{"product_id":"nutraceuticals-and-natural-product-derivatives-isbn-9781119436676","title":"Nutraceuticals and Natural Product Derivatives","description":"\u003cp\u003e\u003cb\u003eIntroduces readers to the growing applications of nutraceuticals and other natural product derivatives\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThis comprehensive book presents a prophylactic and therapeutic approach to chronic disease prevention strategy by highlighting the translational potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies. It also shares the experiences of highly reputed experts working in the area of phytomedicine and nutraceutical agents in chemoprevention, to promote the significance of natural products and dietary factors as an elite priority for containing chronic diseases in the human population.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eNutraceuticals and Natural Product Derivatives: Disease Prevention \u0026amp; Drug Discovery\u003c\/i\u003e starts by examining natural food sources for the control of glycemia and the prevention of diabetic complications. It then looks at the anti-aging effects of sulfur-containing amino acids and nutraceuticals, and the potential of garcinia fruits to combat metabolic syndrome. Other topics covered include honey- and propolis-mediated regulation of protein networks in cancer cells; recent trends in drug discovery against Alzheimer’s disease; the therapeutic potential of metalloherbal nanoceuticals; and much more.\u003c\/p\u003e \u003cul\u003e \u003cli\u003eOffers an alternative, natural approach to the prevention of chronic diseases\u003c\/li\u003e \u003cli\u003eEmphasizes the potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies\u003c\/li\u003e \u003cli\u003eFeatures contributions from world-renowned experts in the field of phytomedicine and nutraceutical agents in chemoprevention\u003c\/li\u003e \u003cli\u003eIncludes prevention strategies in normal\/risk populations through routine inclusion of specific dietary regimens and as therapeutic strategy for better management through adjuvant interventions with conventional treatment protocols\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eNutraceuticals and Natural Product Derivatives: Disease Prevention \u0026amp; Drug Discovery\u003c\/i\u003e will appeal to graduate students and professionals in cell and molecular biology, translational research, pharmacology\/drug discovery, medicinal chemistry, and clinical nutrition.\u003c\/p\u003e \u003cp\u003eList of Contributors xvii\u003c\/p\u003e \u003cp\u003eForeword xxi\u003c\/p\u003e \u003cp\u003ePreface xxv\u003c\/p\u003e \u003cp\u003eBooks Description xxix\u003c\/p\u003e \u003cp\u003eExpert Commentary xxxi\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Natural Food Sources for the Control of Glycemia and the Prevention of Diabetic Complications 1\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eCarlo Pesce, Carla Iacobini, and Stefano Menini\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction: Obesity, Metabolic Syndrome, and Type 2 Diabetes Epidemics: The Role of Nutrition 1\u003c\/p\u003e \u003cp\u003e1.2 Phytochemicals of Nutraceutical Importance and Functional Foods of Plant Origin 3\u003c\/p\u003e \u003cp\u003e1.2.1 Dietary Oils 3\u003c\/p\u003e \u003cp\u003e1.2.2 Vegetables and Fruits 4\u003c\/p\u003e \u003cp\u003e1.3 Nutraceuticals and Functional Foods of Animal Origin 8\u003c\/p\u003e \u003cp\u003e1.3.1 The Case of Carnosine 8\u003c\/p\u003e \u003cp\u003e1.4 Nutraceuticals of Both Plant and Animal Origin 9\u003c\/p\u003e \u003cp\u003e1.5 Probiotics, Prebiotics, and Symbiotics 12\u003c\/p\u003e \u003cp\u003e1.6 Conclusion 15\u003c\/p\u003e \u003cp\u003eReferences 17\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Anti‐Aging Effects of Sulfur‐Containing Amino Acids and Nutraceuticals 25\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eGeetika Garg, Abhishek Kumar Singh, Sandeep Singh, and Syed Ibrahim Rizvi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Aging and Nutrition 25\u003c\/p\u003e \u003cp\u003e2.2 Natural Antioxidants 26\u003c\/p\u003e \u003cp\u003e2.2.1 Sulfur‐Containing Amino Acids and Their Role as Antioxidants 26\u003c\/p\u003e \u003cp\u003e2.2.2 Anti‐Aging Effects of L‐Cysteine 27\u003c\/p\u003e \u003cp\u003e2.3 N‐Acetyl‐L‐Cysteine 28\u003c\/p\u003e \u003cp\u003e2.3.1 Neuroprotective Effects of N‐Acetyl‐L‐Cysteine 29\u003c\/p\u003e \u003cp\u003e2.3.2 N‐Acetyl‐L‐Cysteine in Combination with Other Antioxidants 29\u003c\/p\u003e \u003cp\u003e2.4 Methionine 30\u003c\/p\u003e \u003cp\u003e2.4.1 Methionine Restriction 30\u003c\/p\u003e \u003cp\u003e2.5 Sulfur‐Containing Nutraceuticals and Foods Rich in Sulfur‐Containing Amino Acids 31\u003c\/p\u003e \u003cp\u003e2.5.1 Whey Protein 32\u003c\/p\u003e \u003cp\u003e2.5.2 Anti‐Aging Effects of Whey Protein 32\u003c\/p\u003e \u003cp\u003e2.6 Conclusion 33\u003c\/p\u003e \u003cp\u003eAcknowledgments 33\u003c\/p\u003e \u003cp\u003eConflict of Interest 33\u003c\/p\u003e \u003cp\u003eReferences 33\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Garcinia Fruits: Their Potential to Combat Metabolic Syndrome 39\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eOliver John, Lindsay Brown, and Sunil K. Panchal\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 39\u003c\/p\u003e \u003cp\u003e3.2 Overview of Compounds in Garcinia Species 40\u003c\/p\u003e \u003cp\u003e3.2.1 Garcinia mangostana 44\u003c\/p\u003e \u003cp\u003e3.2.1.1 Chemical Properties 51\u003c\/p\u003e \u003cp\u003e3.2.1.2 Biological Activities of G. mangostana 51\u003c\/p\u003e \u003cp\u003e3.2.1.3 Toxicity 55\u003c\/p\u003e \u003cp\u003e3.2.2 Garcinia cambogia 56\u003c\/p\u003e \u003cp\u003e3.2.2.1 Chemical Properties 56\u003c\/p\u003e \u003cp\u003e3.2.2.2 Biological Activities 57\u003c\/p\u003e \u003cp\u003e3.2.2.3 Toxicity 59\u003c\/p\u003e \u003cp\u003e3.2.2.4 Future Research 59\u003c\/p\u003e \u003cp\u003e3.2.3 Garcinia humilis 59\u003c\/p\u003e \u003cp\u003e3.2.3.1 Chemical Properties 59\u003c\/p\u003e \u003cp\u003e3.2.3.2 Biological Activities 60\u003c\/p\u003e \u003cp\u003e3.2.4 Garcinia dulcis 61\u003c\/p\u003e \u003cp\u003e3.2.4.1 Chemical Properties 61\u003c\/p\u003e \u003cp\u003e3.2.4.2 Biological Properties 61\u003c\/p\u003e \u003cp\u003e3.2.4.3 Potential Research 62\u003c\/p\u003e \u003cp\u003e3.3 Limitations 62\u003c\/p\u003e \u003cp\u003e3.4 Conclusion 64\u003c\/p\u003e \u003cp\u003eReferences 64\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Pro‐Angiogenic and Anti‐Angiogenic Effects of Small Molecules from Natural Products 81\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eJingyi Ma and Xuelin Zhou\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Biological mechanisms of Angiogenesis 81\u003c\/p\u003e \u003cp\u003e4.2 Pharmacological Models for Angiogenesis Study 82\u003c\/p\u003e \u003cp\u003e4.3 Pro‐Angiogenic Effects of Small Molecules from Natural Products 83\u003c\/p\u003e \u003cp\u003e4.3.1 Natural Products as Sources for Screening Pro‐Angiogenic Stimulators 83\u003c\/p\u003e \u003cp\u003e4.3.2 Flavonoids 84\u003c\/p\u003e \u003cp\u003e4.3.3 Saponins 84\u003c\/p\u003e \u003cp\u003e4.3.4 Salvianolic Acids 85\u003c\/p\u003e \u003cp\u003e4.3.5 Other Small Molecules 85\u003c\/p\u003e \u003cp\u003e4.3.5.1 Ferulic Acid 85\u003c\/p\u003e \u003cp\u003e4.3.5.2 Aloe vera–Derived Compounds 85\u003c\/p\u003e \u003cp\u003e4.3.6 Summary 86\u003c\/p\u003e \u003cp\u003e4.4 Anti‐Angiogenic Effects of Small Molecules from Natural Products 86\u003c\/p\u003e \u003cp\u003e4.4.1 Natural Products as Sources for Screening Angiogenic Inhibitors 87\u003c\/p\u003e \u003cp\u003e4.4.2 Flavonoids 87\u003c\/p\u003e \u003cp\u003e4.4.3 Diterpenoids 89\u003c\/p\u003e \u003cp\u003e4.4.4 Polyphenol 90\u003c\/p\u003e \u003cp\u003e4.4.5 Saponins 92\u003c\/p\u003e \u003cp\u003e4.4.6 Alkaloids 93\u003c\/p\u003e \u003cp\u003e4.4.7 Chalcone 93\u003c\/p\u003e \u003cp\u003e4.4.8 Anthraquinone 93\u003c\/p\u003e \u003cp\u003e4.4.9 Carotenoids 94\u003c\/p\u003e \u003cp\u003e4.4.10 Other Small Molecules 94\u003c\/p\u003e \u003cp\u003e4.4.10.1 Cucurbitacin B 94\u003c\/p\u003e \u003cp\u003e4.4.10.2 Honokiol 95\u003c\/p\u003e \u003cp\u003e4.4.10.3 Shikonin 95\u003c\/p\u003e \u003cp\u003e4.4.10.4 Hyperforin 95\u003c\/p\u003e \u003cp\u003e4.4.10.5 Glyceollins 95\u003c\/p\u003e \u003cp\u003e4.4.10.6 Sulforaphane 99\u003c\/p\u003e \u003cp\u003e4.4.11 Summary 99\u003c\/p\u003e \u003cp\u003e4.5 Conclusion 99\u003c\/p\u003e \u003cp\u003eAcknowledgment 99\u003c\/p\u003e \u003cp\u003eConflict of Interest 99\u003c\/p\u003e \u003cp\u003eReferences 100\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Nutraceuticals and Natural Product Derivatives in the Premises of Disease Prevention 111\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMohammad Fahad Ullah, Showket Hussain Bhat, and Faisel M. Abu‐Duhier\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction: How Significant Is the Role of Natural Molecules in Disease Prevention? 111\u003c\/p\u003e \u003cp\u003e5.2 Natural Products in Cancer Chemoprevention 113\u003c\/p\u003e \u003cp\u003e5.3 Natural Products in the Management of Diabetes 117\u003c\/p\u003e \u003cp\u003e5.4 Natural Products as Therapeutic Agents against Gout Disease 122\u003c\/p\u003e \u003cp\u003e5.5 Herbal Derivatives in Prevention of Alzheimer’s Disease 124\u003c\/p\u003e \u003cp\u003e5.6 Conclusion 127\u003c\/p\u003e \u003cp\u003eAcknowledgments 127\u003c\/p\u003e \u003cp\u003eReferences 127\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Honey\u003c\/b\u003e\u003cb\u003e‑ and Propolis\u003c\/b\u003e\u003cb\u003e‐Mediated Regulation of Protein Networks in Cancer Cells 137\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAmmad Ahmad Farooqi, Mirna Azalea Romero, Aliye Aras,Muhammad Zahid Qureshi, and Lara Hanna Wakim\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 137\u003c\/p\u003e \u003cp\u003e6.2 Honey‐Mediated Targeting of Signal Transducer and Activator of Transcription (STAT) Proteins 138\u003c\/p\u003e \u003cp\u003e6.3 Reactive Oxygen Species (ROS) Production in Cancer Cells 138\u003c\/p\u003e \u003cp\u003e6.4 Apoptosis 139\u003c\/p\u003e \u003cp\u003e6.5 Regulation of DNA Damage 139\u003c\/p\u003e \u003cp\u003e6.6 Combinatorial Strategies: It Takes Two to Tango 139\u003c\/p\u003e \u003cp\u003e6.7 Bioactive Propolis Chemicals as Tumor Necrosis Factor (TNF)‐Related Apoptosis‐Inducing Ligand (TRAIL) Sensitizers 141\u003c\/p\u003e \u003cp\u003e6.8 Bioactive Chemicals of Propolis Target Different Proteins of Cell‐Signaling Pathways 142\u003c\/p\u003e \u003cp\u003e6.9 Conclusion 142\u003c\/p\u003e \u003cp\u003eReferences 142\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Antiproliferative Effects and Mechanism of Action of Phytosterols Derived from Bioactive Plant Extracts 145\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eGabriel Lopez‐Garcia, Amparo Alegria, Reyes Barbera, and Antonio Cilla\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 145\u003c\/p\u003e \u003cp\u003e7.2 Mechanisms of the Anticancer Actions of Phytosterols 146\u003c\/p\u003e \u003cp\u003e7.3 Anticancer Effects of Phytosterols 147\u003c\/p\u003e \u003cp\u003e7.3.1 Plant Extracts Containing Phytosterols 148\u003c\/p\u003e \u003cp\u003e7.3.2 Isolated Phytosterols from Plant Extracts 155\u003c\/p\u003e \u003cp\u003e7.4 Conclusions 161\u003c\/p\u003e \u003cp\u003eAcknowledgments 162\u003c\/p\u003e \u003cp\u003eReferences 162\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Yerba Mate (Ilex paraguariensis A. St. Hil.): A Promising Adjuvant in the Treatment of Diabetes, Obesity, and Metabolic Syndrome 167\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eVanesa Gesser Correa, Rubia Carvalho Gomes Correa, Tatiane Francielli Vieira, Adelar Bracht, Rosane Marina Peralta, and Eloa Angelica Koehnlein\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 167\u003c\/p\u003e \u003cp\u003e8.2 Nutritional Composition of Ilex paraguariensis 169\u003c\/p\u003e \u003cp\u003e8.3 Composition in Bioactive Compounds 170\u003c\/p\u003e \u003cp\u003e8.4 Yerba Mate: Research Trends and Main Findings over 20 Years 171\u003c\/p\u003e \u003cp\u003e8.5 Biological Activities of Yerba Mate Related to Diabetes, Obesity,and Metabolic Syndrome 172\u003c\/p\u003e \u003cp\u003e8.5.1 In Vitro Studies 172\u003c\/p\u003e \u003cp\u003e8.5.2 Animal Studies 174\u003c\/p\u003e \u003cp\u003e8.5.3 Clinical Trials 176\u003c\/p\u003e \u003cp\u003e8.6 Summarizing Conclusion and Perspectives 177\u003c\/p\u003e \u003cp\u003eReferences 178\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Role of Natural Antioxidants from Selected Plants Belonging to the Scrophulariaceae and Buddlejaceae Families in the Prevention and Treatment of Neurodegenerative Diseases 183\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eCigdem Kahraman, Zeliha S. Akdemir, and I. Irem Tatli\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 183\u003c\/p\u003e \u003cp\u003e9.2 Natural Antioxidants from Verbascum Species (Mullein) for Their Therapeutic Activities against Neurodegenerative Diseases 188\u003c\/p\u003e \u003cp\u003e9.3 Natural Antioxidants from Scrophularia Species (Figwort) for Their Therapeutic Activities against Neurodegenerative Diseases 200\u003c\/p\u003e \u003cp\u003e9.4 Natural Antioxidants from Buddleja Species (Butterfly Bush) for Their Therapeutic Activities against Neurodegenerative Diseases 209\u003c\/p\u003e \u003cp\u003e9.5 Secondary Metabolites and Their Therapeutic Activities against Neurodegenerative Diseases 221\u003c\/p\u003e \u003cp\u003e9.6 Conclusions 225\u003c\/p\u003e \u003cp\u003eAcknowledgments 226\u003c\/p\u003e \u003cp\u003eReferences 226\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Recent Trends in Drug Discovery against Alzheimer’s Disease: Use of Natural Products and Nutraceuticals from Botanicals 237\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eSudatta Maity, Samapika Nandy, and Abhijit Dey\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 237\u003c\/p\u003e \u003cp\u003e10.2 Symptoms 237\u003c\/p\u003e \u003cp\u003e10.3 Etiopathogenesis 238\u003c\/p\u003e \u003cp\u003e10.4 Conventional Therapy 239\u003c\/p\u003e \u003cp\u003e10.5 Complementary and Alternative Therapies (CATs) for AD 239\u003c\/p\u003e \u003cp\u003e10.6 Research Methodology 240\u003c\/p\u003e \u003cp\u003e10.7 Neuroprotective Biomolecules: Possible Roles against AD Pathogenesis 241\u003c\/p\u003e \u003cp\u003e10.7.1 1‐O‐acetyllycorine 241\u003c\/p\u003e \u003cp\u003e10.7.2 α‐Iso‐cubebenol 245\u003c\/p\u003e \u003cp\u003e10.7.3 α‐Onocerin 245\u003c\/p\u003e \u003cp\u003e10.7.4 Acteoside 256\u003c\/p\u003e \u003cp\u003e10.7.5 Apigenin 256\u003c\/p\u003e \u003cp\u003e10.7.6 β‐Asarone 256\u003c\/p\u003e \u003cp\u003e10.7.7 Baicalein and Baicalin 256\u003c\/p\u003e \u003cp\u003e10.7.8 Bellidin, Bellidifolin, Bellidin 8‐O‐β‐Glucopyranoside and Bellidifolin 8‐O‐β‐Glucopyranoside 256\u003c\/p\u003e \u003cp\u003e10.7.9 Catalpol 257\u003c\/p\u003e \u003cp\u003e10.7.10 Cryptotanshinone 257\u003c\/p\u003e \u003cp\u003e10.7.11 Curcuminoids 257\u003c\/p\u003e \u003cp\u003e10.7.12 Cynatroside B 258\u003c\/p\u003e \u003cp\u003e10.7.13 Galantamine 258\u003c\/p\u003e \u003cp\u003e10.7.14 Genistein 258\u003c\/p\u003e \u003cp\u003e10.7.15 Huperzine A 258\u003c\/p\u003e \u003cp\u003e10.7.16 Icariin 259\u003c\/p\u003e \u003cp\u003e10.7.17 Isorhynchophylline 259\u003c\/p\u003e \u003cp\u003e10.7.18 Luteolin 259\u003c\/p\u003e \u003cp\u003e10.7.19 Melatonin 259\u003c\/p\u003e \u003cp\u003e10.7.20 Naringenin 260\u003c\/p\u003e \u003cp\u003e10.7.21 Piceatannol 260\u003c\/p\u003e \u003cp\u003e10.7.22 p‐coumaric acid 260\u003c\/p\u003e \u003cp\u003e10.7.23 Piperine 260\u003c\/p\u003e \u003cp\u003e10.7.24 Quercetin 261\u003c\/p\u003e \u003cp\u003e10.7.25 Salidroside 261\u003c\/p\u003e \u003cp\u003e10.7.26 Silibinin 261\u003c\/p\u003e \u003cp\u003e10.7.27 Stepharanine, Cyclanoline, and N‐Methyl Stepholidine 262\u003c\/p\u003e \u003cp\u003e10.7.28 Tripchlorolide (T4) 262\u003c\/p\u003e \u003cp\u003e10.7.29 Triptexanthoside C 262\u003c\/p\u003e \u003cp\u003e10.7.30 Ursolic Acid 262\u003c\/p\u003e \u003cp\u003e10.7.31 Xanthoceraside 262\u003c\/p\u003e \u003cp\u003e10.7.32 Xylocoside G 263\u003c\/p\u003e \u003cp\u003e10.7.33 Zeatin 263\u003c\/p\u003e \u003cp\u003e10.7.34 z‐Ligustilide 263\u003c\/p\u003e \u003cp\u003e10.8 Conclusion 263\u003c\/p\u003e \u003cp\u003eAbbreviations 264\u003c\/p\u003e \u003cp\u003eReferences 266\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Therapeutic Potential of Metalloherbal Nanoceuticals: Current Status and Future Perspectives 279\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eShazia Usmani, Muhammad Arif, and Syed Misbah Hasan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Historical Background of Indian Herbal Medicine 279\u003c\/p\u003e \u003cp\u003e11.2 Concept of Herbalism 280\u003c\/p\u003e \u003cp\u003e11.3 Positive Correlation between Phytopharmacology and Phytochemistry: Need of the Hour 280\u003c\/p\u003e \u003cp\u003e11.4 Validation of Herbal Therapeutics: An Indispensable Boon for Ayurveda 281\u003c\/p\u003e \u003cp\u003e11.4.1 Reverse Pharmacology–Based Validation of Herbal Drugs [14] 281\u003c\/p\u003e \u003cp\u003e11.4.2 Amplifying Approaches for Validation of Traditional Medicine 282\u003c\/p\u003e \u003cp\u003e11.4.3 Scientific Integration of Traditional Herbals in Clinical Practice 282\u003c\/p\u003e \u003cp\u003e11.4.3.1 Evidence‐Based Benefits of Herbs 282\u003c\/p\u003e \u003cp\u003e11.4.4 Bhasmas: The Metal‐Based Ayurvedic Medicine 283\u003c\/p\u003e \u003cp\u003e11.4.4.1 Preparation of Bhasmas 283\u003c\/p\u003e \u003cp\u003e11.4.5 Steps Involved in the Preparation of Bhasmas 284\u003c\/p\u003e \u003cp\u003e11.4.5.1 Characterization of Bhasma 285\u003c\/p\u003e \u003cp\u003e11.5 Metals Commonly Employed for Preparation of Bhasmas 286\u003c\/p\u003e \u003cp\u003e11.5.1 Swarna (Gold) 286\u003c\/p\u003e \u003cp\u003e11.5.2 Parada (Mercury) 287\u003c\/p\u003e \u003cp\u003e11.5.2.1 Tamra (Copper) 287\u003c\/p\u003e \u003cp\u003e11.5.2.2 Lauha (Iron) 288\u003c\/p\u003e \u003cp\u003e11.5.2.3 Rajata (Silver) 288\u003c\/p\u003e \u003cp\u003e11.5.2.4 Yashada (Zinc) 289\u003c\/p\u003e \u003cp\u003e11.5.2.5 Naga (Lead) 289\u003c\/p\u003e \u003cp\u003e11.5.2.6 Vanga (Tin) 290\u003c\/p\u003e \u003cp\u003e11.6 Toxicity Aspect: An Issue of Concern in the Use of Herbomineral Formulations 290\u003c\/p\u003e \u003cp\u003e11.6.1 Conflictive Opposition by Western Medicine Philosophy 291\u003c\/p\u003e \u003cp\u003e11.6.2 Conclusive Statements Supported by Varied Research Works 292\u003c\/p\u003e \u003cp\u003e11.6.3 Future Prospects in Light of Knowledge within Ayurvedic Texts and Its Application as Nanomedicine 298\u003c\/p\u003e \u003cp\u003eReferences 298\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Green Tea Polyphenols: A Putative Mechanism for Cytotoxic Action against Cancer Cells 305\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eMohd Farhan, Uzma Shamim, and S.M. Hadi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Dietary Constituents and Their Role in Prevention of Cancer 305\u003c\/p\u003e \u003cp\u003e12.2 Cancer Chemoprevention by Dietary Polyphenols 306\u003c\/p\u003e \u003cp\u003e12.3 Polyphenolic Compounds and Their Chemical Classification 308\u003c\/p\u003e \u003cp\u003e12.4 Dietary Sources of Plant‐Derived Polyphenolic Compounds 311\u003c\/p\u003e \u003cp\u003e12.5 Metabolism of Polyphenolic Compounds in Humans 314\u003c\/p\u003e \u003cp\u003e12.6 Polyphenols and Their Therapeutic Potential 316\u003c\/p\u003e \u003cp\u003e12.6.1 Anticancer Properties 316\u003c\/p\u003e \u003cp\u003e12.6.2 Prospective Anticancer Mechanisms of Plant‐Derived Dietary Polyphenols 318\u003c\/p\u003e \u003cp\u003e12.6.2.1 Antioxidant Action 319\u003c\/p\u003e \u003cp\u003e12.6.2.2 Pro‐Oxidant Action 319\u003c\/p\u003e \u003cp\u003eAcknowledgments 321\u003c\/p\u003e \u003cp\u003eReferences 321\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Nature’s Armamentarium against Malaria: Antimalarials and Their Semisynthetic Derivatives 333\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eFyaz M.D. Ismail\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 333\u003c\/p\u003e \u003cp\u003e13.2 Synthetic Drugs Allow Mass Prophylaxis of Malarial Infections 336\u003c\/p\u003e \u003cp\u003e13.3 The Cooperative World War II Wartime Program 338\u003c\/p\u003e \u003cp\u003e13.4 The Post‐Chloroquine Era: A Return to Finding Drugs from Nature 340\u003c\/p\u003e \u003cp\u003e13.5 Compounds from Plant Sources 340\u003c\/p\u003e \u003cp\u003e13.5.1 South America 342\u003c\/p\u003e \u003cp\u003e13.5.1.1 Quassinoids 342\u003c\/p\u003e \u003cp\u003e13.5.1.2 Amazonia Plants 344\u003c\/p\u003e \u003cp\u003e13.5.1.3 Plants Deserving Further Investigation 345\u003c\/p\u003e \u003cp\u003e13.5.2 Promising Antimalarials Native to Africa 347\u003c\/p\u003e \u003cp\u003e13.5.2.1 Burkina Faso 347\u003c\/p\u003e \u003cp\u003e13.5.2.2 Congo 347\u003c\/p\u003e \u003cp\u003e13.5.2.3 Ethiopia 349\u003c\/p\u003e \u003cp\u003e13.5.2.4 Kenya 350\u003c\/p\u003e \u003cp\u003e13.5.2.5 Madagascar 351\u003c\/p\u003e \u003cp\u003e13.5.3 North America and Europe 351\u003c\/p\u003e \u003cp\u003e13.5.3.1 Helanin 352\u003c\/p\u003e \u003cp\u003e13.5.4 India and East Asia 353\u003c\/p\u003e \u003cp\u003e13.5.4.1 China 354\u003c\/p\u003e \u003cp\u003e13.5.4.2 Japan and Korea 359\u003c\/p\u003e \u003cp\u003e13.5.5 Australia 359\u003c\/p\u003e \u003cp\u003e13.6 The Future 361\u003c\/p\u003e \u003cp\u003e13.7 Conclusion 363\u003c\/p\u003e \u003cp\u003eReferences 363\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Nutraceutical‐Based Pharmacological Intervention in the Management of Liver Diseases 375\u003cbr\u003e\u003c\/b\u003e\u003ci\u003eAaliya Shah and Syed Mudassar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Liver: A Multifunctional Organ 375\u003c\/p\u003e \u003cp\u003e14.2 Biomarkers of Hepatic Injury 377\u003c\/p\u003e \u003cp\u003e14.3 Nutraceutical Intervention in the Management of Liver Diseases 377\u003c\/p\u003e \u003cp\u003e14.3.1 Vitamins 378\u003c\/p\u003e \u003cp\u003e14.3.1.1 Vitamin D 378\u003c\/p\u003e \u003cp\u003e14.3.1.2 Vitamin C 379\u003c\/p\u003e \u003cp\u003e14.3.1.3 Vitamin E 379\u003c\/p\u003e \u003cp\u003e14.3.2 Dietary Polyphenols 380\u003c\/p\u003e \u003cp\u003e14.3.2.1 Flavonoids 380\u003c\/p\u003e \u003cp\u003e14.3.3 Anthocyanins, Isoflavones, and Flavanones 380\u003c\/p\u003e \u003cp\u003e14.3.4 Stilbenes 381\u003c\/p\u003e \u003cp\u003e14.3.5 Curcuminoids 381\u003c\/p\u003e \u003cp\u003e14.3.6 Silymarin 381\u003c\/p\u003e \u003cp\u003e14.3.7 Beverages (Coffee and Tea) 381\u003c\/p\u003e \u003cp\u003e14.3.8 Polyunsaturated Fatty Acids (PUFAs) 382\u003c\/p\u003e \u003cp\u003e14.3.8.1 Short‐Chain, Medium‐Chain, and Long‐Chain Fatty Acids (SCFAs, MCFAs, and LCFAs) 382\u003c\/p\u003e \u003cp\u003e14.3.8.2 Polyunsaturated Fatty Acids 382\u003c\/p\u003e \u003cp\u003e14.3.9 Probiotics 383\u003c\/p\u003e \u003cp\u003e14.3.10 Fruits 384\u003c\/p\u003e \u003cp\u003e14.3.10.1 Grape 384\u003c\/p\u003e \u003cp\u003e14.3.10.2 Black Currant 384\u003c\/p\u003e \u003cp\u003e14.3.10.3 Plum 384\u003c\/p\u003e \u003cp\u003e14.3.10.4 Pomegranate 384\u003c\/p\u003e \u003cp\u003e14.3.10.5 Gac Fruit 385\u003c\/p\u003e \u003cp\u003e14.3.11 Vegetables 385\u003c\/p\u003e \u003cp\u003e14.3.11.1 Celery Seeds 385\u003c\/p\u003e \u003cp\u003e14.3.11.2 Spices 385\u003c\/p\u003e \u003cp\u003e14.3.11.3 Saffron 385\u003c\/p\u003e \u003cp\u003e14.3.11.4 Soy 386\u003c\/p\u003e \u003cp\u003e14.3.11.5 Cereals 386\u003c\/p\u003e \u003cp\u003e14.4 Conclusion 386\u003c\/p\u003e \u003cp\u003eReferences 386\u003c\/p\u003e \u003cp\u003eIndex 395ftoc.\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eAbout the Editors\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003e\u003cb\u003eMohammad Fahad Ullah,\u003c\/b\u003e is an Assistant Professor of Biochemistry in the Department of Medical Laboratory Technology (FAMS) and a Research Scientist at Prince Fahd Research Chair, University of Tabuk, Saudi Arabia. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eAamir Ahmad,\u003c\/b\u003e is an Assistant Professor of Oncologic Sciences at University of South Alabama's Mitchell Cancer Institute, Mobile, AL, USA.   \u003c\/p\u003e\u003cp\u003e\u003cb\u003eIntroduces readers to the growing applications of nutraceuticals and other natural product derivatives\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eThis comprehensive book presents a prophylactic and therapeutic approach to chronic disease prevention strategy by highlighting the translational potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies. It also shares the experiences of highly reputed experts working in the area of phytomedicine and nutraceutical agents in chemoprevention, to promote the significance of natural products and dietary factors as an elite priority for containing chronic diseases in the human population. \u003c\/p\u003e\u003cp\u003e\u003ci\u003eNutraceuticals and Natural Product Derivatives: Disease Prevention \u0026amp; Drug Discovery\u003c\/i\u003e starts by examining natural food sources for the control of glycemia and the prevention of diabetic complications. It then looks at the anti-aging effects of sulfur-containing amino acids and nutraceuticals, and the potential of garcinia fruits to combat metabolic syndrome. Other topics covered include honey- and propolis- mediated regulation of protein networks in cancer cells; recent trends in drug discovery against Alzheimer's disease; the therapeutic potential of metalloherbal nanoceuticals; and much more. \u003c\/p\u003e\u003cul\u003e \u003cli\u003eOffers an alternative, natural approach to the prevention of chronic diseases\u003c\/li\u003e \u003cli\u003eEmphasizes the potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies\u003c\/li\u003e \u003cli\u003eFeatures contributions from world- renowned experts in the field of phytomedicine and nutraceutical agents in chemoprevention\u003c\/li\u003e \u003cli\u003eIncludes prevention strategies in normal\/risk populations through routine inclusion of specific dietary regimens and as therapeutic strategy for better management through adjuvant interventions with conventional treatment protocols\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eNutraceuticals and Natural Product Derivatives: Disease Prevention \u0026amp; Drug Discovery\u003c\/i\u003e will appeal to graduate students and professionals in cell and molecular biology, translational research, pharmacology\/drug discovery, medicinal chemistry, and clinical nutrition.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989704753381,"sku":"NP9781119436676","price":215.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119436676.jpg?v=1761785176","url":"https:\/\/k12savings.com\/products\/nutraceuticals-and-natural-product-derivatives-isbn-9781119436676","provider":"K12savings","version":"1.0","type":"link"}