{"product_id":"pathway-analysis-for-drug-discovery-isbn-9780470107058","title":"Pathway Analysis for Drug Discovery","description":"This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in related fields. \u003cp\u003ePreface vii\u003c\/p\u003e \u003cp\u003eContributors ix\u003c\/p\u003e \u003cp\u003e1 Introduction to Pathway Analysis 1\u003cbr\u003e \u003ci\u003eAnton Yuryev\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Software Infrastructure and Data Model for Pathway Analysis 27\u003cbr\u003e \u003ci\u003eFedor Bokov and Anton Yuryev\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Automatic Pathway Inference in Heterogeneous Biological Association Networks 47\u003cbr\u003e \u003ci\u003eAnton Yuryev, Andrey Kalinin, and Nikolai Daraselia\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Algorithmic Basis for Pathway Visualization 67\u003cbr\u003e \u003ci\u003eSergey Simakov, Iaroslav Ispolatov, Sergei Maslov, and Alexander Nikitin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Pathway Analysis of High-Throughput Experimental Data 103\u003cbr\u003e \u003ci\u003eAndrey Y. Sivachenko\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Integrative Pathway Analysis of Disease Molecular Data 121\u003cbr\u003e \u003ci\u003eAndrej Bugrim, Zoltan Dezso, Yuri Nikolsky, and Tatiana Nikolskaya\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Whole-Genome Expression Profiling of Papillary Serous Ovarian Cancer: Activated Pathways,Potential Targets, and Noise 149\u003cbr\u003e \u003ci\u003eJohn Farley, Laurent L. Ozbun, and Michael J. Birrer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Mammalian Proteome and Toxicant Network Analysis 165\u003cbr\u003e \u003ci\u003eSean Ekins and Craig N. Giroux\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Unraveling Mechanisms of Toxicity with the Power of Pathways: ToxWiz Tool as an IllustrativeExample 195\u003cbr\u003e \u003ci\u003eMark P. Kühnel, Bojana Cosovic, Goran Medic, Robert B. Russell, and Gordana Apic\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Impact of Chemistry Information on Pathway Analysis 219\u003cbr\u003e \u003ci\u003eSreenivas Devidas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Propagation of Concentration Perturbations in Equilibrium Protein Binding Networks 237\u003cbr\u003e \u003ci\u003eSergei Maslov and Iaroslav Ispolatov\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 An Adaptive System Model of the Yeast Glucose Sensor System 263\u003cbr\u003e \u003ci\u003eTodor Vujasinovic and André Siniša Žampera\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Present and Future of Pathway Analysis in Drug Discovery 285\u003cbr\u003e \u003ci\u003eAnton Yuryev\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 297\u003c\/p\u003e \"Pathway analysis will help lead to a better understanding of the chemistry of living systems and the aberrations that disrupt health. This new book will serve as a beacon to research interested in this field.\" (\u003ci\u003eJournal of Medicinal Chemistry\u003c\/i\u003e, April 9, 2009) \u003cb\u003eANTON YURYEV,\u003c\/b\u003e PhD, is the Senior Director of Application Science at Ariadne Genomics Inc. His department studies the topological and evolutionary properties of biological networks and develops algorithms for pathway reconstruction and analysis of high-throughput data. Dr. Yuryev has published more than thirty scientific publications and is the author of several algorithms for primer design and pathway analysis.  \u003cb\u003eNovel computational approaches to improve the effectiveness and efficiency of drug discovery\u003c\/b\u003e  \u003cp\u003eWith chapters contributed by pioneers in the field, \u003ci\u003ePathway Analysis for Drug Discovery\u003c\/i\u003e offers readers both important new research findings and state-of-the-science reviews. The book not only presents the latest developments in pathway analysis, it also explains how these developments can improve and accelerate drug discovery, highlighting new opportunities for drug development.\u003c\/p\u003e \u003cp\u003eRather than search for and pore through scores of articles published in disparate sources, readers can turn to \u003ci\u003ePathway Analysis for Drug Discovery\u003c\/i\u003e. This single, carefully edited work:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eIntroduces drug discovery researchers to novel computational approaches that enable them to better understand molecular function\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eFocuses on cell and molecular signaling pathways, demonstrating how the underlying method theory and algorithm details are used in drug discovery\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eOffers a comprehensive overview and unbiased assessment of applied methods for the pharmaceutical industry\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eIn addition to traditional computational methods and software for pathway analysis, the book also covers:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003ePathway reconstruction of diseases and toxic states\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003ePathway analysis for selection of drug targets, lead compound validation, and prediction of compound ADMET properties\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eDynamic modeling of drug responses\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003ePathway analysis for design of selective drug mixtures and promiscuous drugs\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eResearchers who turn to this book will discover a variety of leading-edge methods to improve both the effectiveness and efficiency of their drug discovery and design efforts and gain an understanding of the role of pathway analysis infrastructure in modern and future drug discovery.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989754560741,"sku":"NP9780470107058","price":149.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470107058.jpg?v=1761785362","url":"https:\/\/k12savings.com\/products\/pathway-analysis-for-drug-discovery-isbn-9780470107058","provider":"K12savings","version":"1.0","type":"link"}