{"product_id":"molecular-pharmacology-isbn-9780470684443","title":"Molecular Pharmacology","description":"\u003cp\u003eThis textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ\/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments.\u003c\/p\u003e \u003cp\u003eProviding an invaluable resource for advanced under-graduate and MSc\/PhD students, new researchers to the field and practitioners for continuing professional development, \u003ci\u003eMolecular Pharmacology\u003c\/i\u003e explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell.\u003c\/p\u003e \u003cul\u003e \u003cli\u003e\n\u003cb\u003eCurrent\u003c\/b\u003e - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data.\u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eCutting Edge\u003c\/b\u003e - highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects.\u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eApplied\u003c\/b\u003e - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect.\u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eAccessible\u003c\/b\u003e - contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book.\u003c\/li\u003e \u003c\/ul\u003e  Preface ix  \u003cp\u003eAbbreviations x\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction to Drug Targets and Molecular Pharmacology 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction to molecular pharmacology 1\u003c\/p\u003e \u003cp\u003e1.2 Scope of this textbook 2\u003c\/p\u003e \u003cp\u003e1.3 The nature of drug targets 3\u003c\/p\u003e \u003cp\u003e1.4 Future drug targets 7\u003c\/p\u003e \u003cp\u003e1.5 Molecular pharmacology and drug discovery 11\u003c\/p\u003e \u003cp\u003eReferences 12\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Molecular Cloning of Drug Targets 13\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction to molecular cloning – from DNA to drug discovery 13\u003c\/p\u003e \u003cp\u003e2.2 ‘Traditional’ pharmacology 14\u003c\/p\u003e \u003cp\u003e2.3 The relevance of recombinant DNA technology to pharmacology\/drug discovery 14\u003c\/p\u003e \u003cp\u003e2.4 The ‘cloning’ of drug targets 15\u003c\/p\u003e \u003cp\u003e2.5 What information can DNA cloning provide? 20\u003c\/p\u003e \u003cp\u003e2.6 Comparing the pharmacologic profile of the ‘cloned’ and the ‘native’ drug target 23\u003c\/p\u003e \u003cp\u003e2.7 Reverse pharmacology illustrated on orphan GPCRs 24\u003c\/p\u003e \u003cp\u003e2.8 Summary 27\u003c\/p\u003e \u003cp\u003eReferences 27\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 G Protein-coupled Receptors 31\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction to G protein-coupled receptors 31\u003c\/p\u003e \u003cp\u003e3.2 Heterotrimeric G-proteins 36\u003c\/p\u003e \u003cp\u003e3.3 Signal transduction pathways 40\u003c\/p\u003e \u003cp\u003e3.4 Desensitisation and down-regulation of GPCR signalling 44\u003c\/p\u003e \u003cp\u003e3.5 Constitutive GPCR activity 45\u003c\/p\u003e \u003cp\u003e3.6 Promiscuous G-protein coupling 47\u003c\/p\u003e \u003cp\u003e3.7 Agonist-directed signalling 48\u003c\/p\u003e \u003cp\u003e3.8 Allosteric modulators of GPCR function 49\u003c\/p\u003e \u003cp\u003e3.9 Pharmacological chaperones for GPCRs 50\u003c\/p\u003e \u003cp\u003e3.10 GPCR dimerisation 51\u003c\/p\u003e \u003cp\u003e3.11 GPCR splice variants 63\u003c\/p\u003e \u003cp\u003e3.12 Summary 67\u003c\/p\u003e \u003cp\u003eReferences 67\u003c\/p\u003e \u003cp\u003eUseful Web sites 70\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Ion Channels 71\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 71\u003c\/p\u003e \u003cp\u003e4.2 Voltage-gated ion channels 73\u003c\/p\u003e \u003cp\u003e4.3 Other types of voltage-gated ion channels 89\u003c\/p\u003e \u003cp\u003e4.4 Ligand-gated ion channels 109\u003c\/p\u003e \u003cp\u003e4.5 Summary 125\u003c\/p\u003e \u003cp\u003eReferences 125\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Transporter Proteins 129\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 129\u003c\/p\u003e \u003cp\u003e5.2 Classification 129\u003c\/p\u003e \u003cp\u003e5.3 Structural analysis of transporters 132\u003c\/p\u003e \u003cp\u003e5.4 Transporter families of pharmacological interest 133\u003c\/p\u003e \u003cp\u003e5.5 Transporters and cellular homeostasis 167\u003c\/p\u003e \u003cp\u003e5.6 Summary 169\u003c\/p\u003e \u003cp\u003eReferences 169\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Cystic Fibrosis: Alternative Approaches to the Treatment of a Genetic Disease 175\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 175\u003c\/p\u003e \u003cp\u003e6.2 Cystic fibrosis transmembrane conductance regulator 179\u003c\/p\u003e \u003cp\u003e6.3 Mutations in CFTR 183\u003c\/p\u003e \u003cp\u003e6.4 Why is cystic fibrosis so common? 184\u003c\/p\u003e \u003cp\u003e6.5 Animal models of Cystic fibrosis 186\u003c\/p\u003e \u003cp\u003e6.6 Pharmacotherapy 186\u003c\/p\u003e \u003cp\u003e6.7 Gene therapy 191\u003c\/p\u003e \u003cp\u003e6.8 Conclusion 195\u003c\/p\u003e \u003cp\u003eReferences 196\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Pharmacogenomics 201\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Types of genetic variation in the human genome 201\u003c\/p\u003e \u003cp\u003e7.2 Thiopurine S-methyltransferase and K+ channel polymorphisms 202\u003c\/p\u003e \u003cp\u003e7.3 Polymorphisms affecting drug metabolism 204\u003c\/p\u003e \u003cp\u003e7.4 Methods for detecting genetic polymorphisms 209\u003c\/p\u003e \u003cp\u003e7.5 Genetic variation in drug transporters 211\u003c\/p\u003e \u003cp\u003e7.6 Genetic variation in G protein coupled receptors 215\u003c\/p\u003e \u003cp\u003e7.7 Summary 225\u003c\/p\u003e \u003cp\u003eReferences 225\u003c\/p\u003e \u003cp\u003eUseful Web sites 226\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Transcription Factors and Gene Expression 227\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Control of gene expression 227\u003c\/p\u003e \u003cp\u003e8.2 Transcription factors 229\u003c\/p\u003e \u003cp\u003e8.3 CREB 233\u003c\/p\u003e \u003cp\u003e8.4 Nuclear receptors 238\u003c\/p\u003e \u003cp\u003e8.5 Peroxisome proliferator-activated receptors 240\u003c\/p\u003e \u003cp\u003e8.6 Growth factors 247\u003c\/p\u003e \u003cp\u003e8.7 Alternative splicing 247\u003c\/p\u003e \u003cp\u003e8.8 RNA editing 251\u003c\/p\u003e \u003cp\u003e8.9 The importance of non-coding RNAs in gene expression 257\u003c\/p\u003e \u003cp\u003e8.10 Summary 270\u003c\/p\u003e \u003cp\u003eReferences 271\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Cellular Calcium 277\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 277\u003c\/p\u003e \u003cp\u003e9.2 Measurement of calcium 278\u003c\/p\u003e \u003cp\u003e9.3 The exocrine pancreas 289\u003c\/p\u003e \u003cp\u003e9.4 Calcium signalling in pancreatic acinar cells 292\u003c\/p\u003e \u003cp\u003e9.5 Nuclear calcium signalling 303\u003c\/p\u003e \u003cp\u003e9.6 Conclusions 310\u003c\/p\u003e \u003cp\u003eReferences 311\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Genetic Engineering of Mice 315\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction to genetic engineering 315\u003c\/p\u003e \u003cp\u003e10.2 Genomics and the accumulation of sequence data 315\u003c\/p\u003e \u003cp\u003e10.3 The mouse as a model organism 318\u003c\/p\u003e \u003cp\u003e10.4 Techniques for genetic engineering 319\u003c\/p\u003e \u003cp\u003e10.5 Examples of genetically-engineered mice 332\u003c\/p\u003e \u003cp\u003e10.6 Summary 334\u003c\/p\u003e \u003cp\u003eReferences 334\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Signalling Complexes: Protein-protein Interactions and Lipid Rafts 339\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction to cell signalling complexes 339\u003c\/p\u003e \u003cp\u003e11.2 Introduction to GPCR interacting proteins 340\u003c\/p\u003e \u003cp\u003e11.3 Methods used to identify GPCR interacting proteins 340\u003c\/p\u003e \u003cp\u003e11.4 Functional roles of GPCR interacting proteins 345\u003c\/p\u003e \u003cp\u003e11.5 GPCR signalling complexes 348\u003c\/p\u003e \u003cp\u003e11.6 GPCR and ion channel complexes 355\u003c\/p\u003e \u003cp\u003e11.7 Ion channel signalling complexes 356\u003c\/p\u003e \u003cp\u003e11.8 Development of pharmaceuticals that target GPCR interacting proteins 356\u003c\/p\u003e \u003cp\u003e11.9 Development of pharmaceuticals that target protein-protein interactions 356\u003c\/p\u003e \u003cp\u003e11.10 Lipid rafts 357\u003c\/p\u003e \u003cp\u003e11.11 Receptor-mediated endocytosis 361\u003c\/p\u003e \u003cp\u003e11.12 Summary 364\u003c\/p\u003e \u003cp\u003eReferences 364\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Recombinant Proteins and Immunotherapeutics 367\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction to immunotherapeutics 367\u003c\/p\u003e \u003cp\u003e12.2 Historical background of immunotherapeutics 368\u003c\/p\u003e \u003cp\u003e12.3 Basis of immunotherapeutics 368\u003c\/p\u003e \u003cp\u003e12.4 Types of immunotherapeutics 369\u003c\/p\u003e \u003cp\u003e12.5 Humanisation of antibody therapy 372\u003c\/p\u003e \u003cp\u003e12.6 Immunotherapeutics in clinical practice 376\u003c\/p\u003e \u003cp\u003e12.7 Advantages and disadvantages of immunotherapy 378\u003c\/p\u003e \u003cp\u003e12.8 The future 379\u003c\/p\u003e \u003cp\u003e12.9 Summary 380\u003c\/p\u003e \u003cp\u003eReferences 380\u003c\/p\u003e \u003cp\u003eGlossary 381\u003c\/p\u003e \u003cp\u003eIndex 403\u003c\/p\u003e  \u003cp\u003e“An informative, comprehensive text, it is highly recommended to postgraduates and researchers in both pharmacology and molecular biology.”  (\u003ci\u003eScience Progress\u003c\/i\u003e, 1 March 2014)\u003c\/p\u003e \u003cp\u003e“Overall, it could be the basis of an excellent course for junior pharmacologists in basic science research who need a greater focus on the mechanisms of drug action rather than an encyclopedic survey of clinical drug use.”  (\u003ci\u003eDoody’s\u003c\/i\u003e, 26 July 2013)\u003c\/p\u003e \u003cp\u003e\u003cb\u003eJohn Dickenson\u003c\/b\u003e, \u003cb\u003eFiona Freeman\u003c\/b\u003e, \u003cb\u003eChris Lloyd Mills\u003c\/b\u003e, \u003cb\u003eShiva Sivasubramaniam\u003c\/b\u003e and \u003cb\u003eChristian Thode\u003c\/b\u003e, all at Nottingham Trent University.\u003c\/p\u003e  \u003cp\u003eThis textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ\/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments.\u003c\/p\u003e \u003cp\u003eProviding an invaluable resource for advanced under-graduate and MSc\/PhD students, new researchers to the field and practitioners for continuing professional development, \u003ci\u003eMolecular Pharmacology\u003c\/i\u003e explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell.\u003c\/p\u003e \u003cul\u003e \u003cli\u003e\n\u003cb\u003eCurrent\u003c\/b\u003e - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data.\u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eCutting Edge\u003c\/b\u003e - highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects.\u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eApplied\u003c\/b\u003e - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect.\u003c\/li\u003e \u003cli\u003e\n\u003cb\u003eAccessible\u003c\/b\u003e - contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eA companion website with additional resources is available at \u003cb\u003ewww.wiley.com\/go\/dickenson\/dnamolecular\u003c\/b\u003e\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989649211621,"sku":"NP9780470684443","price":122.5,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470684443.jpg?v=1761784955","url":"https:\/\/k12savings.com\/products\/molecular-pharmacology-isbn-9780470684443","provider":"K12savings","version":"1.0","type":"link"}