{"product_id":"myeloid-cells-in-health-and-disease-isbn-9781555819187","title":"Myeloid Cells in Health and Disease","description":"\u003cp\u003eThe structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells.\u003c\/p\u003e \u003cp\u003eIn \u003ci\u003eMyeloid Cells in Health and Disease: A Synthesis\u003c\/i\u003e, Editor Siamon Gordon has assembled an international team of esteemed scientists to provide their perspectives of myeloid cells during innate and adaptive immunity. The book begins by presenting the foundational research of Paul Ehrlich, Elie Metchnikoff, and Donald Metcalf. The following chapters discuss evolution and the life cycles of myeloid cells; specific types of differentiated myeloid cells, including macrophage differentiation; and antigen processing and presentation. The rest of the book is organized by broad topics in immunology, including\u003c\/p\u003e \u003cul\u003e \u003cli\u003ethe recruitment of myeloid and other immune cells following microbial infection\u003c\/li\u003e \u003cli\u003ethe role of myeloid cells in the inflammation process and the repair of damaged tissue\u003c\/li\u003e \u003cli\u003ethe vast arsenal of myeloid cell secretory molecules, including metalloproteinases, tumor necrosis factor, histamine, and perforin\u003c\/li\u003e \u003cli\u003ereceptors and downstream signaling pathways that are activated following ligand-receptor binding\u003c\/li\u003e \u003cli\u003eroles of myeloid cells during microbial and parasite infections\u003c\/li\u003e \u003cli\u003econtributions of myeloid cells in atherosclerosis\u003c\/li\u003e \u003cli\u003emyeloid-derived suppressor cells in tumor development and cancer\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eMyeloid Cells in Health and Disease: A Synthesis\u003c\/i\u003e will benefit graduate students and researchers in immunology, hematology, microbial pathogenesis, infectious disease, pathology, and pharmacology. Established scientists and physicians in these and related fields will enjoy the book's rich history of myeloid cell research and suggestions for future research directions and potential therapies.\u003c\/p\u003e \u003cp\u003eContributors\u003c\/p\u003e \u003cp\u003ePreface\u003c\/p\u003e \u003cp\u003eAcknowledgments\u003c\/p\u003e \u003cp\u003eAbout the Editor\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection I Introduction and History\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Paul Ehrlich and the Early History of Granulocytes\u003cbr\u003e\u003ci\u003eA. Barry Kay\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 The Phagocyte, Metchnikoff, and the Foundation of Immunology\u003cbr\u003e\u003ci\u003eGiuseppe Teti, Carmelo Biondo, and Concetta Beninati\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Growth and Differentiation Factors\u003cbr\u003e\u003ci\u003eDonald Metcalf and Nicos A. Nicola\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection II General Aspects \u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4 Evolution of Myeloid Cells\u003cbr\u003e\u003ci\u003eDaniel R. Barreda, Harold R. Neely, and Martin F. Flajnik\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Advances on Myeloid Like-Cell Origins and Functions in the Model Organism Drosophila melanogaster\u003cbr\u003e\u003ci\u003eLaure El Chamy, Nicolas Matt, and Jean-Marc Reichhart\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Monocyte, Macrophage, and Dendritic Cell Development: the Human Perspective\u003cbr\u003e\u003ci\u003eMatthew Collin and Venetia Bigley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Myeloid Cell Turnover and Clearance\u003cbr\u003e\u003ci\u003eWilliam J. Janssen, Donna L. Bratton, Claudia V. Jakubzick, and Peter M. Henson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection III Specialization\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8 Transcriptional Regulation and Macrophage Differentiation\u003cbr\u003e\u003ci\u003eDavid A. Hume, Kim M. Summers, and Michael Rehli\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Murine Monocytes: Origins, Subsets, Fates, and Functions\u003cbr\u003e\u003ci\u003eAlexander Mildner, Goran Marinkovic, and Steffen Jung\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Dendritic Cells in the Immune System—History, Lineages, Tissues, Tolerance, and Immunity\u003cbr\u003e\u003ci\u003eJonathan M. Austyn\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Antigen Processing and Presentation Mechanisms in Myeloid Cells\u003cbr\u003e\u003ci\u003ePaul A. Roche and Peter Cresswell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Microglia\u003cbr\u003e\u003ci\u003eV. Hugh Perry\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Osteoclasts—Key Players in Skeletal Health and Disease\u003cbr\u003e\u003ci\u003eDeborah Veis Novack and Gabriel Mbalaviele\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 The Regulatory Function of Eosinophils\u003cbr\u003e\u003ci\u003eTing Wen and Marc E. Rothenberg\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection IV Recruitment, Inflammation, and Repair\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e15 Intravital Imaging of Myeloid Cells: Inflammatory Migration and Resident Patrolling\u003cbr\u003e\u003ci\u003eJustin F. Deniset and Paul Kubes\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Multifaceted Functions of NOD-Like Receptor Proteins in Myeloid Cells at the Intersection of Innate and Adaptive Immunity\u003cbr\u003e\u003ci\u003eThomas A. Kufer, Giulia Nigro, and Philippe J. Sansonetti\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Inflammasomes in Myeloid Cells: Warriors Within  \u003cbr\u003e\u003ci\u003eSushmita Jha and Jenny Pan-Yun Ting\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Inflammation—a Critical Appreciation of the Role of Myeloid Cells\u003cbr\u003e\u003ci\u003eAsif J. Iqbal, Edward A. Fisher, and David R. Greaves\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19 Lipid Mediators in Inflammation\u003cbr\u003e\u003ci\u003eMelanie Bennett and Derek W. Gilroy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Macrophage Proresolving Mediators—the When and Where\u003cbr\u003e\u003ci\u003eJesmond Dalli and Charles Serhan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Myeloid Cells in Cutaneous Wound Repair\u003cbr\u003e\u003ci\u003eJenna L. Cash and Paul Martin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection V Recognition, Signaling, and Gene Expression\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e22 The Role and Function of Fcγ Receptors on Myeloid Cells\u003cbr\u003e\u003ci\u003eStylianos Bournazos, Taia T. Wang, and Jeffrey V. Ravetch\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 Complement Receptors in Myeloid Cell Adhesion and Phagocytosis\u003cbr\u003e\u003ci\u003eMichael L. Dustin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 Toll-Like Receptor Signaling and Its Inducible Proteins\u003cbr\u003e\u003ci\u003eTakashi Satoh and Shizuo Akira\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25 Lectin Receptors Expressed on Myeloid Cells\u003cbr\u003e\u003ci\u003eGordon D. Brown and Paul R. Crocker\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26 G Protein-Coupled Receptors in Macrophages\u003cbr\u003e\u003ci\u003eHsi-Hsien Lin and Martin Stacey\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e27 Molecular Mechanisms of Phagosome Formation\u003cbr\u003e\u003ci\u003eValentin Jaumouillé and Sergio Grinstein\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e28 Role of the Cytoskeleton in Myeloid Cell Function\u003cbr\u003e\u003ci\u003eNoah Fine, Samira Khaliq, Siavash Hassanpour, and Michael Glogauer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e29 Coordinated Regulation of Signaling Pathways during Macrophage Activation\u003cbr\u003e\u003ci\u003eToby Lawrence\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e30 Genome-Wide Approaches to Defining Macrophage Identity and Function\u003cbr\u003e\u003ci\u003eGregory J. Fonseca, Jason S. Seidman, and Christopher K. Glass\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e31 Epigenetic Regulation of Myeloid Cells\u003cbr\u003e\u003ci\u003eLionel B. Ivashkiv and Sung Ho Park\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection VI Secretion and Defense\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e32 Secretion from Myeloid Cells: Secretory Lysosomes\u003cbr\u003e\u003ci\u003eGillian M. Griffiths\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e33 The NADPH Oxidase and Microbial Killing by Neutrophils, With a Particular Emphasis on the Proposed Antimicrobial Role of Myeloperoxidase within the Phagocytic Vacuole\u003cbr\u003e\u003ci\u003eAdam P. Levine and Anthony W. Segal\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e34 Evolution of Cell-Autonomous Effector Mechanisms in Macrophages versus Non-Immune Cells\u003cbr\u003e\u003ci\u003eRyan G. Gaudet, Clinton J. Bradfield, and John D. MacMicking\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e35 Anti-TNF Therapy\u003cbr\u003e\u003ci\u003eIrina Udalova, Claudia Monaco, Jagdeep Nanchahal, and Marc Feldmann\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e36 Metalloproteinases: a Functional Pathway for Myeloid Cells\u003cbr\u003e\u003ci\u003eJonathan Chou, Matilda F. Chan, and Zena Werb\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection VII Immunoregulation and Infection\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e37 Interplay between Myeloid Cells and Humoral Innate Immunity\u003cbr\u003e\u003ci\u003eSébastien Jaillon, Eduardo Bonavita, Cecilia Garlanda, and Alberto Mantovani\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e38 Adaptive Characteristics of Innate Immune Responses in Macrophages\u003cbr\u003e\u003ci\u003eRob J. W. Arts and Mihai G. Netea\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e39 Intestinal Mononuclear Phagocytes in Health and Disease\u003cbr\u003e\u003ci\u003eTheodore J. Sanders, Ulf Yrlid, and Kevin J. Maloy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e40 Strategies Used by Bacteria to Grow in Macrophages\u003cbr\u003e\u003ci\u003eGabriel Mitchell, Chen Chen, and Daniel A. Portnoy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e41 Mechanisms of Defense against Intracellular Pathogens Mediated by Human Macrophages\u003cbr\u003e\u003ci\u003eBarry R. Bloom and Robert L. Modlin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e42 Myeloid Cells in Asthma\u003cbr\u003e\u003ci\u003eBart N. Lambrecht, Emma Persson, and Hamida Hammad\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e43 Myeloid Cell Phenotypes in Susceptibility and Resistance to Helminth Parasite Infections\u003cbr\u003e\u003ci\u003eRick M. Maizels and James P. Hewitson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e44 Induction of Immunological Tolerance as a Therapeutic Procedure\u003cbr\u003e\u003ci\u003eHerman Waldmann, Duncan Howie, and Stephen Cobbold\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection VIII Metabolic and Malignant Disease\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e45 Glutathione and Glutathione Transferase Omega 1 as Key Post-Translational Regulators in Macrophages\u003cbr\u003e\u003ci\u003eMark M. Hughes, Anne F. McGettrick, and Luke A.J. O’Neill\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e46 Macrophages and Iron Metabolism\u003cbr\u003e\u003ci\u003eTomas Ganz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e47 Mechanisms of Myeloid Cell Modulation of Atherosclerosis\u003cbr\u003e\u003ci\u003eFilip K. Swirski, Matthias Nahrendorf, and Peter Libby\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e48 Macrophages in Endocrine Glands with Emphasis on Pancreatic Islets\u003cbr\u003e\u003ci\u003eEmil R. Unanue\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e59 Tumor-Induced Myeloid-Derived Suppressor Cells\u003cbr\u003e\u003ci\u003eFrancesco De Sanctis, Vincenzo Bronte, and Stefano Ugel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e50 Myeloid Cell Origins, Differentiation, and Clinical Implications\u003cbr\u003e\u003ci\u003eKipp Weiskopf, Peter J. Schnorr, Wendy W. Pang, Mark P. Chao, Akanksha Chhabra, Jun Seita,\u003c\/i\u003e \u003ci\u003eMingye Feng, and Irving L. Weissman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex\u003c\/p\u003e   \u003cp class=\"MsoNormal\"\u003e\u003cb\u003e\u003cspan lang=\"EN-CA\"\u003eREVIEW 1\u003co:p\u003e\u003c\/o:p\u003e\u003c\/span\u003e\u003c\/b\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003eThis book captures the excitement in the field of myeloid cell biology with a fresh look at its many facets and provides both a scholarly reference work and thought-provoking synthesis of the major approaches and viewpoints that currently drive the field.\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cb\u003e\u003cspan lang=\"EN-CA\"\u003e-Alan Sher, PhD\u003c\/span\u003e\u003c\/b\u003e\u003cspan lang=\"EN-CA\"\u003e, NIH Distinguished Investigator; Chief, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cb\u003e\u003cspan lang=\"EN-CA\"\u003eREVIEW 2\u003co:p\u003e\u003c\/o:p\u003e\u003c\/span\u003e\u003c\/b\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003ci\u003e\u003cspan lang=\"EN-CA\"\u003eMyeloid Cells in Health and Disease: A Synthesis\u003c\/span\u003e\u003c\/i\u003e\u003cspan lang=\"EN-CA\"\u003e has much to tell about a subset of our genes that operate in concert, directing the assembly of a machine that protects us against most of the infections we might ever encounter.\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cb\u003e\u003cspan lang=\"EN-CA\"\u003e-Bruce Beutler, MD, \u003c\/span\u003e\u003c\/b\u003e\u003cspan lang=\"EN-CA\"\u003eNobel Laureate in Physiology or Medicine, 2011; Director, Center for the Genetics of Host Defense, UT Southwestern Medical Center at Dallas\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cb\u003e\u003cspan lang=\"EN-CA\"\u003eREVIEW 3\u003co:p\u003e\u003c\/o:p\u003e\u003c\/span\u003e\u003c\/b\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003eAt A Glance\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003eThe structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells. In \u003ci\u003eMyeloid Cells in Health and Disease: A Synthesis\u003c\/i\u003e, Editor Siamon Gordon has assembled an international team of esteemed scientists to provide their perspectives of myeloid cells during innate and adaptive immunity. The book begins by presenting the foundational research of Paul Ehrlich, Elie Metchnikoff, and Donald Metcalf. The following chapters discuss evolution and the life cycles of myeloid cells; specific types of differentiated myeloid cells, including macrophage differentiation; and antigen processing and presentation.\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003eDescription\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003eThis book provides a broad and balanced view of diverse myeloid cell populations and their role in different disease states.\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003ePurpose\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003eThe overall purpose is to provide an overview of myeloid cell biology spanning normal physiology and pathological conditions. Particular emphasis is placed on the history of the field starting in the early 20th century. This is a very active field of investigation and there are other books available. However, this is a worthy contribution because it is fairly comprehensive.\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003eAudience\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003eAn appropriate audience is immunologists who have a special interest in myeloid cells, which includes postdoctoral fellow and advanced graduate students.\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003eFeatures\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003eSome sections are well-written and very readable while a few are more difficult to follow. Generally, the figures are well done and informative, highly descriptive and didactic, summarizing large amounts of data. The literature and authors cited are representative of the state of the field. Information is presented for both murine and human myeloid cells in different models. This is attractive to researchers interested in interspecies comparisons and specific markers and characterization. For example, molecular marker profiles to distinguish functionally different cell populations are described in detail. This is particularly helpful for investigators new to the field.\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003eAssessment\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003eThere are many recent review articles describing aspects of myeloid cell biology as they relate to health and disease. This is in contrast to a dearth of books with up-to-date information. I am aware of only one comparable recently published book, \u003ci\u003eMacrophages: Biology and Role in the Pathology of Diseases\u003c\/i\u003e, Biswas and Mantovani (Springer, 2014).\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003eReview Questionnaire\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003eRange\/ Question\/ Score\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003e1-10 Are the author's objectives met? 8\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003e1-10 Rate the worthiness of those objectives. 8\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003e1-5 Is this written at an appropriate level? 5\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003e1-5 Is there significant duplication? (1=significant, 5=insignificant) 4\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003e1-5 Are there significant omissions? (1=significant, 5=insignificant) 4\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003e1-5 Rate the authority of the authors. 4\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003e1-5 Are there sufficient illustrations? 5\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003e1-5 Rate the pedagogic value of the illustrations. 4\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003e1-5 Rate the print quality of the illustrations. 4\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003e1-5 Are there sufficient references? 5\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003e1-5 Rate the currency of the references. 4\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003e1-5 Rate the pertinence of the references. 4\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003e1-5 Rate the helpfulness of the index. 5\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003e1-5 If important in this specialty, rate the physical appearance of the book 4\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003e1-10 Is this a worthwhile contribution to the field? 8\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003e1-10 If this is a 2nd or later edition, is this new edition needed? N\/A\u003c\/span\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cb\u003e\u003cspan lang=\"EN-CA\"\u003e-Ulrich Rodeck, MD, PhD,\u003c\/span\u003e\u003c\/b\u003e(Thomas Jefferson University)\u003cb\u003e\u003co:p\u003e\u003c\/o:p\u003e\u003c\/b\u003e  \u003c\/p\u003e\u003cp class=\"MsoNormal\"\u003e\u003cspan lang=\"EN-CA\"\u003e  \u003cp\u003e\u003cb\u003eMyeloid Cells in Health and Disease\u003c\/b\u003e \u003c\/p\u003e\n\u003cp\u003eFirst Edition  \u003c\/p\u003e\n\u003cp\u003eThe structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells.  \u003c\/p\u003e\n\u003cp\u003eIn \u003ci\u003eMyeloid Cells in Health and Disease: A Synthesis\u003c\/i\u003e, Editor Siamon Gordon has assembled an international team of esteemed scientists to provide their perspectives of myeloid cells during innate and adaptive immunity. The book begins by presenting the foundational research of Paul Ehrlich, Elie Metchnikoff, and Donald Metcalf. The following chapters discuss evolution and the life cycles of myeloid cells; specific types of differentiated myeloid cells, including macrophage differentiation; and antigen processing and presentation. The rest of the book is organized by broad topics in immunology, including \u003c\/p\u003e\n\u003cul\u003e \u003cli\u003ethe recruitment of myeloid and other immune cells following microbial infection\u003c\/li\u003e \u003cli\u003ethe role of myeloid cells in the inflammation process and the repair of damaged tissue\u003c\/li\u003e \u003cli\u003ethe vast arsenal of myeloid cell secretory molecules, including metalloproteinases, tumor necrosis factor, histamine, and perforin\u003c\/li\u003e \u003cli\u003ereceptors and downstream signaling pathways that are activated following ligand-receptor binding\u003c\/li\u003e \u003cli\u003eroles of myeloid cells during microbial and parasite infections\u003c\/li\u003e \u003cli\u003econtributions of myeloid cells in atherosclerosis\u003c\/li\u003e \u003cli\u003emyeloid-derived suppressor cells in tumor development and cancer\u003c\/li\u003e \u003c\/ul\u003e  \u003cp\u003e\u003ci\u003eMyeloid Cells in Health and Disease: A Synthesis\u003c\/i\u003e will benefit graduate students and researchers in immunology, hematology, microbial pathogenesis, infectious disease, pathology, and pharmacology. Established scientists and physicians in these and related fields will enjoy the book's rich history of myeloid cell research and suggestions for future research directions and potential therapies.\u003c\/p\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"ASM Press","offers":[{"title":"Default Title","offer_id":47989667168485,"sku":"NP9781555819187","price":160.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781555819187.jpg?v=1761785026","url":"https:\/\/k12savings.com\/products\/myeloid-cells-in-health-and-disease-isbn-9781555819187","provider":"K12savings","version":"1.0","type":"link"}