{"product_id":"organic-syntheses-volume-90-isbn-9781118893845","title":"Organic Syntheses, Volume 90","description":"\u003cp\u003eThe current volume continues the tradition of providing significant and interesting procedures, which should prove worthwhile to many synthetic chemists working in increasingly diverse areas. Following precedent, there is no specific or central theme to this volume.\u003c\/p\u003e Synthesis of Koser's Reagent and Derivatives \u003cp\u003eReagent for Divalent Sulfur Protection: Preparation of 4-Methylbenzenesulfonothioic Acid, S-[(1,1-Dimethylethyl)-Dimethylsilyl]oxy]methyl] Ester\u003c\/p\u003e \u003cp\u003eDiscussion Addendum for: Applications of (2S)-3-exo-Morpholinoisoborneol [MIB] in Organic Synthesis\u003c\/p\u003e \u003cp\u003ePreparation of (E)-N, N-Diethyl-2-styrylbenzamide by Rh-Catalyzed C-H Activation\u003c\/p\u003e \u003cp\u003eEnantioselective Nitroaldol (Henry) Reaction of p-Nitrobenzaldehyde and Nitromethane Using a Copper (II) Complex Derived from (R, R)-1,2-Diaminocyclohexane: (1S)-1-(4-Nitrophenyl)-2-nitroethane-1-ol\u003c\/p\u003e \u003cp\u003eSynthesis of N-Acetyl Enamides by Reductive Acetylation of Oximes Mediated with Iron(II) Acetate: N-(1-(4-Bromophenyl)vinyl)acetamide\u003c\/p\u003e \u003cp\u003eOxindole Synthesis via Palladium-catalyzed C-H Functionalization\u003c\/p\u003e \u003cp\u003eIntermolecular retro-Cope Type Hydroxylamination of Alkynes with NH2OH: E-1-(1-Hydroxycyclohexyl)ethanone oxime\u003c\/p\u003e \u003cp\u003ePreparation of 1,5-Disubstituted 1,2,3-Triazoles via Ruthenium-catalyzed Azide Alkyne Cycloaddition\u003c\/p\u003e \u003cp\u003eDiscussion Addendum for: Nickel-catalyzed Homoallylation of Aldehydes with 1,3-Dienes\u003c\/p\u003e \u003cp\u003eEnantioselective Alkylation of N-(Diphenylmethylene)glycinate tert-Butyl Ester: Synthesis of (R)-2-(Benzhydrylidenamino)-3-Phenylpropanoic Acid tert-Butyl Ester\u003c\/p\u003e \u003cp\u003eEnantioselective Alkylation of 2-[(4-Chlorobenzyliden)Amino]Propanoic Acid tert-Butyl Ester: Synthesis of (R)-2-Amino-2-Methyl-3-Phenylpropanoic Acid tert-Butyl Ester\u003c\/p\u003e \u003cp\u003ePreparation of α-Fluorobis(phenylsulfonyl)methane (FBSM)\u003c\/p\u003e \u003cp\u003eDirect Conversion of Benzylic and Allylic Alcohols to Diethyl Phosphonates\u003c\/p\u003e \u003cp\u003eSynthesis of 1-Naphthol via Oxidation of Potassium 1-Naphthyltrifluoroborate\u003c\/p\u003e \u003cp\u003ePotassium tert-Butoxide Mediated Synthesis of Phenanthridinone\u003c\/p\u003e \u003cp\u003ePreparation of N1-Phenylacetamidine 4-Bromobenzoate Using 2,2,2-Trichloroethyl Acetimidate Hydrochloride\u003c\/p\u003e \u003cp\u003ePhenylacetamidine 4-Bromobenzoate Using 2,2,2-Trichloroethyl Acetimidate Hydrochloride\u003c\/p\u003e \u003cp\u003eDiscussion Addendum for: Stereoselective Synthesis of anti alpha-Methyl-beta-Methoxy Carboxylic Compounds\u003c\/p\u003e \u003cp\u003eBimolecular Oxidative Amidation of Phenols: 1-(Acetylamino)-4-oxo-2,5-cyclohexadiene-1-acetic acid, Methyl Ester\u003c\/p\u003e \u003cp\u003eNickel-Catalyzed Cross-Coupling of Aryl Halides with Alkyl Halides: Ethyl 4-(4-(4-methylphenylsulfonamido)-phenyl)butanoate\u003c\/p\u003e \u003cp\u003eSynthesis of 1-Naphthol via Oxidation of Potassium 1-Naphthyltrifluoroborate\u003c\/p\u003e \u003cp\u003ePotassium tert-Butoxide Mediated Synthesis of Phenanthridinone\u003c\/p\u003e \u003cp\u003ePreparation of N1-Phenylacetamidine 4-Bromobenzoate Using 2,2,2-Trichloroethyl Acetimidate Hydrochloride\u003c\/p\u003e \u003cp\u003eDiscussion Addendum for: Stereoselective Synthesis of anti [alpha]-Methyl-[beta]-Methoxy Carboxylic Compounds\u003c\/p\u003e \u003cp\u003eBimolecular Oxidative Amidation of Phenols: 1-(Acetylamino)-4-oxo-2,5-cyclohexadiene-1-acetic acid, Methyl Ester\u003c\/p\u003e \u003cp\u003eNickel-Catalyzed Cross-Coupling of Aryl Halides with Alkyl Halides: Ethyl 4-(4-(4-methylphenylsulfonamido)-phenyl)butanoate\u003c\/p\u003e \u003cp\u003eDiscussion Addendum for: Preparation of 4-Acetylamino-2, 2, 6, 6-tetramethylpiperidine-1-oxoammonium Tetrafluoroborate and the Oxidation of Geraniol to Geranial (2,6-Octadienal, 3,7-dimethyl-, (2e)- )\u003c\/p\u003e \u003cp\u003ePreparation of 3-Oxocyclohex-1-ene-1-carbonitrile\u003c\/p\u003e \u003cp\u003eAir Oxidation of Primary Alcohols Catalyzed by Copper(I)\/TEMPO. Preparation of 2-Amino-5-bromo-benzaldehyde\u003c\/p\u003e \u003cp\u003eOne-Pot Preparation of Cyclic Amines from Amino Alcohols\u003c\/p\u003e \u003cp\u003ePreparation of Tetrabutylammonium (4-fluorophenyl)trifluoroborate\u003c\/p\u003e \u003cp\u003eAllyl Cyanate-To-Isocyanate Rearrangement: Preparation of tert-Butyl 3,7-Dimethylocta-1,6-dien-3-ylcarbamate\u003c\/p\u003e \u003cp\u003ePalladium-Catalyzed Triazolopyridine Synthesis: Synthesis of 7-Chloro-3-(2-Chlorophenyl)-1,2,4-Triazolo[4,3-a]Pyridine\u003c\/p\u003e \u003cp\u003ePreparation of DABSO from Karl-Fischer Reagent\u003c\/p\u003e \u003cp\u003eLow-epimerization Peptide Bond Formation with Oxyma Pure: Preparation of Z-L-Phg-Val-OMe\u003c\/p\u003e \u003cp\u003ePractical Synthesis of Di-tert-Butyl-Phosphinoferrocene\u003c\/p\u003e \u003cp\u003ePreparation of 1-Benzyl-2-methyl-3-(ethoxycarbonyl)-4- (2-phenylethyl)-1H-pyrrole from 4-Phenyl-1,2-butadiene\u003c\/p\u003e \u003cp\u003eSynthesis of Highly Enantiomerically Enriched Amines by Asymmetric Transfer Hydrogenation of N-(tert-Butylsulfinyl)Imines\u003c\/p\u003e \u003cp\u003eSimplified Preparation of Dimethyldioxirane (DMDO)\u003c\/p\u003e \u003cp\u003ePractical and Efficient Synthesis of N-Formylbenzotriazole\u003c\/p\u003e  \u003cp\u003e\u003cstrong\u003eDavid Hughes\u003c\/strong\u003e obtained his Ph.D. in physical organic chemistry under the direction of Professor Fred Bordwell at Northwestern University in 1981. After post-doctoral work in the laboratory of Professor Ned Arnett at Duke University, he joined the Process Research department of Merck Research Laboratories in 1982 and currently holds the position of Executive Director, Scientific Staff. His area of expertise is physical organic chemistry with a focus on elucidation of mechanisms of synthetically important organic reactions. In the mid-1990's, the Hughes group took on the challenge of developing a viable synthesis of a semi-synthetic pneumocandin antifungal candidate that was entering development at that time. This development candidate progressed through many hurdles and was ultimately approved under the trademark CANCIDAS in 2001. Along with his colleagues Robert Schwartz and Jim Balkovec, Dave was awarded the 2006 ACS Heroes of Chemistry Award for this work. Other Merck drugs that Dave has been instrumental in process design and development include Primaxin, Emend, and Cozaar. Dave has co-authored over 100 papers and has been a member of the editorial board for \u003cem\u003eOrganic Synthesis\u003c\/em\u003e since 2008.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989734047973,"sku":"NP9781118893845","price":115.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118893845.jpg?v=1761785293","url":"https:\/\/k12savings.com\/products\/organic-syntheses-volume-90-isbn-9781118893845","provider":"K12savings","version":"1.0","type":"link"}