Natural Products in Chemical Biology

Based on the award winning Wiley Encyclopedia of Chemical Biology, this book provides a general overview of the unique features of the small molecules referred to as "natural products", explores how this traditionally organic chemistry-based field was transformed by insights from genetics and biochemistry, and highlights some promising future directions. The book begins by introducing natural products from different origins, moves on to presenting and discussing biosynthesis of various classes of natural products, and then looks at natural products as models and the possibilities of using them in medicine.

Preface vii

Contributors ix

Part I Chemical Diversity of Natural Products 1

1 Plant Natural Products 3
A. Leslie Gunatilaka

2 Marine Natural Products 31
Nobuhiro Fusetani

3 Microbial Natural Products 65
Sergio Sanchez, Silvia Guzmán-Trampe, Mariana Ávalos, Beatriz Ruiz, Romina Rodríguez-Sanoja, and Manuel Jiménez-Estrada Copyrighted Material

Part II Biosynthesis of Natural Products 109

4 Nonribosomal Peptides 111
Georg Schoenafinger and Mohamed A. Marahiel

5 Plant Terpenoids 127
Christopher I. Keeling and Jörg Bohlmann

6 Polyketides in Fungi 143
Thomas J. Simpson and Russell J. Cox

7 Modular Polyketide Synthases 163
Tonia J. Buchholz, Jeffrey D. Kittendorf, and David H. Sherman

8 Polyketide Polyethers 189
Alison M. Hill

9 Alkaloids 209
Sarah E. O’Connor

10 Cofactors 239
Ilka Haase, Markus Fischer, Adelbert Bacher, Wolfgang Eisenreich, and Felix Rohdich

11 Antibiotics 269
Sergey B. Zotchev

Part III Natural Products in Medicine 287

12 Pharmaceuticals: Natural Products and Natural Product Models 289
Sheo B. Singh

13 Natural Products as Anticancer Agents 325
DavidG.I.KingstonandDavidJ.Newman

14 Plant-Derived Natural Products Research in Drug Discovery 351
Kuo-Hsiung Lee, Hideji Itokawa, Toshiyuki Akiyama, and Susan L. Morris-Natschke

Index 389

“In summary, this is a really good book from a number of prominent research groups who have made important contributions to their fields. Some chapters are well suited for newcomers to the subject, as well as for teaching or for reading by interested students.” (Angewandte Chemie International Edition, 19 March 2014)

NATANYA CIVJAN, PhD, is a freelance editor with a doctorate in biochemistry. Formerly with John Wiley & Sons, she has developed and edited the Wiley Encyclopedia of Chemical Biology and was part of the team responsible for the Wiley Interdisciplinary Reviews, which won top prizes in publishing from the American Publishers Awards for Professional and Scholarly Excellence.

A timely and authoritative look at the chemistry of natural products

Based on the acclaimed Wiley Encyclopedia of Chemical Biology, this book focuses on natural products and explores their impact on drug discovery and design. With emphasis on the gamut of biological diversity and activities of natural products, the book examines the unique features of these molecules, highlights influences from genetics and biochemistry, and points to promising future trends. Divided into three parts, Natural Products in Chemical Biology first introduces sources of natural products, then goes on to present the biosynthesis of main classes of natural products and their uses in medicine. The book presents fourteen self-contained, peer-reviewed articles carefully selected from the Wiley Encyclopedia of Chemical Biology and new material. Clear, authoritative coverage includes:

• A discussion of the chemical diversity of plant, marine, and microbial natural products
• Biosynthesis of nonribosomal peptides, plant terpenoids, polyketides, alkaloids, cofactors, and antibiotics
• Use of natural products and natural product models in the pharmaceutical industry

Natural Products in Chemical Biology is an excellent introduction to the ongoing research in the chemistry of natural products for researchers in diverse fields, from organic and medicinal chemistry to molecular biology and the pharmaceutical industry.