{"product_id":"molecular-genetics-of-mycobacteria-isbn-9781555818838","title":"Molecular Genetics of Mycobacteria","description":"\u003cp\u003e\u003cb\u003eA comprehensive collection of perspectives by experts in mycobacterial molecular biology\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eMycobacterium tuberculosis causes one in four avoidable deaths in the developing world and kills more adults than malaria, AIDS, and all tropical diseases combined. Tuberculosis was named a global health emergency by the World Health Organization, a distinction no other disease has received. Although the study of mycobacterial genetics has expanded dramatically, with new investigations into mycobacterial growth, replication, metabolism, physiology, drug susceptibility, and virulence, most of the problems in tuberculosis control that existed in 2000 remain today.\u003c\/p\u003e \u003cp\u003eAdvances in our understanding of mycobacterial genetics have been reflected in exciting recent developments. New diagnostic approaches can identify drug resistance within a few hours, promising new drugs are progressing through the pipeline and into the clinic, and a range of newly developed vaccines are being evaluated. It is an exciting time as the fruits of 30 years of intensive genetic investigation are finally beginning to emerge.\u003c\/p\u003e \u003cp\u003eWritten by leading experts in the field, \u003ci\u003eMolecular Genetics of Mycobacteria\u003c\/i\u003e, Second Edition,\u003c\/p\u003e \u003cul\u003e \u003cli\u003eDiscusses key areas of current research in mycobacterial genetics\u003c\/li\u003e \u003cli\u003eExplains the genetics of the physiology, metabolism, and drug sensitivities of M. tuberculosis\u003c\/li\u003e \u003cli\u003ePresents genetic approaches for manipulating M. tuberculosis\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThis book is an invaluable resource for anyone interested in the molecular genetics and molecular biology of mycobacteria.\u003c\/p\u003e \u003cp\u003eContributors ix\u003c\/p\u003e \u003cp\u003ePreface xvii\u003c\/p\u003e \u003cp\u003e\u003cb\u003eI. Genomes, Genomics, and Genetic Exchange\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1. Gene Transfer in \u003ci\u003eMycobacterium tuberculosis\u003c\/i\u003e: Shuttle Phasmids to Enlightenment 3\u003cbr\u003e\u003ci\u003eWilliam R. Jacobs, Jr.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2. Mycobacterial Pathogenomics and Evolution 27\u003cbr\u003e\u003ci\u003eDaria Bottai, Timothy P. Stinear, Philip Supply, and Roland Brosch\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3. BCG Vaccines 49\u003cbr\u003e\u003ci\u003eVanessa Tran, Jun Liu, and Marcel A. Behr\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4. Distributive Conjugal Transfer: New Insights into Horizontal Gene Transfer and Genetic Exchange in Mycobacteria 61\u003cbr\u003e\u003ci\u003eKeith M. Derbyshire and Todd A. Gray\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5. Molecular Genetics of Mycobacteriophages 81\u003cbr\u003e\u003ci\u003eGraham F. Hatfull\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6. Genetics of Phage Lysis 121\u003cbr\u003e\u003ci\u003eMadalena Pimentel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIi. Gene Expression and Regulation\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7. Sigma Factors: Key Molecules in \u003ci\u003eMycobacterium tuberculosis \u003c\/i\u003ePhysiology and Virulence 137\u003cbr\u003e\u003ci\u003eRiccardo Manganelli\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8. Transcription Factor Binding Site Mapping Using ChIP-Seq 161\u003cbr\u003e\u003ci\u003eSuma Jaini, Anna Lyubetskaya, Antonio Gomes, Matthew Peterson, Sang Tae Park, Sahadevan Raman, Gary Schoolnik, and James Galagan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9. Noncoding RNA in Mycobacteria 183\u003cbr\u003e\u003ci\u003eKristine B. Arnvig, Teresa Cortes, and Douglas B. Young\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10. Two-Component Regulatory Systems of Mycobacteria 209\u003cbr\u003e\u003ci\u003eTanya Parish\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11. Regulated Expression Systems for Mycobacteria and Their Applications 225\u003cbr\u003e\u003ci\u003eDirk Schnappinger and Sabine Ehrt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIii. The Mycobacterial Proteome\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12. \u003ci\u003eMycobacterium tuberculosis \u003c\/i\u003ein the Proteomics Era 241\u003cbr\u003e\u003ci\u003eMartin Gengenbacher, Jeppe Mouritsen, Olga T. Schubert, Ruedi Aebersold, and Stefan H. E. Kaufmann\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13. Structural Annotation of the \u003ci\u003eMycobacterium tuberculosis \u003c\/i\u003eProteome 261\u003cbr\u003e\u003ci\u003eNagasuma Chandra, Sankaran Sandhya, and Praveen Anand\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14. Cyclic AMP Signaling in Mycobacteria 281\u003cbr\u003e\u003ci\u003eGwendowlyn S. Knapp and Kathleen A. McDonough\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIV. Metabolism\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e15. The Physiology and Genetics of Oxidative Stress in Mycobacteria 299\u003cbr\u003e\u003ci\u003eBridgette M. Cumming, Dirk Lamprecht, Ryan M. Wells, Vikram Saini, James H. Mazorodze, and Adrie J. C. Steyn\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16. Metabolomics of Central Carbon Metabolism in \u003ci\u003eMycobacterium tuberculosis \u003c\/i\u003e323\u003cbr\u003e\u003ci\u003eAnthony D. Baughn and Kyu Y. Rhee\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17. Mycobacterial Lipidomics 341\u003cbr\u003e\u003ci\u003eEmilie Layre, Reem Al-Mubarak, John T. Belisle, and D. Branch Moody\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18. Genetics of Mycobacterial Trehalose Metabolism 361\u003cbr\u003e\u003ci\u003eRainer Kalscheuer and Hendrik Koliwer-Brandl\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19. Metallobiology of Tuberculosis 377\u003cbr\u003e\u003ci\u003eG. Marcela Rodriguez and Olivier Neyrolles\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20. Energetics of Respiration and Oxidative Phosphorylation in Mycobacteria 389\u003cbr\u003e\u003ci\u003eGregory M. Cook, Kiel Hards, Catherine Vilcheze, Travis Hartman, and Michael Berney\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eV. Genetics of Drug Resistance\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e21. Molecular Basis of Drug Resistance in \u003ci\u003eMycobacterium tuberculosis \u003c\/i\u003e413\u003cbr\u003e\u003ci\u003eKeira A. Cohen, William R. Bishai, and Alexander S. Pym\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22. Resistance to Isoniazid and Ethionamide in \u003ci\u003eMycobacterium tuberculosis\u003c\/i\u003e: Genes, Mutations, and Causalities 431\u003cbr\u003e\u003ci\u003eCatherine Vilcheze and William R. Jacobs, Jr.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23. The Molecular Genetics of Fluoroquinolone Resistance in \u003ci\u003eMycobacterium tuberculosis \u003c\/i\u003e455\u003cbr\u003e\u003ci\u003eClaudine Mayer and Howard Takiff\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24. Mechanisms of Pyrazinamide Action and Resistance 479\u003cbr\u003e\u003ci\u003eYing Zhang, Wanliang Shi, Wenhong Zhang, and Denis Mitchison\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25. Genetic Strategies for Identifying New Drug Targets 493\u003cbr\u003e\u003ci\u003eAndrej Trauner, Christopher M. Sassetti, and Eric J. Rubin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eVI. Genetics of Membrane and Cell Wall Biosynthesis\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e26. Genetics of Peptidoglycan Biosynthesis 513\u003cbr\u003e\u003ci\u003eMartin S. Pavelka, Jr., Sebabrata Mahapatra, and Dean C. Crick\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e27. Genetics of Mycobacterial Arabinogalactan and Lipoarabinomannan Assembly 535\u003cbr\u003e\u003ci\u003eMonika Jankute, Shipra Grover, Helen L. Birch, and Gurdyal S. Besra\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e28. Genetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipids 559\u003cbr\u003e\u003ci\u003eMamadou Daffe, Dean C. Crick, and Mary Jackson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e29. The Molecular Genetics of Mycolic Acid Biosynthesis 611\u003cbr\u003e\u003ci\u003eJakub Pawełczyk and Laurent Kremer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eVII. Genetics of Macromolecular Biosynthesis\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e30. Nucleotide Metabolism and DNA Replication 635\u003cbr\u003e\u003ci\u003eDigby F. Warner, Joanna C. Evans, and Valerie Mizrahi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e31. Double-Strand DNA Break Repair in Mycobacteria 657\u003cbr\u003e\u003ci\u003eMichael S. Glickman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e32. The Pup-Proteasome System of Mycobacteria 667\u003cbr\u003e\u003ci\u003eNadine J. Bode and K. Heran Darwin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e33. \u003ci\u003eMycobacterium tuberculosis \u003c\/i\u003eSerine\/Threonine Protein Kinases 681\u003cbr\u003e\u003ci\u003eSladjana Prisic and Robert N. Husson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eVIII. The Mycobacterial Lifestyle, Persistence, and Macrophage Survival\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e34. The Spectrum of Drug Susceptibility in Mycobacteria 711\u003cbr\u003e\u003ci\u003eBree B. Aldridge, Iris Keren, and Sarah M. Fortune\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e35. The Sculpting of the \u003ci\u003eMycobacterium tuberculosis \u003c\/i\u003eGenome by Host Cell–Derived Pressures 727\u003cbr\u003e\u003ci\u003eDavid G. Russell, Wonsik Lee, Shumin Tan, Neelima Sukumar, Maria Podinovskaia, Ruth J. Fahey, and Brian C. VanderVen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e36. Evasion of Innate and Adaptive Immunity by \u003ci\u003eMycobacterium tuberculosis \u003c\/i\u003e747\u003cbr\u003e\u003ci\u003eMichael F. Goldberg, Neeraj K. Saini, and Steven A. Porcelli\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e37. Mycobacterial Biofilms 773\u003cbr\u003e\u003ci\u003eJacobs P. Richards and Anil K. Ojha\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 785\u003c\/p\u003e  \u003cp\u003e\u003cb\u003eMolecular Genetics of Mycobacteria\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eSecond Edition \u003c\/p\u003e\u003cp\u003e\u003ci\u003eA comprehensive collection of perspectives by experts in mycobacterial molecular biology\u003c\/i\u003e  \u003c\/p\u003e\u003cp\u003e Mycobacterium tuberculosis causes one in four avoidable deaths in the developing world and kills more adults than malaria, AIDS, and all tropical diseases combined. Tuberculosis was named a global health emergency by the World Health Organization, a distinction no other disease has received. Although the study of mycobacterial genetics has expanded dramatically, with new investigations into mycobacterial growth, replication, metabolism, physiology, drug susceptibility, and virulence, most of the problems in tuberculosis control that existed in 2000 remain today. \u003c\/p\u003e\u003cp\u003e Advances in our understanding of mycobacterial genetics have been reflected in exciting recent developments. New diagnostic approaches can identify drug resistance within a few hours, promising new drugs are progressing through the pipeline and into the clinic, and a range of newly developed vaccines are being evaluated. It is an exciting time as the fruits of 30 years of intensive genetic investigation are finally beginning to emerge. \u003c\/p\u003e\u003cp\u003e Written by leading experts in the field, Molecular Genetics of Mycobacteria, Second Edition, \u003c\/p\u003e\u003cul\u003e \u003cli\u003e Discusses key areas of current research in mycobacterial genetics\u003c\/li\u003e \u003cli\u003eExplains the genetics of the physiology, metabolism, and drug sensitivities of M. tuberculosis\u003c\/li\u003e \u003cli\u003ePresents genetic approaches for manipulating M. tuberculosis\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e This book is an invaluable resource for anyone interested in the molecular genetics and molecular biology of mycobacteria.\u003c\/p\u003e","brand":"ASM Press","offers":[{"title":"Default Title","offer_id":47989648294117,"sku":"NP9781555818838","price":160.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781555818838.jpg?v=1761784952","url":"https:\/\/k12savings.com\/products\/molecular-genetics-of-mycobacteria-isbn-9781555818838","provider":"K12savings","version":"1.0","type":"link"}