{"product_id":"osteoarthritic-joint-pain-isbn-9780470867617","title":"Osteoarthritic Joint Pain","description":"Osteoarthritis is a chronic degenerative disease associated with joint pain and loss of joint function. It has an estimated incidence of 4 out of every 100 people and significantly reduces the quality of life in affected individuals. The major symptoms are chronic pain, swelling and stiffness; severe, chronic joint pain is often the central factor that causes patients to seek medical attention. Within the affected joint, there is focal degradation and remodelling of articular cartilage, new bone formation (osteophytes) and mild synovitis.  \u003cp\u003eSeveral mechanisms are thought to contribute to osteoarthritic joint pain. These include mild synovial inflammation, bone oedema, ligament stretching, osteophyte formation and cartilage-derived mediators. Changes in joint biomechanics and muscle strength also influence the severity and duration of joint pain in osteoarthritis. Within the nervous system, the relative contributions of peripheral afferent nociceptive fibres and central mechanisms remain to be defined, and there is limited information on the phenotype of sensory neurons in the OA joint. Importantly, there is no relation between clinical severity, as measured by radiographic changes, and the presence and severity of joint pain. Patients with severe joint pain may have normal joint architecture as determined by X-ray, whereas patients with considerable evidence of joint remodelling may not have significant joint pain. Treatments for osteoarthritic joint pain include non-steroidal anti-inflammatory compounds, exercise, corrective shoes and surgical intervention. There remains a critical need for improved control of joint pain in osteoarthritis.\u003c\/p\u003e \u003cp\u003eThis book brings together contributions from key investigators in the area of osteoarthritic joint pain.  It covers the clinical presentation of joint pain, the pathways involved in joint pain, osteoarthritis disease processes and pain, experimental models and pain control. The discussions provide insights into the nature of osteoarthritic joint pain, identify key studies needed to advance understanding of the problem, highlight possible intervention points and indicate future pathways towards a better treatment of osteoarthritic joint pain.\u003cbr\u003e \u003c\/p\u003e  Chair's Introduction (D. Felson).  \u003cp\u003eSpinal mechanisms contributing to joint pain (H. Schaible).\u003c\/p\u003e \u003cp\u003eActivation of sensory neurons in the arthritic joint (B. Grubb).\u003c\/p\u003e \u003cp\u003eNeuromuscular aspects of osteoarthritis: a perspective (K. Brandt).\u003c\/p\u003e \u003cp\u003eCurrent perspectives on the clinical presentation of joint pain in human osteoarthritis (P. Creamer).\u003c\/p\u003e \u003cp\u003eJoint mechanics in osteoarthritis (W. Herzog, \u003ci\u003eet al\u003c\/i\u003e.).\u003c\/p\u003e \u003cp\u003eGeneral discussion I Developing animal models of RA.\u003c\/p\u003e \u003cp\u003eCharacterization of joint pain in human osteoarthritis (G. Ordeberg).\u003c\/p\u003e \u003cp\u003eThe role of inflammatory mediators on nociception and pain in arthritis (B. Kidd, \u003ci\u003eet al\u003c\/i\u003e.).\u003c\/p\u003e \u003cp\u003eMolecular events of chronic pain: from neurone to whole animal in an animal model of osteoarthritis (J. Henry).\u003c\/p\u003e \u003cp\u003ePhantoms of rheumatology (C. McCabe, \u003ci\u003eet al\u003c\/i\u003e.).\u003c\/p\u003e \u003cp\u003eBone pain and pressure in osteoarthritic joints (P. Simkin).\u003c\/p\u003e \u003cp\u003eStructural associations of osteoarthritis pain: lessons from magnetic resonance imaging (P. Conaghan \u0026amp; D. Felson).\u003c\/p\u003e \u003cp\u003eThe role of TRP channels in sensory neurons (M. Koltenberg)\u003c\/p\u003e \u003cp\u003eMechanisms that generate and maintain bone cancer pain (P. Mantyh \u0026amp; S. Hunt).\u003c\/p\u003e \u003cp\u003eSymmetry, T cells and neurogenic arthritis (N. Shenker, \u003ci\u003eet al\u003c\/i\u003e.).\u003c\/p\u003e \u003cp\u003eLessons from fibromyalgia: abnormal pain sensitivity in knee ostheoarthritis (L. Bradley, \u003ci\u003eet al\u003c\/i\u003e.).\u003c\/p\u003e \u003cp\u003eChair's summing up (D. Felson).\u003c\/p\u003e \u003cp\u003eIndex of contributors.\u003c\/p\u003e \u003cp\u003eSubject index.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eDerek J. Chadwick\u003c\/b\u003e and \u003cb\u003eJamie A. Goode\u003c\/b\u003e are editors for \u003ci\u003eOsteoarthritic Joint Pain\u003c\/i\u003e and other scientific titles.\u003c\/p\u003e  Osteoarthritis is a chronic degenerative disease associated with joint pain and loss of joint function. It has an estimated incidence of four in every 100 people and significantly reduces the quality of life in affected individuals. The major symptoms are chronic joint pain, swelling and stiffness; severe pain is often the key factor causing patients to seek medical attention. Within the affected joint there is focal degradation and remodelling of articular cartilage, new bone formation and mild synovitis.  \u003cp\u003eSeveral mechanisms are thought to contribute to osteoarthritic joint pain, including mild synovial inflammation, bone oedema, ligament stretching, osteophyte formation and cartilage-derived mediators. Changes in joint biomechanics and muscle strength may also affect the severity and duration of the joint pain. From a nervous system perspective, the relative contributions of peripheral afferent nociceptive fibres and central mechanisms remain to be defined. Importantly, there is a clear disconnect between clinical severity, as measured radiographically, and the presence and severity of joint pain. Treatments for osteoarthritic joint pain include non-steroidal anti-inflammatory compounds, exercise and surgical intervention. There remains a critical need for improved control of joint pain in osteoarthritis.\u003c\/p\u003e \u003cp\u003eThis book covers the clinical presentation of joint pain, the cellular pathways involved, osteoarthritis disease processes and pain, experimental models and pain control. The discussions provide insights into the nature of joint pain, identify key studies needed to advance understanding, highlight possible intervention points and indicate opportunities for better treatment of OA joint pain.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989738897637,"sku":"NP9780470867617","price":211.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470867617.jpg?v=1761785312","url":"https:\/\/k12savings.com\/products\/osteoarthritic-joint-pain-isbn-9780470867617","provider":"K12savings","version":"1.0","type":"link"}