{"product_id":"peptide-science-isbn-9781119824671","title":"Peptide Science","description":"\u003cp\u003e\u003cb\u003eUnderstand the nature and applications of peptides with this clear and comprehensive guide\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003ePeptides are signaling molecules comprised of amino acids which play an important role in modulating certain physiological processes. They have a wide range of applications, particularly with respect to biological studies and therapeutical potentials. The explosive growth of peptide science in recent years and the variety of achievements in peptide drug discovery and related areas have made it an important area of study for new researchers and industry professionals. \u003c\/p\u003e\u003cp\u003e\u003ci\u003ePeptide Science\u003c\/i\u003e offers a clear, systematic overview of this burgeoning field and its major applications. Covering the chemistry, the pertinent technologies, and major existing therapies, it provides the tools required to integrate peptide research with virtually any area of research and development. Fully cognizant of the latest technological advances, it’s a must-own for anyone looking to understand a vital field of chemistry. \u003c\/p\u003e\u003cp\u003e\u003ci\u003ePeptide Science\u003c\/i\u003e readers will also find: \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eThrough coverage of peptide hit generation technologies from nature, to various display libraries and to modern computational designs\u003c\/li\u003e \u003cli\u003eDetailed discussion of therapies for conditions including cancer, diabetes, infectious diseases, and more\u003c\/li\u003e \u003cli\u003eA section dedicated to key challenges and future directions in peptide therapeutics\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003e\u003ci\u003ePeptide Science\u003c\/i\u003e is ideal for industry professionals and researchers in organic chemistry, peptide science\/chemistry, protein chemistry, biochemistry, and pharmaceutical sciences. \u003c\/p\u003e\u003cp\u003eList of contributors xiii\u003c\/p\u003e \u003cp\u003ePreface xvii\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection I New Developments in Peptide Chemistry 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Chemical Peptide Ligations 3\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eYihui Cao and Xuechen Li\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 3\u003c\/p\u003e \u003cp\u003e1.2 Ligation Driven by Trans-esterification 4\u003c\/p\u003e \u003cp\u003e1.3 Ligation Driven by Imine Capture 8\u003c\/p\u003e \u003cp\u003e1.4 Ligation Initiated by Hydroxylamine 10\u003c\/p\u003e \u003cp\u003e1.5 Ligation in Protein Synthesis 12\u003c\/p\u003e \u003cp\u003e1.6 Ligations in Drug Development 17\u003c\/p\u003e \u003cp\u003e1.7 Summary and Outlook 21\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Protein and Peptide Ligation Using Peptide Ligases 29\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAnna Koijen and Leendert J. van den Bos\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 29\u003c\/p\u003e \u003cp\u003e2.2 Peptide Ligases Mechanism of Action 32\u003c\/p\u003e \u003cp\u003e2.3 Sortase 33\u003c\/p\u003e \u003cp\u003e2.4 Peptide Asparaginyl Ligases 38\u003c\/p\u003e \u003cp\u003e2.5 Subtilisin-derived Peptide Ligases 41\u003c\/p\u003e \u003cp\u003e2.6 Trypsiligase 44\u003c\/p\u003e \u003cp\u003e2.7 Conclusion 46\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Modern Methods for Late-stage Peptide Modification 55\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eYuxuan Ding and Zachary T. Ball\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 55\u003c\/p\u003e \u003cp\u003e3.2 Methionine 57\u003c\/p\u003e \u003cp\u003e3.3 Aspartate and Glutamate 59\u003c\/p\u003e \u003cp\u003e3.4 Arginine 61\u003c\/p\u003e \u003cp\u003e3.5 Tryptophan 62\u003c\/p\u003e \u003cp\u003e3.6 Functionalization of sp2 C-H Bonds: Tyr, Phe, and His 66\u003c\/p\u003e \u003cp\u003e3.7 Functionalization of sp3 C-H Bonds 71\u003c\/p\u003e \u003cp\u003e3.8 Other X-H Functionalizations 73\u003c\/p\u003e \u003cp\u003e3.9 Conclusion 74\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection II Peptide Drug Hit Identification 87\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Generating Phage Libraries Bearing Unnatural Pharmacophores 89\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eChristin Kossmann, Arunika Ekanayake and Ratmir Derda\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 89\u003c\/p\u003e \u003cp\u003e4.2 Biotin Capture Assay to Detect Chemical Modification of Phage Libraries 93\u003c\/p\u003e \u003cp\u003e4.3 N-terminal Oxidation and Functionalization to Incorporate Unnatural Fragments 106\u003c\/p\u003e \u003cp\u003e4.4 Macrocyclization of Phage-displayed Peptides Bearing Cysteines 110\u003c\/p\u003e \u003cp\u003e4.5 Macrocyclization and Installation of Warheads in Phage-displayed Libraries 114\u003c\/p\u003e \u003cp\u003e4.6 Outlook 120\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Computational Peptide Design for Diverse Structures and Functions 127\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eStephen Rettie, David Juergens and Gaurav Bhardwaj\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 The Various Types of Peptides 128\u003c\/p\u003e \u003cp\u003e5.2 In Silico Peptide Design: From Physics-based Methods to DL 129\u003c\/p\u003e \u003cp\u003e5.3 Physics-based Methods 130\u003c\/p\u003e \u003cp\u003e5.4 DL Methods for Peptide Design 136\u003c\/p\u003e \u003cp\u003e5.5 Optimizing for Membrane Permeability and Stability 140\u003c\/p\u003e \u003cp\u003e5.6 Remaining Challenges 141\u003c\/p\u003e \u003cp\u003e5.7 Conclusion 143\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection III Peptide Drug Lead Generation and Optimization 151\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Peptide Discovery: Lead Generation 153\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eYvonne Angell, Wendy Hartsock, Hans Melo and Timothy M. Reichart\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 153\u003c\/p\u003e \u003cp\u003e6.2 Approved Drugs Discovered Through Phage Display 174\u003c\/p\u003e \u003cp\u003e6.3 Approved Drugs Discovered Through mRNA Display 177\u003c\/p\u003e \u003cp\u003e6.4 A Successful Example 185\u003c\/p\u003e \u003cp\u003e6.5 Conclusion 188\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 A Survey and Guide to the Development of Fatty Acid-derivatized Peptide Therapeutics 203\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMichael T. Jacobsen, Christian Poulsen, Katharina L. Kopp, Jørgen Olsen and Nick Cox\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 203\u003c\/p\u003e \u003cp\u003e7.2 Basics of Fatty Acid Derivatization of Peptides 204\u003c\/p\u003e \u003cp\u003e7.3 Evolution of GLP-1-based Incretins into Stable, Long-acting Therapeutics 205\u003c\/p\u003e \u003cp\u003e7.4 Diverse Mechanisms of Fatty Acid Derivatization to Extend Insulin Half-life 210\u003c\/p\u003e \u003cp\u003e7.5 Development of a Stable, Fatty Acid-derivatized Amylin Analog 214\u003c\/p\u003e \u003cp\u003e7.6 Stabilization and Fatty Acid Derivatization of Peptide YY (PYY) 217\u003c\/p\u003e \u003cp\u003e7.7 Guidance for Advancing Fatty Acid-derivatized Peptides 222\u003c\/p\u003e \u003cp\u003e7.8 Concluding Remarks 242\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection IV Peptide Drug Case Studies 269\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Insulin in Its Second Century: History, Evolution, and Aspirations 271\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJohn P. Mayer, Kishore Thalluri, Ethan Mickelson, Michael H.B. Stowell and Richard D. DiMarchi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 271\u003c\/p\u003e \u003cp\u003e8.2 The Evolution of Insulin Therapy 272\u003c\/p\u003e \u003cp\u003e8.3 Structure 278\u003c\/p\u003e \u003cp\u003e8.4 Synthesis 280\u003c\/p\u003e \u003cp\u003e8.5 Aspirational Aims 286\u003c\/p\u003e \u003cp\u003e8.6 Concluding Thoughts 290\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Incretins and Development of Incretin-based Therapeutics 305\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eNan Zheng, Xiao-xuan Su, Shengping Zhang and Weijun Shen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 305\u003c\/p\u003e \u003cp\u003e9.2 Development of Novel GLP-1 and GIP-based Therapeutics 309\u003c\/p\u003e \u003cp\u003e9.3 Development of Multi-receptor Agonists Targeting Incretin and Other Hormonal Receptors 315\u003c\/p\u003e \u003cp\u003e9.4 Summary and Perspective 329\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Peptide-based Therapeutics for Inflammatory and Autoimmune Diseases 339\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSunay V. Chankeshwara, Werngard Czechtizky and Wu Su\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 339\u003c\/p\u003e \u003cp\u003e10.2 Literature Search and Methods 341\u003c\/p\u003e \u003cp\u003e10.3 Representative Anti-inflammatory Peptides in Clinical Trials 342\u003c\/p\u003e \u003cp\u003e10.4 Summary and Discussion 351\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Radioligand as a Unique Rising Modality for Cancer Diagnosis and Treatment 359\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMing-Jin Jheng, Xiaozhu Wang, Pengyun Li and Fa Liu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Radioligand Introduction 359\u003c\/p\u003e \u003cp\u003e11.2 Radionuclides and Chelators Developed for Medical Imaging and Cancer Treatment 361\u003c\/p\u003e \u003cp\u003e11.3 Notable Radioligands Developed for Cancer Diagnosis and Treatment 364\u003c\/p\u003e \u003cp\u003e11.4 Emerging Targets 371\u003c\/p\u003e \u003cp\u003e11.5 Emerging Binder Modalities as Radioligand Vector 379\u003c\/p\u003e \u003cp\u003e11.6 Perspectives: Promises and Challenges 384\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Peptide-small Molecule Drug Conjugates for Cancer, Metabolic Diseases, and Beyond 401\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eRongjun He, Sumeet Singh and Adam Mezo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 401\u003c\/p\u003e \u003cp\u003e12.2 Peptide-drug Conjugates for Cancer 402\u003c\/p\u003e \u003cp\u003e12.3 Peptide-drug Conjugates for Metabolic Diseases 409\u003c\/p\u003e \u003cp\u003e12.4 Peptide-drug Conjugates for Other Diseases 415\u003c\/p\u003e \u003cp\u003e12.5 Challenges in Peptide-drug Conjugate Design 415\u003c\/p\u003e \u003cp\u003e12.6 Summary 416\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Emerging Landscape of Therapeutic Oligonucleotide Delivery by Cell-penetrating Peptide 425\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eXiang Li, Xiulong Shen, Ashweta Sahni and Ziqing Qian\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 425\u003c\/p\u003e \u003cp\u003e13.2 Cell-penetrating Peptides 426\u003c\/p\u003e \u003cp\u003e13.3 Applications of CPPs for the Delivery of Therapeutic Oligonucleotides 433\u003c\/p\u003e \u003cp\u003e13.4 Future Perspectives and Summary 447\u003c\/p\u003e \u003cp\u003eSection V Peptide CMC and Regulatory 469\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Peptides Chemistry, Manufacturing, and Controls 471\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJack Xu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 471\u003c\/p\u003e \u003cp\u003e14.2 CMC Information and Format for DS 472\u003c\/p\u003e \u003cp\u003e14.3 CMC Information and Format for DP 477\u003c\/p\u003e \u003cp\u003e14.4 Synthetic Peptide CMC Development 483\u003c\/p\u003e \u003cp\u003e14.5 Conclusions 504\u003c\/p\u003e \u003cp\u003eIndex 509\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eFa Liu, PhD,\u003c\/b\u003e is the CSO of Full-Life Technologies, which centers on targeted alpha-radionuclide therapies. Prior to joining Full-Life, he was the CEO and Co-founder of Focus-X Therapeutics (2020-2022), later acquired by Full-Life. Before founding Focus-X, Dr. Liu headed the Chemistry of Novo Nordisk US sites, and Calibrium LLC (acquired by Novo Nordisk) (2014-2020), and served as a Group Leader at the Eli Lilly Peptide Discovery (2009-2014). Prior to Lilly, Dr. Liu worked at National Cancer Institute as a Staff Scientist (2004-2009). He received his Ph.D. in Synthetic Organic Chemistry from Shanghai Institute of Organic Chemistry in 2004.   \u003c\/p\u003e\u003cp\u003e\u003cb\u003eUnderstand the nature and applications of peptides with this clear and comprehensive guide\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003ePeptides are signaling molecules comprised of amino acids which play an important role in modulating certain physiological processes. They have a wide range of applications, particularly with respect to biological studies and therapeutical potentials. The explosive growth of peptide science in recent years and the variety of achievements in peptide drug discovery and related areas have made it an important area of study for new researchers and industry professionals. \u003c\/p\u003e\u003cp\u003e\u003ci\u003ePeptide Science\u003c\/i\u003e offers a clear, systematic overview of this burgeoning field and its major applications. Covering the chemistry, the pertinent technologies, and major existing therapies, it provides the tools required to integrate peptide research with virtually any area of research and development. Fully cognizant of the latest technological advances, it’s a must-own for anyone looking to understand a vital field of chemistry. \u003c\/p\u003e\u003cp\u003e\u003ci\u003ePeptide Science\u003c\/i\u003e readers will also find: \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eThrough coverage of peptide hit generation technologies from nature, to various display libraries and to modern computational designs\u003c\/li\u003e \u003cli\u003eDetailed discussion of therapies for conditions including cancer, diabetes, infectious diseases, and more\u003c\/li\u003e \u003cli\u003eA section dedicated to key challenges and future directions in peptide therapeutics\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003e\u003ci\u003ePeptide Science\u003c\/i\u003e is ideal for industry professionals and researchers in organic chemistry, peptide science\/chemistry, protein chemistry, biochemistry, and pharmaceutical sciences.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989763309797,"sku":"NP9781119824671","price":215.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119824671.jpg?v=1761785386","url":"https:\/\/k12savings.com\/products\/peptide-science-isbn-9781119824671","provider":"K12savings","version":"1.0","type":"link"}