CLINICAL POTENTIAL 119\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eAnthony Park, Louis Chan, Mayur Danny I. Gohel, Sean Murphy, Ursula Manuelpillai, Ann Chidgey, and Richard Boyd\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 120\u003c\/p\u003e \u003cp\u003eThe Newborn Offers an Enormous Opportunity for Stem Cells 120\u003c\/p\u003e \u003cp\u003eAmnion 120\u003c\/p\u003e \u003cp\u003eIsolation and Phenotypic Characterization of Amnion Cells 121\u003c\/p\u003e \u003cp\u003eTherapeutic Potential of Amnion Membrane 123\u003c\/p\u003e \u003cp\u003eMechanisms of AEC-Enhanced Wound Repair 125\u003c\/p\u003e \u003cp\u003eTherapeutic Potential of Amnion as Single Cells 127\u003c\/p\u003e \u003cp\u003eAmnion Immunogenicity and Immunosuppressive Properties 127\u003c\/p\u003e \u003cp\u003eAmnion-Derived Mesenchymal Stromal Cells 128\u003c\/p\u003e \u003cp\u003eUmbilical Cord Mesenchymal Stromal Cells 130\u003c\/p\u003e \u003cp\u003eChorion MSCs 131\u003c\/p\u003e \u003cp\u003eReferences 133\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 BIOMEDICAL POTENTIAL OF HUMAN PERINATAL STEM CELLS 139\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eOleg V. Semenov and Christian Breymann\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eRole of Stem Cells in Regenerative Medicine 139\u003c\/p\u003e \u003cp\u003ePerinatal Stem Cell Sources 140\u003c\/p\u003e \u003cp\u003eProperties of Perinatal Mesenchymal Stem Cells 143\u003c\/p\u003e \u003cp\u003eProperties of Perinatal Hematopoietic Stem Cells 144\u003c\/p\u003e \u003cp\u003eBiomedical Applications of Human Perinatal Stem Cells 145\u003c\/p\u003e \u003cp\u003ePerspectives and Obstacles 147\u003c\/p\u003e \u003cp\u003eReferences 148\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 PROGENITOR CELL THERAPY FOR THE TREATMENT OF TRAUMATIC BRAIN INJURY 155\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eAlex Bryan Olsen, Robert A. Hetz, Supinder S. Bedi, and Charles S. Cox, Jr.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 155\u003c\/p\u003e \u003cp\u003eCellular Therapy for the Treatment of TBI 159\u003c\/p\u003e \u003cp\u003eNeural Stem Progenitor Cells 159\u003c\/p\u003e \u003cp\u003eHuman Multipotent Adult Progenitor Cells 160\u003c\/p\u003e \u003cp\u003eMesenchymal Stem Cells 163\u003c\/p\u003e \u003cp\u003eUmbilical Cord Blood 165\u003c\/p\u003e \u003cp\u003eWharton’s Jelly 166\u003c\/p\u003e \u003cp\u003eAmniotic Fluid-Derived Stem Cells 167\u003c\/p\u003e \u003cp\u003eThe Inflammatory Reflex 168\u003c\/p\u003e \u003cp\u003eConclusion 170\u003c\/p\u003e \u003cp\u003eReferences 171\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 THE HUMAN AMNIOTIC MEMBRANE: A TISSUE WITH MULTIFACETED PROPERTIES AND DIFFERENT POTENTIAL CLINICAL APPLICATIONS 177\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eMaddalena Caruso, Antonietta Silini, and Ornella Parolini\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 177\u003c\/p\u003e \u003cp\u003eStructure and Histology of the Human Amniotic Membrane 178\u003c\/p\u003e \u003cp\u003ePreparation, Preservation, and Sterilization of the Human Amniotic Membrane 179\u003c\/p\u003e \u003cp\u003eBiological and Structural Properties of the Human Amniotic Membrane Generally Invoked to Explain Its Effects in Vivo 180\u003c\/p\u003e \u003cp\u003eEstablished Clinical Applications of the Human Amniotic Membrane 183\u003c\/p\u003e \u003cp\u003eProspective Applications of the Human Amniotic Membrane: Lessons from Preclinical Studies 187\u003c\/p\u003e \u003cp\u003eConclusions and Perspectives 190\u003c\/p\u003e \u003cp\u003eReferences 190\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 ADVANCES AND POSSIBLE APPLICATIONS OF HUMAN AMNION FOR THE MANAGEMENT OF LIVER DISEASE 197\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eFabio Marongiu, Maria Paola Serra, Marcella Sini, Ezio Laconi, Marc C. Hansel, Kristen J. Skvorak, Roberto Gramignoli, and Stephen C. Strom\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 197\u003c\/p\u003e \u003cp\u003eHuman Amnion for the Management of Liver Fibrosis 198\u003c\/p\u003e \u003cp\u003eAmnion-Derived Hepatocytes and Their Possible Applications 199\u003c\/p\u003e \u003cp\u003eConclusions 204\u003c\/p\u003e \u003cp\u003eReferences 205\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 AMNION-DERIVED CELLS FOR STROKE RESTORATIVE THERAPY 209\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eNaoki Tajiri, Loren E. Glover, and Cesar V. Borlongan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 209\u003c\/p\u003e \u003cp\u003eStem Cell Therapy: Beyond Stroke Neuroprotection 210\u003c\/p\u003e \u003cp\u003eTherapeutic Potential of Adult Stem Cells 210\u003c\/p\u003e \u003cp\u003eThe Biology of Amnion-Derived Cells 211\u003c\/p\u003e \u003cp\u003eAmnion-Derived Cells for Cell Therapy 212\u003c\/p\u003e \u003cp\u003eConclusion 215\u003c\/p\u003e \u003cp\u003eReferences 216\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 PREGNANCY-ACQUIRED FETAL PROGENITORS AS NATURAL CELL THERAPY 221\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eElke Seppanen, Nicholas M. Fisk,and Kiarash Khosrotehrani\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 221\u003c\/p\u003e \u003cp\u003eFetal Cell Microchimerism, a Widespread Phenomenon 222\u003c\/p\u003e \u003cp\u003eThe Kinetics of Fetal Cell Detection 222\u003c\/p\u003e \u003cp\u003eFactors Modifying the Level of Microchimerism 222\u003c\/p\u003e \u003cp\u003eDetecting FMC 223\u003c\/p\u003e \u003cp\u003eHoming and Plasticity of FMC 224\u003c\/p\u003e \u003cp\u003eHematopoietic Capacity of FMC 224\u003c\/p\u003e \u003cp\u003eEpithelial, Neuronal and Hepatic Capacity of FMC 228\u003c\/p\u003e \u003cp\u003eMesenchymal Capacity of FMC 228\u003c\/p\u003e \u003cp\u003eFMC Includes Functional Endothelial Progenitor Cells that Contribute to Tissue Repair 229\u003c\/p\u003e \u003cp\u003eFMC Likely Includes Cells of Placental Origin 230\u003c\/p\u003e \u003cp\u003eConclusions 230\u003c\/p\u003e \u003cp\u003eReferences 231\u003c\/p\u003e \u003cp\u003eINDUSTRY REVIEW 235\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 PERINATAL STEM CELLS: AN INDUSTRY PERSPECTIVE 237\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eKyle J. Cetrulo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 237\u003c\/p\u003e \u003cp\u003eThe Public Cord Blood Banking Industry 238\u003c\/p\u003e \u003cp\u003eThe Private Banking Industry 239\u003c\/p\u003e \u003cp\u003eResearch and Cord Blood Clinical Trials 240\u003c\/p\u003e \u003cp\u003eThe Mesenchymal Stem Cell Regenerative Medicine Industry 241\u003c\/p\u003e \u003cp\u003eWharton’s Jelly\/Cord Tissue 242\u003c\/p\u003e \u003cp\u003ePlacental Stem Cells and Placental Tissue 243\u003c\/p\u003e \u003cp\u003eAmniotic Fluid 244\u003c\/p\u003e \u003cp\u003eConclusion 245\u003c\/p\u003e \u003cp\u003eReferences 245\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 PATENT PROTECTION OF STEM CELL INNOVATIONS 249\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eJohn R. Wetherell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eThe Role of Patents in Commercialization 249\u003c\/p\u003e \u003cp\u003eBackground of the Patent System 250\u003c\/p\u003e \u003cp\u003ePatentable Subject Matter 251\u003c\/p\u003e \u003cp\u003eStatutory Requirements for a Patent 252\u003c\/p\u003e \u003cp\u003eWritten Description\/Enablement\/Best Mode 254\u003c\/p\u003e \u003cp\u003eImportant Future Changes 256\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 INTERVIEW WITH FRANCES VERTER, FOUNDER OF PARENT’S GUIDE TO CORD BLOOD FOUNDATION 259\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eFrances Verter and Kyle J. Cetrulo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eReferences 269\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 UMBILICAL CORD BLOOD BANKING: AN OBSTETRICIAN’S PERSPECTIVE 271\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eJordan H. Perlow\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eReferences 277\u003c\/p\u003e \u003cp\u003eIndex 279\u003c\/p\u003e  \u003cp\u003e“A classic text, focuses on recent research and advances in the clinical use of mesenchyme stem cells from pregnancy sources.”  (\u003ci\u003ePediatric Endocrinology Reviews\u003c\/i\u003e, 1 June 2014)\u003c\/p\u003e  \u003cp\u003e\u003cstrong\u003eKyle J. Cetrulo\u003c\/strong\u003e is the founder and CEO of Auxocell Laboraties, Inc, as well as the founder and Director of the Perinatal Stem Cell Society.?Co-editor of the first edition of \u003cem\u003ePerinatal Stem Cells\u003c\/em\u003e, Dr. Cetrulo is an active member of the stem cell research community, serving as Director of the International Cord Blood Society since 1998. \u003c\/p\u003e\u003cp\u003eCurtis Cetrulo Jr., M.D. is Assistant Professor of Surgery at Harvard Medical School, Boston. A co-editor of the first edition of \u003cem\u003ePerinatal Stem Cells\u003c\/em\u003e, he is also Director of the Reconstructive Transplantation Service in the Divisions of Transplant Surgery and Plastic and Reconstructive Surgery at Massachusetts General Hospital, and a senior investigator for the Composite Tissue Allograft Laboratory at Massachusetts General.  \u003c\/p\u003e\u003cp\u003e\u003cb\u003eThe definitive guide to the state of the art of perinatal stem cells\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eNow in a fully updated second edition, this seminal work on perinatal stem cells focuses on the very latest research and major advances in the clinical use of mesenchymal stem cells (MSCs) from pregnancy-related sources. With contributions from world-renowned stem cell scientists, this volume showcases the enormous therapeutic potential of these cell sources and reviews the growing perinatal stem cell industry within the stem cell and regenerative medicine field.\u003c\/p\u003e \u003cp\u003eThe new edition presents cutting-edge information on stem cells harvested from amniotic fluid, the placenta, maternal blood supply, the umbilical cord, and Wharton's jelly. For each of the sources of pregnancy-related stem cells, the book describes the underlying biology, cell culture, and potential therapeutic uses. It also offers insights from obstetricians and gynecologists, cardiologists, hematologists, tissue engineers, and cord blood bankers. \u003ci\u003ePerinatal Stem Cells, Second Edition\u003c\/i\u003e:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eIncludes a new industry section on stem cell banking and regenerative medicine as well as the patenting of stem cell innovations\u003c\/li\u003e \u003cli\u003eHighlights the advantages of using perinatal stem cells over induced pluripotent stem cells (iPSCs) or embryonic stem cells\u003c\/li\u003e \u003cli\u003eDetails specific stem cell isolation techniques and other strategies for collecting, processing, and using perinatal cell sources\u003c\/li\u003e \u003cli\u003eDescribes clinical applications in such areas as transplantation, traumatic brain injury, liver disease, and stroke therapy\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eReaders will find a comprehensive overview of this rapidly emerging field, discover what some of the top researchers from around the world are working on, and learn about the remarkable regenerative qualities and clinical potential of perinatal stem cells.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989765964005,"sku":"NP9781118209448","price":184.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118209448.jpg?v=1761785396","url":"https:\/\/k12savings.com\/products\/perinatal-stem-cells-isbn-9781118209448","provider":"K12savings","version":"1.0","type":"link"}