{"product_id":"pain-free-biochemistry-isbn-9780470060469","title":"Pain-Free Biochemistry","description":"\u003ci\u003e\"It’s not every day that one picks up a textbook that can claim to occupy a unique niche, given the multitude of scientific textbooks that are vying for a medical readership. However, with the recent publication of 'Pain-Free Biochemistry: An Essential Guide for the Health Sciences', which is specifically aimed at students of medicine and nursing, one could be left wondering just why nobody thought of this sooner.”\u003c\/i\u003e –Irish Medical Times, September 14, 2010  \u003cp\u003eIf you are an undergraduate nursing or healthcare student about to embark on a short course in biochemistry and feel daunted by the prospect because you’ve done very little chemistry in the past, found it difficult or studied it so long ago you’ve forgotten it all, then this is the book for you. Equally, if clinical practice has brought you back to biochemistry just when you were hoping you could forget it all, this could be your lifeline!\u003c\/p\u003e \u003cp\u003eHaving taught biochemistry to all sorts of students, from nurses to chemical engineers, for more than 30 years, Professor Paul Engel knows how to take the ‘pain’ out of your studies. For those who are a bit wobbly on molecules, bonds, ions, etc. this text also has just enough supporting chemistry slipped in where appropriate to help things make sense. Accessible, enjoyable to read and packed with a wealth of clinical examples from heart disease to cancer and blood clotting to antibiotics, this handy textbook will reveal how biochemistry is fundamental to clinical practice and everyday life. Drugs, diet, disease, DNA – it all comes down to biochemistry.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eKey Features:\u003c\/b\u003e\u003c\/p\u003e \u003cul\u003e \u003cli\u003e\n\u003cb\u003eEasy to digest:\u003c\/b\u003e ‘Bite sized’ topics lead you through essential biochemistry without going into intimidating detail. \u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eDoesn’t assume you’ve studied chemistry before: \u003c\/b\u003e Focuses on key concepts and provides all the basic chemistry you might need. \u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eColour coded:\u003c\/b\u003e Specially designed so you can see, at a glance, which chapters focus on underpinning chemistry, which on basic biochemistry and which on clinical applications. \u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eClinically relevant:\u003c\/b\u003eTopical examples throughout the text show how getting to grips with biochemistry will help you succeed in healthcare practice. \u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eReinforces your learning:\u003c\/b\u003e Includes numerous self-test questions with answers throughout. \u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eCompanion website includes:\u003c\/b\u003e  \u003cul\u003e \u003cli\u003eA complete set of figures from within the book.\u003c\/li\u003e \u003cli\u003eExtended MCQs with answers and further explanation where relevant.\u003c\/li\u003e \u003c\/ul\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003ePreface x\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 1 Foundations 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eTopic 1 Why biochemistry? 3\u003c\/p\u003e \u003cp\u003eTopic 2 Remarkableness of life 9\u003c\/p\u003e \u003cp\u003eChemistry I The basic structure of substances: atoms, molecules, elements and compounds 13\u003c\/p\u003e \u003cp\u003eChemistry II Atomic structure, valency and bonding 16\u003c\/p\u003e \u003cp\u003eChemistry III Protons, acids, bases, concentration and the pH scale 25\u003c\/p\u003e \u003cp\u003eTopic 3 Shape, molecular recognition and proteins: an example 32\u003c\/p\u003e \u003cp\u003eTopic 4 Proteins: molecular necklaces 38\u003c\/p\u003e \u003cp\u003eTopic 5 Chemical transformations in the living organism: metabolism 43\u003c\/p\u003e \u003cp\u003eTopic 6 Reactions, catalysts and enzymes 46\u003c\/p\u003e \u003cp\u003eTopic 7 Specificity, saturation and active sites 49\u003c\/p\u003e \u003cp\u003eTopic 8 Structure of metabolism: anabolism and catabolism 54\u003c\/p\u003e \u003cp\u003eChemistry IV Equilibrium 56\u003c\/p\u003e \u003cp\u003eTopic 9 Catabolism: degradation vs energy metabolism 60\u003c\/p\u003e \u003cp\u003eChemistry V Oxidation and reduction 63\u003c\/p\u003e \u003cp\u003eTopic 10 Oxidation and reduction in metabolism 67\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 2 Catabolism 71\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChemistry VI Aldehydes, ketones and sugars 73\u003c\/p\u003e \u003cp\u003eTopic 11 Carbohydrates: sugars and polysaccharides in metabolism 81\u003c\/p\u003e \u003cp\u003eTopic 12 Glucose inside the body 85\u003c\/p\u003e \u003cp\u003eTopic 13 Breakdown of sugar: glycolysis 88\u003c\/p\u003e \u003cp\u003eTopic 14 Aerobic oxidation of pyruvate: Krebs cycle 94\u003c\/p\u003e \u003cp\u003eTopic 15 Respiratory chain, oxidative phosphorylation and overall ATP yields 98\u003c\/p\u003e \u003cp\u003eTopic 16 Mobilising the carbohydrate store: glycogenolysis 103\u003c\/p\u003e \u003cp\u003eChemistry VII Alcohols, esters, glycerol, fatty acids and triglycerides 106\u003c\/p\u003e \u003cp\u003eChemistry VIII Hydrophobic, hydrophilic and amphiphilic 109\u003c\/p\u003e \u003cp\u003eTopic 17 Phospholipids and membranes 111\u003c\/p\u003e \u003cp\u003eChemistry IX Saturated and unsaturated 114\u003c\/p\u003e \u003cp\u003eTopic 18 Fats as an energy source 119\u003c\/p\u003e \u003cp\u003eTopic 19 Fats: digestion, transport, storage and mobilisation 122\u003c\/p\u003e \u003cp\u003eTopic 20 Fats: oxidation of fatty acids 126\u003c\/p\u003e \u003cp\u003eTopic 21 Ketone bodies in health and disease 133\u003c\/p\u003e \u003cp\u003eTopic 22 Dietary fat: essential fatty acids 137\u003c\/p\u003e \u003cp\u003eTopic 23 Protein and amino acid breakdown 140\u003c\/p\u003e \u003cp\u003eTopic 24 Shedding excess amino groups: urea cycle 147\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 3 Anabolism and Control 151\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eTopic 25 Is anabolism just catabolism backwards? 153\u003c\/p\u003e \u003cp\u003eTopic 26 Making new glucose: gluconeogenesis 156\u003c\/p\u003e \u003cp\u003eTopic 27 Fatty acid biosynthesis 161\u003c\/p\u003e \u003cp\u003eTopic 28 Providing reducing power: NADPH and the pentose phosphate pathway 164\u003c\/p\u003e \u003cp\u003eChemistry X Isotopes 168\u003c\/p\u003e \u003cp\u003eTopic 29 Red cells and white cells: defence against reactive oxygen and reactive oxygen as defence! 172\u003c\/p\u003e \u003cp\u003eTopic 30 The need for metabolic control 176\u003c\/p\u003e \u003cp\u003eTopic 31 Relationship of fats and carbohydrates: use by different tissues 179\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 4 Genes and Protein Synthesis 181\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eTopic 32 The idea of genes 183\u003c\/p\u003e \u003cp\u003eTopic 33 The chemistry of genes: DNA and the double helix 186\u003c\/p\u003e \u003cp\u003eTopic 34 The genetic code and mRNA 190\u003c\/p\u003e \u003cp\u003eTopic 35 Protein synthesis, ribosomes and tRNA 193\u003c\/p\u003e \u003cp\u003eTopic 36 Genetic differences and disease 197\u003c\/p\u003e \u003cp\u003eTopic 37 Genetic variability: drug metabolism and disease susceptibility 203\u003c\/p\u003e \u003cp\u003eTopic 38 Mutation, radiation and ageing 205\u003c\/p\u003e \u003cp\u003eTopic 39 Switching genes on and off: development, tissue specificity, adaptation and tolerance 207\u003c\/p\u003e \u003cp\u003eTopic 40 DNA and protein synthesis as targets: chemotherapy, antibiotics, etc. 210\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 5 Physiological Systems and Clinical Issues 217\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eTopic 41 Hormones and second messengers 219\u003c\/p\u003e \u003cp\u003eTopic 42 Switching enzymes on and off: coarse and fine control 222\u003c\/p\u003e \u003cp\u003eTopic 43 Insulin, glucagon and adrenaline 224\u003c\/p\u003e \u003cp\u003eTopic 44 Diabetes 229\u003c\/p\u003e \u003cp\u003eTopic 45 Steroid hormones and receptors: fertility control, pregnancy testing, etc. 233\u003c\/p\u003e \u003cp\u003eTopic 46 Pituitary hormones and feedback loops 238\u003c\/p\u003e \u003cp\u003eTopic 47 Thyroid hormones 240\u003c\/p\u003e \u003cp\u003eTopic 48 Adrenal cortex 244\u003c\/p\u003e \u003cp\u003eTopic 49 Prostaglandins and inflammation: aspirin 246\u003c\/p\u003e \u003cp\u003eTopic 50 Membrane transport 250\u003c\/p\u003e \u003cp\u003eTopic 51 Nerve and muscle 255\u003c\/p\u003e \u003cp\u003eTopic 52 pH homeostasis 258\u003c\/p\u003e \u003cp\u003eTopic 53 Diagnostic markers: biochemical tests 261\u003c\/p\u003e \u003cp\u003eTopic 54 Blood, bleeding and clotting 265\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 6 Appendices 271\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAppendix 1 pH and neutrality 273\u003c\/p\u003e \u003cp\u003eAppendix 2 Crystallography 274\u003c\/p\u003e \u003cp\u003eAppendix 3 Protein forces, secondary structure and folding 277\u003c\/p\u003e \u003cp\u003eAppendix 4 Equilibrium constant 281\u003c\/p\u003e \u003cp\u003eAppendix 5 Phosphorus, phosphoric acid and phosphate esters 283\u003c\/p\u003e \u003cp\u003eAppendix 6 Coenzymes, cofactors and prosthetic groups 285\u003c\/p\u003e \u003cp\u003eAppendix 7 Coenzyme A 287\u003c\/p\u003e \u003cp\u003eAppendix 8 Krebs cycle and evidence for a catalytic reaction sequence 289\u003c\/p\u003e \u003cp\u003eAppendix 9 Knoop’s experiment pointing to \u003ci\u003eβ\u003c\/i\u003e-oxidation of fatty acids 291\u003c\/p\u003e \u003cp\u003eAppendix 10 Isoenzymes 293\u003c\/p\u003e \u003cp\u003eAppendix 11 Genetic code 295\u003c\/p\u003e \u003cp\u003eAppendix 12 Different kinds of mutation 297\u003c\/p\u003e \u003cp\u003eAppendix 13 Restriction enzymes 299\u003c\/p\u003e \u003cp\u003eAppendix 14 Enzyme inhibition 301\u003c\/p\u003e \u003cp\u003eAppendix 15 Electrophoresis to separate proteins 304\u003c\/p\u003e \u003cp\u003eAppendix 16 Chromatography and mass spectrometry to\u003c\/p\u003e \u003cp\u003eseparate and identify metabolites 308\u003c\/p\u003e \u003cp\u003eGlossary 313\u003c\/p\u003e \u003cp\u003eMCQ answers 322\u003c\/p\u003e \u003cp\u003eIndex 323\u003c\/p\u003e  \"For students embarking on careers in the health sciences, it is an essential academic companion and, retailing at approximately £28, it is excellent value for money\". (The Biochemist, 1 June 2011)\u003cbr\u003e \u003cbr\u003e   \u003cp\u003e\"It's not every day that one picks up a textbook that can claim to occupy a unique niche, given the multitude of scientific textbooks that are vying for a medical readership. However, with the recent publication of \u003ci\u003ePain-Free Biochemistry: An Essential Guide for the Health Sciences\u003c\/i\u003e, which is specifically aimed at students of medicine and nursing, one could be left wondering just why nobody thought of this sooner.\" (\u003ci\u003eIrish Medical News\u003c\/i\u003e, September 08, 2010)\u003c\/p\u003e \u003cp\u003e\u003cb\u003eProfessor Paul Engel\u003c\/b\u003e is professor of biochemistry at University College Dublin. He has had extensive experience teaching biochemistry to undergraduate and postgraduate biochemistry, biology, medicine, engineering and nursing students, in his current post at UCD and at the universities of Sheffield, Oxford and Hong Kong. He is on the Editorial Board of \u003ci\u003eBiochemical Journal\u003c\/i\u003e, and \u003ci\u003eEssays in Biochemistry\u003c\/i\u003e, and is the author of the highly successful textbook: \u003ci\u003eEnzyme Kinetics\u003c\/i\u003e (Outline Series) published by Chapman and Hall.\u003c\/p\u003e If you are an undergraduate nursing or healthcare student about to embark on a short course in biochemistry and feel daunted by the prospect because you’ve done very little chemistry in the past, found it difficult or studied it so long ago you’ve forgotten it all, then this is the book for you. Equally, if clinical practice has brought you back to biochemistry just when you were hoping you could forget it all, this could be your lifeline! \u003cp\u003eHaving taught biochemistry to all sorts of students, from nurses to chemical engineers, for more than 30 years, Professor Paul Engel knows how to take the ‘pain’ out of your studies. For those who are a bit wobbly on molecules, bonds, ions, etc. \u003ci\u003ePain-Free Biochemistry\u003c\/i\u003e also has just enough supporting chemistry slipped in where appropriate to help things make sense. Accessible, enjoyable to read and packed with a wealth of clinical examples from heart disease to cancer and blood clotting to antibiotics, this handy textbook will reveal how biochemistry is fundamental to clinical practice and everyday life. Drugs, diet, disease, DNA – it all comes down to biochemistry.\u003c\/p\u003e \u003cul\u003e \u003cli\u003e\n\u003cb\u003eEasy to digest\u003c\/b\u003e. ‘Bite-sized’ topics lead you through essential biochemistry without going into intimidating detail.\u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eDoesn’t assume you’ve studied chemistry before.\u003c\/b\u003e Focuses on key concepts and provides all the basic chemistry you might need.\u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eColour coded.\u003c\/b\u003e Specially designed so you can see, at a glance, which topics focus on underpinning chemistry, which on basic biochemistry and which on clinical applications.\u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eClinically relevant.\u003c\/b\u003e Topical examples throughout the text show how getting to grips with biochemistry will help you succeed in healthcare practice.\u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eReinforces your learning.\u003c\/b\u003e Includes numerous self-test questions with answers throughout.\u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eCompanion website includes:\u003c\/b\u003e A Complete set of figures within the book; extended MCQs with answers and further explanation where relevant. Please visit the book’s companion website at \u003ca href=\"http:\/\/www.wileyeurope.com\/college.engel\"\u003ewww.wileyeurope.com\/college.engel\u003c\/a\u003e.\u003c\/li\u003e \u003c\/ul\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989746860261,"sku":"NP9780470060469","price":67.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470060469.jpg?v=1761785332","url":"https:\/\/k12savings.com\/products\/pain-free-biochemistry-isbn-9780470060469","provider":"K12savings","version":"1.0","type":"link"}