{"product_id":"natural-products-isbn-9781118298060","title":"Natural Products","description":"\u003cp\u003e\u003ci\u003eNatural Products: Discourse, Diversity and Design\u003c\/i\u003e provides an informative and accessible overview of discoveries in the area of natural products in the genomic era, bringing together advances across the kingdoms.  As genomics data makes it increasingly clear that the genomes of microbes and plants contain far more genes for natural product synthesis than had been predicted from the numbers of previously identified metabolites, the potential of these organisms to synthesize diverse natural products is likely to be far greater than previously envisaged.  \u003ci\u003eNatural Products\u003c\/i\u003e addresses not only the philosophical questions of the natural role of these metabolites, but also the evolution of single and multiple pathways, and how these pathways and products may be harnessed to aid discovery of new bioactives and modes of action.\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003eEdited by recognized leaders in the fields of plant and microbial biology, bioorganic chemistry and natural products chemistry, and with contributions from researchers at top labs around the world, \u003ci\u003eNatural Products\u003c\/i\u003e is unprecedented in its combination of disciplines and the breadth of its coverage. \u003ci\u003eNatural Produces: Discourse, Diversity and Design  \u003c\/i\u003ewill appeal to advanced students and experienced researchers, from academia to industry, in diverse areas including ecology, industrial biotechnology, drug discovery, medicinal chemistry, agronomy, crop improvement, and natural product chemistry.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION I NATURAL PRODUCTS IN THE NATURAL WORLD 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 1 Role and Reason 3\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 The Role of Phytochemicals in Relationships of Plants with Other Organisms 5\u003cbr\u003e\u003ci\u003ePaweł Bednarek\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Designer Microbial Ecosystems – Toward Biosynthesis with Engineered Microbial Consortia 23\u003cbr\u003e\u003ci\u003eDavid M. Babson, Mark Held, and Claudia Schmidt-Dannert\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Marine Natural Products – Chemical Defense\/Chemical Communication in Sponges and Corals 39\u003cbr\u003e\u003ci\u003eElodie Quévrain, Isabelle Domart-Coulon, and Marie-Lise Bourguet-Kondracki\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 2 Self-Protection – Avoiding Autotoxicity 67\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4 How Plants Avoid the Toxicity of Self-Produced Defense Bioactive Compounds 69\u003cbr\u003e\u003ci\u003eSupaart Sirikantaramas, Mami Yamazaki, and Kazuki Saito\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 3 Fishing and Pharming 83\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5 Marine Bioprospecting 85\u003cbr\u003e\u003ci\u003eAmanda M. Fenner and William H. Gerwick\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Myxobacteria: Chemical Diversity and Screening Strategies 103\u003cbr\u003e\u003ci\u003eAlberto Plaza and Rolf Müller\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Fungal Endophytes of Grasses and Morning Glories, and their Bioprotective Alkaloids 125\u003cbr\u003e\u003ci\u003eChristopher L. Schardl, Li Chen, and Carolyn A. Young\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Fungal-Actinomycete Interactions –Wakening of Silent Fungal Secondary Metabolism Gene Clusters via Interorganismic Interactions 147\u003cbr\u003e\u003ci\u003eVolker Schroeckh, Hans-Wilhelm Nützmann, and Axel A. Brakhage\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Secondary Metabolites Produced by Plant Pathogens 159\u003cbr\u003e\u003ci\u003eBarbara J. Howlett\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION II FROM GENES TO MOLECULES 171\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 1 Reading the Genome 173\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10 Analyzing Fungal Secondary Metabolite Genes and Gene Clusters 175\u003cbr\u003e\u003ci\u003eYi-Ming Chiang, Clay C. C. Wang, and Berl R. Oakley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 2 Biosynthesis and Heterologous Expression 195\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11 RiPPs: Ribosomally Synthesized and Posttranslationally Modified Peptides 197\u003cbr\u003e\u003ci\u003eNoah A. Bindman and Wilfred A. Van Der Donk\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Polyketide Synthase: Sequence, Structure, and Function 219\u003cbr\u003e\u003ci\u003eJoel Bruegger, Grace Caldara, Joris Beld, Michael D. Burkart and Shiou-Chuan (Sheryl) Tsai\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Manipulation of Fungal Natural Product Pathways 245\u003cbr\u003e\u003ci\u003eRussell J. Cox and Katherine Williams\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Production of Therapeutic Products 261\u003cbr\u003e\u003ci\u003eGuojian Zhang and Blaine A. Pfeifer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 3 Regulation: Waking Sleeping Pathways 277\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e15 Waking Sleeping Pathways in Filamentous Fungi 279\u003cbr\u003e\u003ci\u003eJoe Spraker and Nancy Keller\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION III EVOLVING ENZYMES, EVOLVING PATHWAYS: SYNTHETIC BIOLOGY 293\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 1 Chemical Diversification 295\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e16 The Oxidosqualene Cyclases: One Substrate, Diverse Products 297\u003cbr\u003e\u003ci\u003eIkuro Abe\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Harnessing Sugar Biosynthesis and Glycosylation to Redesign Natural Products and to Increase Structural Diversity 317\u003cbr\u003e\u003ci\u003eCarlos Olano, Carmen M\u003c\/i\u003e\u003ci\u003endez, and José A. Salas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 2 Evolving Pathways 341\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e18 Evolutionary Mechanisms Involved in Development of Fungal Secondary Metabolite Gene Clusters 343\u003cbr\u003e\u003ci\u003eGeromy G. Moore, Jérôme Collemare, Marc-Henri Lebrun, and Rosie E. Bradshaw\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 3 Synthetic Biology 357\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e19 Synthetic Biology of Natural Products 359\u003cbr\u003e\u003ci\u003eRainer Breitling and Eriko Takano\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION IV SCREENING FOR BIOACTIVITY 371\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e20 Image-Based Screening Approaches to Natural Products Discovery 373\u003cbr\u003e\u003ci\u003eChristopher J. Schulze and Roger G. Linington\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Making Sense of Structures by Utilizing Mother Nature’s Chemical Libraries as Leads to Potential Drugs 397\u003cbr\u003e\u003ci\u003eDavid J. Newman and Gordon M. Cragg\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 Is There an Ideal Database for Natural Products Research? 413\u003cbr\u003e\u003ci\u003eJohn W. Blunt and Murray H. G. Munro\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSECTION V TO APPLICATION 433\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eCase Studies 435\u003c\/p\u003e \u003cp\u003e23 Daptomycin and A54145: Structure–Activity Relationship (SAR) Studies Enabled by Combinatorial Biosynthesis 437\u003cbr\u003e\u003ci\u003eRichard H. Baltz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 Discovery and Development of NVB302, a Semisynthetic Antibiotic for Treatment of Clostridium difficile Infection 455\u003cbr\u003e\u003ci\u003eSteven Boakes and Michael J. Dawson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25 ILS-920: A Rapamycin Analog for Ischemic Stroke 469\u003cbr\u003e\u003ci\u003eEdmund I. Graziani\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26 BC265: A Nonquinone Ansamycin Hsp90 Inhibitor Developed Using Biosynthetic Medicinal Chemistry 483\u003cbr\u003e\u003ci\u003eMatthew A. Gregory, Steven J. Moss, and Barrie Wilkinson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e27 Discovery and Development of Caspofungin (CANCIDAS): Concept to Clinic 497\u003cbr\u003e\u003ci\u003eJames M. Balkovec, David L. Hughes, Prakash S. Masurekar, Carole A. Sable, Robert E. Schwartz, and Sheo B. Singh\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 523\u003c\/p\u003e  \u003cp\u003eThe editors\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAnne Osbourn\u003c\/b\u003e is Professor at the University of East Anglia, UK, and Director of the Norwich Research Park Industrial Biotechnology and Bioenergy Alliance, and is based at the John Innes Centre.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eRebecca J. Goss\u003c\/b\u003e is Reader in Organic\/Biomolecular Chemistry at the School of Chemistry and also at the Biomedical Sciences Research Complex at the University of St Andrews, UK.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eGuy T. Carter\u003c\/b\u003e has over 30 years of experience working in Pharmaceutical R\u0026amp;D, primarily in the discovery and development of microbial products. He is currently CEO of Carter–Bernan Consulting and Chief Scientific Officer at Biosortia Pharmaceuticals, USA.\u003c\/p\u003e  \u003cp\u003e\u003ci\u003eNatural Products: Discourse, Diversity, and Design\u003c\/i\u003e explores the natural products, or the secondary metabolites, produced by microbes, fungi, and plants. Natural products can be used in the development of a wide array of products such as drugs, herbicides, antioxidants, preservatives, pigments and dyes for materials, food, flavors, and fragrances. As science advances, it has become exceedingly clear that the potential of biological organisms to synthesize diverse natural products is likely to be far greater than ever previously imagined.\u003c\/p\u003e \u003cp\u003eAn accessible and informative overview of these natural products in the genomic era, Natural Products: Discourse, Diversity, and Design delves into the discovery, examination, and application of natural products across different kingdoms. Chapters explore their genetics and synthetic biology, methods for screening for bioactivity and their practical applications. Its wide scope guarantees its appeal to plant scientists, fungal biologists, and microbiologists, as well as those who work with industrial biotechnology, drug discovery, medicinal chemistry, agronomy, crop improvement, and natural product chemistry.\u003c\/p\u003e \u003cp\u003eThe volume is comprehensive in its treatment of biologically based products in the natural world. Natural Products: Discourse, Diversity, and Design will be a vital resource for anyone working in this rapidly developing field.\u003c\/p\u003e \u003cp\u003eCovers a range of important natural products from microbes, plants, fungi, and marine organisms.\u003c\/p\u003e \u003cp\u003e• Explores the role of various metabolites as well as the evolution of their unique biochemical pathways.\u003c\/p\u003e \u003cp\u003e• Chapters cover topics including biosynthesis and heterologous expression, avoiding autotoxicity, and chemical diversification.\u003c\/p\u003e \u003cp\u003e• Includes case studies on the development of commercial products from natural products from industry experts.\u003c\/p\u003e \u003cp\u003e• Wide-ranging and in-depth coverage of an expanding field.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989677129957,"sku":"NP9781118298060","price":238.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118298060.jpg?v=1761785065","url":"https:\/\/k12savings.com\/products\/natural-products-isbn-9781118298060","provider":"K12savings","version":"1.0","type":"link"}