{"product_id":"molecules-and-medicine-isbn-9780470227497","title":"Molecules and Medicine","description":"\u003ci\u003eMolecules and Medicine\u003c\/i\u003e provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine. It delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules in use in modern medicine. Opening sections of the book provide a unique, clear, and concise introduction, which enables readers to understand chemical formulas. \u003cp\u003e\u003cb\u003ePart I.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIntroduction 2\u003c\/p\u003e \u003cp\u003eUnderstanding Structural Diagrams of Organic Molecules 4\u003c\/p\u003e \u003cp\u003eSome Common Molecules 23\u003c\/p\u003e \u003cp\u003eProteins and Three-Dimensional Protein Structure 26\u003c\/p\u003e \u003cp\u003eSome of the Protein Structures That Appear in This Book 32\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II. Inflammatory, Cardiovascular and Metabolic Diseases\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAnti-Inflammatory Agents\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAcetylsalicylic acid (Aspirin\u003csup\u003eTM\u003c\/sup\u003e) 38\u003c\/p\u003e \u003cp\u003eNaproxen (Aleve\u003csup\u003eTM\u003c\/sup\u003e) 39\u003c\/p\u003e \u003cp\u003eHow Do Anti-Inflammatory Drugs Work? 40\u003c\/p\u003e \u003cp\u003eOther Eicosanoids in Inflammation 41\u003c\/p\u003e \u003cp\u003eAn Overview of Inflammation 42\u003c\/p\u003e \u003cp\u003eCelecoxib (Celebrex\u003csup\u003eTM\u003c\/sup\u003e) 43\u003c\/p\u003e \u003cp\u003ePrednisone (Deltasone\u003csup\u003eTM\u003c\/sup\u003e) 44\u003c\/p\u003e \u003cp\u003eMethotrexate (Trexall\u003csup\u003eTM\u003c\/sup\u003e) 46\u003c\/p\u003e \u003cp\u003eAllopurinol (Zyloprim\u003csup\u003eTM\u003c\/sup\u003e) 47\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAntiasthmatic and Antiallergic Agents \u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSalmeterol (Serevent\u003csup\u003eTM\u003c\/sup\u003e) 50\u003c\/p\u003e \u003cp\u003eFluticasone Propionate (Flovent\u003csup\u003eTM\u003c\/sup\u003e) 51\u003c\/p\u003e \u003cp\u003eMontelukast Sodium (Singulair\u003csup\u003eTM\u003c\/sup\u003e) 52\u003c\/p\u003e \u003cp\u003eTiotropium Bromide (Spiriva\u003csup\u003eTM\u003c\/sup\u003e) 53\u003c\/p\u003e \u003cp\u003eLoratadine (Claritin\u003csup\u003eTM\u003c\/sup\u003e) 54\u003c\/p\u003e \u003cp\u003e\u003cb\u003eType 2 Diabetes\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAn Overview of Metabolic Syndrome 56\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAntidiabetic and Cholesterol-Lowering Agents\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMetformin (Glucophage\u003csup\u003eTM\u003c\/sup\u003e) 60\u003c\/p\u003e \u003cp\u003eGlipizide (Glucotrol\u003csup\u003eTM\u003c\/sup\u003e) 61\u003c\/p\u003e \u003cp\u003ePioglitazone (Actos\u003csup\u003eTM\u003c\/sup\u003e) 62\u003c\/p\u003e \u003cp\u003eSitagliptin (Januvia\u003csup\u003eTM\u003c\/sup\u003e) 63\u003c\/p\u003e \u003cp\u003eAtorvastatin (Lipitor\u003csup\u003eTM\u003c\/sup\u003e) 64\u003c\/p\u003e \u003cp\u003eEzetimibe (Zetia\u003csup\u003eTM\u003c\/sup\u003e) 65\u003c\/p\u003e \u003cp\u003e\u003cb\u003eCardiovascular Agents\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAtenolol (Tenormin\u003csup\u003eTM\u003c\/sup\u003e) 68\u003c\/p\u003e \u003cp\u003eEnalapril (Vasotec\u003csup\u003eTM\u003c\/sup\u003e) 69\u003c\/p\u003e \u003cp\u003eCandesartan Cilexetil (Atacand\u003csup\u003eTM\u003c\/sup\u003e) 70\u003c\/p\u003e \u003cp\u003eAliskiren (Tekturna\u003csup\u003eTM\u003c\/sup\u003e) 71\u003c\/p\u003e \u003cp\u003eAmlodipine (Norvasc\u003csup\u003eTM\u003c\/sup\u003e) 72\u003c\/p\u003e \u003cp\u003eNitroglycerin 73\u003c\/p\u003e \u003cp\u003eClopidogrel Bisulfate (Plavix\u003csup\u003eTM\u003c\/sup\u003e) 74\u003c\/p\u003e \u003cp\u003eDigoxin (Lanoxin\u003csup\u003eTM\u003c\/sup\u003e) 75\u003c\/p\u003e \u003cp\u003e\u003cb\u003eReceptors and Signaling \u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eInformation Flow into the Cell by Chemical Signaling 78\u003c\/p\u003e \u003cp\u003eReferences for Part II 80\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III. Reproductive Medicine\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eOral Contraceptives 90\u003c\/p\u003e \u003cp\u003eTestosterone 91\u003c\/p\u003e \u003cp\u003eMifepristone (Mifeprex\u003csup\u003eTM\u003c\/sup\u003e) 92\u003c\/p\u003e \u003cp\u003eOxytocin (Oxytocin\u003csup\u003eTM\u003c\/sup\u003e) 93\u003c\/p\u003e \u003cp\u003eSildenafil (Viagra\u003csup\u003eTM\u003c\/sup\u003e) 94\u003c\/p\u003e \u003cp\u003e\u003cb\u003eOsteoporosis\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eSome Aspects of Osteoporosis 96\u003c\/p\u003e \u003cp\u003eAlendronate (Fosamax\u003csup\u003eTM\u003c\/sup\u003e) 97\u003c\/p\u003e \u003cp\u003eCalcitriol (Rocaltrol\u003csup\u003eTM\u003c\/sup\u003e) 98\u003c\/p\u003e \u003cp\u003eRaloxifene (Evista\u003csup\u003eTM\u003c\/sup\u003e) 99\u003c\/p\u003e \u003cp\u003eTeriparatide (Forteo\u003csup\u003eTM\u003c\/sup\u003e) 100\u003c\/p\u003e \u003cp\u003e\u003cb\u003eGlaucoma and Antiulcer Agents\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eLatanoprost (Xalatan\u003csup\u003eTM\u003c\/sup\u003e) 102\u003c\/p\u003e \u003cp\u003eRanitidine (Zantac\u003csup\u003eTM\u003c\/sup\u003e) 103\u003c\/p\u003e \u003cp\u003eOmeprazole (Prilosec\u003csup\u003eTM\u003c\/sup\u003e) 104\u003c\/p\u003e \u003cp\u003eReferences for Part III 105\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV.  Autoimmune Disease and Organ Transplant\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eA Brief Survey of the Immune System 112\u003c\/p\u003e \u003cp\u003e\u003cb\u003eImmunosuppressive Agents\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAzathioprine (Imuran\u003csup\u003eTM\u003c\/sup\u003e) 122\u003c\/p\u003e \u003cp\u003eMycophenolate Mofetil (CeIlCept\u003csup\u003eTM\u003c\/sup\u003e) 123\u003c\/p\u003e \u003cp\u003eCyclosporin (Neoral\u003csup\u003eTM\u003c\/sup\u003e) 124\u003c\/p\u003e \u003cp\u003eTacrolimus (Prograf\u003csup\u003eTM\u003c\/sup\u003e) 125\u003c\/p\u003e \u003cp\u003eFTY720 (Fingolimod) 126\u003c\/p\u003e \u003cp\u003e\u003cb\u003eInfectious Diseases \u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAntibiotics\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAmoxicillin (Amoxil\u003csup\u003eTM\u003c\/sup\u003e) 130\u003c\/p\u003e \u003cp\u003eCefaclor (Ceclor\u003csup\u003eTM\u003c\/sup\u003e) 132\u003c\/p\u003e \u003cp\u003eDoxycycline (Vibramycin\u003csup\u003eTM\u003c\/sup\u003e) 133\u003c\/p\u003e \u003cp\u003eAzithromycin (Zithromax\u003csup\u003eTM\u003c\/sup\u003e) 134\u003c\/p\u003e \u003cp\u003eCiprofloxacin (Cipro\u003csup\u003eTM\u003c\/sup\u003e) 135\u003c\/p\u003e \u003cp\u003eTrimethoprim (Triprim\u003csup\u003eTM\u003c\/sup\u003e) 136\u003c\/p\u003e \u003cp\u003eAmikacin (Amikin\u003csup\u003eTM\u003c\/sup\u003e) 137\u003c\/p\u003e \u003cp\u003eVancomycin (Vancocin\u003csup\u003eTM\u003c\/sup\u003e) 138\u003c\/p\u003e \u003cp\u003eLinezolid (Zyvox\u003csup\u003eTM\u003c\/sup\u003e) 139\u003c\/p\u003e \u003cp\u003eIsoniazid (Laniazid\u003csup\u003eTM\u003c\/sup\u003e) 140\u003c\/p\u003e \u003cp\u003eAncillary Antibiotics 142\u003c\/p\u003e \u003cp\u003eDrug Resistance 143\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAntiviral Agents\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eOn Viruses and Viral Diseases 146\u003c\/p\u003e \u003cp\u003eAcyclovir (Zovirax\u003csup\u003eTM\u003c\/sup\u003e) 148\u003c\/p\u003e \u003cp\u003eRibavirin (Virazole\u003csup\u003eTM\u003c\/sup\u003e) 149\u003c\/p\u003e \u003cp\u003eOseltamivir (Tamiflu\u003csup\u003eTM\u003c\/sup\u003e) 150\u003c\/p\u003e \u003cp\u003eZidovudine (Retrovir, AZT\u003csup\u003eTM\u003c\/sup\u003e) 151\u003c\/p\u003e \u003cp\u003eZalcitabine (Hivid\u003csup\u003eTM\u003c\/sup\u003e) 152\u003c\/p\u003e \u003cp\u003eNevirapine (Viramune\u003csup\u003eTM\u003c\/sup\u003e) 153\u003c\/p\u003e \u003cp\u003eEfavirenz (Sustiva\u003csup\u003eTM\u003c\/sup\u003e) 154\u003c\/p\u003e \u003cp\u003eLopinavir + Ritonavir (Kaletra\u003csup\u003eTM\u003c\/sup\u003e) 155\u003c\/p\u003e \u003cp\u003eUK427857 (Maraviroc) 156\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAntifungal Agents\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAmphotericin (Fungizone\u003csup\u003eTM\u003c\/sup\u003e) 160\u003c\/p\u003e \u003cp\u003eFluconazole (Diflucan\u003csup\u003eTM\u003c\/sup\u003e) 161\u003c\/p\u003e \u003cp\u003eCaspofungin (Cancidas\u003csup\u003eTM\u003c\/sup\u003e) 162\u003c\/p\u003e \u003cp\u003eTerbinafine (Lamisil\u003csup\u003eTM\u003c\/sup\u003e) 163\u003c\/p\u003e \u003cp\u003e\u003cb\u003eAntimalarial and Antiparasitic Agents\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eParasitic Diseases: A Focus on Malaria 166\u003c\/p\u003e \u003cp\u003eChloroquine (Arden\u003csup\u003eTM\u003c\/sup\u003e) 167\u003c\/p\u003e \u003cp\u003eArtemether + Lumefantrine (CoArtem\u003csup\u003eTM\u003c\/sup\u003e) 168\u003c\/p\u003e \u003cp\u003eAtovaquone + Proguanil (Malarone\u003csup\u003eTM\u003c\/sup\u003e) 169\u003c\/p\u003e \u003cp\u003eMiltefosine (I mpavido\u003csup\u003eTM\u003c\/sup\u003e) 170\u003c\/p\u003e \u003cp\u003eNitazoxanide (Alinia\u003csup\u003eTM\u003c\/sup\u003e) 171\u003c\/p\u003e \u003cp\u003eIvermectin (Stromectol\u003csup\u003eTM\u003c\/sup\u003e) 172\u003c\/p\u003e \u003cp\u003eReferences for Part IV 173\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart V. Malignant Disease\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAn Overview of Cancer 184\u003c\/p\u003e \u003cp\u003eCapecitabine (Xeloda\u003csup\u003eTM\u003c\/sup\u003e) 187\u003c\/p\u003e \u003cp\u003eCarboplatin (Paraplatin\u003csup\u003eTM\u003c\/sup\u003e) 188\u003c\/p\u003e \u003cp\u003eVinblastine (Velban\u003csup\u003eTM\u003c\/sup\u003e) 189\u003c\/p\u003e \u003cp\u003ePaclitaxel (Taxol\u003csup\u003eTM\u003c\/sup\u003e) 190\u003c\/p\u003e \u003cp\u003eCyclophosphamide (Cytoxan\u003csup\u003eTM\u003c\/sup\u003e) 191\u003c\/p\u003e \u003cp\u003eTamoxifen (Nolvadex\u003csup\u003eTM\u003c\/sup\u003e) 192\u003c\/p\u003e \u003cp\u003eIrinotecan (Camptosar\u003csup\u003eTM\u003c\/sup\u003e) 193\u003c\/p\u003e \u003cp\u003eBleomycin (Blenoxane\u003csup\u003eTM\u003c\/sup\u003e) 194\u003c\/p\u003e \u003cp\u003eImatinib (Gleevec\u003csup\u003eTM\u003c\/sup\u003e) 195\u003c\/p\u003e \u003cp\u003eSunitinib (Sutent\u003csup\u003eTM\u003c\/sup\u003e) 196\u003c\/p\u003e \u003cp\u003eBortezomib (Velcade\u003csup\u003eTM\u003c\/sup\u003e) 197\u003c\/p\u003e \u003cp\u003eAncillary Anticancer Agents 198\u003c\/p\u003e \u003cp\u003eReferences for Part V 200\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart VI. Drugs Acting on the Nervous System\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePain and Analgesia\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eLidocaine (Xylocaine\u003csup\u003eTM\u003c\/sup\u003e) 208\u003c\/p\u003e \u003cp\u003eMorphine (Avinza\u003csup\u003eTM\u003c\/sup\u003e) 209\u003c\/p\u003e \u003cp\u003eAcetaminophen (Tylenol \u003csup\u003eTM\u003c\/sup\u003e) 210\u003c\/p\u003e \u003cp\u003eFentanyl (Duragesic\u003csup\u003eTM\u003c\/sup\u003e) 211\u003c\/p\u003e \u003cp\u003eSodium Thiopental (Sodium Pentothal\u003csup\u003eTM\u003c\/sup\u003e) 212\u003c\/p\u003e \u003cp\u003eGabapentin (Neurontin\u003csup\u003eTM\u003c\/sup\u003e) 213\u003c\/p\u003e \u003cp\u003eDiazepam (Valium\u003csup\u003eTM\u003c\/sup\u003e) 214\u003c\/p\u003e \u003cp\u003eSumatriptan (Imitrex\u003csup\u003eTM\u003c\/sup\u003e) 215\u003c\/p\u003e \u003cp\u003e\u003cb\u003eHypnotics (Insomnia) and Antismoking\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eZolpidem (Ambien\u003csup\u003eTM\u003c\/sup\u003e) 218\u003c\/p\u003e \u003cp\u003eRamelteon (Rozerem\u003csup\u003eTM\u003c\/sup\u003e) 219\u003c\/p\u003e \u003cp\u003eVarenicline (Chantix\u003csup\u003eTM\u003c\/sup\u003e) 220\u003c\/p\u003e \u003cp\u003eThe Brain, Neurotransmission and Molecular Neurotransmitters 221\u003c\/p\u003e \u003cp\u003e\u003cb\u003eNeurodegenerative and Psychiatric Diseases\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eLevodopa (Larodopa\u003csup\u003eTM\u003c\/sup\u003e) 224\u003c\/p\u003e \u003cp\u003eDonepezil (Aricept\u003csup\u003eTM\u003c\/sup\u003e) 225\u003c\/p\u003e \u003cp\u003eAntiepileptic Agents 226\u003c\/p\u003e \u003cp\u003eAntianxiety Agents 228\u003c\/p\u003e \u003cp\u003eAntidepressants 229\u003c\/p\u003e \u003cp\u003eAntipsychotics 232\u003c\/p\u003e \u003cp\u003eReferences for Part VI 233\u003c\/p\u003e \u003cp\u003eGlossary 237\u003c\/p\u003e \u003cp\u003eIndex 249\u003c\/p\u003e  “\u003ci\u003eMolecules and Medicine\u003c\/i\u003e is a fascinating introduction to the convergence of chemistry and physiology, and to the emergence of the science of molecular medicine.” (\u003ci\u003eThe Nucleus\u003c\/i\u003e, January 2010)  \u003cp\u003e\"\u003ci\u003eMolecules and Medicine\u003c\/i\u003e is extremely well organized and integrates history, chemistry, biology, and pharmacology of drug development seamlessly.\" (\u003ci\u003eThe Quarterly Review of Biology\u003c\/i\u003e, September 2008)\u003c\/p\u003e \u003cp\u003e\"…I find this to be a useful book for somemone teaching a biochemistry class.  Use of examples and information from Molecules and Medicine should make material in lectures seem more relevant to students and assist motivation for learning.\" (\u003ci\u003eBiochemistry and Molecular Biology Education\u003c\/i\u003e, May\/June 2008)\u003c\/p\u003e \u003cp\u003e\"This is a treasure trove of information about molecules as medicines.\" (\u003ci\u003eEducation in Chemistry\u003c\/i\u003e, May 2008)\u003c\/p\u003e \u003cp\u003e\"Molecules and Medicine is an engaging book that takes the reader into the world of small molecule clinical therapeutics and how they are discovered and used to improve health.\" (\u003ci\u003eCHOICE\u003c\/i\u003e, March 2008)\u003c\/p\u003e \u003cp\u003e\"…numerous colorful illustrations that help to explain the various topics covered make it easy and interesting reading.\" (\u003ci\u003eChemBioChem\u003c\/i\u003e, March 2008)\u003c\/p\u003e  \"Dieses Werk schlie?t eine Lucke in der didaktischen Literatur und wird in der Ausbildung von Wissenschaftlern enorm von Nutzen sein.\"\u003cbr\u003e Angewandte Chemie, 2008, 120, 2203-2205\u003cbr\u003e  \u003cb\u003eE. J. Corey\u003c\/b\u003e has been a Professor at Harvard University since 1959. He was educated at The Massachusetts Institute of Technology (1945-1950) and served as a faculty member at the University of Illinois from1951 to 1959. He is the 1990 Nobel Laureate in Chemistry, and the recipient of over seventy international awards and honorary degrees, including the U.S. National Medal of Science, the Japan Prize in Science, and the Priestley Medal of the American Chemical Society. He is amember of the U.S. National Academy of Sciences and the U.S. National Institute of Medicine. Professor Corey is the author of more than 1,000 publications and is one of the most cited authors in science.  \u003cp\u003e\u003cb\u003eBarbara Czakó\u003c\/b\u003e completed undergraduate studies at the University of Debrecen, Hungary, where she worked with Dr. Sándor Berényi. She obtained a Master of Science degree at the University of Missouri-Columbia with Professor Shon R. Pulley. Dr. Czakó received her Ph.D. degree (2006) in synthetic organic chemistry under the guidance of Professor Gary A. Molander at the University of Pennsylvania. Currently she is a postdoctoral fellow with Professor E.J. Corey at Harvard University. In 2005 she published with László Kürti the textbook \u003ci\u003eStrategic Applications of Named Reactions in Organic Synthesis\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eLászló Kürti\u003c\/b\u003e was born and raised in Hungary. He received his diploma from the University of Debrecen, Hungary, where he conducted research in the laboratory of Professor Sándor Antus. Subsequently he received his Master of Science degree at the University of Missouri-Columbia working with Professor Michael Harmata, and his Ph.D. degree (2006) in synthetic organic chemistry under the supervision of Professor Amos B. Smith III (the University of Pennsylvania). Currently he is a Damon Runyon Cancer Fellow in the group of Professor E.J. Corey at Harvard University. In 2005 he published with Barbara Czakó the textbook \u003ci\u003eStrategic Applications of Named Reactions in Organic Synthesis\u003c\/i\u003e.\u003c\/p\u003e  \u003cb\u003eMolecules And Medicine\u003c\/b\u003e  \u003cp\u003eThis book is appropriate for a broad readership, starting with curious and thoughtful college undergraduates and reaching beyond to professors and researchers in the life sciences, chemistry, and medicine. This book provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eMolecules and Medicine\u003c\/i\u003e delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules now in use in modern medicine. Molecule structures and shapes are shown for all of these medicines. The opening sections of the book provide a unique, clear, and concise introduction which enables the reader to understand chemical formulas.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989650227429,"sku":"NP9780470227497","price":46.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470227497.jpg?v=1761784959","url":"https:\/\/k12savings.com\/products\/molecules-and-medicine-isbn-9780470227497","provider":"K12savings","version":"1.0","type":"link"}