{"product_id":"molecular-and-biochemical-toxicology-isbn-9781119042419","title":"Molecular and Biochemical Toxicology","description":"Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses.\u003cbr\u003e\u003cbr\u003e•    Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies\u003cbr\u003e•    Uses a didactic approach with basic biological or theoretical background for the methodology presented\u003cbr\u003e•    Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology\u003cbr\u003e•    Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts\u003cbr\u003e•    “A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail.... It offers good value for money and can be recommended as a textbook for appropriate courses” – BTS Newsletter review of the 4th edition \u003cp\u003ePreface xxix\u003c\/p\u003e \u003cp\u003eList of Contributors xxxi\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 1 Introduction 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Molecular and Biochemical Toxicology: Definition and Scope 3\u003cbr\u003e \u003ci\u003eErnest Hodgson and Robert C. Smart\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 2 Techniques in Biochemical and Molecular Toxicology 11\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2 Molecular Techniques for the Study of Gene Function 13\u003cbr\u003e \u003ci\u003eYoshiaki Tsuji and Robert C. Smart\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Transcriptomics 55\u003cbr\u003e \u003ci\u003eB. Alex Merrick\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Proteomics 91\u003cbr\u003e \u003ci\u003eMichael S. Bereman\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Metabolomics 115\u003cbr\u003e \u003ci\u003eSusan C. J. Sumner, Wimal Pathmasiri, James E. Carlson, Susan L. McRitchie, and Timothy R. Fennell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Cellular Techniques 135\u003cbr\u003e \u003ci\u003eSharon A. Meyer and Barbara A. Wetmore\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Basic Concepts of Molecular Epidemiological Research Methods 159\u003cbr\u003e \u003ci\u003eCathrine Hoyo, David A. Skaar, and Randy L. Jirtle\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 3 Mechanisms in Molecular and Biochemical Toxicology 187\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8 Phase I and Phase II Metabolism and Metabolic Interactions: A Summary 189\u003cbr\u003e \u003ci\u003eErnest Hodgson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Structure, Mechanism, and Regulation of Cytochromes P 450 209\u003cbr\u003e \u003ci\u003eJohn M. Seubert, Matthew L. Edin, and Darryl C. Zeldin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Polymorphisms in Phase I and Phase II Genes and Outcomes 239\u003cbr\u003e \u003ci\u003eYoshiaki Tsuji, Edward L. Croom, and Ernest Hodgson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11 Cellular Transport and Elimination 273\u003cbr\u003e \u003ci\u003eDavid S. Miller and Ronald E. Cannon\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Nuclear Receptors 293\u003cbr\u003e \u003ci\u003eSeth W. Kullman, William S. Baldwin, and Gerald A. LeBlanc\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13 Mechanisms of Cell Death 327\u003cbr\u003e \u003ci\u003eMac Law and Susan Elmore\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14 Mitochondrial Dysfunction 371\u003cbr\u003e \u003ci\u003eJun Ninomiya‐Tsuji\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15 Reactive Metabolites, Reactive Oxygen Species (ROS), and Toxicity 391\u003cbr\u003e \u003ci\u003eElizabeth L. MacKenzie and Yoshiaki Tsuji\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16 DNA Damage and Mutagenesis 421\u003cbr\u003e \u003ci\u003eZhigang Wang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17 DNA Repair 485\u003cbr\u003e \u003ci\u003eIsabel Mellon\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18 Carcinogenesis 535\u003cbr\u003e \u003ci\u003eRobert C. Smart and Jonathan R. Hall\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 4 Molecular and Biochemical Aspects of Organ Toxicology 589\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e19 Molecular Mechanisms of Respiratory Toxicity 591\u003cbr\u003e \u003ci\u003eJames C. Bonner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20 Molecular Mechanisms of Hepatotoxicity 629\u003cbr\u003e \u003ci\u003eSupriya R. Kulkarni, Andrew D. Wallace, Sharon A. Meyer, and Angela L. Slitt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21 Molecular Mechanisms of Renal Toxicology 665\u003cbr\u003e \u003ci\u003eLawrence H. Lash\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22 Molecular Mechanisms of Neurotoxicity 709\u003cbr\u003e \u003ci\u003eKimberly P. Keil, Marianna Stamou, and Pamela J. Lein\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23 Molecular Mechanisms of Immunotoxicity 773\u003cbr\u003e \u003ci\u003eTai L. Guo, Joella Xu, Yingjia Chen, Daniel E. Lefever, Guannan Huang, and David A. Lawrence\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24 Molecular Mechanisms of Reproductive Toxicity 823\u003cbr\u003e \u003ci\u003eAyelet Ziv‐Gal, Catheryne Chiang, and Jodi Anne Flaws\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25 Molecular Mechanisms of Developmental Toxicity 851\u003cbr\u003e \u003ci\u003eAntonio Planchart\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 5 Emerging Areas in Molecular and Biochemical Toxicology 877\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e26 Computational and Molecular Approaches to Risk Assessment 879\u003cbr\u003e \u003ci\u003eRichard S. Judson, John Wambaugh, Kristin Isaacs, and Russell S. Thomas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e27 Nanotoxicology 909\u003cbr\u003e \u003ci\u003eJames C. Bonner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e28 Developmental Origins of Health and Disease 933\u003cbr\u003e \u003ci\u003eMichael Cowley\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e29 Exposome 945\u003cbr\u003e \u003ci\u003eStephen M. Rappaport\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 969\u003c\/p\u003e   \u003cp\u003e\u003cb\u003e ROBERT C. SMART, PhD,\u003c\/b\u003e is a William Neal Reynolds Professor of Toxicology, the Director of the Center for Human Health and the Environment, and the former Director of the Toxicology Graduate Program at North Carolina State University. Together with Dr. Hodgson, he coedited the two previous editions of this book.   \u003c\/p\u003e\u003cp\u003e\u003cb\u003e ERNEST HODGSON, PhD,\u003c\/b\u003e is Distinguished Professor Emeritus of Environmental and Molecular Toxicology and Executive Director of the Foundation for Agromedicine and Toxicology at North Carolina State University. Alongside the previous editions of this book, he edited four editions of\u003ci\u003e A Textbook of Modern Toxicology\u003c\/i\u003e (Wiley) and is the Editor of the \u003ci\u003eJournal of Biochemical and Molecular Toxicology. \u003c\/i\u003e     \u003c\/p\u003e\u003cp\u003e\u003cb\u003e An essential resource for students, academic, and industrial toxicologists and environmental health scientists \u003c\/b\u003e  \u003c\/p\u003e\u003cp\u003e Throughout its past editions, this text has been an important source for defining the biochemical, cellular, and molecular events that toxicants induce at the cellular and organismic levels and linking molecular and cellular biology as well as genomic sciences to mechanistic toxicology.   \u003c\/p\u003e\u003cp\u003e\u003ci\u003e Molecular and Biochemical Toxicology\u003c\/i\u003e provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses. Toxicological mechanisms are discussed and described in detail from the biomolecule, pathway, cell, tissue, organ, model organism, human to the individual human population.   \u003c\/p\u003e\u003cp\u003e As the field of toxicology has evolved and advanced so has \u003ci\u003eMolecular and Biochemical Toxicology.\u003c\/i\u003e Changes in this new edition stress advances in our understanding in how toxicants produce their adverse outcomes as well as the use of cutting-edge technology\/methodology in contemporary toxicology.   \u003c\/p\u003e\u003cp\u003e The organization of the 5\u003csup\u003eth\u003c\/sup\u003e edition is divided into sections which include: Techniques in Biochemical and Molecular Toxicology, Mechanisms in Molecular and Biochemical Toxicology, Molecular and Biochemical Aspects of Organ Toxicology; as well as a new section on Emerging Areas in Molecular and Biochemical Toxicology.   \u003c\/p\u003e\u003cp\u003e The fifth edition has been substantially updated and includes 12 new chapters, like those on: nuclear receptors, nanotoxicology, computational and molecular approaches to risk assessment, developmental origins of health and disease, exposome, and basic concepts of molecular epidemiological research methods.   \u003c\/p\u003e\u003cp\u003e Chapters on \"Omics\" technologies provide an understanding of these technologies\/approaches and how they can be used to understand the complex mechanisms of toxicity.   \u003c\/p\u003e\u003cp\u003e Whether used in the classroom or in industry, research, or academia; \u003ci\u003eMolecular and Biochemical Toxicology\u003c\/i\u003e remains essential for anyone interested in understanding the molecular mechanisms through which toxicant produce adverse effects.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989646655717,"sku":"NP9781119042419","price":149.5,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119042419.jpg?v=1761784944","url":"https:\/\/k12savings.com\/products\/molecular-and-biochemical-toxicology-isbn-9781119042419","provider":"K12savings","version":"1.0","type":"link"}