{"product_id":"model-organisms-in-drug-discovery-isbn-9780470848937","title":"Model Organisms in Drug Discovery","description":"Fruit flies are \"little people with wings\" goes the saying in the scientific community, ever since the completion of the Human Genome Project and its revelations about the similarity amongst the genomes of different organisms. It is humbling that most signalling pathways which \"define\" humans are conserved in Drosophila, the common fruit fly.  \u003cp\u003eFeed a fruit fly caffeine and it has trouble falling asleep; feed it antihistamines and it cannot stay awake. A C. elegans worm placed on the antidepressant flouxetine has increased serotonin levels in its tiny brain. Yeast treated with chemotherapeutics stop their cell division. Removal of a single gene from a mouse or zebrafish can cause the animals to develop Alzheimer’s disease or heart disease. These organisms are utilized as surrogates to investigate the function and design of complex human biological systems.\u003c\/p\u003e \u003cp\u003eAdvances in bioinformatics, proteomics, automation technologies and their application to model organism systems now occur on an industrial scale. The integration of model systems into the drug discovery process, the speed of the tools, and the in vivo validation data that these models can provide, will clearly help definition of disease biology and high-quality target validation. Enhanced target selection will lead to the more efficacious and less toxic therapeutic compounds of the future.\u003c\/p\u003e \u003cp\u003eLeading experts in the field provide detailed accounts of model organism research that have impacted on specific therapeutic areas and they examine state-of-the-art applications of model systems, describing real life applications and their possible impact in the future.\u003c\/p\u003e \u003cp\u003eThis book will be of interest to geneticists, bioinformaticians, pharmacologists, molecular biologists and people working in the pharmaceutical industry, particularly genomics.\u003c\/p\u003eModellorganismen sind sehr hilfreich bei einem systematischen Ansatz zur Klärung einer breiten Palette krankheitsbezogener Fragestellungen.\u003cbr\u003e \u003cbr\u003e Aufgrund fortgeschrittener Gentechniken für Modellorganismen und die Verfügbarkeit ihrer Genomsequenzen, können diese Organismen einen großen Einfluss auf die Wirkstoffentdeckung haben, insbesondere in dem kritischen Bereich der Targetvalidierung krankheitsrelevanter Proteine.\u003cbr\u003e \u003cbr\u003e Dieses topaktuelle Buch erläutert die neuesten Fortschritte in den Bereichen Bioinformatik, Proteomik, Genomik sowie Biochemische- und Automationstechnologien, soweit sie sich auf einfache Organismen beziehen, die in der Wirkstoffentdeckung eingesetzt werden.\u003cbr\u003e \u003cbr\u003e Führende Experten auf diesem Gebiet berichten hier umfassend über den Bereich der Erforschung von Modellorganismem, die einen großen Einfluss auf spezifische Therapiebereiche ausgeübt hat.\u003cbr\u003e \u003cbr\u003e Darüber hinaus analysieren sie topaktuelle Anwendungen von Modellsystemen, beschreiben Anwendungen in der Praxis und mögliche Zukunftsperspektiven.\u003cbr\u003e \u003cbr\u003e \"Model Organisms in Drug Discovery\" - eine nützliche Lektüre nicht nur für Fachleute in der Wirkstoffentdeckung, sondern für eine Vielzahl von Wissenschaftlern.  List of contributors.  \u003cp\u003eAcknowledgments.\u003c\/p\u003e \u003cp\u003e1. Introduction to Model Systems in Drug Discovery (\u003ci\u003eKevin Fitzgerald and Pamela M. Carroll\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e2. Growing Yeast for Fun and Profit: Use of \u003ci\u003eSaccharomyces cerevisiae\u003c\/i\u003e as a Model System in Drug Discovery (\u003ci\u003ePetra Ross-Macdonald\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e3. \u003ci\u003eCaenorhabditis elegans\u003c\/i\u003e Functional Genomics in Drug Discovery: Expanding Paradigms (\u003ci\u003eTitus Kaletta, Lynn Butler and Thierry Bogaert\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e4. \u003ci\u003eDrosophila\u003c\/i\u003e as a Tool for Drug Discovery (\u003ci\u003eHao Li and Dan Garza\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003ci\u003e5. Drosophila –\u003c\/i\u003e a Model System for Targets and Lead Identification in Cancer and Metabolic Disorders (\u003ci\u003eCorina Schütt, Barbara Froesch and Ernst Hafen\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e6. Mechanism of Action in Model Organisms: Interfacing Chemistry, Genetics and Genomics (\u003ci\u003ePamela M. Carroll, Kevin Fitzgerald and Rachel Kindt\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e7. Gene tics and Genomics in the Zebrafish: from Gene to Function and Back (\u003ci\u003eStefan Schulte-Merker\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e8. Lipid Metabolism and Signaling in Zebrafish (\u003ci\u003eShiu-Ying Ho, Steven A. Farber and Michael Pack\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e9. Chemical Mutagenesis in the Mouse: a Powerful Tool in Drug Target Identification and Validation (\u003ci\u003eAndreas Russ, Neil Dear, Geert Mudde, Gabriele Stumm, Johannes Grosse, Andreas Schröder, Reinhard Sedlmeier, Sigrid Wattler and Michael Nehls\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e10. Saturation Screening of the Druggable Mammalian Genome (\u003ci\u003eHector Beltrandelrio, Francis Kern, Thomas Lanthorn, Tamas Oravecz, James Piggott, David Powell, Ramiro Ramirez-Solis, Arthur T. Sands and Brian Zambrowicz\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eIndex.\u003c\/p\u003e  \"...an invaluable resource for an researcher in the academic or private sector...essential for any graduate level course...\" (Drug Discovery Today, Vol 9(7), April 2004)  \u003cp\u003e\"...summarised the major organisms of use in this area together with their relative strengths and weaknesses...\" (British Society of Cell Biology Newsletter, Summer 2004)\u003c\/p\u003e  \u003cp\u003e\u003cstrong\u003ePamela M. Carroll\u003c\/strong\u003e is the editor of \u003cem\u003eModel Organisms in Drug Discovery\u003c\/em\u003e, published by Wiley. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eKevin Fitzgerald\u003c\/strong\u003e is the editor of \u003cem\u003eModel Organisms in Drug Discovery\u003c\/em\u003e, published by Wiley.   Fruit flies are \"little people with wings\" goes the saying in the scientific community, ever since the completion of the Human Genome Project and its revelations about the similarity amongst the genomes of different organisms. It is humbling that most signaling pathways which \"define\" humans are conserved in \u003ci\u003eDrosophila\u003c\/i\u003e, the common fruit fly. Feed a fruit fly caffeine and it has trouble falling asleep; feed it antihistamines and it cannot stay awake. A \u003ci\u003eC. elegans\u003c\/i\u003e worm placed on the antidepressant flouxetine has increased serotonin levels in its tiny brain. Yeast treated with chemotherapeutics stop their cell division. Removal of a single gene from a mouse or zebrafish can cause the animals to develop Alzheimer’s disease or heart disease. These organisms are utilized as surrogates to investigate the function and design of complex human biological systems.  \u003c\/p\u003e\u003cp\u003eAdvances in bioinformatics, proteomics, automation technologies and their application to model organism systems now occur on an industrial scale. The integration of model systems into the drug discovery process, the speed of the tools, and the \u003ci\u003ein vivo\u003c\/i\u003e validation data that these models can provide, will clearly help definition of disease biology and high-quality target validation. Enhanced target selection will lead to the more efficacious and less toxic therapeutic compounds of the future.\u003c\/p\u003e \u003cp\u003eThis book will be of interest to geneticists, bioinformaticians, pharmacologists, molecular biologists and people working in the pharmaceutical industry, particularly genomics.\u003c\/p\u003e","brand":"Wiley","offers":[{"title":"Default Title","offer_id":47989635383525,"sku":"NP9780470848937","price":236.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1842\/7735\/files\/9780470848937.jpg?v=1761784899","url":"https:\/\/k12savings.com\/products\/model-organisms-in-drug-discovery-isbn-9780470848937","provider":"K12savings","version":"1.0","type":"link"}