Myasthenia Gravis and Related Disorders I

Myasthenia gravis (MG), an acquired immune syndrome affecting proteins at the neuromuscular junction, causes significant muscular functional impairment and can compromise patients’ quality of life, including fatigue, disability, and increased mortality rates. Continued efforts in the last decades have begun to produce significant progress in our understanding of this rare condition, yet considerable challenges remain for improving diagnosis and developing effective treatments for MG. The present volume comprises papers stemming from the “12th International Conference on Myasthenia Gravis and Related Disorders,” held May 21–23, 2012 at the New York Academy of Sciences in New York City.

The papers collected in this first of two Annals volumes highlight some of the key developments in neuroscience and immunology in MG and related syndromes presented at the conference, including structure and function of the neuromuscular junction, advances in immunology and their relationship to myasthenia gravis, clinical and laboratory developments, outcome measurements and clinical trial development, and animal models of neuromuscular junction disease.

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Acetylcholine Receptor Structure

Immunopathogenesis of Myasthenia Gravis

Animal Models of Myasthenia Gravis for Preclinical Evaluation

Epidemiology and Genetics of Myasthenia Gravis

Clinical Presentations of Myasthenia Gravis

Ocular Myasthenia

Thymoma-Associated Myasthenia Gravis

Electrodiagnosis of Neuromuscular Junction Disorders

Autoantibody Testing in the Diagnosis and Management of Autoimmune Disorders of Neuromuscular Transmission and Related Diseases

Treatment of Myasthenia Gravis

Neurocritical Care of Myasthenic Crisis

Thymectomy for Non-thymomatous Myasthenia Gravis

Lambert-Eaton Syndrome

Acquired Neuromyotonia

Congenital Myasthenic Syndromes

Toxic Neuromuscular Transmission Disorders

Predictors of Psychological Health in Myasthenia Gravis

Myasthenia Gravis: Classification and Outcome Measurements

Emerging Therapeutics for Myasthenia Gravis

Clinical Trial Design for Myasthenia Gravis

Gil Wolfe is the editor of Myasthenia Gravis and Related Disorders I: 12th International Conference, Volume 1274, published by Wiley. Emma Ciafalonia is the editor of Myasthenia Gravis and Related Disorders I: 12th International Conference, Volume 1274, published by Wiley.