{"product_id":"pathogenesis-of-bacterial-infections-in-animals-isbn-9781119754794","title":"Pathogenesis of Bacterial Infections in Animals","description":"\u003cb\u003ePATHOGENESIS OF BACTERIAL INFECTIONS IN ANIMALS\u003c\/b\u003e \u003cp\u003e\u003cb\u003eComprehensive review of the major bacterial pathogens of animals, focusing on the current understanding of how they cause disease \u003c\/b\u003e  \u003c\/p\u003e\u003cp\u003e\u003ci\u003ePathogenesis of Bacterial Infections in Animals, Fifth Edition\u003c\/i\u003e is a specialist reference that provides a comprehensive review of bacterial pathogens in animals and their complex interplay with disease processes, offering a complete understanding of how bacteria cause disease in animals. It covers the many recent advances in the field including the newest taxonomies. In this revised and long anticipated fifth edition, additional introductory chapters have been added to set the material in context, and more figures added to integrate and improve understanding and comprehension throughout the text. A companion website presents the figures from the book in PowerPoint and references.  \u003c\/p\u003e\u003cp\u003eThis detailed reference includes novel approaches to controlling bacterial pathogens in the light of growing concerns about antimicrobial resistance, with more than 70 expert authors sharing their wisdom on the topic. While molecular pathogenesis is a major aspect in almost every chapter, the authors have been careful to place pathogens in their broader context.  \u003c\/p\u003e\u003cp\u003e\u003ci\u003ePathogenesis of Bacterial Infections in Animals, Fifth Edition\u003c\/i\u003e also contains information on:  \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eThemes in bacterial pathogenesis, covering the basic elements of pathogenesis, concepts of virulence, host-pathogen interactions and communication, and pathogenesis in the post-genomic era\u003c\/li\u003e \u003cli\u003eEvolution of bacterial pathogens, covering what they are and how they emerge, along with sources of genetic diversity, population structure, and genome plasticity\u003c\/li\u003e \u003cli\u003eUnderstanding of pathogenesis through pathogenomics and bioinformatics, including how mutations generate pathogen diversity, and an overview of genome sequencing technologies\u003c\/li\u003e \u003cli\u003eSubversion of the immune response by bacterial pathogens, covering subversion of both innate responses and adaptive immunity\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003e\u003ci\u003ePathogenesis of Bacterial Infections in Animals, Fifth Edition\u003c\/i\u003e is an essential resource for graduate students in veterinary medicine and animal science, and for veterinary microbiologists, pathologists, infectious disease experts, and others interested in bacterial disease. It is the only book to cover this topic to this depth through the wealth of insight of dozens of qualified and practicing professionals. \u003c\/p\u003e\u003cp\u003ePreface xv\u003c\/p\u003e \u003cp\u003eList of Contributors xvii\u003c\/p\u003e \u003cp\u003eAbout the Companion Website xxv\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Themes in Bacterial Pathogenesis \u003c\/b\u003e\u003cb\u003e1\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJohn F. Prescott\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 1\u003c\/p\u003e \u003cp\u003eThe Basic Elements of Bacterial Pathogenesis 1\u003c\/p\u003e \u003cp\u003eConcepts of Bacterial Virulence are Being Refined 5\u003c\/p\u003e \u003cp\u003eHost–Pathogen Communications are Critical 9\u003c\/p\u003e \u003cp\u003ePathogenesis in the Post-Genomic Era 11\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 13\u003c\/p\u003e \u003cp\u003eReferences 13\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Evolution of Bacterial Pathogens \u003c\/b\u003e\u003cb\u003e15\u003cbr\u003e\u003c\/b\u003e\u003ci\u003ePatrick Boerlin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eWhat are Pathogens and How Do They Emerge? 15\u003c\/p\u003e \u003cp\u003eBacterial Fitness and Virulence 17\u003c\/p\u003e \u003cp\u003eSources of Genetic Diversity, Population Structure, and Genome Plasticity 18\u003c\/p\u003e \u003cp\u003ePathogenicity Islands 20\u003c\/p\u003e \u003cp\u003eBacteriophages and Their Role in Pathogen Evolution and Virulence 22\u003c\/p\u003e \u003cp\u003eExamples of Virulence Evolution 23\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 27\u003c\/p\u003e \u003cp\u003eReferences 28\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Understanding Pathogenesis Through Pathogenomics and Bioinformatics \u003c\/b\u003e\u003cb\u003e32\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eGregorio Iraola and John D. Boyce\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 32\u003c\/p\u003e \u003cp\u003eHow Mutations Generate Bacterial Diversity 34\u003c\/p\u003e \u003cp\u003eGenome Sequencing Technologies 36\u003c\/p\u003e \u003cp\u003eGenome Assembly 38\u003c\/p\u003e \u003cp\u003eGene Prediction and Annotation 39\u003c\/p\u003e \u003cp\u003eDefining Prokaryotic Species from Genomes 41\u003c\/p\u003e \u003cp\u003eThe Pangenome Concept, Reconstruction, and Comparative Analyses 41\u003c\/p\u003e \u003cp\u003ePhylogenomics and Genome-Wide Association Studies 42\u003c\/p\u003e \u003cp\u003eFunctional Genomics for Understanding Host–Pathogen Interactions 44\u003c\/p\u003e \u003cp\u003eReverse Vaccinology 48\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 51\u003c\/p\u003e \u003cp\u003eReferences 52\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Experimental Approaches to Understanding Pathogenesis \u003c\/b\u003e\u003cb\u003e57\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eFrancesca L. Short and Janet I. MacInnes\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 57\u003c\/p\u003e \u003cp\u003eTesting Koch’s Postulates 57\u003c\/p\u003e \u003cp\u003eVirulence Factors and Main Steps in Pathogenesis 58\u003c\/p\u003e \u003cp\u003eMolecular Koch’s Postulates 60\u003c\/p\u003e \u003cp\u003eRefining Animal Usage 60\u003c\/p\u003e \u003cp\u003eExperimental Approaches for Virulence Factor Discovery and Validation 62\u003c\/p\u003e \u003cp\u003eApproaches for Virulence Factor Discovery 63\u003c\/p\u003e \u003cp\u003eGene Disruption Approaches for Virulence Factor Discovery 71\u003c\/p\u003e \u003cp\u003eBringing It All Together: Validation and Further Characterization of Virulence Factors 73\u003c\/p\u003e \u003cp\u003eTwo Stories of Virulence Factor Discovery and Characterization: \u003ci\u003ePasteurella multocida \u003c\/i\u003eCapsule, and \u003ci\u003eMycoplasma bovis \u003c\/i\u003eAdhesins 74\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 75\u003c\/p\u003e \u003cp\u003eReferences 76\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Subversion of the Immune Response by Bacterial Pathogens \u003c\/b\u003e\u003cb\u003e79\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eDouglas C. Hodgins, Raveendra R. Kulkarni, and Patricia E. Shewen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 79\u003c\/p\u003e \u003cp\u003eSubversion of Innate Responses 80\u003c\/p\u003e \u003cp\u003eSubversion of Adaptive Immunity 85\u003c\/p\u003e \u003cp\u003eManipulation of Cell Fate 88\u003c\/p\u003e \u003cp\u003eNon-Coding RNA and Host-Pathogen Interactions 91\u003c\/p\u003e \u003cp\u003eEpigenetic and Genetic Modulation 92\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 94\u003c\/p\u003e \u003cp\u003eReferences 94\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Chinks in the Armor \u003c\/b\u003e\u003cb\u003e99\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAllison C. Leonard, Celine Stoica, and Georgina Cox\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 99\u003c\/p\u003e \u003cp\u003eVirulence Factors: Pathogenesis-Based Targets to Combat Bacterial Pathogens 99\u003c\/p\u003e \u003cp\u003eTargeting Bacterial Host Cell Adhesion and Biofilm Formation 100\u003c\/p\u003e \u003cp\u003eQuorum Sensing Inhibition 104\u003c\/p\u003e \u003cp\u003eInterfering with Two-Component Regulatory Systems 105\u003c\/p\u003e \u003cp\u003eInhibiting Bacterial Motility 106\u003c\/p\u003e \u003cp\u003eToxin Neutralization 107\u003c\/p\u003e \u003cp\u003eInhibitors of Bacterial Secretion Systems 107\u003c\/p\u003e \u003cp\u003eTargeting Nutrient Acquisition: Starving the Pathogen 110\u003c\/p\u003e \u003cp\u003eAntivirulence Phage Therapy 111\u003c\/p\u003e \u003cp\u003eBacterial Drug Efflux Pumps as Pathogenesis-Based Antibacterial Targets 112\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 112\u003c\/p\u003e \u003cp\u003eReferences 113\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 \u003ci\u003eEscherichia coli \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e117\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJohn M. Fairbrother and Carlton L. Gyles\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 117\u003c\/p\u003e \u003cp\u003ePathotypes of \u003ci\u003eE. coli \u003c\/i\u003eand Associated Disease and Pathological Changes in Animals 119\u003c\/p\u003e \u003cp\u003eVirulence Factors of Pathogenic \u003ci\u003eE. coli \u003c\/i\u003e126\u003c\/p\u003e \u003cp\u003ePathogenesis of Enterotoxigenic \u003ci\u003eE. coli \u003c\/i\u003e141\u003c\/p\u003e \u003cp\u003ePathogenesis of Enteropathogenic \u003ci\u003eE. coli \u003c\/i\u003eDisease 144\u003c\/p\u003e \u003cp\u003ePathogenesis of Shiga Toxin-Producing \u003ci\u003eE. coli \u003c\/i\u003eDisease 146\u003c\/p\u003e \u003cp\u003ePathogenesis of Extraintestinal Pathogenic \u003ci\u003eE. coli \u003c\/i\u003eInfections 149\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 156\u003c\/p\u003e \u003cp\u003eReferences 157\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 \u003ci\u003eSalmonella \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e162\u003cbr\u003e\u003c\/b\u003e\u003ci\u003ePaul A. Barrow, Michael A. Jones, Kate C. Mellor, and Nick R. Thomson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 162\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organism 162\u003c\/p\u003e \u003cp\u003eTypes of Disease and Pathologic Changes 167\u003c\/p\u003e \u003cp\u003e\u003ci\u003eSalmonella \u003c\/i\u003eInfections in Different Major Farmed Animal Species 169\u003c\/p\u003e \u003cp\u003eVirulence Factors 174\u003c\/p\u003e \u003cp\u003ePathogenesis 179\u003c\/p\u003e \u003cp\u003eImmunity to Infection and its Manipulation by \u003ci\u003eSalmonella \u003c\/i\u003e186\u003c\/p\u003e \u003cp\u003eAntimicrobial Resistance 190\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 191\u003c\/p\u003e \u003cp\u003eReferences 192\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 \u003ci\u003eYersinia \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e200\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAnne-Sophie Le Guern and Javier Pizarro-Cerdá\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 200\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organism 200\u003c\/p\u003e \u003cp\u003ePathogenic Species 200\u003c\/p\u003e \u003cp\u003eTaxonomy 201\u003c\/p\u003e \u003cp\u003eMajor Virulence Factors of the Highly Pathogenic \u003ci\u003eYersinia \u003c\/i\u003e203\u003c\/p\u003e \u003cp\u003e\u003ci\u003eYersinia pestis \u003c\/i\u003e205\u003c\/p\u003e \u003cp\u003e\u003ci\u003eYersinia pseudotuberculosis \u003c\/i\u003eand \u003ci\u003eYersinia enterocolitica \u003c\/i\u003e209\u003c\/p\u003e \u003cp\u003e\u003ci\u003eYersinia ruckeri \u003c\/i\u003e213\u003c\/p\u003e \u003cp\u003e\u003ci\u003eYersinia entomophaga \u003c\/i\u003e213\u003c\/p\u003e \u003cp\u003eControl of \u003ci\u003eYersinia \u003c\/i\u003eInfections 214\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 214\u003c\/p\u003e \u003cp\u003eReferences 215\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 \u003ci\u003ePasteurella \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e221\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMarina Harper, Thomas R. Smallman, and John D. Boyce\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 221\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organism 221\u003c\/p\u003e \u003cp\u003eSource of Infection: Ecology, Evolution, and Epidemiology 223\u003c\/p\u003e \u003cp\u003eTypes of Disease and Pathologic Changes 223\u003c\/p\u003e \u003cp\u003eVirulence Factors and Pathogenomics 225\u003c\/p\u003e \u003cp\u003eRegulation of Virulence 233\u003c\/p\u003e \u003cp\u003ePathogenesis 235\u003c\/p\u003e \u003cp\u003eImmunity 236\u003c\/p\u003e \u003cp\u003eControl 238\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 239\u003c\/p\u003e \u003cp\u003eReferences 239\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 \u003ci\u003eMannheimia \u003c\/i\u003eand \u003ci\u003eBibersteinia \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e244\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJeff L. Caswell and Charles J. Czuprynski\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 244\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organism 244\u003c\/p\u003e \u003cp\u003ePathogenic Species 245\u003c\/p\u003e \u003cp\u003eSource of Infection: Ecology, Evolution, and Epidemiology 245\u003c\/p\u003e \u003cp\u003eTypes of Disease and Pathologic Changes 247\u003c\/p\u003e \u003cp\u003eVirulence Factors and Pathogenomics 249\u003c\/p\u003e \u003cp\u003eRegulation of Virulence 250\u003c\/p\u003e \u003cp\u003ePathogenesis 251\u003c\/p\u003e \u003cp\u003eImmunity 254\u003c\/p\u003e \u003cp\u003eControl 254\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 255\u003c\/p\u003e \u003cp\u003eReferences 256\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 \u003ci\u003eActinobacillus \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e262\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJanine T. Bossé, Adina R. Bujold, and Lu Li\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 262\u003c\/p\u003e \u003cp\u003e\u003ci\u003eActinobacillus pleuropneumoniae \u003c\/i\u003e262\u003c\/p\u003e \u003cp\u003e\u003ci\u003eActinobacillus lignieresii \u003c\/i\u003e277\u003c\/p\u003e \u003cp\u003e\u003ci\u003eActinobacillus equuli \u003c\/i\u003e278\u003c\/p\u003e \u003cp\u003e\u003ci\u003eActinobacillus suis \u003c\/i\u003e279\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Future Directions 281\u003c\/p\u003e \u003cp\u003eReferences 283\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Other Pasteurellaceae: \u003ci\u003eAvibacterium\u003c\/i\u003e, \u003ci\u003eBibersteinia\u003c\/i\u003e, \u003ci\u003eGallibacterium\u003c\/i\u003e, \u003ci\u003eGlaesserella\u003c\/i\u003e, and \u003ci\u003eHistophilus \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e290\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAnders M. Bojesen, Virginia Aragon, and Pat J. Blackall\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 290\u003c\/p\u003e \u003cp\u003e\u003ci\u003eAvibacterium \u003c\/i\u003e290\u003c\/p\u003e \u003cp\u003e\u003ci\u003eBibersteinia \u003c\/i\u003e292\u003c\/p\u003e \u003cp\u003e\u003ci\u003eGallibacterium \u003c\/i\u003e295\u003c\/p\u003e \u003cp\u003e\u003ci\u003eGlaesserella parasuis \u003c\/i\u003e301\u003c\/p\u003e \u003cp\u003e\u003ci\u003eHistophilus \u003c\/i\u003e309\u003c\/p\u003e \u003cp\u003eReferences 311\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 \u003ci\u003ePseudomonas \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e318\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eErin L. Westman, Véronique L. Taylor, and Joseph S. Lam\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 318\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organism 318\u003c\/p\u003e \u003cp\u003ePathogenic Species 319\u003c\/p\u003e \u003cp\u003eSources of Infection: Ecology, Evolution, and Epidemiology 320\u003c\/p\u003e \u003cp\u003eTypes of Disease and Pathologic Changes 320\u003c\/p\u003e \u003cp\u003eVirulence Factors and Pathogenomics 321\u003c\/p\u003e \u003cp\u003ePathogenesis 328\u003c\/p\u003e \u003cp\u003eImmunity 330\u003c\/p\u003e \u003cp\u003eControl, Prevention, and Treatment 331\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 335\u003c\/p\u003e \u003cp\u003eReferences 337\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Moraxella \u003c\/b\u003e\u003cb\u003e344\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJohn A. Angelos\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 344\u003c\/p\u003e \u003cp\u003eInfectious Bovine Keratoconjunctivitis 344\u003c\/p\u003e \u003cp\u003ePathogenesis of \u003ci\u003eMoraxella bovis \u003c\/i\u003eInfection 346\u003c\/p\u003e \u003cp\u003eImmunity 352\u003c\/p\u003e \u003cp\u003eControl 354\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Future Directions 354\u003c\/p\u003e \u003cp\u003eReferences 355\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 \u003ci\u003eBrucella \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e361\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eClayton C. Caswell, Angela Arenas-Gamboa, and Jeff T. Foster\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 361\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organism 361\u003c\/p\u003e \u003cp\u003ePathogenic Species 362\u003c\/p\u003e \u003cp\u003eSource of Infection: Ecology, Evolution, and Epidemiology 362\u003c\/p\u003e \u003cp\u003eTypes of Disease and Pathologic Changes 363\u003c\/p\u003e \u003cp\u003eVirulence Factors 366\u003c\/p\u003e \u003cp\u003eRegulation of Virulence 368\u003c\/p\u003e \u003cp\u003ePathogenomics 369\u003c\/p\u003e \u003cp\u003ePathogenesis 370\u003c\/p\u003e \u003cp\u003eImmunity 370\u003c\/p\u003e \u003cp\u003eControl 371\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 371\u003c\/p\u003e \u003cp\u003eReferences 372\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 \u003ci\u003eBordetella \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e376\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eColleen J. Sedney, Tracy L. Nicholson, and Eric T. Harvill\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 376\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organisms 376\u003c\/p\u003e \u003cp\u003ePathogenic Species 377\u003c\/p\u003e \u003cp\u003eSource of Infection: Ecology and Epidemiology 379\u003c\/p\u003e \u003cp\u003eTypes of Disease and Pathologic Changes 380\u003c\/p\u003e \u003cp\u003eVirulence Factors 380\u003c\/p\u003e \u003cp\u003eRegulation of Virulence 385\u003c\/p\u003e \u003cp\u003ePathogenesis 385\u003c\/p\u003e \u003cp\u003eImmunity 385\u003c\/p\u003e \u003cp\u003eControl 387\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 389\u003c\/p\u003e \u003cp\u003eReferences 389\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 \u003ci\u003eCampylobacter \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e393\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eZuowei Wu, Orhan Sahin, and Qijing Zhang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 393\u003c\/p\u003e \u003cp\u003eDiseases, Etiology, and Ecology 394\u003c\/p\u003e \u003cp\u003eClinical Observations and Pathologic Changes 397\u003c\/p\u003e \u003cp\u003ePathogenesis and Virulence Factors 398\u003c\/p\u003e \u003cp\u003ePathogenomics and Evolution 402\u003c\/p\u003e \u003cp\u003eImmunity 405\u003c\/p\u003e \u003cp\u003eControl 406\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Future Directions 407\u003c\/p\u003e \u003cp\u003eReferences 408\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 \u003ci\u003eHelicobacter \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e413\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eChloë De Witte, Helena Berlamont, and Freddy Haesebrouck\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 413\u003c\/p\u003e \u003cp\u003eGastric Helicobacters 413\u003c\/p\u003e \u003cp\u003eEnterohepatic Helicobacters 425\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Future Directions 426\u003c\/p\u003e \u003cp\u003eReferences 427\u003c\/p\u003e \u003cp\u003e\u003cb\u003e20 \u003ci\u003eChlamydia and Coxiella \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e433\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMartina Jelocnik, Wilhelmina M. Huston, and Hayley J. Newton\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 433\u003c\/p\u003e \u003cp\u003eChlamydiae 433\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organism 433\u003c\/p\u003e \u003cp\u003eSource of Infection: Ecology, Evolution and Epidemiology 436\u003c\/p\u003e \u003cp\u003eTypes of Disease and Pathologic Changes 436\u003c\/p\u003e \u003cp\u003ePathogenesis 442\u003c\/p\u003e \u003cp\u003eImmunity and Control 442\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 443\u003c\/p\u003e \u003cp\u003e\u003ci\u003eCoxiella burnetii \u003c\/i\u003e443\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organism 444\u003c\/p\u003e \u003cp\u003eSource of Infection: Ecology, Evolution and Epidemiology 445\u003c\/p\u003e \u003cp\u003eTypes of Disease and Pathologic Changes 445\u003c\/p\u003e \u003cp\u003eVirulence Factors and Pathogenomics 447\u003c\/p\u003e \u003cp\u003eImmunity and Control 448\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 449\u003c\/p\u003e \u003cp\u003eReferences 449\u003c\/p\u003e \u003cp\u003e\u003cb\u003e21 Rickettsiales \u003c\/b\u003e\u003cb\u003e456\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJere W. McBride, Roman R. Ganta, and David H. Walker\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 456\u003c\/p\u003e \u003cp\u003eFamily Anaplasmataceae 457\u003c\/p\u003e \u003cp\u003e\u003ci\u003eAnaplasma \u003c\/i\u003eSpecies 457\u003c\/p\u003e \u003cp\u003e\u003ci\u003eEhrlichia \u003c\/i\u003eSpecies 463\u003c\/p\u003e \u003cp\u003e\u003ci\u003eNeorickettsia \u003c\/i\u003eSpecies 474\u003c\/p\u003e \u003cp\u003eFamily Rickettsiaceae 476\u003c\/p\u003e \u003cp\u003e\u003ci\u003eRickettsia \u003c\/i\u003eSpecies 476\u003c\/p\u003e \u003cp\u003eReferences 480\u003c\/p\u003e \u003cp\u003e\u003cb\u003e22 \u003ci\u003eLawsonia intracellularis \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e486\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eRoberto M. C. Guedes, Fabio A. Vannucci, and Connie J. Gebhart\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 486\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organism 486\u003c\/p\u003e \u003cp\u003eSources of Infection: Ecology and Epidemiology 489\u003c\/p\u003e \u003cp\u003eTypes of Disease and Pathologic Changes 490\u003c\/p\u003e \u003cp\u003eVirulence Factors and Pathogenomics 491\u003c\/p\u003e \u003cp\u003ePathogenesis 492\u003c\/p\u003e \u003cp\u003eImmunity 496\u003c\/p\u003e \u003cp\u003eControl 497\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 497\u003c\/p\u003e \u003cp\u003eReferences 498\u003c\/p\u003e \u003cp\u003e\u003cb\u003e23 \u003ci\u003eLeptospira \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e502\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eCyrille Goarant, Ben Adler, and Alejandro de la Peña Moctezuma\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 502\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organism 502\u003c\/p\u003e \u003cp\u003e\u003ci\u003eLeptospira \u003c\/i\u003eSpecies 505\u003c\/p\u003e \u003cp\u003eSource of Infection: Ecology, Evolution, and Epidemiology 505\u003c\/p\u003e \u003cp\u003eClinical Presentation and Signs 511\u003c\/p\u003e \u003cp\u003eVirulence Factors and Pathogenomics 511\u003c\/p\u003e \u003cp\u003eRegulation of Virulence 514\u003c\/p\u003e \u003cp\u003ePathogenesis 514\u003c\/p\u003e \u003cp\u003eImmunity 516\u003c\/p\u003e \u003cp\u003eControl 518\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 518\u003c\/p\u003e \u003cp\u003eReferences 519\u003c\/p\u003e \u003cp\u003e\u003cb\u003e24 \u003ci\u003eBrachyspira \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e528\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJoseph E. Rubin and Judith Rohde\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 528\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organism 528\u003c\/p\u003e \u003cp\u003ePathogenic Species and Disease Associations 529\u003c\/p\u003e \u003cp\u003eSource of Infection: Ecology, Evolution, and Epidemiology 530\u003c\/p\u003e \u003cp\u003eVirulence Factors and Pathogenomics 531\u003c\/p\u003e \u003cp\u003ePathogenesis 531\u003c\/p\u003e \u003cp\u003eImmunity 537\u003c\/p\u003e \u003cp\u003eControl 538\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 538\u003c\/p\u003e \u003cp\u003eReferences 539\u003c\/p\u003e \u003cp\u003e\u003cb\u003e25 \u003ci\u003eStaphylococcus \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e543\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAmy C. Pickering, Andreas F. Haag, José R. Penades, and J. Ross Fitzgerald\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 543\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organism 543\u003c\/p\u003e \u003cp\u003ePathogenic Species 544\u003c\/p\u003e \u003cp\u003e\u003ci\u003eStaphylococcus aureus \u003c\/i\u003eInfections in Cattle 546\u003c\/p\u003e \u003cp\u003e\u003ci\u003eStaphylococcus aureus \u003c\/i\u003eInfections in Poultry 551\u003c\/p\u003e \u003cp\u003e\u003ci\u003eStaphylococcus aureus \u003c\/i\u003eInfections in Rabbits 553\u003c\/p\u003e \u003cp\u003e\u003ci\u003eStaphylococcus hyicus \u003c\/i\u003eInfections in Pigs 554\u003c\/p\u003e \u003cp\u003e\u003ci\u003eStaphylococcus pseudintermedius \u003c\/i\u003eInfections in Dogs 556\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Future Directions 559\u003c\/p\u003e \u003cp\u003eReferences 560\u003c\/p\u003e \u003cp\u003e\u003cb\u003e26 \u003ci\u003eStreptococcus \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e565\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJohn F. Timoney\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 565\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organism 565\u003c\/p\u003e \u003cp\u003ePathogenic Species 565\u003c\/p\u003e \u003cp\u003e\u003ci\u003eStreptococcus agalactiae \u003c\/i\u003e567\u003c\/p\u003e \u003cp\u003e\u003ci\u003eStreptococcus dysgalactiae \u003c\/i\u003e569\u003c\/p\u003e \u003cp\u003e\u003ci\u003eStreptococcus uberis \u003c\/i\u003e570\u003c\/p\u003e \u003cp\u003e\u003ci\u003eStreptococcus equi \u003c\/i\u003e571\u003c\/p\u003e \u003cp\u003e\u003ci\u003eStreptococcus zooepidemicus \u003c\/i\u003e577\u003c\/p\u003e \u003cp\u003e\u003ci\u003eStreptococcus canis \u003c\/i\u003e579\u003c\/p\u003e \u003cp\u003e\u003ci\u003eStreptococcus suis \u003c\/i\u003e580\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 583\u003c\/p\u003e \u003cp\u003eReferences 583\u003c\/p\u003e \u003cp\u003e\u003cb\u003e27 \u003ci\u003eBacillus anthracis \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e588\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJoachim Frey\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 588\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organism: Taxonomy and Phylogeny 588\u003c\/p\u003e \u003cp\u003eSource and Spread of the Infection: Ecology, Evolution, and Epidemiology 591\u003c\/p\u003e \u003cp\u003eTypes of Disease and Pathologic Changes 592\u003c\/p\u003e \u003cp\u003eVirulence Factors and Pathogenomics 594\u003c\/p\u003e \u003cp\u003eRegulation of Virulence 595\u003c\/p\u003e \u003cp\u003ePathogenesis 596\u003c\/p\u003e \u003cp\u003eImmunity and Vaccines 598\u003c\/p\u003e \u003cp\u003eControl and Prevention of Anthrax 598\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 600\u003c\/p\u003e \u003cp\u003eReferences 601\u003c\/p\u003e \u003cp\u003e\u003cb\u003e28 Enteric Clostridia \u003c\/b\u003e\u003cb\u003e607\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eEvelien Dierick, Evy Goossens, John F. Prescott, Richard Ducatelle, and Filip Van Immerseel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 607\u003c\/p\u003e \u003cp\u003e\u003ci\u003eClostridium perfringens \u003c\/i\u003e607\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organism 607\u003c\/p\u003e \u003cp\u003ePathogenic Types 608\u003c\/p\u003e \u003cp\u003eSources of Infections: Ecology, Evolution and Epidemiology 608\u003c\/p\u003e \u003cp\u003eTypes of Disease and Pathologic Changes 611\u003c\/p\u003e \u003cp\u003eVirulence Factors 616\u003c\/p\u003e \u003cp\u003eRegulation of Virulence 622\u003c\/p\u003e \u003cp\u003eThe Pathogenesis of \u003ci\u003eClostridium perfringens \u003c\/i\u003eEnteric Disease 622\u003c\/p\u003e \u003cp\u003eControl 625\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 625\u003c\/p\u003e \u003cp\u003e\u003ci\u003eClostridioides difficile \u003c\/i\u003e626\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organism 626\u003c\/p\u003e \u003cp\u003eSource of Infection: Ecology, Evolution and Epidemiology 626\u003c\/p\u003e \u003cp\u003eTypes of Disease and Pathologic Changes 627\u003c\/p\u003e \u003cp\u003eDisease 627\u003c\/p\u003e \u003cp\u003eVirulence Factors and Pathogenomics 627\u003c\/p\u003e \u003cp\u003eRegulation of Virulence 628\u003c\/p\u003e \u003cp\u003ePathogenesis 629\u003c\/p\u003e \u003cp\u003eImmunity 630\u003c\/p\u003e \u003cp\u003eControl 630\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 630\u003c\/p\u003e \u003cp\u003eOther Enteric Clostridia 630\u003c\/p\u003e \u003cp\u003eReferences 631\u003c\/p\u003e \u003cp\u003e\u003cb\u003e29 Histotoxic Clostridia \u003c\/b\u003e\u003cb\u003e635\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAndrew N. Rycroft\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 635\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organisms 635\u003c\/p\u003e \u003cp\u003eSource of Infection and Basic Pathogenesis 636\u003c\/p\u003e \u003cp\u003ePathogenic Species 636\u003c\/p\u003e \u003cp\u003e\u003ci\u003eClostridium septicum \u003c\/i\u003e(Malignant Edema\/Gas Gangrene) 638\u003c\/p\u003e \u003cp\u003e\u003ci\u003eClostridium chauvoei \u003c\/i\u003e(Blackleg) 639\u003c\/p\u003e \u003cp\u003e\u003ci\u003ePaeniclostridium sordellii \u003c\/i\u003e640\u003c\/p\u003e \u003cp\u003e\u003ci\u003eClostridium novyi \u003c\/i\u003eType B (Black Disease\/Bighead) 642\u003c\/p\u003e \u003cp\u003e\u003ci\u003eClostridium haemolyticum \u003c\/i\u003e643\u003c\/p\u003e \u003cp\u003e\u003ci\u003eClostridium perfringens \u003c\/i\u003e644\u003c\/p\u003e \u003cp\u003eControl 645\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Future Directions 645\u003c\/p\u003e \u003cp\u003eReferences 646\u003c\/p\u003e \u003cp\u003e\u003cb\u003e30 Neurotoxic Clostridia \u003c\/b\u003e\u003cb\u003e648\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMichel R. Popoff\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 648\u003c\/p\u003e \u003cp\u003eCharacteristic of the Organisms 648\u003c\/p\u003e \u003cp\u003e\u003ci\u003eClostridium botulinum \u003c\/i\u003e648\u003c\/p\u003e \u003cp\u003e\u003ci\u003eClostridium tetani \u003c\/i\u003e650\u003c\/p\u003e \u003cp\u003eSources of Infection: Ecology and Epidemiology 652\u003c\/p\u003e \u003cp\u003eDiseases 656\u003c\/p\u003e \u003cp\u003eBotulism 656\u003c\/p\u003e \u003cp\u003eTetanus 657\u003c\/p\u003e \u003cp\u003eVirulence Factors 658\u003c\/p\u003e \u003cp\u003ePathogenesis 659\u003c\/p\u003e \u003cp\u003eControl 663\u003c\/p\u003e \u003cp\u003eReferences 664\u003c\/p\u003e \u003cp\u003e\u003cb\u003e31 Mycoplasmas \u003c\/b\u003e\u003cb\u003e667\u003cbr\u003e\u003c\/b\u003e\u003ci\u003ePollob K. Shil, Nadeeka K. Wawegama, Glenn F. Browning, Amir H. Noormohammadi, and Marc\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eS. Marenda\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 667\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organisms 667\u003c\/p\u003e \u003cp\u003ePathogenic Species 668\u003c\/p\u003e \u003cp\u003eSource of Infection: Ecology, Evolution, and Epidemiology 668\u003c\/p\u003e \u003cp\u003eVirulence Factors and Pathogenomics 670\u003c\/p\u003e \u003cp\u003eRegulation of Virulence 674\u003c\/p\u003e \u003cp\u003eTypes of Disease and Pathologic Changes 674\u003c\/p\u003e \u003cp\u003ePathogenesis 680\u003c\/p\u003e \u003cp\u003eImmunity 688\u003c\/p\u003e \u003cp\u003eControl 690\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 690\u003c\/p\u003e \u003cp\u003eReferences 691\u003c\/p\u003e \u003cp\u003e\u003cb\u003e32 \u003ci\u003eCorynebacterium\u003c\/i\u003e, \u003ci\u003eArcanobacterium\u003c\/i\u003e, and \u003ci\u003eTrueperella \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e701\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eThiago D. Barral, Ricardo W. Portela, Núbia Seyffert, and Robert J. Moore\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eCorynebacterium \u003c\/i\u003e701\u003c\/p\u003e \u003cp\u003e\u003ci\u003eCorynebacterium pseudotuberculosis \u003c\/i\u003e701\u003c\/p\u003e \u003cp\u003eBovine Pyelonephritis Caused by \u003ci\u003eCorynebacterium \u003c\/i\u003eSpecies 706\u003c\/p\u003e \u003cp\u003eOther Animal Pathogenic \u003ci\u003eCorynebacterium \u003c\/i\u003eSpecies 706\u003c\/p\u003e \u003cp\u003e\u003ci\u003eArcanobacterium \u003c\/i\u003e707\u003c\/p\u003e \u003cp\u003e\u003ci\u003eTrueperella \u003c\/i\u003e709\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Future Directions 710\u003c\/p\u003e \u003cp\u003eReferences 710\u003c\/p\u003e \u003cp\u003e\u003cb\u003e33 \u003ci\u003eRhodococcus equi \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e715\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJosé A. Vázquez-Boland, Macarena G. Sanz, and John F. Prescott\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 715\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organism 715\u003c\/p\u003e \u003cp\u003eSource of Infection and Epidemiology 717\u003c\/p\u003e \u003cp\u003eTypes of Disease and Pathologic Changes 720\u003c\/p\u003e \u003cp\u003eVirulence Factors 721\u003c\/p\u003e \u003cp\u003eEvolution of \u003ci\u003eRhodococcus equi \u003c\/i\u003eVirulence 723\u003c\/p\u003e \u003cp\u003ePathogenesis 724\u003c\/p\u003e \u003cp\u003eImmunity 726\u003c\/p\u003e \u003cp\u003eTreatment and Control 728\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 730\u003c\/p\u003e \u003cp\u003eReferences 731\u003c\/p\u003e \u003cp\u003e\u003cb\u003e34 \u003ci\u003eMycobacterium \u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e736\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eKarren M. Plain, Karen Stevenson, Richard J. Whittington, and Nathalie Winter\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 736\u003c\/p\u003e \u003cp\u003eCharacteristics of the Organism 736\u003c\/p\u003e \u003cp\u003eSources of Infection 738\u003c\/p\u003e \u003cp\u003eSource of Infection: Evolution and Epidemiology 739\u003c\/p\u003e \u003cp\u003eVirulence Factors and Pathogenomics 740\u003c\/p\u003e \u003cp\u003eRegulation of Virulence 742\u003c\/p\u003e \u003cp\u003eTypes of Disease 743\u003c\/p\u003e \u003cp\u003ePathogenesis 744\u003c\/p\u003e \u003cp\u003eAdaptive Immunity and Mycobacterial Pathogenesis 748\u003c\/p\u003e \u003cp\u003eControl 750\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Directions 750\u003c\/p\u003e \u003cp\u003eReferences 752\u003c\/p\u003e \u003cp\u003e\u003cb\u003e35 \u003ci\u003eGram-Negative \u003c\/i\u003eAnaerobes \u003c\/b\u003e\u003cb\u003e757\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJohn F. Prescott\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 757\u003c\/p\u003e \u003cp\u003eGeneral Bacterial Pathogenesis Aspects 757\u003c\/p\u003e \u003cp\u003e\u003ci\u003eFusobacterium \u003c\/i\u003e759\u003c\/p\u003e \u003cp\u003e\u003ci\u003eBacteroides \u003c\/i\u003e763\u003c\/p\u003e \u003cp\u003e\u003ci\u003ePrevotella \u003c\/i\u003eand \u003ci\u003ePorphyromonas \u003c\/i\u003e764\u003c\/p\u003e \u003cp\u003e\u003ci\u003eDichelobacter nodosus \u003c\/i\u003e765\u003c\/p\u003e \u003cp\u003e\u003ci\u003eTreponema \u003c\/i\u003e767\u003c\/p\u003e \u003cp\u003eGaps in Knowledge and Anticipated Developments 768\u003c\/p\u003e \u003cp\u003eReferences 768\u003c\/p\u003e \u003cp\u003eIndex 773\u003c\/p\u003e \u003cp\u003e\"The book is well-produced and a useful update on bacterial pathogenesis from a genomics standpoint. It belongs in the diagnostic laboratory, and not just on the bacteriologist's shelf.\"\u003cbr\u003e—\u003cb\u003e\u003ci\u003eJournal of Veterinary Diagnostic Investigation,\u003c\/i\u003e 2023, Vol. 35(2) 217-218\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e John F. Prescott\u003c\/b\u003e is University Professor Emeritus at the University of Guelph, in Guelph, Ontario, Canada. \u003c\/p\u003e \u003cp\u003e\u003cb\u003eJanet I. MacInnes\u003c\/b\u003e is Professor Emerita at the University of Guelph in Guelph, Ontario, Canada.  \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFilip Van Immerseel\u003c\/b\u003e is Professor at Ghent University in Merelbeke, Belgium.  \u003c\/p\u003e\u003cp\u003e\u003cb\u003eJohn D. Boyce\u003c\/b\u003e is Associate Professor at Monash Biomedicine Discovery Institute, Monash University, in Clayton, Victoria, Australia.  \u003c\/p\u003e\u003cp\u003e\u003cb\u003eAndrew N. Rycroft\u003c\/b\u003e is Professor at the Royal Veterinary College, in Hatfield, Hertfordshire, United Kingdom. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eJosé A. Vázquez-Boland\u003c\/b\u003e is Professor at the University of Edinburgh in Edinburgh, United Kingdom.  \u003c\/p\u003e\u003cp\u003e\u003cb\u003eComprehensive review of the major bacterial pathogens of animals, focusing on the current understanding of how they cause disease \u003c\/b\u003e \u003c\/p\u003e \u003cp\u003e\u003ci\u003ePathogenesis of Bacterial Infections in Animals, Fifth Edition\u003c\/i\u003e is a specialist reference that provides a comprehensive review of bacterial pathogens in animals and their complex interplay with disease processes, offering a complete understanding of how bacteria cause disease in animals. It covers the many recent advances in the field including the newest taxonomies. In this revised and long anticipated fifth edition, additional introductory chapters have been added to set the material in context, and more figures added to integrate and improve understanding and comprehension throughout the text. A companion website presents the figures from the book in PowerPoint and references.  \u003c\/p\u003e\u003cp\u003eThis detailed reference includes novel approaches to controlling bacterial pathogens in the light of growing concerns about antimicrobial resistance, with more than 70 expert authors sharing their wisdom on the topic. While molecular pathogenesis is a major aspect in almost every chapter, the authors have been careful to place pathogens in their broader context.  \u003c\/p\u003e\u003cp\u003e\u003ci\u003ePathogenesis of Bacterial Infections in Animals, Fifth Edition\u003c\/i\u003e also contains information on:  \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eThemes in bacterial pathogenesis, covering the basic elements of pathogenesis, concepts of virulence, host-pathogen interactions and communication, and pathogenesis in the post-genomic era\u003c\/li\u003e \u003cli\u003eEvolution of bacterial pathogens, covering what they are and how they emerge, along with sources of genetic diversity, population structure, and genome plasticity\u003c\/li\u003e \u003cli\u003eUnderstanding of pathogenesis through pathogenomics and bioinformatics, including how mutations generate pathogen diversity, and an overview of genome sequencing technologies\u003c\/li\u003e \u003cli\u003eSubversion of the immune response by bacterial pathogens, covering subversion of both innate responses and adaptive immunity\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003e\u003ci\u003ePathogenesis of Bacterial Infections in Animals, Fifth Edition\u003c\/i\u003e is an essential resource for graduate students in veterinary medicine and animal science, and for veterinary microbiologists, pathologists, infectious disease experts, and others interested in bacterial disease. It is the only book to cover this topic to this depth through the wealth of insight of dozens of qualified and practicing professionals.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989754167525,"sku":"NP9781119754794","price":249.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119754794.jpg?v=1761785360","url":"https:\/\/k12savings.com\/products\/pathogenesis-of-bacterial-infections-in-animals-isbn-9781119754794","provider":"K12savings","version":"1.0","type":"link"}