{"product_id":"modern-organic-synthesis-isbn-9781119086536","title":"Modern Organic Synthesis","description":"\u003cp\u003eThis book bridges the gap between sophomore and advanced \/ graduate level organic chemistry courses, providing students with a necessary background to begin research in either an industry or academic environment.\u003c\/p\u003e \u003cp\u003e• Covers key concepts that include retrosynthesis, conformational analysis, and functional group transformations as well as presents the latest developments in organometallic chemistry and C–C bond formation\u003cbr\u003e• Uses a concise and easy-to-read style, with many illustrated examples\u003cbr\u003e• Updates material, examples, and references from the first edition\u003cbr\u003e• Adds coverage of organocatalysts and organometallic reagents\u003c\/p\u003e \u003cp\u003eAbout the Authors ix\u003c\/p\u003e \u003cp\u003ePreface to the Second Edition xi\u003c\/p\u003e \u003cp\u003ePrefacetothefirstedition xiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 SyntheticDesign 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Retrosynthetic Analysis 1\u003c\/p\u003e \u003cp\u003e1.2 Reversal of the Carbonyl Group Polarity (Umpolung) 6\u003c\/p\u003e \u003cp\u003e1.3 Steps in Planning a Synthesis 11\u003c\/p\u003e \u003cp\u003e1.4 Choice of Synthetic Method 16\u003c\/p\u003e \u003cp\u003e1.5 Domino Reactions (Cascade or Tandem Reactions) 18\u003c\/p\u003e \u003cp\u003e1.6 Computer-Assisted Retrosynthetic Analysis 19\u003c\/p\u003e \u003cp\u003eReferences 19\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Stereochemical Considerations in Planning Syntheses 21\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Conformational Analysis 21\u003c\/p\u003e \u003cp\u003e2.2 Evaluation of Non-Bonded Interactions 25\u003c\/p\u003e \u003cp\u003e2.3 Six-Membered Heterocyclic Systems 29\u003c\/p\u003e \u003cp\u003e2.4 Polycyclic Ring Systems 30\u003c\/p\u003e \u003cp\u003e2.5 Cyclohexyl Systems with sp 2 -Hybridized Atoms 33\u003c\/p\u003e \u003cp\u003e2.6 Significant Energy Difference 35\u003c\/p\u003e \u003cp\u003e2.7 Computer-Assisted Molecular Modeling 35\u003c\/p\u003e \u003cp\u003e2.8 Reactivity and Product Determination as a Function of Conformation 36\u003c\/p\u003e \u003cp\u003eReferences 42\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 The Concept of Protecting Functional Groups 45\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Protection of N–H Groups 45\u003c\/p\u003e \u003cp\u003e3.2 Protection of OH Groups 48\u003c\/p\u003e \u003cp\u003e3.3 Protection of Diols as Acetals 55\u003c\/p\u003e \u003cp\u003e3.4 Protection of Carbonyl Groups in Aldehydes and Ketones 56\u003c\/p\u003e \u003cp\u003e3.5 Protection of the Carboxyl Group 62\u003c\/p\u003e \u003cp\u003e3.6 Protection of Double Bonds 66\u003c\/p\u003e \u003cp\u003e3.7 Protection of Triple Bonds 66\u003c\/p\u003e \u003cp\u003eReferences 66\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Functional Group Transformations 71\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Oxidation of Alcohols to Aldehydes and Ketones 71\u003c\/p\u003e \u003cp\u003e4.2 Reagents and Procedures for Alcohol Oxidation 72\u003c\/p\u003e \u003cp\u003e4.3 Chemoselective Oxidizing Agents 76\u003c\/p\u003e \u003cp\u003e4.4 Oxidation of Acyloins 79\u003c\/p\u003e \u003cp\u003e4.5 Oxidation of Tertiary Allylic Alcohols 79\u003c\/p\u003e \u003cp\u003e4.6 Oxidative Procedures to Carboxylic Acids 80\u003c\/p\u003e \u003cp\u003e4.7 Allylic Oxidation of Alkenes 82\u003c\/p\u003e \u003cp\u003e4.8 Terminology for Reduction of Carbonyl Compounds 85\u003c\/p\u003e \u003cp\u003e4.9 Nucleophilic Reducing Agents 86\u003c\/p\u003e \u003cp\u003e4.10 Electrophilic Reducing Agents 91\u003c\/p\u003e \u003cp\u003e4.11 Regio- and Chemoselective Reductions 93\u003c\/p\u003e \u003cp\u003e4.12 Diastereoselective Reductions of Cyclic Ketones 97\u003c\/p\u003e \u003cp\u003e4.13 Inversion of Secondary Alcohol Stereochemistry 98\u003c\/p\u003e \u003cp\u003e4.14 Diastereofacial Selectivity in Acyclic Systems 99\u003c\/p\u003e \u003cp\u003e4.15 Enantioselective Reductions 104\u003c\/p\u003e \u003cp\u003eReferences 108\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Functional Group Transformations 115\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Reactions of Carbon–Carbon Double Bonds 115\u003c\/p\u003e \u003cp\u003e5.2 Reactions of Carbon–Carbon Triple Bonds 160\u003c\/p\u003e \u003cp\u003eReferences 167\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Formation of Carbon–Carbon Single Bonds via Enolate Anions 175\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 1,3-Dicarbonyl Compounds 175\u003c\/p\u003e \u003cp\u003e6.2 Direct Alkylation of Enolates 185\u003c\/p\u003e \u003cp\u003e6.3 Cyclization Reactions—Baldwin’s Rules for Ring Closure 193\u003c\/p\u003e \u003cp\u003e6.4 Stereochemistry of Cyclic Ketone Alkylation 195\u003c\/p\u003e \u003cp\u003e6.5 Imine and Hydrazone Anions 196\u003c\/p\u003e \u003cp\u003e6.6 Enamines 197\u003c\/p\u003e \u003cp\u003e6.7 The Aldol Reaction 199\u003c\/p\u003e \u003cp\u003e6.8 Condensation Reactions of Enols and Enolates 213\u003c\/p\u003e \u003cp\u003e6.9 Robinson Annulation 217\u003c\/p\u003e \u003cp\u003eReferences 220\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Formation of Carbon–Carbon Bonds via Organometallic Reagents 227\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Organolithium Reagents 227\u003c\/p\u003e \u003cp\u003e7.2 Organomagnesium Reagents 236\u003c\/p\u003e \u003cp\u003e7.3 Organotitanium Reagents 239\u003c\/p\u003e \u003cp\u003e7.4 Organocerium Reagents 240\u003c\/p\u003e \u003cp\u003e7.5 Organocopper Reagents 241\u003c\/p\u003e \u003cp\u003e7.6 Organochromium Reagents 251\u003c\/p\u003e \u003cp\u003e7.7 Organozinc Reagents 252\u003c\/p\u003e \u003cp\u003e7.8 Organoboron Reagents 256\u003c\/p\u003e \u003cp\u003e7.9 Organosilicon Reagents 264\u003c\/p\u003e \u003cp\u003e7.10 Organogold Chemistry 274\u003c\/p\u003e \u003cp\u003eReferences 278\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Palladium-Catalyzed Coupling Reactions 285\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Palladium Oxidation State 285\u003c\/p\u003e \u003cp\u003e8.2 Organic Synthesis with Palladium(0) Complexes 286\u003c\/p\u003e \u003cp\u003e8.3 The Heck Reaction—Palladium(0)-Catalyzed Olefin Insertion Reactions 288\u003c\/p\u003e \u003cp\u003e8.4 Palladium-Catalyzed Cross-Coupling with Organometallic Reagents 292\u003c\/p\u003e \u003cp\u003e8.5 Cross-Coupling Reactions Involving sp-Carbons 301\u003c\/p\u003e \u003cp\u003e8.6 The Trost–Tsuji Reaction 304\u003c\/p\u003e \u003cp\u003eReferences 307\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Formation of Carbon–Carbon π-Bonds 313\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Formation of Carbon–Carbon Double Bonds 313\u003c\/p\u003e \u003cp\u003e9.2 Formation of Carbon–Carbon Triple Bonds 343\u003c\/p\u003e \u003cp\u003eReferences 350\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Syntheses of Carbocyclic Systems 355\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Intramolecular Free Radical Cyclizations 355\u003c\/p\u003e \u003cp\u003e10.2 Cation–π Cyclizations 361\u003c\/p\u003e \u003cp\u003e10.3 Pericyclic Reactions 364\u003c\/p\u003e \u003cp\u003e10.4 Ring-Closing Olefin Metathesis 375\u003c\/p\u003e \u003cp\u003eReferences 378\u003c\/p\u003e \u003cp\u003eIndex 383 \u003c\/p\u003e   \u003cp\u003e\u003cb\u003e GEORGE S. ZWEIFEL, PhD,\u003c\/b\u003e is Professor Emeritus at the University of California, Davis.   \u003c\/p\u003e\u003cp\u003e\u003cb\u003e MICHAEL H. NANTZ, PhD,\u003c\/b\u003e is Professor of Chemistry and Distinguished University Scholar at the University of Louisville.   \u003c\/p\u003e\u003cp\u003e\u003cb\u003e PETER SOMFAI, PhD,\u003c\/b\u003e is Professor of Chemistry at Lund University.      \u003c\/p\u003e\u003cp\u003e Organized into 10 chapters, Modern Organic Synthesis covers key concepts that include retrosynthesis, conformational analysis, and functional group transformations as well as presents the latest developments in organometallic chemistry and C–C bond formation. The new edition thoroughly updates the material, examples, and literature references.   \u003c\/p\u003e\u003cp\u003e Continuing the legacy of its innovative predecessor, this second edition is designed for senior undergraduate and beginning graduate students to provide them with a necessary background to begin research in either an industry or academic environment.   \u003c\/p\u003e\u003cp\u003e The authors, all of whom are experienced researchers in organic chemistry, have selected and present the modern techniques and methods likely to be encountered in a synthetic project – with examples based on applicability, versatility, and selectivity.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989643149541,"sku":"NP9781119086536","price":106.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9781119086536.jpg?v=1761784931","url":"https:\/\/k12savings.com\/products\/modern-organic-synthesis-isbn-9781119086536","provider":"K12savings","version":"1.0","type":"link"}