{"product_id":"molecular-pharming-isbn-9781118801284","title":"Molecular Pharming","description":"\u003cp\u003e\u003cb\u003eA single volume collection that surveys the exciting field of plant-made pharmaceuticals and industrial proteins\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThis comprehensive book communicates the recent advances and exciting potential for the expanding area of plant biotechnology and is divided into six sections. The first three sections look at the current status of the field, and advances in plant platforms and strategies for improving yields, downstream processing, and controlling post-translational modifications of plant-made recombinant proteins. Section four reviews high-value industrial and pharmacological proteins that are successfully being produced in established and emerging plant platforms. The fifth section looks at regulatory challenges facing the expansion of the field. The final section turns its focus toward small molecule therapeutics, drug screening, plant specialized metabolites, and plants as model organisms to study human disease processes.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eMolecular Pharming: Applications, Challenges and Emerging Areas\u003c\/i\u003e offers in-depth coverage of molecular biology of plant expression systems and manipulation of glycosylation processes in plants; plant platforms, subcellular targeting, recovery, and downstream processing; plant-derived protein pharmaceuticals and case studies; regulatory issues; and emerging areas. It is a valuable resource for researchers that are in the field of plant molecular pharming, as well as for those conducting basic research in gene expression, protein quality control, and other subjects relevant to molecular and cellular biology.\u003c\/p\u003e \u003cul\u003e \u003cli\u003eBroad ranging coverage of a key area of plant biotechnology\u003c\/li\u003e \u003cli\u003eDescribes efforts to produce pharmaceutical and industrial proteins in plants\u003c\/li\u003e \u003cli\u003eProvides reviews of recent advances and technology breakthroughs\u003c\/li\u003e \u003cli\u003eAssesses realities of regulatory and cost hurdles\u003c\/li\u003e \u003cli\u003eForward looking with coverage of small molecule technologies and the use of plants as models of human disease processes\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eProviding wide-ranging and unique coverage, \u003ci\u003eMolecular Pharming: Applications, Challenges and Emerging Areas\u003c\/i\u003e will be of great interest to the plant science, plant biotechnology, protein science, and pharmacological communities. \u003c\/p\u003e \u003cp\u003eList of Contributors ix\u003c\/p\u003e \u003cp\u003ePreface xiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart One The Molecular Farming\/Pharming Landscape 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Current Status and Perspectives of the Molecular Farming Landscape 3\u003cbr\u003e\u003ci\u003eHolger Spiegel, Eva Stöger, Richard M. Twyman, and Johannes F. Buyel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart Two Molecular Biology of Plant Expression Systems and Manipulation of Glycosylation Processes in Plants 25\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2 Synthetic Transcription Activator‐Like Effector‐Activated Promoters for Coordinated Orthogonal Gene Expression in Plants: Applications for Regulatory Circuit and Metabolic Engineering 27\u003cbr\u003e\u003ci\u003eTom Schreiber and Alain Tissier\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Contemporary and Emerging Technologies for Precise N‐glycan Analyses 43\u003cbr\u003e\u003ci\u003eIain B.H. Wilson, Katharina Paschinger, Jorick Vanbeselaere, and Chunsheng Jin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Production of Functionally Active Recombinant Proteins in Plants: Manipulating N‐ and O‐glycosylation 67\u003cbr\u003e\u003ci\u003eAlexandra Castilho and Richard Strasser\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart Three Plant Platforms, Subcellular Targeting, Recovery, and Downstream Processing 91\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5 Seeds as Bioreactors 93\u003cbr\u003e\u003ci\u003eJinbo Shen, Xiangfeng Wang, and Liwen Jiang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Strategies to Increase Expression and Accumulation of Recombinant Proteins 119\u003cbr\u003e\u003ci\u003eReza Saberianfar and Rima Menassa\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 The Impact of Six Critical Impurities on Recombinant Protein Recovery and Purification from Plant Hosts 137\u003cbr\u003e\u003ci\u003eChelsea Dixon, Lisa R. Wilken, Susan L. Woodard, and Georgia O.F. Barros\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Plant Recombinant Lysosomal Enzymes as Replacement Therapeutics for Lysosomal Storage Diseases: Unique Processing for Lysosomal Delivery and Efficacy 181\u003cbr\u003e\u003ci\u003eAllison R. Kermode, Grant McNair, and Owen Pierce\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart Four Plant‐Derived Protein Pharmaceuticals and Case Studies 217\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9 Plant‐Produced Antibodies and Post‐Translational Modification 219\u003cbr\u003e\u003ci\u003eAndreas Loos and Herta Steinkellner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Molecular Pharming: Plant‐Made Vaccines 231\u003cbr\u003e\u003ci\u003eQiang Chen, Matthew Dent, and Hugh Mason\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Transgenic Rice for the Production of Recombinant Pharmaceutical Proteins: A Case Study of Human Serum Albumin 275\u003cbr\u003e\u003ci\u003eDaichang Yang, Jiquan Ou, Jingni Shi, Zhibin Guo, Bo Shi, and Naghmeh Abiri\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Enzymes for Industrial and Pharmaceutical Applications – From Individual to Population Level Impact 309\u003cbr\u003e\u003ci\u003eElizabeth E. Hood and Carole L. Cramer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart Five Regulatory Issues 327\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13 Biosafety, Risk Assessment, and Regulation of Molecular Farming 329\u003cbr\u003e\u003ci\u003ePenny A.C. Hundleby (nee Sparrow), Markus Sack, and Richard M. Twyman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart Six Emerging Areas: Plant Specialized Metabolites and Small Molecule Drugs 353\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14 Harnessing Plant Trichome Biochemistry for the Production of Useful Compounds 355\u003cbr\u003e\u003ci\u003eAlain Tissier\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Reconstitution of Medicinally Important Plant Natural Products in Microorganisms 383\u003cbr\u003e\u003ci\u003eOzkan Fidan and Jixun Zhan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 Screening of Epidermal Growth Factor Receptor Inhibitors in Natural Products Derived From Extracts of Traditional Chinese Medicines 417\u003cbr\u003e\u003ci\u003eLi Feng and Jingwu Kang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 Target-Directed Evolution of Mutant Transgenic Plant Cells as a Novel Source of Drugs 435\u003cbr\u003e\u003ci\u003eJohn Littleton, Dustin Brown, Deane Falcone, Gregory Gerhardt, Samir Gunjan, Dennis T. Rogers, and Jatinder Sambi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Plant Thermotolerance Proteins, Misfolded Proteins, and Neurodegenerative Diseases 457\u003cbr\u003e\u003ci\u003eIndranil Basak and Simon G. Møller\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 475\u003c\/p\u003e    \u003cp\u003e\u003cb\u003eAllison R. Kermode\u003c\/b\u003e is Professor and Michael Smith Senior Scholar at Simon Fraser University. Her work on plant-derived human proteins was recently featured in \u003ci\u003eNature\u003c\/i\u003e magazine. Dr. Kermode is also the editor of \u003ci\u003eSeed Dormancy: Methods and Protocols\u003c\/i\u003e. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eLiwen Jiang\u003c\/b\u003e is Choh-Ming Li Professor of Life Sciences at the Chinese University of Hong Kong. He is a leader in research on protein targeting and trafficking in plant cells, plant organelle biogenesis and function, and the application of these processes to plant biotechnology.     \u003c\/p\u003e\u003cp\u003eThis comprehensive book communicates the recent advances in, and exciting potential for, the expanding area of plant biotechnology and is divided into six sections. The first three sections look at the current status of the field, and advances in plant platforms and strategies for improving yields, downstream processing, and controlling post-translational modifications of plant-made recombinant proteins. Section four reviews high-value industrial and pharmacological proteins that are successfully being produced in established and emerging plant platforms. The fifth section looks at regulatory challenges facing the expansion of the field. The final section turns its focus toward small molecule therapeutics, drug screening, plant-specialized metabolites, and plants as model organisms to study human disease processes. \u003c\/p\u003e\u003cp\u003e\u003ci\u003eMolecular Pharming: Applications, Challenges, and Emerging Areas\u003c\/i\u003e offers in-depth coverage of molecular biology of plant expression systems and manipulation of glycosylation processes in plants; plant platforms, subcellular targeting, recovery, and downstream processing; plant-derived protein pharmaceuticals and case studies; regulatory issues; and emerging areas. It is a valuable resource for researchers that are in the field of plant molecular pharming, as well as for those conducting basic research in gene expression, protein quality control, and other subjects relevant to molecular and cellular biology. \u003c\/p\u003e\u003cul\u003e \u003cli\u003eBroad-ranging coverage of a key area of plant biotechnology\u003c\/li\u003e \u003cli\u003eDescribes efforts to produce pharmaceutical and industrial proteins in plants\u003c\/li\u003e \u003cli\u003eProvides reviews of recent advances and technology breakthroughs\u003c\/li\u003e \u003cli\u003eAssesses realities of regulatory and cost hurdles\u003c\/li\u003e \u003cli\u003eForward-looking with coverage of small molecule technologies and the use of plants as models of human disease processes\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eProviding wide-ranging and unique coverage, \u003ci\u003eMolecular Pharming: Applications, Challenges, and Emerging Areas\u003c\/i\u003e will be of great interest to the plant science, plant biotechnology, protein science, and pharmacological communities.\u003c\/p\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Default Title","offer_id":47989649146085,"sku":"NP9781118801284","price":242.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781118801284.jpg?v=1761784954","url":"https:\/\/k12savings.com\/products\/molecular-pharming-isbn-9781118801284","provider":"K12savings","version":"1.0","type":"link"}