{"product_id":"organic-syntheses-volume-88-isbn-9781118173978","title":"Organic Syntheses, Volume 88","description":"The current volume continues the tradition of the Organic Synthesis series, providing carefully checked and edited experimental procedures that describe important synthetic methods, transformations, reagents, and synthetic building blocks or intermediates with demonstrated utility in organic synthesis. These significant and interesting procedures should prove worthwhile to many synthetic chemists working in increasingly diverse areas. A trusted guide for professionals in organic and medicinal chemistry in academia, government, and industries, including phar-maceuticals, fine chemicals, agrochemicals, and biotech.  Editorial: Organic Syntheses: The “Gold Standard” for Experimental Synthetic Organic Chemistry 1\u003cbr\u003e \u003ci\u003eRick L. Danheiser\u003c\/i\u003e  \u003cp\u003eα-Arylation of Esters Catalyzed by the Pd(I) Dimer [P(t-Bu)\u003csub\u003e3\u003c\/sub\u003ePd(µ-Br)] 4\u003cbr\u003e \u003ci\u003eDavid S. Huang, Ryan J. DeLuca, and John F. Hartwig\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eThe Preparation of Amides by Copper-medicated Oxidative Coupling of Aldehydes and Amine Hydrochloride Salts 14\u003cbr\u003e \u003ci\u003eMaxime Giguère-Bisson, Woo-Jin Yoo, and Chao-Jun Li\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSynthesis of 2-Aryl Pyridines by Palladium-Catalyzed Direct Arylation of Pyridine N-Oxides 22\u003cbr\u003e \u003ci\u003eLouis-Charles Campeau and Keith Fagnou\u003c\/i\u003e\u003cbr\u003e \u003cbr\u003e \u003c\/p\u003e \u003cp\u003eThe Preparation of Indazoles via Metal Free Intramolecular Electrophilic Animation of 2-Aminophenyl  Ketoximes 33\u003cbr\u003e \u003ci\u003eCarla M. Councellar, Chad C. Eichman, Brenda C. Wray, Eric R. Welin, and James P. Stambuli\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eThe Preparation of (2R,5S)-2-t-Butyl-3,5-Dimethylimidazolidin-4-One 42\u003cbr\u003e \u003ci\u003eThomas H. Graham, Benjamin D. Horning, and David W. C. MacMillan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSynthesis of Et\u003csub\u003e2\u003c\/sub\u003eSB•SbCl\u003csub\u003e5\u003c\/sub\u003eBr and Its Use in Biomimetic Brominative Polyene Cyclizations 54\u003cbr\u003e \u003ci\u003eScott A. Snyder and Daniel S. Treitler\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eDiscussion Addendum for: Asymmetric Synthesis of (M)-2- Hydroxymethyl-1-(2-Hydroxy-3,6-Dimethylphenyl)Naphthalene via a Configurationally Unstable Biaryl Lactone 70\u003cbr\u003e \u003ci\u003eG. Bringmann, T. A. M. Gulder, and T. Gulder\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSynthesis of Lithium 2-Pyridyltriolborate and Its Cross-Coupling Reaction with Aryl Halides 79\u003cbr\u003e \u003ci\u003eYasunori Yamamoto, Juugaku Sigai, Miho Takizawa, and Norio Miyaura\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSynthesis of (+)-B-Allyldiisopinocampheylborane and It Reaction with Aldehydes 87\u003cbr\u003e \u003ci\u003eHuikai Sun and William R. Roush\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eDiscussion Addendum for: Palladium-Catalyzed Cross-Coupling of (Z)-1-Heptenyldimethylsilanol with 4-Iodoanisole: (Z)-(1-Heptenyl)-4-Methoxybenzene 102\u003cbr\u003e \u003ci\u003eScott E. Denmark and Jack Hung-Chang Liu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eThe Preparation of Cyclohept-4-Enones by Rhodium-Catalyzed Intermolecular [5+2] Cycloaddition 109\u003cbr\u003e \u003ci\u003ePaul A. Wender, Adam B. Lesser, and Lauren E. Sirois\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eOrganocatalytic Enantioselective Synthesis of Bicyclic ß-Lactones from Aldehyde Acids via Nucleophile-Catalyzed Aldol-Lactonization (NCAL) 121\u003cbr\u003e \u003ci\u003eHenry Nguyen, Seongho Oh, Huda Henry-Riyad, Diana Sepulveda, and Daniel Romo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003ePhosphine-Catalyzed [3 + 2) Annulation: Synthesis of Ethyl 5-(tert-Butyl)-2-Phenyl-1-Tosyl-3-Pyrroline-3-Carboxylate 138\u003cbr\u003e \u003ci\u003eIan P. Andrews and Ohyun Kwon\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003ePreparation of Horner-Wadsworth-Emmons Reagent: Methyl 2-Benzyloxycarbonylamino-2-(Dimethoxy-Phosphinyl)Acetate 152\u003cbr\u003e \u003ci\u003eHiroki Azuma, Kentaro Okano, Tohru Fukuyama, and Hidetoshi Tokuyama\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eDiscussion Addendum for: 5-ENDO-TRIG Cyclization of 1,1-Difluoro-1-Alkenes: Synthesis of 3-Butyl-2-Fluoro-1-Tosylindole (1H-Indole, 3-Butyl-2-Fluoro-1-[(4-Methylphenyl)Sulfonyl-) 162\u003cbr\u003e \u003ci\u003eJunji Ichikawa\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003ePreparation of a Thrifluoromethyl Transfer Agent: 1-Trifloromethyl-1,3-Dihydro-3,3-Dimenthyl-1,2-Benziodoxole 168\u003cbr\u003e \u003ci\u003ePatrick Eisenberger, Iris Kieltsch, Raffael Koller, Kyrill Stanek, and Antonio Tongni\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSynthesis of (S,S)-Diisopropyl Tartrate (E)-Crothylboronate and Its Reaction with Aldehydes: (2R,3R,4R)-1,2-Dideoxy-2-Ethenyl-4,5,-O-(1-Methylethylidene)-Xylitol 181\u003cbr\u003e \u003ci\u003eHuikai Sun and William R. Roush\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eDiscussion Addendum for: 4-Methoxy-4’-Nitrophenyl. Recent Advances in the Stille Biaryl Coupling Reaction and Applications in Complex Natural Products Synthesis 197\u003cbr\u003e \u003ci\u003eRobert M. Williams\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eDiscussion Addendum for: Palladium-Catalyzed Reaction of 1-Alkenylboronates with Vinylic Halides: (1Z,3E)-1-Phenyl-1,3-Octadiene 202\u003cbr\u003e \u003ci\u003eNorio Miyaura\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eDiscussion Addendum for: Palladium (0)-Catalyzed Reaction of 9-Alkyl-9-Borabicyclo[3.3.1]Nonane with 1-Bromo-1-Phenylthioethene: 4-(3-Cyclohexenyl )-2-Phenylthio-1-1-Butene  207\u003cbr\u003e \u003ci\u003eNorio Miyaura\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003ePreparation of Isopropyl 2-Diazoacetyl(Phenyl)Carbamate 212\u003cbr\u003e \u003ci\u003eHubert Muchalski, Amanda B. Doody, Timothy L. Troyer, and Jeffrey N. Johnson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eGram Scale Catalytic Asymmetric Aziridination: Preparation of (2R,3R)-Ethyl 1-Benzhydryl-3-(4-Bromopheneyl)Aziridine 2-Carboxylate 224\u003cbr\u003e \u003ci\u003eAman A. Desai, Roberto Morán-Ramallal, and William D. Wulff\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eCu-Catalyzed Azide-Alkyne Cycloaddition: Preparation of Tris((1-Benzyl-1H-1,2,3-Triazolyl )Methyl)Amine 238\u003cbr\u003e \u003ci\u003eJason E. Hein, Larissa B. Krasnova, Masayuki Iwasaki, and Valery V. Fokin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eLithiated Primary Alkyl Carbamates for the Homologation of Boronic Esters\u003cbr\u003e \u003ci\u003eMatthew P. Webster, Benjamin M. Partridge, and Varinder K. Aggarwal\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eDiscussion Addendum for: Palladium-Catalyzed Reduction of Vinyl Trifluoromethanesulfonates to Alkenes: Cholesta-3,5-Diene 260\u003cbr\u003e \u003ci\u003eSandro Cacchi, Enrico Morera, and Giorgio Ortar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eDiscussion Addendum for: Synthesis of Indoles by Palladium-Catalyzed Reductive N-Heteroannulation of 2-Nitrostyrenes: Methyl Indole-4-Carboxylate 291\u003cbr\u003e \u003ci\u003eBjörn C. Söderberg\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eAn Economical Synthesis of 4-Trimethysilyl-2-Butyn-1-OL 296\u003cbr\u003e \u003ci\u003eAlexander N. Wein, Rongbiao Tong, and Frank E. McDonald\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSilver-Catalyzed Rearrangement of Propargylic Sulfinates: Synthesis of Allengic Sulfones 309\u003cbr\u003e \u003ci\u003eMichael Harmata, Zhengxin Cai and Chaofeng Huang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e (Sa,S)-N-[2’-(Methylphenylsulfonamido)-1-1’-Binaphthyl-2-YL]Pyrrolidine-2-Carboxamide: An Organocatalyst for the Direct Aldol Reaction 317\u003cbr\u003e \u003ci\u003eSantiago F. Viózquez, Gabriela Guillene, Carmen Nájera, Ben Bradshaw, Gorka Etxebarria-Jardi, and Josep Bonjoch\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSynthesis of (S)-8a-Methyl-3,4,8,8a-Tetrahydro-1,6-(2H,7H)-Naphthalenedione via N-Tosyl-(S\u003csub\u003ea\u003c\/sub\u003e)-Binam-L-Pholinamide Organocatalysis 330\u003cbr\u003e \u003ci\u003eBen Bradshaw, Gorka Etxebarria-Jardi, Josep Bonjoch, Santiago F. Viózquez, Gabriela Guillena, and Carmen Nájera\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eStereoselective Nickel-Catalyzed 1,4-Hydroboration of 1,3-Dienes 342\u003cbr\u003e \u003ci\u003eRobert J. Ely and James P. Morken\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eTandem Nucleophilic Addition\/Fragmentation of Vinylogous Acyl Triflates: 2-Methyl-2-(1-Oxo-5-Heptynyl)-1-3-Dithiane 353\u003cbr\u003e \u003ci\u003eMarilda P. Lisboa, Tunf T. Hoang, and Gregory B. Dudley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSynthesis and Diasteroselective Aldol Reactions of a Thiazolidinethione Chiral Auxiliary 364\u003cbr\u003e \u003ci\u003eMichael T. Crimmins, Hamish S. Christie, and Colin O. Hughes\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eSynthesis of 2,3-Disubstituted Indoles via Palladium-Catalyzed Annulation of Internal Alkynes: 3-Methyl-2-(Trimethylsilyl)Indole 377\u003cbr\u003e \u003ci\u003eYu Chen, Nataliya A. Markina, Tuanli Yao, and Richard C. Larock\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eAn Intramolecular Amination of Aryyl Halides with a Combination of Copper (I) and Cesium Acetate: Preparation of 5,6-Dimethoxyindole-1,2-Dicarboxylic Acid 1-Benzyl Ester 2-Methyl Ester 388\u003cbr\u003e \u003ci\u003eToshiharu Noji, Kentaro Okano, Tohru Fukuyama, and Hidetoshi Tokuyama\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eLigand-Free Copper(II) Oxide Nanoparticles-Catalyzed Synthesis of Substituted Benzoxazoles 398\u003cbr\u003e \u003ci\u003ePrasenjit Saha, Md Ashif Ali, and Tharmalingam Punniyamurthy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e (R)-3,3’-Bis(9-Phenanthyryl)-1,1’-Binaphthalene-2,2’-Diyl Hydrogen Phosphate 406\u003cbr\u003e \u003ci\u003eWenhao Hu, Jing Zhou, Xinfang Xu, Weijun Liu, and Liuzhu Gong\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eEnantioselective Three-Component Reaction for the Preparation of ß-Amino-a-Hydroxy Esters 418\u003cbr\u003e \u003ci\u003eJing Zhou, Xinfang Xu, and Wenhao Hu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eMild Conversion of Tertiary Amides to Aldehydes Using Cp\u003csub\u003e2\u003c\/sub\u003eZr(H)Cl (Schwartz’s Reagent) 427\u003cbr\u003e \u003ci\u003eMatthew W. Leighty, Jared T. Spletstoser, and Gunda I. Georg\u003c\/i\u003e\u003c\/p\u003e  \u003cp\u003e\u003cstrong\u003eJonathan A. Ellman\u003c\/strong\u003e is Eugene Higgins Professor of Chemistry at Yale University. He received his B.S. in Chemistry from MIT and his PhD in Organic Chemistry from Harvard University. His research efforts are focused on the development of efficient, systematic chemical tools to establish protein function through the design and synthesis of small molecule libraries targeting protein families, methods for the asymmetric synthesis of amines, and the development of synthetic applications of C-H activation.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989733851365,"sku":"NP9781118173978","price":91.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118173978.jpg?v=1761785293","url":"https:\/\/k12savings.com\/products\/organic-syntheses-volume-88-isbn-9781118173978","provider":"K12savings","version":"1.0","type":"link"}