Name Reactions for Homologation, 2 Part Set

This guide provides a comprehensive and authoritative review of name reactions on homologation. Each section includes a description of the reaction, the historical perspective, a mechanism for the reaction, variations and improvements on the reaction, synthetic utilities of the reaction, experimental details, and current references to the primary literature. The primary topics include organometallics (palladium, organozinc, organocopper, other organometallics), carbon-chain homologation, (rearrangement, concerted rearrangement, cationic rearrangement, anionic rearrangement, other rearrangements), radical chemistry, asymmetric C-C bond formation, and other types (such as Cannizzaro disproportionation, Eschenmoser coupling, Mannich, Mitsunobu, Passerini, and Ugi). TOC for PART 1

Foreword.

Preface.

Contributing Authors.

Chapter 1: Organometallics.

Section 1.1 Palladium Chemistry.

Section 1.2 Organocopper Reagents.

Section 1.3 Other Organometallic Reagents.

Chapter 2: Carbon-Chain Homologations.

2.1 Arndt-Eistert homologation.

2.2 Morita-Baylis-Hillman reaction.

2.3 Benzoin condensation.

2.4 Corey-Fuchs reaction.

2.5 Henry reaction.

2.6 Horner-Wadsworth-Emmons reaction.

2.7 Julia-Lythgoe olefination.

2.8 Knoevenagel condensation.

2.9 Mukaiyama aldol reaction.

2.10 Peterson olefination.

2.11 Sakurai allylation reaction.

2.12 Stetter reaction.

2.13 Wittig reaction.

Chapter 3: Radical Chemistry.

3.1 Barton-McCombie deoxygenation.

3.2 Barton nitrite photolysis.

3.3 Sandmeyer reaction.

3.4 Wohl-Ziegler reaction.

Appendixes.

Appendix 1, Table of Contents for Volume 1: Name Reactions in Heterocyclic Chemistry.

Appendix 2, Table of Contents for Volume 2: Name Reactions for Functional Group Transformations.

Appendix 3, Table of Contents for Volume 4: Name Reactions for Homologations-2.


TOC for PART 2:

Foreword.

Preface.

Contributing Authors.

Chapter 1: Rearrangements.

Section 1.1 Concerted rearrangement.

Section 1.2 Cationic rearrangement.

Section 1.3 Anionic rearrangement.

Chapter 2: Asymmetric CC bond formation.

2.1 Evans aldol reaction.

2.2 Hajos-Wiechert reaction.

2.3 Keck stereoselective allylation.

2.4 Roush allylboronation.

Chapter 3: Miscellaneous homologation reactions.

3.1 Bamford-Stevens reaction.

3.2 Mannich reaction.

3.3 Mitsunobu reaction.

3.4 Parham cyclization.

3.5 Passerini reaction.

3.6 Ugi reaction.

Appendixes.

Appendix 1, Table of Contents for Volume 1: Name Reactions in Heterocyclic Chemistry.

Appendix 2, Table of Contents for Volume 2: Name Reactions for Functional Group Transformations.

Appendix 3, Table of Contents for Volume 3: Name Reactions for Homologations-I.

Appendix 4, Table of Contents for Volume 5: Name Reactions for Ring Formations.

Appendix 5, Table of Contents for Volume 6: Name Reactions in Heterocyclic Chemistry-II.

Subject index.

Jie Jack Li, PhD, is a chemist at Bristol-Myers Squibb Company. He has authored or edited several books published by Wiley, including Name Reactions in Heterocyclic Chemistry, Name Reactions for Functional Group Transformations, Name Reactions for Homologations - Part I and Part II -, Name Reactions for Carbocyclic Ring Formations, Contemporary Drug Synthesis, The Art of Drug Synthesis, and Modern Drug Synthesis.

E. J. Corey , PhD, has been a Professor at Harvard University since 1959. The 1990 Nobel Laureate in Chemistry, Dr. Corey has also been the recipient of more than seventy international awards and honorary degrees, including the U.S. National Medal of Science, the Japan Prize in Science, and the Priestley Medal. Author of more than 1,500 publications, he is one of the most cited authors in science. "Jack Li and his illustrious team of chemists have done it again. It is hard to imagine how one could organize and categorize a topic so broad as "homologation" reactions. These are some of the bread and butter transforms of organic chemistry ? reactions that are fundamentally important to the practice of chemical synthesis. This two book series is masterfully organized and easy to use both as a reference work for the classroom and a springboard for practitioners to rapidly apply these reactions in the laboratory. The extensive coverage of these critical reactions, including a historical perspective, mechanism, synthetic utility, and actual experimental details will ensure that these books will be on the shelf of every serious organic chemist for years to come."

--Phil S. Baran, The Scripps Research Institute