{"product_id":"on-line-lc-nmr-and-related-techniques-isbn-9780471496496","title":"On-line LC-NMR and Related Techniques","description":"This book gives a comprehensive overview of the basis and the current applications of LC-NMR and related techniques. It deals with the practical aspects of the hardware and software set-up for a successful performance of on-line coupling experiments. It covers the solution of real-word problems from the fields of biomedical, pharmaceutical and environmental studies as well as the analysis of natural products and polymeric compounds. Thus guidelines for an efficient application of the powerful hyphenated technique LC-NMR in combination with LC-MS are presented. Besides LC-NMR, important techniques such as the on-line coupling of gel permeation chromatography and supercritical fluid chromatography, together with 1H NMR spectroscopy, are described in detail.\u003cbr\u003e Fascinating further aspects, such as the application of capillary separation techniques either in the single or parallel detection mode, together with the possibilities of direct 13C monitoring of chromatographic events, are also discussed.\u003cbr\u003e Key features include:\u003cbr\u003e * Up-to-date information on the theoretical and experimental methodology\u003cbr\u003e * Coverage of applications in biomedical, pharmaceutical and natural product analysis, as well as environmental polymer and related hyphenated techniques\u003cbr\u003e * Information appropriate for researchers in organic, pharmaceutical and medical chemistry\u003cbr\u003e Overall, this book is a requirement for all researchers and staff members dealing with structure elucidation problems in separation science.Die Kopplung der NMR mit Stofftrennverfahren, insbesondere chromatographischen Methoden, gehört inzwischen zu den wichtigsten Ansätzen der analytischen Chemie. Dieser experimentell orientierte Band, verfaßt von Herstellern von LC-NMR-Ausrüstung, macht Sie mit dem modernsten Stand der Technik und ihrer Anwendung auf spezielle Probleme vertraut. Contributors.\u003cbr\u003e \u003cbr\u003e Preface.\u003cbr\u003e \u003cbr\u003e 1. LC-NMR: Theory and Experiment (Klaus Albert).\u003cbr\u003e \u003cbr\u003e 1.1 Introduction.\u003cbr\u003e \u003cbr\u003e 1.2 NMR in a Flowing Liquid.\u003cbr\u003e \u003cbr\u003e 1.3 Design of Continuous-Flow NMR Probes.\u003cbr\u003e \u003cbr\u003e 1.4 Experimental Arrangement for HPLC-1H NMR Coupling.\u003cbr\u003e \u003cbr\u003e 1.5 Practical Considerations, Solvent Suppression Techniques, Gradient Elution and Purity of HPLC Solvent.\u003cbr\u003e \u003cbr\u003e References.\u003cbr\u003e \u003cbr\u003e 2. LC-NMR: Automation (Ulrich Braumann and Manfred Spraul).\u003cbr\u003e \u003cbr\u003e 2.1 Practical Use of LC-NMR and LC-NMR\/MS.\u003cbr\u003e \u003cbr\u003e 2.2 Different Working Modes in LC-NMR.\u003cbr\u003e \u003cbr\u003e 2.3 Use of Mass Spectrometry in the Set-Up.\u003cbr\u003e \u003cbr\u003e 2.4 Measurement Procedures.\u003cbr\u003e \u003cbr\u003e 2.5 Conclusions.\u003cbr\u003e \u003cbr\u003e References.\u003cbr\u003e \u003cbr\u003e 3. Biomedical and Pharmaceutical Applications of HPLC-NMR and HPLC-NMR-MS (John C. Lindon, Jeremy K. Nicholson and Ian D. Wilson).\u003cbr\u003e \u003cbr\u003e 3.1 Introduction.\u003cbr\u003e \u003cbr\u003e 3.2 Technical and Operational Overview.\u003cbr\u003e \u003cbr\u003e 3.3 Applications in Combinatorial Chemistry.\u003cbr\u003e \u003cbr\u003e 3.4 Application to Chemical Impurities.\u003cbr\u003e \u003cbr\u003e 3.5 Application to Chiral Separations of Pharmaceutical Mixtures.\u003cbr\u003e \u003cbr\u003e 3.6 Application to Natural Products.\u003cbr\u003e \u003cbr\u003e 3.7 Application to Chemical Reactivity of Drug Glucuronides.\u003cbr\u003e \u003cbr\u003e 3.8 Application to Futile Deacetylation Reactions.\u003cbr\u003e \u003cbr\u003e 3.9 Application to Trapping of Reactive Intermediates.\u003cbr\u003e \u003cbr\u003e 3.10 Application to Uptake and Transformation of Xenobiotics by Plants.\u003cbr\u003e \u003cbr\u003e 3.11 Separation of Lipoproteins and their Characterisation using HPLC-NMR.\u003cbr\u003e \u003cbr\u003e 3.12 Superheated-Water HPLC-NMR and HPLC-NMR-MS Studies on Pharmaceuticals.\u003cbr\u003e \u003cbr\u003e 3.13 Application of Hypernation to a Mixture of Non-Steroidal Anti-Inflammatory Drugs.\u003cbr\u003e \u003cbr\u003e 3.14 Concluding Remarks.\u003cbr\u003e \u003cbr\u003e References.\u003cbr\u003e \u003cbr\u003e 4. Application of On-Line LC-NMR and Related Techniques to Drug Metabolism Studies (John P. Shockcor).\u003cbr\u003e \u003cbr\u003e 4.1 Introduction.\u003cbr\u003e \u003cbr\u003e 4.2 LC-NMR Techniques.\u003cbr\u003e \u003cbr\u003e 4.3 Application of LC-NMR-MS to Drug Metabolism: The Structure Elucidation of Rat Urinary Metabolites of Efavirenz by LC-NMR-MS.\u003cbr\u003e \u003cbr\u003e References.\u003cbr\u003e \u003cbr\u003e 5. LC-NMR for Natural Products Analysis.\u003cbr\u003e \u003cbr\u003e 5.1 Application of LC-NMR and LC-NMR-MS Hyphenation to Natural Products Analysis (Martin Sandvoss).\u003cbr\u003e \u003cbr\u003e References.\u003cbr\u003e \u003cbr\u003e 5.2 Hyphenation of Modern Extraction Techniques to LC-NMR for the Analysis of Geometrical Carotenoid Isomers in Functional Food and Biological Tissues (Tobias Glaser and Klaus Albert).\u003cbr\u003e \u003cbr\u003e References.\u003cbr\u003e \u003cbr\u003e 6. LC-NMR in Environmental Analysis (Alfred Preiss and Markus Godejohann).\u003cbr\u003e \u003cbr\u003e 6.1 Introduction.\u003cbr\u003e \u003cbr\u003e 6.2 Target and Non-Target Analysis.\u003cbr\u003e \u003cbr\u003e 6.3 LC-NMR Coupling in Non-Target Analysis.\u003cbr\u003e \u003cbr\u003e 6.4 Application of LC-NMR and LC-NMR in Combination with LC-MS to Environmental Samples.\u003cbr\u003e \u003cbr\u003e 6.5 Simulation of Environmental Processes.\u003cbr\u003e \u003cbr\u003e 6.6 Conclusions.\u003cbr\u003e \u003cbr\u003e References.\u003cbr\u003e \u003cbr\u003e 7. Related Techniques -\u003cbr\u003e Introduction.\u003cbr\u003e \u003cbr\u003e 7.1 GPC-NMR Coupling (Heidrun Händel and Klaus Albert).\u003cbr\u003e \u003cbr\u003e References.\u003cbr\u003e \u003cbr\u003e 7.2 SFC-NMR and SFE-NMR (Holger Fischer and Klaus Albert).\u003cbr\u003e \u003cbr\u003e 7.3 Nanoliter NMR.\u003cbr\u003e \u003cbr\u003e 8. Future Developments -\u003cbr\u003e Introduction\u003cbr\u003e \u003cbr\u003e 8.1 HPLC-13C NMR (Klaus Albert).\u003cbr\u003e \u003cbr\u003e 8.2 Parallel NMR Detection (Andrew G. Webb, Jonathan V. Sweedler and Daniel Raftery).\u003cbr\u003e \u003cbr\u003e Concluding Remarks (Klaus Albert).\u003cbr\u003e \u003cbr\u003e Index.  \"...It is a useful book...\" (Organic Process Research \u0026amp; Development)  \u003cp\u003e\"...this is a stimulating book, written by experts in the field, with a state-of-the-art presentation ...\" (Chromatographia, May 2003)\u003c\/p\u003e \u003cp\u003e\"...the best compilation of LC-NMR knowledge and related techniques to date and therefore is a must for anyone who wants to use this methodology to solve everyday analytical problems.\" (\u003ci\u003eJournal of the American Chemical Society\u003c\/i\u003e, Vol. 125, No. 21, 2003)\u003c\/p\u003e \u003cp\u003e\"...this fascinating book is an invaluable reference source for researchers...\" (\u003ci\u003eAngewandte Chemie, International Edition\u003c\/i\u003e, Vol. 42)\u003c\/p\u003e \u003cp\u003e\"...an invaluable reference source for researchers...gives a comprehensive overview of the basis and the current applications...\" (Angewandte Chemie, 2003)\u003c\/p\u003e \u003cp\u003e\"...a stimulating book, written by experts in the field...an indispensable tool in bio-related research...\" (Chromatographia, 2003)\u003c\/p\u003e \u003cp\u003e\"…well written and informative…\" (Anal. Bioanal. Chem. 2004;379)\u003c\/p\u003e \u003cp\u003e\u003cb\u003eKlaus Albert\u003c\/b\u003e is the editor of \u003ci\u003eOn-line LC-NMR and Related Techniques\u003c\/i\u003e, published by Wiley.\u003c\/p\u003e \u003cp\u003eThis book gives a comprehensive overview of the basis and the current applications of LC-NMR and related techniques. It deals with the practical aspects of the hardware and software set-up for a successful performance of on-line coupling experiments. It covers the solution of real-word problems from the fields of biomedical, pharmaceutical and environmental studies as well as the analysis of natural products and polymeric compounds. Thus guidelines for an efficient application of the powerful hyphenated technique LC-NMR in combination with LC-MS are presented. Besides LC-NMR, important techniques such as the on-line coupling of gel permeation chromatography and supercritical fluid chromatography, together with 1H NMR spectroscopy, are described in detail.\u003c\/p\u003e \u003cp\u003eFascinating further aspects, such as the application of capillary separation techniques either in the single or parallel detection mode, together with the possibilities of direct 13C monitoring of chromatographic events, are also discussed.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eKey features include:\u003c\/b\u003e\u003c\/p\u003e \u003cul\u003e \u003cli\u003eUp-to-date information on the theoretical and experimental methodology\u003c\/li\u003e \u003cli\u003eCoverage of applications in biomedical, pharmaceutical and natural product analysis, as well as environmental polymer and related hyphenated techniques\u003c\/li\u003e \u003cli\u003eInformation appropriate for researchers in organic, pharmaceutical and medical chemistry\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eOverall, this book is a requirement for all researchers and staff members dealing with structure elucidation problems in separation science.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989713109221,"sku":"NP9780471496496","price":287.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780471496496.jpg?v=1761785212","url":"https:\/\/k12savings.com\/products\/on-line-lc-nmr-and-related-techniques-isbn-9780471496496","provider":"K12savings","version":"1.0","type":"link"}