{"product_id":"molecular-clocks-and-light-signalling-isbn-9780470852835","title":"Molecular Clocks and Light Signalling","description":"The ability at the molecular level to keep track of time is a property shared by organisms ranging from the simplest unicells to humans. The primary feature of these biological clocks is their ability to entrain to environmental stimuli. The dominant stimulus comes from environmental light cues, which requires the existence of photopigments sensitive to light. The exact identity of the molecules involved in circadian photoreception has remained elusive.  \u003cp\u003eThe classical view of the circadian system is of diverse physiological rhythms regulated by a centralized clock structure. This book presents evidence that challenges this view. Experiments in both vertebrate and invertebrate systems demonstrate that the circadian timing system is dispersed throughout the animal and suggest that possibly every cell contains an autonomous clock mechanism. A variety of tissues and cells contain have been shown to maintain an oscillation when placed in vitro and removed from any external cues or signals that originate from the classical clock structures and\/or the environment.\u003c\/p\u003e \u003cp\u003eThis book draws together contributions from an international and interdisciplinary group of experts whose work is focused on all aspects of the topic. Coverage includes the mechanisms of light signalling to the vertebrate clock, the connections between central and peripheral clocks, circadian gene expression patterns and output pathways of clock mechanisms.\u003c\/p\u003e  Chair's Introduction (M. Menaker).  \u003cp\u003eNon-rod, non-cone photoreception in rodents and teleost fish (R. Foster, et al.).\u003c\/p\u003e \u003cp\u003eCryptochromes and inner retinal non-visual irradiance detection (R. Van Gelder and A. Sancar).\u003c\/p\u003e \u003cp\u003eGeneral discussion I.\u003c\/p\u003e \u003cp\u003eLight signalling in \u003ci\u003eCryptochrome-\u003c\/i\u003edeficient mice (X. Bonnefont, et al.).\u003c\/p\u003e \u003cp\u003eCircadian light input in plants, flies and mammals (S. Panda, et al.).\u003c\/p\u003e \u003cp\u003eOrphan nuclear receptors, molecular clockwork and the entrainment of peripheral oscillators (N. Preitner, et al.).\u003c\/p\u003e \u003cp\u003eSCN: ringmaster of the circadian circus or conductor of the circadian orchestra? (A. Davidson, et al.).\u003c\/p\u003e \u003cp\u003eOn the communication pathways between the central pacemaker and peripheral oscillators (N. Cermakian, et al.).\u003c\/p\u003e \u003cp\u003eCentral and peripheral circadian oscialltors in \u003ci\u003eDrosophila\u003c\/i\u003e (P. Hardin, et al.).\u003c\/p\u003e \u003cp\u003eIntegration of molecular rhythms in mammalian circadian system (H. Okamura).\u003c\/p\u003e \u003cp\u003eCircadian transcriptional output in the SCN and liver of the mouse (J. Hogenesch, et al.).\u003c\/p\u003e \u003cp\u003eThe molecular workings of the \u003ci\u003eNeurospora\u003c\/i\u003e biological clock (A. Froehlich, et al.).\u003c\/p\u003e \u003cp\u003eExpression of the clock gene products in the suprachiasmatic nucleus in relation to circadian behaviour (M. Hastings, et al.).\u003c\/p\u003e \u003cp\u003eCircadian rhythms in \u003ci\u003eDrosophila\u003c\/i\u003e (M. Rosbash, et al.).\u003c\/p\u003e \u003cp\u003eThe role of phosphorylation and degradation of hPer proteins oscillation in normal human fibroblasts (K. Miyazaki, et al.).\u003c\/p\u003e \u003cp\u003eRegulation of daily locomotor activity and sleep by hypothalamic EGF receptor signalling (A. Kramer, et al.).\u003c\/p\u003e \u003cp\u003eCK1 and GSK-3 in the \u003ci\u003eDrosophila\u003c\/i\u003e and mammalian circadian clock (E. Harms, et al.).\u003c\/p\u003e \u003cp\u003eFinal general discussion.\u003c\/p\u003e \u003cp\u003eClosing remarks (M. Menaker).\u003c\/p\u003e \u003cp\u003eIndex of Contributors.\u003c\/p\u003e \u003cp\u003eSubject Index.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eDerek J. Chadwick\u003c\/b\u003e and \u003cb\u003eJamie A. Goode\u003c\/b\u003e are editors for \u003ci\u003eMolecular Clocks and Light Signalling\u003c\/i\u003e and other scientific titles.\u003c\/p\u003e  The ability at the molecular level to keep track of time is a property shared by organisms ranging from the simplest unicells to humans. The primary feature of these biological clocks is their ability to entrain to environmental stimuli. The dominant stimulus comes from environmental light cues, which requires the existence of photopigments sensitive to light. The exact identity of the molecules involved in circadian photoreception has remained elusive.  \u003cp\u003eThe classical view of the circadian system is of diverse physiological rhythms regulated by a centralized clock structure. This book presents evidence that challenges this view. Experiments in both vertebrate and invertebrate systems demonstrate that the circadian timing system is dispersed throughout the animal and suggest that possibly every cell contains an autonomous clock mechanism. A variety of tissues and cells contain have been shown to maintain an oscillation when placed \u003ci\u003ein vitro\u003c\/i\u003e and removed from any external cues or signals that originate from the classical clock structures and\/or the environment.\u003c\/p\u003e \u003cp\u003eThis book draws together contributions from an international and interdisciplinary group of experts whose work is focused on all aspects of the topic. Coverage includes the mechanisms of light signalling to the vertebrate clock, the connections between central and peripheral clocks, circadian gene expression patterns and output pathways of clock mechanisms.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989647573221,"sku":"NP9780470852835","price":211.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470852835.jpg?v=1761784948","url":"https:\/\/k12savings.com\/products\/molecular-clocks-and-light-signalling-isbn-9780470852835","provider":"K12savings","version":"1.0","type":"link"}