{"product_id":"pathological-pain-isbn-9780470869109","title":"Pathological Pain","description":"This book brings together contributions from key investigators in the area of pathological pain. It covers the molecular basis of receptors and channels involved in nociception, the possible messages that cause neuropathic plasticity, spinal plasticity in neuropathy, plastic changes in opioid systems in neuropathy and opioid tolerance, and plastic changes related to pathological pain.  Chair's Introduction (Takao Kumazawa).  \u003cp\u003eRegulation Mechanisms of Vanilloid Receptors (Makoto Tominagaet, \u003ci\u003eet al\u003c\/i\u003e.).\u003c\/p\u003e \u003cp\u003eSodium channels and neuropathic pain (Jin Mo Chung and Kyungsoon Chung).\u003c\/p\u003e \u003cp\u003eIon channel activities implicated in pathological pain (John N. Wood, \u003ci\u003eet al\u003c\/i\u003e.).\u003c\/p\u003e \u003cp\u003eGeneral Discussion I.\u003c\/p\u003e \u003cp\u003eChronic pain and microglia: the role of ATP (Kazuhide Inoue, \u003ci\u003eet al\u003c\/i\u003e.).\u003c\/p\u003e \u003cp\u003eNeurotrophic influences on neuropathic pain (Stephen B. McMahon and William B. J. Cafferty).\u003c\/p\u003e \u003cp\u003eChanges in DRG neurons and spinal excitability in neuropathy (Koichi Noguchi, \u003ci\u003eet al\u003c\/i\u003e.).\u003c\/p\u003e \u003cp\u003eFunctional reorganization of the spinal pain pathways in developmental and pathological conditions (M. Yoshimura, \u003ci\u003eet al\u003c\/i\u003e.).\u003c\/p\u003e \u003cp\u003eCentral plasticity in pathological pain (Min Zhuo).\u003c\/p\u003e \u003cp\u003eGeneral Discussion II.\u003c\/p\u003e \u003cp\u003eAnti-opioid systems in morphine tolerance and addiction: locus-specific involvement of nociceptin and NMDA receptor (Hiroshi Ueda).\u003c\/p\u003e \u003cp\u003eChronic morphine-induced plasticity among signalling molecules (Alan R. Gintzler and Sumita Chakrabarti).\u003c\/p\u003e \u003cp\u003eOpioid tolerance and neuroplasticity (Jianren Mao).\u003c\/p\u003e \u003cp\u003eGeneral Discussion III.\u003c\/p\u003e \u003cp\u003eA mechanism-based understanding of bone cancer pain (Patrick W. Mantyh).\u003c\/p\u003e \u003cp\u003eMechanistic and clinical aspects of complex regional pain syndrome (CRPS)(Ralf Baron).\u003c\/p\u003e \u003cp\u003eCortical pathophysiology of chronic pain (A. Vania Apkarian).\u003c\/p\u003e \u003cp\u003eFinal Discussion: Translating basic research to the clinic.\u003c\/p\u003e \u003cp\u003eIndex of contributors.\u003c\/p\u003e \u003cp\u003eSubject index.\u003c\/p\u003e \"…an excellent book to review the electrophysiological and molecular aspects of pathological pain…can be of great value to both basic scientists and clinicians.\" (\u003ci\u003eAnnals of Neurology\u003c\/i\u003e, August 2005) \u003cp\u003e\u003cb\u003eDerek J. Chadwick\u003c\/b\u003e and \u003cb\u003eJamie A. Goode\u003c\/b\u003e are editors for \u003ci\u003ePathological Pain: From Molecular to Clinical Aspects\u003c\/i\u003e and other scientific titles.\u003c\/p\u003e  Recent decades have seen an explosion of research into the mechanisms of pain in both normal and pathological states. Neurobiological studies have revealed the detailed characteristics of nociceptive systems and endogenous analgesic systems. Such studies are, however, of only limited use in explaining the mechanisms implicated in pathological pain. Plastic changes in pain systems occur in chronic neuropathic pain, even resulting in structural changes within the CNS, and neuronal plasticity seems to be the key to a better understanding of pathological pain, perhaps reflecting the primitive and poorly differentiated nature of the pain system.  \u003cp\u003eIn evolutionary terms, the pain system emerged at a very early stage of neuronal development. These early origins are reflected by its plasticity, its intimate relationship with instinctive and other fundamental bodily functions such as the autonomic nervous system, and the involvement of humoral signalling messengers.\u003c\/p\u003e \u003cp\u003eRecent progress in pain research has shed light on some of the molecules involved in humoral messenger systems, including cytokines, neurotrophins, neuropeptides, inflammatory mediators and ion channels. Precise electrophysiological investigations combined with a detailed molecular understanding are providing important clues about the mechanisms involved in pathological pain. This work is aided by studies of the cellular mechanisms involved in the development of opioid tolerance. In addition, non-invasive brain imaging technologies continue to shed light on pain mechanisms at a cognitive level.\u003c\/p\u003e \u003cp\u003eThis book brings together contributions from key investigators in the area of pathological pain. It covers the receptors and channels involved in nociception, the possible messages that cause neuropathic plasticity, spinal plasticity in neuropathy, plastic changes in opioid systems in neuropathy and opioid tolerance, and plastic changes related to pathological pain. It should be essential reading for pain researchers and clinicians involved in the treatment of chronic or pathological pain.\u003c\/p\u003e \u003cp\u003eRelated books\u003cbr\u003e 260 Osteoarthritic joint pain\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989753938149,"sku":"NP9780470869109","price":211.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470869109.jpg?v=1761785359","url":"https:\/\/k12savings.com\/products\/pathological-pain-isbn-9780470869109","provider":"K12savings","version":"1.0","type":"link"}